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領域代表者：岩間厚志

千葉大学大学院医学研究院
細胞分子医学 教授

〒260-8670
千葉市中央区亥鼻1-8-1

E-mail
matsumura0405@chiba-u.jp

研究成果：原著論文
2014年 2015年 2016年 2017年
原著論文 総説・図書(英文)
2015年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A01. 幹細胞の維持と老化
【計画班】
  1. *Chiba T, Suzuki E, Saito T, Ogasawara S, Ooka Y, Tawada A, Iwama A and Yokosuka O. (2015) Biological features and biomarkers in hepatocellular carcinoma. World J Hepatol. 7:2020-2028.
  2. Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and *Iwama A. (2015) Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner. Blood. 126:1172-1183.
  3. Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z-I, Wu X, Helin K, Iwama A, Suda T, Inaba T, and *Honda H. (2015) Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood. 125:3437-46.
  4. *Kamiya A, Ito K, Yanagida A, Iwama A, and Nakauchi H. (2015) MEK-ERK activity regulates the proliferative activity of fetal hepatoblasts through accumulation of p16/19cdkn2a. Stem Cells and Dev. 24:2525-2535.
  5. Wang C, Oshima M, Gashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, and *Iwama A. (2015) Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice. Plos One. 10:e0132041.
  6. Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, *Shimoda K. (2015) Loss-of-TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator. Blood. 125:304-315.
  7. Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, *Shimoda K. (2015) Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasm. Genom Data. 4:102-108.
  8. *Matsushita M, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Kaneda A, Iwama A and Nomura F. (2015) Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget. 6:5102-5017.
  9. *Chiba T, Saito T, Yuki K, Zen Y, Koide S, Kanogawa N, Motoyama T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Ohtsuka M, Miyazaki M, Iwama A, and Yokosuka O. (2015) Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma. Int J Cancer. 136:289-298.
  10. Ohnishi T., Yanazawa M., Kitamura Y, Sasahara T., Nishiyama T., Komura H., Hiroaki H., Fukazawa Y., Kaji I., Kakita A., Takeuchi A., Ito A., Takeda H., Hirano H., Inoue M., Muramatsu S.i., Matsui K., Tada M., Sato M., Goda N., Takino N., Sakai S., Arai Y., Umetsu Y., Takahashi H., Hagiwara M., Sawasaki T., Iwasaki G., Nakamura Y., Nabeshima Y., Teplow DG., Hoshi M*. Na,K-ATPasea3 is a death target of Alzheimer patient amyloid-b assembly. Proc. Natl. Acad. Sci. USA. 112(32) E4465-E4474 (2015)
  11. Parthasarathy S, Inoue M, Xiao Y, Matsumura Y, Nabeshima YI, Hoshi M, Ishii Y*. Structural Insight into an Alzheimer's Brain-Derived Spherical Assembly of Amyloid β by Solid-state NMR. J Am Chem Soc. May 4. PMID: 25938164 (2015)
  12. #Nakamura-Ishizu A, #Takubo K, Kobayashi H, Suzuki-Inoue K, *Suda T. (2015). CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. J Exp Med. 212: 2133-2146. (#equal contribution)
  13. Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, Takubo K, Horiuchi K, Miyamoto T, Nakamura M, *Matsumoto M. (2015). Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 17:316.
  14. Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, *Ikeda E. (2015). ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Sci Rep. 5:12796.
  15. *Nagamatsu G, Saito S, Takubo K, Suda T. (2015). Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling. Stem Cell Reports. 5:111-124.
  16. Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, *Honda H. (2015). Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood. 125:3437-3446.
  17. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, *Suda T, *Takubo K. (2015). Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 11:71-84.
  18. Taimatsu K, Takubo K, Maruyama K, Suda T, *Kudo A. (2015). Proliferation following tetraploidization regulates the size and number of erythrocytes in the blood flow during medaka development, as revealed by the abnormal karyotype of erythrocytes in the medaka TFDP1 mutant. Dev Dyn. 244:651-668.
  19. Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, Takasugi M, Yamakoshi K, Sorimachi H, Kanda H, Ishikawa Y, Sone S, Nishioka Y, *Ohtani N, *Hara E. (2015) Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice. Nature Commun 6,: 7035. doi: 10.1038/ncomms8035
  20. *Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto-Uezumi M, Ohtani N, Hara E, Maruyama M. (2015) Dysregulation of the Bmi-1/p16Ink4a pathway provokes an aging-associated decrease in submandibular gland function. Aging Cell 14:616-24
【公募班】
  1. Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, KI., Hirabayashi, Y., and Gotoh, Y.
    Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.
    Nat. Neurosci. 18, 657-665, 2015.
  2. Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, *Suda T, *Takubo K. (2015). Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 11:71-84.
  3. Kawahara T, Kagaya N, Masuda Y, Doi T, Izumikawa M, Ohta K, Hirao A, Shin-ya K. (2015). Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142. Org Lett. 17:5476-9.
  4. Nakagawa T, Araki T, Nakagawa M, Hirao A, Unno M, Nakayama K.(2015). S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation. Mol Cell Biol. 3517-27.
  5. Fahkri H, Zhang B, Fajol A, Hernando N, Elvira B, Mannheim JG, Pichler BJ, Daniel C, Amann K, Hirao A, Haight J, Mak TW, Lang F, Föller M.(2015). Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism. Pflugers Arch. 467:1871-80.
  6. Tanaka T, Kanatsu-Shinohara M, Hirose M, Ogura A, *Shinohara T. (2015). Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53. J Reprod Dev. 61(5):473-484.
  7. Tanaka T, Kanatsu-Shinohara M, *Shinohara T. (2015). The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage. J Reprod Dev. 61:305-316.
  8. Morimoto H, Kanatsu-Shinohara M, *Shinohara T. (2015). ROS-generating oxidase Nox3 regulates the self-renewal of mouse spermatogonial stem cells. Biol Reprod. 92(6): 147.
  9. Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, *Honda H. (2015) Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood 125:3437-46.
  10. Okuda H, Kanai A, Ito S, Matsui H, *Yokoyama A. (2015) AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription. Nat. Commun 23; 6: 8869.
  11. Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, *Chayama K. (2015) Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. J Viral Hepat 22: 158-65.
  12. Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, *Kitamura T. (2015) SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia 29: 847-57.
  13. Ikami K, Tokue M, Sugimoto R, Noda C, Kobayashi S, Hara K, *Yoshida S. (2015). Hierarchical differentiation competence in response to retinoic acid ensures stem cell maintenance during mouse spermatogenesis. Development. 142:1582-92.
  14. Juliandi B., Tanemura K., Igarashi K., Tominaga T., Furukawa Y., Otsuka I.M., Moriyama N., Ikegami D., Abematsu M., Sanosaka T., Tsujimura K., Narita M., Kanno J. & Nakashima K. (2015). Reduced adult hippocampal neurogenesis and cognitive impairments following prenatal administration of the antiepileptic drug, valproic acid. Stem Cell Reports 5, 996-1009
  15. Tsujimura K., Irie K., Nakashima H., Egashira Y., Fukao Y., Fujiwara M., Itoh M., Uesaka M., Imamura T., Nakahata Y., Yamashita Y., Abe T., Takamori S. & Nakashima K. (2015).miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes. Cell reports 12, 1887-1901
  16. Nakamura A., Funaya H., Uezono N., Nakashima K., Ishida Y., Suzuki T., Wakana S. & Shibata T. (2015).Low-cost three-dimensional gait analysis system for mice with an infrared depth sensor. Neurosci Res 100, 55-62
  17. Andoh-Noda T., Akamatsu W., Miyake K., Matsumoto T., Yamaguchi R., Sanosaka T., Okada Y., Kobayashi T., Ohyama M., Nakashima K., Kurosawa H., Kubota T. & Okano H. (2015). Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage. Mol Brain 8, 31
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