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領域代表者：岩間厚志

千葉大学大学院医学研究院
細胞分子医学 教授

〒260-8670
千葉市中央区亥鼻1-8-1

E-mail
matsumura0405@chiba-u.jp

研究成果：原著論文
2014年 2015年 2016年 2017年
原著論文 総説・図書(英文)
2015年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A02. 幹細胞の老化と疾患
【計画班】
  1. Fujii M, Matano M, Nanki K, *Sato T. Effcient gene engineering of human intestinal organoid using electroporation. Nature protocol. 2015;10:1474-85.
  2. Seishima R, Wada T, Tsuchihashi K, Okazaki S, Yoshikawa M, Oshima H, Oshima M, Sato T, Hasegawa H, Kitagawa Y, Goldenring JR, Saya H, *Nagano O. Ink4a/Arf-dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-dependent Gastric Tumorigenesis. Cancer Prev Res. 2015; 8:492-501.
  3. Matano M, Date S, Shimokawa M, Takano A, Fujii M, Ohta Y, Watanabe T, Kanai T, *Sato T.　Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nature Medicine. 2015;21:256-62.
  4. Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, *Sato T, Sato H, Taketo MM, Oshima M. Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. Cancer Res. 2015;75:766-76. doi: 10.1158/0008-5472.CAN-14-2036.
  5. *Pin C, Parker A, Gunning AP, Ohta Y, Johnson IT, Carding SR, Sato T.　An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. Integr Biol (Camb). 2015 Feb;7(2):213-28. doi: 10.1039/c4ib00236a.
  6. *Tagawa M, Nanba H, Suzuki H, Nakamura Y, Uchiyama H, Ochiai S, Terunuma M, Yahata K, Minamino T. Ventricular Rhythm and Hypotension in a Patient with Pheochromocytoma-induced Myocardial Damage and Reverse Takotsubo Cardiomyopathy. Intern Med 2015; 54: 2343-9.
  7. *Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W. Effect of a Low-Intensity Pulsed Ultrasound Device, SX-1001, on Clinical Symptoms in Buerger Disease With Limb Ischemia. Int Heart J 2015; 56: 632-8.
  8. Sonoda K, *Watanabe H, Hisamatsu T, Ashihara T, Ohno S, Hayashi H, Horie M, Minamino T. High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia. Ann Noninvasive Electrocardiol 2015.
  9. Hayashi Y, *Hanawa H, Jiao S, Hasegawa G, Ohno Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T. Elevated Endomyocardial Biopsy Macrophage-Related Markers in Intractable Myocardial Diseases. Inflammation 2015.
  10. Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, *Minamino T. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol 2015; 85: 183-98.
  11. *Iijima K, Chinushi M, Saitoh O, Hasegawa K, Sonoda K, Yagihara N, Sato A, Izumi D, Watanabe H, Furushima H, Aizawa Y, Minamino T. Frequency characteristics and associations with the defibrillation threshold of ventricular fibrillation in patients with implantable cardioverter defibrillators. Intern Med 2015; 54: 1175-82.
  12. Takayama T, *Okura Y, Okada Y, Honma K, Nashimoto A, Sato N, Yokoyama A, Minamino T. Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients. Int J Clin Oncol 2015.
  13. Ohno Y, *Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T. Liver congestion in heart failure contributes to inappropriately increased serum hepcidin despite anemia. Tohoku J Exp Med 2015; 235: 69-79.
  14. Nagao S, *Watanabe H, Sobue Y, Kodama M, Tanaka J, Tanabe N, Suzuki E, Narita I, Watanabe E, Aizawa Y, Minamino T. Electrocardiographic abnormalities and risk of developing cardiac events in extracardiac sarcoidosis. Int J Cardiol 2015; 189: 1-5.
  15. Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, *Komuro I. Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. Nat Commun 2015; 6: 6241.
  16. Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, *Utsunomiya K. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy. Diabetes 2015; 64: 618-30.
  17. Shimizu I, Yoshida Y, *Minamino T. Maintenance of Subcutaneous Fat Homeostasis Improves Systemic Metabolic Dysfunction in Obesity. Diabetes 2015; 64: 3984-6.
  18. Shimizu I, Yoshida Y, *Minamino T. Pathological Role of Adipose Tissue Dysfunction in Cardio-Metabolic Disorders. Int Heart J 2015; 56: 255-9.
  19. Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, Mayakonda A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Myklebost O, Yang H, Dugas M, Meza-Zepeda LA, Silberman AW, Forscher C, Tyner JW, Ogawa S, Koeffler HP. (2015). Genomic landscape of liposarcoma. Oncotarget. 6(40):42429-44.
  20. Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa Y, Kishimoto H, Taki T, Akiyama M, Shiraishi Y, Chiba K, Tanaka H, Mitsuiki N, Kajiwara M, Mizutani S, Sanada M, Miyano S, Ogawa S, Koh K, Takita J. (2015). Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukaemia. Br J Haematol. in press
  21. Garg M, Nagata Y, Kanojia D, M T A, Yoshida K, Keloth SH, Jiang ZZ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SY, Yeoh AE, Sanada M, Schiller J, Kreuzer KA, Kornblau SM, Kantarjian HM, Haferlach T, Lill M, Kuo MC, Shih LY, Blau IW, Blau O, Yang H, Ogawa S, Koeffler HP. (2015). Profiling of somatic mutations of acute myeloid leukemia, FLT3-ITD subgroup at diagnosis and relapse. Blood. 26;126(22):2491-501.
  22. Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga JI, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S. (2015). Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet. 47(11):1304-15.
  23. Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S. (2015). Genome-wide surveillance of mismatched alleles for graft versus host disease in stem cell transplantation. Blood. 126(25):2752-63.
  24. Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, Wada T, Gunji M, Toma T, Kato T, Shiraishi Y, Iwata A, Hori T, Kitoh T, Chiba K, Tanaka H, Sanada M, Takahashi Y, Nonoyama S, Ito M, Miyano S, Ogawa S, Kojima S, Kanegane H. (2015). Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism. J Clin Immunol. 35(7):610-4.
  25. Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S. (2015). Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia. N Engl J Med. 2;373(1):35-47.
  26. Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, Hosono N, Schnittger S, Sanada M, Przychodzen B, Kon A, Polprasert C, Shen W, Clemente MJ, Phillips JG, Alpermann T, Yoshida K, Nadarajah N, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H. (2015). BRCC3 mutations in myeloid neoplasms. Haematologica. 100(8):1051-7.
  27. Suzuki H, Aoki K, Chiba K, Sato Y, Shiozawa Y, Shiraishi Y, Shimamura T, Niida A, Motomura K, Ohka F, Yamamoto T, Tanahashi K, Ranjit M, Wakabayashi T, Yoshizato T, Kataoka K, Yoshida K, Nagata Y, Sato-Otsubo A, Tanaka H, Sanada M, Kondo Y, Nakamura H, Mizoguchi M, Abe T, Muragaki Y, Watanabe R, Ito I, Miyano S, Natsume A, Ogawa S. (2015). Mutational landscape and clonal architecture in grade II and III gliomas. Nat Genet. 47(5):458-68.
  28. Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Satoru M, Thol F, Ganser A, Yang H, Haferlach T, Ogawa S, Koeffler HP. (2015). Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. Nature Commun. 6:6042.
  29. Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, *Akashi K. A TIM-3/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression. Cell Stem Cell 17, 341-52, 2015.
  30. Takashima S, *Miyamoto T, Kamimura T, Yoshimoto G, Yoshida S, Henzan H, Takase K, Kato K, Ito Y, Ohno Y, Nagafuji K, Eto T, Teshima T, Akashi K. Effects of conditioning intensity in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Int J Hematol 102, 689-96, 2015.
  31. Sugita J, Kawashima N, Fujisaki T, Kakihana K, Ota S, Matsuo K, Miyamoto T, Akashi K, Taniguchi S, Harada M, *Teshima T. HLA-Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide following busulfan-containing reduced-intensity conditioning. Biol Blood Marrow Transplant 21, 1646-52, 2015.
  32. Shima T, Iwasaki H, Yamauchi T, Kadowaki M, Kiyosuke M, Mochimaru T, Takenaka K, Miyamoto T, Akashi K, *Teshima T. Preserved in vivo reconstitution ability of PBSCs cryopreserved for a decade at -80℃. Bone Marrow Transplant 50, 1195-200, 2015.
  33. Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Tsudo M, Kobayashi H, Maesako Y, Eto T, Adachi S, Ichinohe T, Atsuta Y, *Kanda Y. A Single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch. Am J Hematol 90, 618-23, 2015.
  34. Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, *Teshima T. α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice.
    Blood 125, 3014-23, 2015.
  35. *Ishida T, Jo T, Takemoto S, Suzushima H, Uozumi K, Yamamoto K, Uike N, Saburi Y, Nosaka K, Utsunomiya A, Tobinai K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Moriuchi Y, Imada K, Miyamoto T, Akinaga S, Tomonaga M, Ueda R.
    Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study.
    Br J Haematol 169, 672-82, 2015.
  36. *Yamasaki S, Yoshimoto G, Ogawa R, Aoki K, Higuchi M, Harada N, Arima F, Kondo S, Matubara F, Takahashi T, Uike N, Miyamoto T, Okamura S, Akashi K. Factors prognostic of eligibility for allogeneic HCT among older patients with AML-CR1 and adverse- or intermediate-risk cytogenetics. Ann Hematol 94, 1159-65, 2015.
  37. Takamatsu H*, Honda S, Miyamoto T, Yokoyama K, Hagiwara S, Ito T, Tomita N, Iida S, Iwasaki T, Sakamaki H, Suzuki R, Sunami K. Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era. Cancer Sci 106, 179-85, 2015.
  38. Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, *Akashi K. CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: Redefinition of murine common myeloid progenitor. Stem Cells 33, 976-87, 2015.
  39. Ito Y, *Miyamoto T, Kamimura T, Aoki K, Henzan H, Aoki T, Shiratsuchi M, Kato K, Nagafuji K, Ogawa R, Eto T, Iwasaki H, Akashi K. Characteristics of patients with development of large granular lymphocytes expansion among dasatinib-treated patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic stem cell transplantation. Clinical Lymphoma, Myeloma & Leukemia 15,47-54, 2015. (contributed equally)
  40. Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.(2015). Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. Sci Rep. 5:17565.
  41. Endo Y, Asou HK, Matsugae N, Hirahara K, Shinoda K, Tumes DJ, Tokuyama H, Yokote K, Nakayama T.(2015). Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1. Cell Rep. 12(6):1042-1055.
  42. Komai E, Takemoto M, Yokote K.(2015). Atorvastatin-induced dermatomyositis in a 47-year-old woman with Sjögren's syndrome. Acta Cardiol. 70(3):373.
  43. Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka T.(2015). Germline deletion of ARMC5 in familial primary macronodular adrenal hyperplasia. Endocr Pract. 21(10):1152-1160.
  44. Koike M, Nojiri H, Ozawa Y, Watanabe K, Muramatsu Y, Kaneko H, Morikawa D, Kobayashi K, Saita Y, Sasho T, Shirasawa T, Yokote K, Kaneko K, Shimizu T.(2015). Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration. Sci Rep. 5:11722.
  45. Takemoto M, Yamaga M, Furuichi Y, Yokote K.(2015). Astaxanthin improves nonalcoholic fatty liver disease in werner syndrome with diabetes mellitus. J Am Geriatr Soc. 63(6):1271-1273.
  46. Hayashi A, Takemoto M, Shoji M, Hattori A, Sugita K, Yokote K.(2015). Pioglitazone improves fat tissue distribution and hyperglycemia in a case of cockayne syndrome with diabetes. Diabetes Care. 38(5):e76.
  47. Matsumoto J, Hirano Y, Numata N, Matzuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.(2015).　Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns. J Eat Disord. 3:14.
  48. Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K.(2015). Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone (Study for an Ultimate Combination Therapy to Control Diabetes with Sitagliptin-1): A multicenter, randomized, open-label, non-inferiority trial. J Diabetes Investig. 6(2):182-191.
  49. Kobayashi K, Nojiri H, Saita Y, Morikawa D, Ozawa Y, Watanabe K, Koike M, Asou Y, Shirasawa T, Yokote K, Kaneko K, Shimizu T.(2015). Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis. Sci Rep. 5:9148
  50. Ishibashi R, Nakamura S, Takemoto M, Mukai C, Yokote K.(2015). Helicobacter cinaedi infection in patients with diabetes: a case report. Springerplus. 4:72.
  51. Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru J, Bujo H, Nakaseko C.(2015). Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 56(10):2982-2985.
  52. Tachibana K, Sakurai K, Yokoh H, Ishibashi T, Ishikawa K, Shirasawa T, Yokote K.(2015). Mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: reduced insulin signaling and ROS. Horm Metab Res. 47(3):176-183.
  53. Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, Iwama A.(2015). Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice. Leuk Lymphoma. 56(2):520-523.
【公募班】
  1. Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, *Ogawa S. (2015). Variegated RHOA mutations in adult T-cell leukemia/lymphoma. Blood. 127(5):596-604.
  2. *Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, Kiyoi H, Naoe T, Yokoyama Y, Chiba S, Hata T, Miyazaki Y, Hatta Y, Takeuchi J, Nannya Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F. (2015). Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood. Int J Hematol. 103(1):53-62.
  3. Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, *Ogawa S. (2015). Genome-wide surveillance of mismatched alleles for graft versus host disease in stem cell transplantation. Blood. 126(25):2752-2763.
  4. Truong TP, Sakata-Yanagimoto M, Yamada M, Nagae G, Enami T, Nakamoto-Matsubara R, Aburatani H, *Chiba S. (2015). Age-Dependent Decrease of DNA Hydroxymethylation in Human T Cells. J Clin Exp Hematop. 55(1):1-6.
  5. *Iriyama N, Fujisawa S, Yoshida C, Wakita H, Chiba S, Okamoto S, Kawakami K, Takezako N, Kumagai T, Inokuchi K, Ohyashiki K, Taguchi J, Yano S, Igarashi T, Kouzai Y, Morita S, Sakamoto J, Sakamaki H. (2015). Early cytotoxic lymphocyte expansion contributes to a deep molecular response to dasatinib in patients with newly diagnosed chronic myeloid leukemia in the chronic phase: Results of the D-First study. Am J Hematol. 90(9):819-824.
  6. Ogawa S, Yokoyama Y, Suzukawa K, Nanmoku T, Kurita N, Seki M, Maie K, Suyama T, Takaiwa N, Sakata-Yanagimoto M, Obara N, Hasegawa Y, *Chiba S. (2015). Identification of a fusion gene composed of a Hippo pathway gene MST2 and a common translocation partner ETV6 in a recurrent translocation t(8;12)(q22;p13) in acute myeloid leukemia. Ann Hematol. 94(8):1431-1433.
  7. Son BK, Sawaki D, Tomida S, Fujita D, Aizawa K, Aoki H, Akishita M, Manabe I, Komuro I, Friedman SL, Nagai R, *Suzuki T. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nat Commun. 6:6994, 2015.
  8. Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee J-K, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I. Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. Nat Commun 6:6241, 2015.
  9. Okada-Iwabu M, Iwabu M, Ueki K, *Yamauchi T, *Kadowaki T. (2015). Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity. Diabetes Metab J. 39:363-372.
  10. Shibata S, Tada Y, Hau CS, Mitsui A, Kamata M, Asano Y, Sugaya M, Kadono T, Masamoto Y, Kurokawa M, Yamauchi T, Kubota N, Kadowaki T, Sato S. (2015). Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from-T cells. Nat Commun. 6 7687. doi: 10.1038/ncomms8687.
  11. Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, *Kadowaki T. (2015). A novel peroxisome proliferator-activated receptor (PPAR)g agonist and PPARg antagonist, Z-551, ameliorates high-fat diet-induced obesity and metabolic disorders in mice. J Biol Chem. 290:14567-14581.
  12. Nishiyama M, Nita A, Yumimoto K, *Nakayama KI. (2015). FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development. Stem Cells, (査読有) 33: 3327-3340.
  13. Okamoto K, *Tsunematsu R, Tahira T, Sonoda K, Asanoma K, Yagi H, Yoneda T,
    Hayashi K, Wake N, Kato K：SNP55, a new functional polymorphism of MDM2-P2
    promoter, contributes to allele-specific expression of MDM2 in endometrial cancers.
    BMC Med Genet (BMC medical genetics). 16(1): 1-15, 2015.8
  14. Ohmaru T, *Fujita Y , Sugitani M, Shimokawa M, Fukushima K, Kato K： Placental elasticity evaluation using virtual touch tissue quantification during pregnancy. Placenta. 36(8): 915-20, 2015.8
  15. *Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K：Regulation Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells.Mol Cell Biol. 35(24):4096-109, 2015.9
  16. Hachisuga M, Oki S, Kitajima K, Ikuta S, Sumi T, Kato K, Wake N, *Meno C：
    Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.Proc Natl Acad Sci U S A. 112(38): E5300-7, 2015.9
  17. Yamane T, *Asanoma K, Kobayashi H, Ge L, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K：Identification of the Critical Site of Calponin 1 for Suppression of Ovarian Cancer Properties. Anticancer Res. 35(11):5993-9, 2015.11
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