The Dendritic Cell Vaccination in AIDSGCOE Program Seminar(Global Education Seminar)
学友会セミナー:2012年08月03日
開催日時: | 2012年08月03日 16:00-17:00 |
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開催場所: | Auditorium, 1st building |
講師: | Dr. Zwi Berneman |
所属: | Antwerp University Hospital,University of Antwerp |
演題: | "The Dendritic Cell Vaccination in AIDS"GCOE Program Seminar(Global Education Seminar) |
概要: | Control of HIV-1 replication, sometimes leading to undetectable viremia in the absence of highly active antiretroviral therapy (HAART), has been associated with magnitude and breadth of T-cell response preferentially targeting Gag, T-cell polyfunctionality and proliferation and direct in vitro CD8+ T-cell HIV-suppressive capacity. In an effort to raise these antiviral T-cell responses, we performed therapeutic dendritic cell (DC) vaccination in 6 HIV-1 subtype B-infected patients, stable under HAART. DC were derived from autologous monocytes, transfected with HIV-1 strain IIIB-derived mRNA encoding Gag and a chimeric Tat-Rev-Nef protein and administered intradermally and subcutaneously, while patients remained on HAART.
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世話人: | ○Arinobu Tojo, M.D.,Ph.D. (Division of Molecular Therapy),
Toshiki Watanabe, M.D.,Ph.D. (MGS, Laboratory of Tumor Cell Biology) |