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領域代表者：岩間厚志

千葉大学大学院医学研究院
細胞分子医学 教授

〒260-8670
千葉市中央区亥鼻1-8-1

E-mail
matsumura0405@chiba-u.jp

研究成果：原著論文
2014年 2015年 2016年 2017年
原著論文 総説・図書(英文)
2017年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A02. 幹細胞の老化と疾患
【計画班】
  1. Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T*. Visualization and Targeting of LGR5+ Human Colon Cancer Stem Cells. Nature. 545:187-192. 2017.
  2. Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi H, Yako Y, Kamasaki T, Nishikawa A, Kameda I, Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T, Miyazaki J, Duchen MR, Nam J, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, Nishida E, Fujioka Y, Ohba Y, Sato T, Fujita Y. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nature Cell Biology. 19:530-541. 2017.
  3. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017 in press. [Epub ahead of print]
  4. Loomans CJM, Giuliani NW, Balak J, Ringnalda F,van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJP. Expansion of adult human pancreatic tissue yields organoids harbouring progenitor cells with endocrine differentiation potential. Science Translational Medicine. 2017 in press.
  5. Yoshizato T, Nannya Y, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Suzuki H, Nagata Y, Sato Y, Kakiuchi N, Matsuo K, Onizuka M, Kataoka K, Chiba K, Tanaka H, Ueno H, Nakagawa MM, Przychodzen B, Haferlach C, Kern W, Aoki K, Itonaga H, Kanda Y, Sekeres MA, Maciejewski JP, Haferlach T, Miyazaki Y, Horibe K, Sanada M, Miyano S, Makishima H, Ogawa S. Impact of genetic alterations in stem-cell transplantation for myelodysplasia and secondary acute myeloid leukemia. Blood. 129:2347-2358. 2017.
  6. Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H. Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. Blood. 129:2148-2160. 2017.
  7. Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP. Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. Int J Oncol. 50:863-872. 2017.
  8. Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S. Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. Genet Med. 2017 in press. [Epub ahead of print]
  9. Nadeau SA, An W, Mohapatra BC, Mushtaq I, Bielecki TA, Luan H, Zutshi N, Ahmad G, Storck MD, Sanada M, Ogawa S, Band V, Band H. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene. J Biol Chem. 292:3666-3682. 2017.
  10. Ding LW, Sun QY, Tan KT, Chien W, Thippeswamy AM, Juh AYE, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Lim SL, Liu LZ, Madan V, Jiang YY, Xu L, Sanada M, Fernández LT, Preethi H, Lill M, Kantarjian H, Kornblau SM, Miyano S, Ogawa S, Liang DC, Shih LY, Yang H, Koeffler HP. Mutational landscape of pediatric acute lymphoblastic leukemia. Cancer Research. 77:390-400. 2017.
  11. *Arai H, Yamashita S, Yokote K, Araki E, Suganami H, Ishibashi S, K-877 Study Group. (2017) Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia. Atherosclerosis. 261:144-152.
  12. Ide K, Baba Y, *Takemoto M, Koide H, Ide S, Yamaga M, Kobayashi K, Yokote K. (2017) Case of Werner syndrome complicated by adrenal insufficiency due to hypothalamic dysfunction. Geriatr Gerontol Int. 17:346-347.
  13. Hattori A, *Takemoto M, Tokuyama H, Koshizaka M, Yokote K. (2107) Sitagliptin but not alpha glucosidase inhibitor reduced the serum soluble CD163, a marker for activated macrophage, in individuals with type 2 diabetes mellitus. Diabetes Res Clin Pract. 126:138-143.
  14. Hayashi A, Maeda Y, *Takemoto M, Tokuyama H, Koide H, Kitahara A, Hayashi H, Kitamoto T, Yamaga M, Kobayashi K, Yokote K. (2017) Outcomes of laparoscopic sleeve gastrectomy in elderly obese Japanese patients. Geriatr Gerontol Int. in press. [Epub ahead of print]
  15. Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Kanahara N, Niitsu T, Shiina A, Hashimoto T, Sato Y, Yokote K, Murano S, Kimura H, Hosoda Y, Shimizu E, Iyo M, *Nakazato M. (2017) Psychiatry Clin Neurosci. 71:124-134.
  16. Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, *Iwama A. (2017) Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia. 31:861-871.
  17. Endo Y, Yokote K, *Nakayama T. The obesity-related pathology and Th17 cells. (2017) Cell Mol Life Sci. 74:1231-1245.
  18. Yokote K, Chanprasert S, Lee L, Eirich K, Takemoto M, Watanabe A, Koizumi N, Lessel D, Mori T, Hisama FM, Ladd PD, Angle B, Baris H, Cefle K, Palanduz S, Ozturk S, Chateau A, Deguchi K, Easwar TK, Federico A, Fox A, Grebe TA, Hay B, Nampoothiri S, Seiter K, Streeten E, Piña-Aguilar RE, Poke G, Poot M, Posmyk R, Martin GM, Kubisch C, Schindler D, *Oshima J. (2017) WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. Hum Mutat. 38:7-15.
  19. K. Miyawaki, H. Iwasaki, T. Jiromaru, H. Kusumoto, A. Yurino, T. Sugio, Y. Uehara, J. Odawara, S. Daitoku, Y. Kunisaki, Y. Mori, Y. Arinobu, H. Tsuzuki, Y. Kikushige, T. Iino, K. Kato, K. Takenaka, T. Miyamoto, T. Maeda, *K. Akashi, Identification of unipotent megakaryocyte progenitors in human hematopoiesis. Blood. in press (2017). [Epub ahead of print]
  20. S. Shimoji, D. Hashimoto, H. Tsujigiwa, K. Miyawaki, K. Kato, S. Takahashi, R. Ogasawara, T. Jiromaru, H. Iwasaki, T. Miyamoto, K. Akashi, *T. Teshima, Graft-versus-host disease targets ovary and causes female infertility in mice. Blood. 129. 1216-1225 (2017).
  21. *T. Miyamoto, T. Fukuda, M. Nakashima, T. Henzan, S. Kusakabe, N. Kobayashi, J. Sugita, T. Mori, M. Kurokawa, S. I. Mori, Donor Lymphocyte Infusion for Relapsed Hematological Malignancies after Unrelated Allogeneic Bone Marrow Transplantation Facilitated by the Japan Marrow Donor Program. Biol Blood Marrow Transplant. 23:938-944. 2017.
  22. T. Tochigi, T. Aoki, *Y. Kikushige, T. Kamimura, Y. Ito, T. Shima, T. Yamauchi, Y. Mori, G. Yoshimoto, K. Kamezaki, K. Kato, K. Takenaka, H. Iwasaki, K. Akashi, T. Miyamoto, Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs. Int J Hematol. 105. 423-432. 2017.
  23. M. Minami, T. Arita, H. Iwasaki, T. Muta, T. Aoki, K. Aoki, S. Yamasaki, T. Matsushima, K. Kato, K. Takenaka, K. Tanimoto, T. Kamimura, R. Ogawa, K. Akashi, *T. Miyamoto, Comparative analysis of pulmonary hypertension in patients treated with imatinib, nilotinib and dasatinib. Br J Haematol. 177:578-587. 2017.
  24. Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yohko Y, Tsuchida M, Iwama A, Hayano T and *Minamino T. Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. Oncotarget. 8:34045-34056. 2017.
  25. Aoyama N, Nishinari M, Ohtani S, Kanai A, Noda C, Hirata M, Miyamoto A, Watanabe M, Minamino T, Izumi T, Ako J. Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis. Heart Vessels. 2017 Mar 29. doi: 10.1007/s00380-017-0968-5. [Epub ahead of print]
  26. Iijima K, Ishida N, Izumi D, Minamino T. Inappropriate inhibition of biventricular pacing due to diaphragmatic myopotentials amplified by the selectable sensing filter. Europace. 2017 Mar 13. doi: 10.1093/europace/euw372. [Epub ahead of print]
  27. Yamamoto KN, Yachida S, Nakamura A, Niida A, Oshima M, De S, Rosati LM, Herman JM, Iacobuzio-Donahue CA, Haeno H. (Accepted) Personalized Management of Pancreatic Ductal Adenocarcinoma Patients Through Computational Modeling. Cancer Res. [Epub ahead of print]
【公募班】
  1. *Horiguchi H, *Endo M, Kawane K, Kadomatsu T, Terada K, Morinaga J, Araki K, Miyata K, *Oike Y. (2017). ANGPTL2 expression in intestinal stem cell niche controls epithelial regeneration and homeostasis. EMBO J. 36:409-424.
  2. Kim, YG., Sakamoto, K., Seo1, SU., Pickard, JM., Gillilland, M.G. 3rd, Pudlo, NA., Hoostal, M., Li, X., Feehley, T., Stefka, AT., Schmidt, TM., Martens, EC., Fukuda, S., Inohara, N., Nagler, CR., *Núñez, G. Neonatal acquisition of clostridia species protects against colonization by bacterial pathogens. Science. 356:315-319.
  3. #Mishima, E., #Fukuda, S., Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., *Abe, T. Evaluation of the impact of gut microbiota on uremic solute accumulation by CE-TOFMS-based metabolomics approach. Kidney Int. S0085-2538(17)30116-3. (#equal contribution)
  4. *Nishihara, T., Inoue, J., Tabata, S., Murakami, S., Ishikawa, T., Saito, N., Fukuda, S., Tomita, M., Soga, T. Synthetic biomarker design using analyte-responsive acetaminophen. Chembiochem. 18:910-913.
  5. Jia, H., Hanate, M., Aw, W., Itoh, H., Saito, K., Kobayashi, S., Hachimura, S., Fukuda, S., Tomita, M., Hasebe, Y., *Kato, H. (2017). Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis. Sci. Rep. 7:43993.
  6. Yang, JY., Lee, YS., Kim, Y., Lee, SH., Ryu, S., Fukuda, S., Hase, K., Yang, CS., Lim, HS., Kim, MS., Kim, HM., Ahn, SH., Kwon, BE., Ko, HJ., *Kweon, MN. (2017). Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice. Mucosal Immunol. 10: 104-116.
  7. *Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 25:412-427. 2017.
  8. #Pierini A, #Nishikii H, Baker J, Kimura T, Kwon H-S, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, *Negrin RS. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. Nat Commun. 8:15068. (#equal contribution)
  9. Nguyen TB, *Sakata-Yanagimoto M, Asabe Y, Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyoshi H, Ohshima K, Minowa T, Ogawa S, Noguchi M, *Chiba S. Identification of cell-type-specific mutations in nodal T-cell lymphomas. Blood Cancer J. 7:e516. 2017
  10. Nishizawa S, *Sakata-Yanagimoto M, Hattori K, Muto H, Nguyen T, Izutsu K, Yoshida K, Ogawa S, Nakamura N, *Chiba S. BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma. Int J Hematol. 105:465-9. 2017.
  11. Michikawa T, Morokuma S, Yamazaki S, Fukushima K, Kato K , Nitta H. Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan. Epidemiology. 28:190-196. 2017.
  12. Yamauchi T, *Nishiyama M, Moroishi T, Kawamura A, *Nakayama KI. (2017). FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells. Mol. Cell. Biol. (査読有) 37: e00470-16. (*Corresponding author)
  13. Shimojima M, Yuasa S, Motoda C, Yozu G,Nagai T, Ito S, Lachmann M, Kashimura S, Takei M, Kusumoto D, Kunitomi A, Hayashiji N, Seki T, Tohyama S, Hashimoto H, Kodaira M, Egashira T, Hayashi K, Nakanishi C, Sakata K, Yamagishi M, Fukuda K. Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient. Scientific Reports. 7:44312. 2017.
  14. Ikemura N, Sawano M, Shiraishi Y, Ueda I, Miyata H, Numasawa Y, Noma S, Suzuki M, Momiyama Y, Inohara T, Hayashida K, Yuasa S, Maekawa Y, Fukuda K, Kohsaka S. Barriers Associated With Door-to-Balloon Delay in Contemporary Japanese Practice. Circ J. 81:815-822. 2017.
  15. Fukuoka R, Kohno T, Kohsaka S, Yanagisawa R, Kawakami T, Hayashida K, Kanazawa H, Yuasa S, Maekawa Y, Sano M, Fukuda K. Nocturnal intermittent hypoxia and short sleep duration are independently associated with elevated C-reactive protein levels in patients with coronary artery disease. Sleep Med. 29:29-34. 2017.
  16. Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Horie M, Kamiya K, Fukuda K. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes. Biochemistry and Biophysics Reports. 2017 Mar:9:245-256.
  17. Kimura M, Fujisawa T, Aizawa Y, Matsuhashi N, Ito S, Nakajima K, Kashimura S, Kunitomi A, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Yuasa S, Takatsuki S, Kosaki K, Fukuda K. An RyR2 mutation found in a family with a short-coupled variant of torsade de pointes. Int J Cardiol. 227:367-369. 2017.
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