Foxp3+ regulatory T (Treg) cells play an indispensable role for the maintenance
of immune and tissue homeostasis. The transcription factor Foxp3 and T cell
receptor (TCR) signals represent key determinants of Treg cell differentiation
and function. Treg cells require TCR signals at two distinct phases; one is for
the induction and epigenetic imprinting of Foxp3 expression during thymic and
extrathmic Treg cell differentiation, and the other for their differentiation to
effector states and adaptation to tissue environments. In my talk, I will show
evidence that Foxp3 and TCR signals interact to control the phenotype and
function of Treg cells. The molecular mechanisms of their interaction and its
implication in antigen-specific tolerance to tissues will be discussed.
Molecular control of regulatory T cell development and function by the transcription factor Foxp3 and T cell receptor signals
学友会セミナー
開催情報
| 開催日時 | 2020年9月4日（金）14：00～15:00 |
|---|---|
| 開催場所 | ZoomによるWEB開催（聴講希望者はvaccine@ims.u-tokyo.ac.jpまで） |
| 講師 | 堀 昌平（Shohei Hori） |
| 所属・職名 | Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo ／ Professor |
| 国名 | Japan |
| 演題 | Molecular control of regulatory T cell development and function by the transcription factor Foxp3 and T cell receptor signals |
| 世話人 | 主たる世話人：石井 健（ワクチン科学分野） 世話人：三宅 健介（感染遺伝学分野） |