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原著論文 総説・図書(英文)
2014年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A01. 幹細胞の維持と老化
【計画班】
  1. Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, and *Iwama A. (2014) Histone acetylation mediated by Brd1/Brpf2 is crucial for Cd8 gene activation during early thymocyte development. Nat Commun. 5:5872.
  2. Mimura N, Hideshima T, Suzuki R, Ohguchi H, Cottini F, Tai U-T, Cirstea D, Gorgun G, Minami J, Shimomura T, Utsugi T, Richardson PG, Iwama A, and *Anderson KC. (2014) Preclinical activity of a novel selective Akt inhibitor TAS-117 in multiple myeloma. Cancer Res. 74:4458-4469.
  3. Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Inaba T, Koseki H, Huang G, Kitamura T, and *Iwama A. (2014) Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukemic transformation. Nat Commun. 5:4177.
  4. Wang C, Sashida G, Saraya A, Ishiga R, Koide S, Oshima M, Ishono K, Koseki H, and *Iwama A. (2014) Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia. Blood. 123:3336-3343.
  5. Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, and *Taga T. (2014) Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ. 56:469-479.
  6. Hayashi Y, Kuroda T, Kishimoto H, Wang C, Iwama A, *Kimura K. (2014) Downregulation of rRNA transcription triggers cell differentiation. PLoS One. 9:e98586.
  7. Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K and *Iwama A. MDS with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice. Leuk Lymphoma. 17:1-4.
  8. Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, Okamoto A, Yamaguchi N, Iwama A, Nakayama Y and *Yamaguchi N. (2014) Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 289:12313-12329.
  9. Yamaguchi Y, Takenobu H, Ohira M, Nakazawa A, Yoshida S, Akita N, Shimozato O, Iwama A, Nakagawara A, *Kamijo T. (2014) Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. Eur J Cancer. 50:1555-1565, 2014.
  10. Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A and *Taga T. (2014) Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 34:1976-1990.
  11. Nishimura YV., Shikanai M., Hoshino M., Ohshima T., Nabeshima Y., Mizutani K., Nagata K., Kazunori K., Kawauchi T. Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
    Development ;141(18):3540-50 (2014) doi: 10.1242/dev.111294.
  12. Nabeshima Y., Washida M., Tamura M., Maeno A., Ohnishi M., Shiroishi T., Imura A., Razzaque MS., Nabeshima Y*. Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.
    Sci Rep. Aug 1; 4: 5847. (2014) doi: 10.1038/srep05847.
  13. Hayashi Y., Nabeshima Y., Kobayashi K., Miyakawa T., Tanda K., Takao K., Suzuki H., Esumi E., Noguchi S. Matsuda Y., Sasaoka T., Noda T., Miyazaki J., Mishina M., Funabiki K. Nabeshima Y.* Enhanced Stability of Hippocampal Place Representation Caused by Reduced Magnesium Block of NMDA Receptors in the Dentate Gyrus.
    Molecular Brain 7, 44-61(2014) MS ID1850664515130282
  14. Yamada M., Seto Y., Taya S., Owa T., Inoue Y., Inoue T., Kawaguchi Y., Nabeshima Y., Hoshino M*. Specification of spatial identities of cerebellar neuronal progenitors by Ptf1a and Atoh1 for proper production of GABAergic and glutamatergic neurons.
    J. Neurosci. Apr 2;34(14):4786-800. (2014) doi: 10.1523/JNEUROSCI.2722-13.2014
  15. Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y*. Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism.
    PLoS One. 9(1); e86301 (2014) PMID: 24466013
  16. #Nakamura-Ishizu A, *#Takubo K, Fujioka M, *Suda T. (2014). Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin. Biochem Biophys Res Commun. 454:353-357. (#equal contribution)
  17. Kunimoto H, Fukuchi Y, Sakurai M, Takubo K, Okamoto S, Nakajima H. (2014). Tet2-mutated myeloid progenitors possess aberrant in vitro self-renewal capacity. Blood. 123:2897-2899.
  18. Kinoshita T, *Nagamatsu G, Saito S, Takubo K, Horimoto K, *Suda T. (2014). Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming. J Biol Chem. 289:15776-15787.
  19. Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, *Ohazama A. (2014). R-spondins/Lgrs expression in tooth development. Dev Dyn. 243:844-851.
  20. #Kobayashi CI, *#Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, *Suda T. (2014). The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. Blood. 123:2540-2549. (#equal contribution)
  21. Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge R-M, Jan Vijg J, Van Steeg H, Dollé MET, Hoeijmakers JHJ, de Bruin A, Hara E, *Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell 31:722-33.
  22. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, *Nakanishi M. (2014) Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction. Molecular Cell. 55: 1-12
  23. Imai Y, Takahashi A, Hanyuu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, *Hara E. (2014) Crosstalk between the RB-pathway and AKT signaling forms a Quiescence-Senescence switch. Cell Reports 7:194-207,