Role of kisspeptin/GPR54 in hippocampal function
学友会セミナー:2007年5月31日
開催日時: | 2007年5月31日 16:00~ |
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開催場所: | クレストホール 大会議室(2階) |
講師: | Amy C. Arai, Ph.D. (新井えいみ博士) |
所属: | Associate Professor,
President, Society for Neurosciece Sangamon Chapter Department of Pharmacology Southern Illinois University School of Medicine |
演題: | Role of kisspeptin/GPR54 in hippocampal function |
概要: | Kisspeptins are peptides encoded by the antimetastatic KiSS-1 gene that was originally discovered in melanomas. Subsequent studies found that kisspeptins are ligands for the orphan G-protein coupled receptor GPR54. Both ligand and receptor were also identified in the placenta and pituitary as well as in various brain regions such as the hypothalamus, amygdala and hippocampal dentate gyrus. Based on recent insights in the field of neuroendocrinology, the KiSS-1/GPR54 system is now considered as being the gatekeeper for the release of gonadotropic hormone and for the onset of puberty. However, its function in the hippocampus is not yet known. This presentation will show that kisspeptins have major effects on excitatory synaptic transmission in granule cells of the dentate gyrus and that specific postsynaptic signaling mechanisms are involved. The presentation also includes our recent findings on the regulation of KiSS-1 and GPR54 gene expression in the hippocampus in in vivo and in vitro preparations.
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世話人: | ○関野 祐子 、 渡辺すみ子 |