業績（2001~2010年） | 東京大学医科学研究所実験動物研究施設先進動物ゲノム研究分野

論文

Survey of live laboratory animals reared in Japan (2009).
Yagami K, Mashimo T, Sekiguchi F, Sugiyama F, Yamamura K, Serikawa T.
Exp Anim 59(4):531-535, 2010
Scn1a missense mutation impairs GABA(A) receptor-mediated synaptic transmission in the rat hippocampus.
Ohno Y, Sofue N, Ishihara S, Mashimo T, Sasa M, Serikawa T.
Biochem Biophys Res Commun. 400(1):117-22, 2010
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases.
Mashimo T, Takizawa A, Voigt B, Yoshimi K, Hiai H, Kuramoto T, Serikawa T.
PLoS One 5(1):e8870. 2010
A missense mutation of the gene encoding voltage-dependent sodium channel Nav1.1 confers susceptibility to febrile seizures in rats.
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
J Neuroscience 30(16):5744-5753, 2010
Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat.
Kuramoto T, Nakanishi S, Yamasaki K, Kumafuji K, Sakakibara Y, Neoda Y, Takizawa A, Kaneko T, Okajima R, Otsuki M, Hashimoto R, Voigt B, Mashimo T, Serikawa T.
IBC, 2(12):1-7, 2010
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat.
Yoshimi K, Tanaka T, Takizawa A, Kato M, Hirabayashi M, Mashimo T, Serikawa T, Kuramoto T.
Cancer Sci. 100(11):2022-7, 2009
An informative set of SSLP markers and genomic profiles in the rat MHC, the RT1 complex.
Takagi Y, Kuramoto T, Voigt B, Tsurumi T, Nakanishi S, Mashimo T, Masui N, Serikawa T:
Immunogenetics 61(3):189-197, 2009
Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.
Mashimo T, Hadjebi O, Amair-Pinedo F, Tsurumi T, Langa F, Serikawa T, Sotelo C, Guénet JL, Rosa JL.
PLoS Genet. 5(12):e1000784, 2009
Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits.
Voigt B, Kuramoto T, Mashimo T, Tsurumi T, Sasaki Y, Hokao R, Serikawa T:
Physiological Genomics 32(3): 335-342, 2008
SNP and haplotype mapping for genetic analysis in the rat.
STAR Consortium; Saar K, Beck A, Bihoreau MT, Birney E, Brocklebank D, Chen Y, Cuppen E, Demonchy S, Dopazo J, Flicek P, Foglio M, Fujiyama A, Gut IG, Gauguier D, Guigo R, Guryev V, Heinig M, Hummel O, Jahn N, Klages S, Kren V, Kube M, Kuhl H, Kuramoto T, Kuroki Y, Lechner D, Lee YA, Lopez-Bigas N, Lathrop GM, Mashimo T, Medina I, Mott R, Patone G, Perrier-Cornet JA, Platzer M, Pravenec M, Reinhardt R, Sakaki Y, Schilhabel M, Schulz H, Serikawa T, Shikhagaie M, Tatsumoto S, Taudien S, Toyoda A, Voigt B, Zelenika D, Zimdahl H, Hubner N:
Nature Genetics, 40(5): 560-566, 2008
An ENU-induced mutant archive for gene targeting in rats.
Mashimo T, Yanagihara K, Tokuda S, Voigt B, Takizawa A, Nakajima R, Kato M, Hirabayashi M, Kuramoto T, Serikawa T.
Nature Genetics, 40(5): 514-515, 2008
A comprehensive QTL analysis of serum cholesterol levels before and after a high-cholesterol diet in SHRSP.
Mashimo T, Ogawa H, Cui ZH, Harada Y, Kawakami K, Masuda J, Yamori Y, Nabika T.
Physiological Genomics 30:95-101, 2007
A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.
Mashimo T, Voigt B, Tsurumi T, Naoi K, Nakanishi S, Yamasaki K, Kuramoto T and Serikawa T.
BMC Genetics 7:19, 2006
Two quantitative trait loci affecting progressive hearing loss in 101/H mice.
Mashimo T, Erven AE, Spiden SL, Guenet JL, Steel KP.
BMC Genetics 17(8):841-50, 2006
The 2',5' oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.
Kajaste-Rudnitski A, Mashimo T, Frenkiel MP, Guenet JL, Lucas M, Despres P.
J Biol Chem 281(8):4624-37, 2006
Rat Phenome Project: The untapped potential of existing rat strains.
Mashimo T, Voigt B, Kuramoto T, Serikawa T.
Appl J Physiol 98, 371-379, 2005
Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat.
Inomata H, Watanabe T, Iizuka Y, Liang YQ, Mashimo T, Nabika T, Ikeda K, Yanai K, Gotoda T, Yamori Y, Isobe M, Kato N.
Hypertens Res 28(3):273-81, 2005
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World.
Lucas M, Frenkiel MP, Mashimo T, Guenet JL, Deubel V, Despres P, Ceccaldi PE.
Viol J 1(1):9, 2004
Structural and Functional Genomics, and Evolutionary Relationships in the Cluster of Genes Encoding Murine 2’-5’-Oligoadenylate Synthetases.
Mashimo T, Glaser P, Lucas M, Simon-Chazottes D, Ceccaldi PE, Montagutelli X, Desprès P, Guénet JL.
Genomics 82(5): 537-552, 2003
Infection of mouse neurons by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.
Lucas M, Mashimo T, Frenkiel MP, Simon-Chazottes D, Montagutelli X, Ceccaldi PE, Guénet JL, Desprès P.
Immunol Cell Biol 81: 230-236, 2003
Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model.
Kato N, Nabika T, Liang YQ, Mashimo T, Inomata H, Watanabe T, Yanai K, Yamori Y, Yazaki Y, Sasazuki T.
Hypertension 42(6):1191-1197, 2003
Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony.
Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y.
J Hypertens 21: 1-9, 2003
Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.
Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X, Thalmann I, Thalmann R, Ornitz DM.
Hum Mol Genet 12(7): 777-789, 2003
A nonsense mutation in the gene encoding 2’-5’-Oligoadenylate Synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.
Mashimo T, Lucas M, Simon-Chazottes D, Frenkiel MP, Montagutelli X, Ceccaldi PE, Deubel V, Guénet JL, Desprès P.
Proc. Natl. Acad. Sci. USA 99: 11311-11316, 2002

著書・総説

便利なデータべース紹介とその使用法＋便利な受託機関紹介とその使用法
真下知士、中釜斉（編）、北田一博（編）、庫本高志（編）
無敵のバイオテクニカルシリーズ「マウス・ラット実験ノート」 p139-155, 2009
ラット：多様なニーズに応える実験動物
真下知士、芹川忠夫
細胞工学別冊「バイオリソース＆データベース活用術」 p146-148, 2009
実験用ラットの有用性－ナショナルバイオリソースプロジェクト「ラット」
真下知士、直井国子、庫本高志、芹川忠夫
遺伝 59(3): 79-84, 2005

業績

業績 2001~2010年

論文

Survey of live laboratory animals reared in Japan (2009).

Scn1a missense mutation impairs GABA(A) receptor-mediated synaptic transmission in the rat hippocampus.

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases.

A missense mutation of the gene encoding voltage-dependent sodium channel Nav1.1 confers susceptibility to febrile seizures in rats.

Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat.

Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat.

An informative set of SSLP markers and genomic profiles in the rat MHC, the RT1 complex.

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.

Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits.

SNP and haplotype mapping for genetic analysis in the rat.

An ENU-induced mutant archive for gene targeting in rats.

A comprehensive QTL analysis of serum cholesterol levels before and after a high-cholesterol diet in SHRSP.

A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.

Two quantitative trait loci affecting progressive hearing loss in 101/H mice.

The 2',5' oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.

Rat Phenome Project: The untapped potential of existing rat strains.

Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat.

The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World.

Structural and Functional Genomics, and Evolutionary Relationships in the Cluster of Genes Encoding Murine 2’-5’-Oligoadenylate Synthetases.

Infection of mouse neurons by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.

Isolation of a chromosome 1 region affecting blood pressure and vascular disease traits in the stroke-prone rat model.

Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony.

Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.

A nonsense mutation in the gene encoding 2’-5’-Oligoadenylate Synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.

著書・総説

便利なデータべース紹介とその使用法＋便利な受託機関紹介とその使用法

ラット：多様なニーズに応える実験動物

実験用ラットの有用性－ナショナルバイオリソースプロジェクト「ラット」