業績

業績 2020

論文

  • Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
    Oka Y, Hamada M, Nakazawa Y, Muramatsu H, Okuno Y, Higasa K, Shimada M, Takeshima H, Hanada K, Hirano T, Kawakita T, Sakaguchi H, Ichimura T, Ozono S, Yuge K, Watanabe Y, Kotani Y, Yamane M, Kasugai Y, Tanaka M, Suganami T, Nakada S, Mitsutake N, Hara Y, Kato K, Mizuno S, Miyake N, Kawai Y, Tokunaga K, Nagasaki M, Kito S, Isoyama K, Onodera M, Kaneko H, Matsumoto N, Matsuda F, Matsuo K, Takahashi Y, Mashimo T, Kojima S, Ogi T.
    Sci Adv. 2020 Dec 18;6(51):eabd7197. doi: 10.1126/sciadv.abd7197.
  • CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia.
    Fujihara K, Yamada K, Ichitani Y, Kakizaki T, Jiang W, Miyata S, Suto T, Kato D, Saito S, Watanabe M, Kajita Y, Ohshiro T, Mushiake H, Miyasaka Y, Mashimo T, Yasuda H, Yanagawa Y.
    Transl Psychiatry. 2020 Dec 8;10(1):426. doi: 10.1038/s41398-020-01108-6.
  • Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
    Hayase Y, Amano S, Hashizume K, Tominaga T, Miyamoto H, Kanno Y, Ueno-Inoue Y, Inoue T, Yamada M, Ogata S, Balan S, Hayashi K, Miura Y, Tokudome K, Ohno Y, Nishijo T, Momiyama T, Yanagawa Y, Takizawa A, Mashimo T, Serikawa T, Sekine A, Nakagawa E, Takeshita E, Yoshikawa T, Waga C, Inoue K, Goto YI, Nabeshima Y, Ihara N, Yamakawa K, Taya S, Hoshino M.
    Acta Neuropathol Commun. 2020 Nov 30;8(1):206. doi: 10.1186/s40478-020-01082-6.
  • Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo.
    Yoshimi K, Yamauchi Y, Tanaka T, Shimada T, Sato M, Mashimo T.
    Lab Invest. 2020 Sep 5. doi: 10.1038/s41374-020-00482-5.
  • Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan.
    Yamaguchi T, Uchida E, Okada T, Ozawa K, Onodera M, Kume A, Shimada T, Takahashi S, Tani K, Nasu Y, Mashimo T, Mizuguchi H, Mitani K, Maki K.
    Hum Gene Ther. 2020 Oct;31(19-20):1043-1053. doi: 10.1089/hum.2020.156.
  • Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9.
    Hashikawa Y, Hayashi R, Tajima M, Okubo T, Azuma S, Kuwamura M, Takai N, Osada Y, Kunihiro Y, Mashimo T, Nishida K.
    Sci Rep. 2020 Jun 19;10(1):9957. doi: 10.1038/s41598-020-66780-6.
  • Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
    Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A.
    Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711.
  • LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) Deletion Has Protective Effects on Stroke in the Genetic Background of Stroke-Prone Spontaneously Hypertensive Rat.
    Liang YQ, Kakino A, Matsuzaka Y, Mashimo T, Isono M, Akamatsu T, Shimizu H, Tajima M, Kaneko T, Li L, Takeuchi F, Sawamura T, Kato N.
    Stroke. 2020 May 1:STROKEAHA120029421. doi: 10.1161/STROKEAHA.120.029421.
  • Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
    Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T.
    Cell. 2020 Feb 26. pii: S0092-8674(20)30154-9. doi: 10.1016/j.cell.2020.02.010
  • Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
    Konishi S, Tanaka N, Mashimo T, Yamamoto T, Sakuma T, Kaneko T, Tanaka M, Izawa T, Yamate J, Kuwamura M.
    Exp Anim. 2020 Jan 29;69(1):26-33. doi: 10.1538/expanim.19-0005. Epub 2019 Jul 23.

著書・総説

  • ゲノム編集技術CRISPR-Cas3とその遺伝子治療および診断への応用
    藤井智明、吉見一人、真下知士
    実験医学増刊「新規の創薬モダリティ 細胞医療」 Vol.38, No.17, p49-54, 2020
  • ゲノム編集医療－技術開発・治療応用戦略を中心に
    真下知士、吉見一人
    遺伝子医学 第10巻第4号（通巻34号）2020年10月
  • 高血圧関連疾患モデル動物作製の現状と展望
    山内祐子、真下知士
    日本臨牀増刊号「高血圧学（上）」 78巻、p379-384、2020年6月30日
  • ゲノム編集を用いた遺伝子治療 特集編集・総論
    真下知士
    Precision Medicine Vol.3 No.6、2020年6月25日
  • CRISPR-Cas3を用いた新しいゲノム編集
    吉見一人、真下知士
    医学のあゆみ「ゲノム編集の未来」 Vol.273(9), p751-755, 2020年5月30日
  • ゲノム編集技術を用いた遺伝子改変ラットの作製
    宮坂佳樹、真下知士
    医学のあゆみ「ゲノム編集の未来」 Vol.273(9), p785-794, 2020年5月30日