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糞便移植治療によって腸内細菌叢が機能回復するメカニズムを解明
~抗菌薬投与によって起こる再発性C. difficile関連腸炎の治療に光~

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論文情報

"Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation"

Gastroenterology (IF=17.373) オンライン版 2021年2月9日(日本時間) doi:10.1053/j.gastro.2021.02.013

Kosuke Fujimoto1,2,3, Yasumasa Kimura4, Jessica R Allegretti5, Mako Yamamoto6, Yao-zhong Zhang6, Kotoe Katayama6, Georg Tremmel7, Yunosuke Kawaguchi1, Masaki Shimohigoshi1, Tetsuya Hayashi1, Miho Uematsu1, Kiyoshi Yamaguchi8, Yoichi Furukawa8, Yutaka Akiyama9, Rui Yamaguchi7, Sheila E. Crowe10, Peter B. Ernst11,12,13, Satoru Miyano7, Hiroshi Kiyono11,12,14,15, Seiya Imoto6,16* and Satoshi Uematsu1,2,3,16* (*責任著者)

【所属】
1Department of Immunology and Genomics, Osaka City University Graduate School of Medicine 
2Division of Metagenome Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo
3Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
4Division of Systems Immunology, The Institute of Medical Science, The University of Tokyo
5Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women’s Hospital
6Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo
7Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo
8Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo
9Department of Computer Science, Tokyo Institute of Technology
10Department of Medicine, University of California, San Diego
11Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego
12Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego
13Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego
14Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo
15International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
16Collaborative Research Institute for Innovative Microbiology, The University of Tokyo

 

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