Press release
Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation
Description
In a study published in Gastroenterology – Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo (IMSUT), in collaboration with Brigham and Women's Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile infection (rCDI). This comprehensive analysis reveals the bacteria and phages involved in pathogenesis in rCDI, and their remarkable pathways important for the recovery of intestinal flora function.
Press release
Press release
Published Article
"Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation"
Gastroenterology (IF=17.373) online February 9, 2021 doi:10.1053/j.gastro.2021.02.013
Kosuke Fujimoto1,2,3, Yasumasa Kimura4, Jessica R Allegretti5, Mako Yamamoto6, Yao-zhong Zhang6, Kotoe Katayama6, Georg Tremmel7, Yunosuke Kawaguchi1, Masaki Shimohigoshi1, Tetsuya Hayashi1, Miho Uematsu1, Kiyoshi Yamaguchi8, Yoichi Furukawa8, Yutaka Akiyama9, Rui Yamaguchi7, Sheila E. Crowe10, Peter B. Ernst11,12,13, Satoru Miyano7, Hiroshi Kiyono11,12,14,15, Seiya Imoto6,16* and Satoshi Uematsu1,2,3,16* （*Corresponding-author）
1Department of Immunology and Genomics, Osaka City University Graduate School of Medicine
2Division of Metagenome Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo
3Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
4Division of Systems Immunology, The Institute of Medical Science, The University of Tokyo
5Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women’s Hospital
6Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo
7Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo
8Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo
9Department of Computer Science, Tokyo Institute of Technology
10Department of Medicine, University of California, San Diego
11Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego
12Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego
13Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego
14Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo
15International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
16Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
1Department of Immunology and Genomics, Osaka City University Graduate School of Medicine
2Division of Metagenome Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo
3Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
4Division of Systems Immunology, The Institute of Medical Science, The University of Tokyo
5Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women’s Hospital
6Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo
7Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo
8Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo
9Department of Computer Science, Tokyo Institute of Technology
10Department of Medicine, University of California, San Diego
11Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego
12Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego
13Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego
14Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo
15International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo
16Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
