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領域代表者：岩間厚志

千葉大学大学院医学研究院
細胞分子医学 教授

〒260-8670
千葉市中央区亥鼻1-8-1

E-mail
matsumura0405@chiba-u.jp

研究成果：原著論文
2014年 2015年 2016年 2017年
原著論文 総説・図書(英文)
2014年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A02. 幹細胞の老化と疾患
【計画班】
  1. Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, *Deschamps J. Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728
  2. Suzuki H, Hoshina S, Ozawa J, Sato A, Minamino T, Aizawa Y, *Saitoh A. Short QT syndrome in a boy diagnosed on screening for heart disease. Pediatr Int 2014; 56: 774-6.
  3. Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, *Minamino T. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. PLoS One 2014; 9: e102186.
  4. Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, *Nishiyama A. Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complications 2014; 28: 604-11.
  5. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A,Yamashita M, Kobayashi Y, Shimizu I, *Minamino T. Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One 2014; 9: e100359.
  6. *Hamada N, Fujimichi Y, Iwasaki T, Fujii N, Furuhashi M, Kubo E, Minamino T, Nomura T, Sato H. Emerging issues in radiogenic cataracts and cardiovascular disease. J Radiat Res 2014; 55: 831-846.
  7. Yokoyama M, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, *Minamino T. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell Rep 2014; 7: 1691-1703.
  8. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, Ito TK, Minamino T, Nakamura H, Yamaguchi S, Shibata T, *Masutomi K. Involvement of TERT in heterochromatin maintenance. Mol Cell Biol 2014; 34: 1576-93.
  9. Katsuumi G, Shimizu W, *Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol 2014; 172: 519-522.
  10. Suzuki T, Hanawa H, Jiao S, Ohno Y, Hayashi Y, Yoshida K, Kashimura T, Obata H, *Minamino T. Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency. J Card Fail 2014; 20: 268-77
  11. Sato A, *Watanabe H, Sonoda K, Chinushi M, Tsuda T, Izumi D, Furushima H, Minamino T. Augmentation of the J wave by rapid pacing in a patient with vasospastic angina. Int J Cardiol 2014; 172: e111-3.
  12. *Kashimura T, Kodama M, Watanabe T, Tanaka K, Hayashi Y, Ohno Y, Obata H, Ito M, Hirono S, Hanawa H, Minamino T. Relative refractoriness of left ventricular contraction underlies human tachycardia-induced mechanical and electrical alternans. Pacing Clin Electrophysiol 2014; 37: 197-206.
  13. Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S. (2014). Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice. Blood Cancer J. 4:e264.
  14. Nowak D, Liem NL, Mossner M, Klaumünzer M, Papa RA, Nowak V, Jann JC, Akagi T, Kawamata N, Okamoto R, Thoennissen NH, Kato M, Sanada M, Hofmann WK, Ogawa S, Marshall GM, Lock RB, Koeffler HP. (2014). Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Exp Hematol. 43(1):32-43.e35.
  15. Ahmad G, Mohapatra BC, Schulte NA, Nadeau SA, Luan H, Zutshi N, Tom E, Ortega-Cava C, Tu C, Sanada M, Ogawa S, Toews ML, Band V, Band H. (2014). Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis. Int J Biochem Cell Biol. 57C:123-134.
  16. Nakamoto-Matsubara R, Sakata-Yanagimoto M, Enami T, Yoshida K, Yanagimoto S, Shiozawa Y, Nanmoku T, Satomi K, Muto H, Obara N, Kato T, Kurita N, Yokoyama Y, Izutsu K, Ota Y, Sanada M, Shimizu S, Komeno T, Sato Y, Ito T, Kitabayashi I, Takeuchi K, Nakamura N, Ogawa S, Chiba S. (2014). Detection of the G17V RHOA Mutation in Angioimmunoblastic T-Cell Lymphoma and Related Lymphomas Using Quantitative Allele-Specific PCR. PLoS One 9(10):e109714.
  17. Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H, Shiozawa Y, Kataoka K, Kon A, Aoki K, Chiba K, Tanaka H, Kume H, Miyano S, Fukayama M, Nureki O, Homma Y, Ogawa S. (2014). Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. Science. 344(6186):917-20.
  18. Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R. (2014). KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells. Cancer Res. 74(10):2882-91.
  19. Matsunawa M*, Yamamoto R*, Sanada M*, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S. (2014). Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia. Leukemia. 28:1844-50.　(*equal contribution)
  20. Hosono N, Makishima H, Jerez A, Yoshida K, Przychodzen B, McMahon S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Gómez-Segui I, Verma AK, McDevitt MA, Sekeres MA, Ogawa S, Maciejewski JP. (2014). Recurrent genetic defects on chromosome 7q in myeloid neoplasms. Leukemia. 28:1348-51.
  21. Takita J, Chen Y, Kato M, Ohki K, Sato Y, Ohta S, Sugita K, Nishimura R, Hoshino N, Seki M, Sanada M, Oka A, Hayashi Y, Ogawa S. (2014). Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays. Cancer Sci. 105(3):258-64.
  22. Damm, F., Mylonas, E., Cosson, A., Yoshida, K., Della Valle, V., Mouly, E., Diop, M., Scourzic, L., Shiraishi, Y., Chiba, K., Tanaka, H., Miyano, S., Kikushige, Y., Davi, F., Lambert, J., Gautheret, D., Merle-Beral, H., Sutton, L., Dessen, P., Solary, E., Akashi, K., Vainchenker, W., Mercher, T., Droin, N., *Ogawa, S., *Nguyen-Khac, F. & *Bernard, O.A. (2014) Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov, 4, 1088-1101.
  23. Iwamoto C, Takenaka K, Urata S, Yamauchi T, Shima T, Kuriyama T, Daitoku S, Saito Y, Miyamoto T, Iwasaki H, Kitabayashi I, Itoh K, Kishimoto J, Kohda D, Matozaki T, *Akashi K. The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. Exp Hematol 42, 163-171, 2014.
  24. *Chong Y, Shimoda S, Yakushiji H, Ito Y, Aoki T, Miyamoto T, Kamimura T, Shimono N, Akashi K. Clinical impact of fluoroquinolone-resistant Escherichia coli in the fecal flora of hematological patients with neutropenia and levofloxacin prophylaxis. PLoS One 9, e85210, 2014.
  25. *Ogura M, Ishida T, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T, Uike N, Tanimoto M, Tsukasaki K, Ishizawa K, Suzumiya J, Inagaki H, Tamura K, Akinaga S, Tomonaga M, Ueda R.
    Multicenter phase II Study of mogamulizumab (KW-0761), a defucosylated Anti-CC chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol 32, 1157-63. 2014.
  26. Takashima S, *Miyamoto T, Kadowaki M, Ito Y, Aoki T, Takase K, Shima T, Yoshimoto G, Kato K, Muta T, Shiratsuchi M, Takenaka K, Iwasaki H, Teshima T, Kamimura T, Akashi K. Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients.
    Int J Hematol 100, 159-164, 2014.
  27. Fuji S, Kanda J, Kato S, Ikegame K, Morishima S, Miyamoto T, Hidaka M, Kubo K, Miyamura K, Ohashi K, Kobayashi H, Maesako Y, Adachi S, Ichinohe T, Atsuta Y, *Kanda Y. Impact of HLA allele mismatch on the clinical outcome in serologically matched related hematopoietic SCT. Bone Marrow Transplant 49, 1187-92, 2014.
  28. Shima, T., Miyamoto, T., Kikushige, Y., Yuda, J., Tochigi, T., Yoshimoto, G., Kato, K., Takenaka, K., Iwasaki, H., Mizuno, S., Goto, N. & *Akashi, K. (2014) The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. Exp Hematol, 42, 955-965 e955.
  29. Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H; Japan CDM group.(2014). Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals. Int J Cardiol. 177(3):860-6.
  30. Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.(2014). Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture. PLoS One. 9(11):e112900.
  31. Shibuya S, Ozawa Y, Watanabe K, Izuo N, Toda T, Yokote K, Shimizu T.(2014). Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice. PLoS One. 5;9(10):e109288.
  32. Watanabe K, Shibuya S, Ozawa Y, Nojiri H, Izuo N, Yokote K, Shimizu T.(2014). Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes. Biomed Res Int. 2014:140165.
  33. Toda N, Ihara K, Takemoto M, Yokote K, Hara T.(2014). Endocrine and metabolic abnormalities in a girl with childhood Werner syndrome: case report. J Am Geriatr Soc. 62(7):1404-1405.
  34. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J.(2014). Sci Rep. 4:5412.
  35. Isshiki Y, Ohwada C, Togasaki E, Shimizu R, Hasegawa N, Yamazaki A, Sugita Y, Kawaguchi T, Tsukamoto S, Sakai S, Takeda Y, Takeuchi M, Sakaida E, Shimizu N, Ota S, Yokote K, Iseki T, Nakaseko C.(2014). Acute myeloid leukemia concurrent with spinal epidural extramedullary myeloid sarcoma accompanied by a high CD25 expression and the FLT3-ITD mutation. Intern Med. 53(11):1159-1164.
  36. Ishikawa K, Yokote K.(2014). Is obesity an absolute evil? Increase in adipose tissue does not always decrease insulin sensitivity. J Diabetes Investig. 5(3):278-280.
  37. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K; Japan Atherosclerosis Society Committee for Epidemiology and Clinical Management of Atherosclerosis.(2014). J Atheroscler Thromb. 21(4):299-303.
  38. Tsukamoto S, Takeuchi M, Kawaguchi T, Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C.(2014). Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes. Exp Mol Med. 46:e89.
  39. Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru J, Bujo H, Nakaseko C.(2014). Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma. Leuk Lymphoma. 55(10):2391-2394.
  40. Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K; SUCCESS Study Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with α-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial. Diabetes Obes Metab. 16(8):761-765.
  41. Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H.(2014). G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow. Ann Hematol. 93(7):1111-1122.
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