業績

業績 2019

論文

  • Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.
    Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y.
    Stem Cell Reports. 2019 Dec 10;13(6):992-1005. doi: 10.1016/j.stemcr.2019.11.002.
  • CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.
    Morisaka H, Yoshimi K, Okuzaki Y, Gee P, Kunihiro Y, Sonpho E, Xu H, Sasakawa N, Naito Y, Nakada S, Yamamoto T, Sano S, Hotta A, Takeda J, Mashimo T.
    Nat Commun. 2019 Dec 6;10(1):5302. doi: 10.1038/s41467-019- 13226-x.
  • Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.
    Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y,Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.
    Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2.
  • Null mutation of the endothelin receptor type B gene causes embryonic death in the GK rat.
    Wang J, Dang R, Miyasaka Y, Hattori K, Torigoe D, Okamura T, Tag-Ei-Din-Hassan HT, Morimatsu M, Mashimo T, Agui T.
    PLoS One. 2019 Jun 6;14(6):e0217132. doi: 10.1371/journal.pone.0217132.
  • Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.
    Serikawa T, Kunisawa N, Shimizu S, Kato M, Alves Iha H, Kinboshi M, Nishikawa H, Shirakawa Y, Voigt B, Nakanishi S, Kuramoto T, Kaneko T, Yamamoto T, Mashimo T, Sasa M, Ohno Y.
    Behav Brain Res. 2019 Sep 2;369:111922. doi: 10.1016/j.bbr.2019.111922.
  • Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
    Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, Takahashi R, Ohno Y.
    Int J Mol Sci. 2019 Feb 26;20(5). pii: E1013. doi: 10.3390/ijms20051013.
  • Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
    Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.
    Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.
  • Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
    Mahal Z, Fujikawa K, Matsuo H, Zahid HM, Koike M, Misumi M, Kaneko T, Mashimo T, Ohara H, Nabika T.
    Hypertens Res. 2019 May;42(5):610-617. doi: 10.1038/s41440-019-0207-9. Epub 2019 Jan 17.
  • Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
    Mahal Z, Fujikawa K, Matsuo H, Zahid HM, Koike M, Misumi M, Kaneko T, Mashimo T, Ohara H, Nabika T.
    Hypertens Res. 2019 May;42(5):610-617. doi: 10.1038/s41440-019-0207-9. Epub 2019 Jan 17.

著書・総説

  • 疾患モデルラットの国内外トレンド
    真下知士
    実験動物技術 一般社団法人日本実験動物技術者協会 Vol.54, No.2, p91-95, 2019年12月
  • 実験動物としてのラットの有用性 免疫不全ラットの開発と利用
    山内祐子、吉見一人、真下知士
    Labio 21 日本実験動物協会 No.78 p16-19、2019年12月
  • ラット受精卵でのゲノム編集
    吉見一人、真下知士
    実験医学別冊「ゲノム編集実験スタンダード」 2019年12月
  • ゲノム編集技術によるモデル動物の作製
    真下 知士
    メディカル・サイエンス・ダイジェスト「ゲノム編集の最近の進歩」 Vol.45, No.9, p17-20, 2019年07月20日