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領域代表者：岩間厚志

千葉大学大学院医学研究院
細胞分子医学 教授

〒260-8670
千葉市中央区亥鼻1-8-1

E-mail
matsumura0405@chiba-u.jp

研究成果：原著論文
2014年 2015年 2016年 2017年
原著論文 総説・図書(英文)
2016年
A01. 幹細胞の維持と老化 A02. 幹細胞の老化と疾患
原著論文
A01. 幹細胞の維持と老化
【計画班】
  1. Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, *Iwama A. (2016) The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 213:1459-1477. 2016.
  2. Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt G, Saraya A, Wang C, Shimoda K, Suzuki Y, *Iwama A. Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells. Exp Hematol. 44:282-296.
  3. Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, *Iwama A. (2016) Loss of Pcgf5 affects global H2A monoubiquitination but not the function of hematopoietic stem and progenitor cells. Plos One. 11:e0154561.
  4. Sekine A, Nishiwaki T, Nishimura R, Kawasaki T, Urishibara T, Suda R, Suzuki T, Takayanagi S, Terada J, Sakao S, Tada Y, Iwama A, *Tatsumi K. (2016) Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation. Am Physiol Lung Cell Mol Physiol. 310:L1130-42. 2016.
  5. *Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, Shterev I, Sempowski G, Macchiarini F, Nakachi K, Kunugi KC, Hammer CG, Dewerd LA. (2016) An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned. Int J Radiat Biol. 92:59-70.
  6. Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, *Levantini E. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Sci Transl Med. 8:350ra104. 2016.
  7. Shimizu R, Muto T, Aoyama K, Choi K, Takeuchi M, Koide S, Hasegawa N, Isshiki Y, Togasaki E, Kawajiri C, Nagao Y, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Ohwada C, Sakaida E, Iseki T, Starczynowski D-T, Iwama A, Yokote K, *Nakaseko C. Possible role of intragenic hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia. Leuk Lymphoma. 50:85-94. 2016.
  8. Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, and *Iwama A. (2016) Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes. Blood. 128:638-649. 2016.
  9. Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, and Nishimura EK.(201) Hair f6ollicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science. 351:575. 2016
  10. Inada A*., Inada O., Nagafuchi S., Katsuta H., Yasunami Y., Fujii NL., Matsubara T., Arai H., Fukatsu A. Nabeshima Y. Adjusting the 17β-Estradiol to Androgen Ratio Ameriorates Diabetic Nephropathy J. American Society of Nephrology. 27: 3035-3050. 2016.
  11. Kobayashi K., Tanaka T., Okada S., Morimoto Y., Matsumura S., InoueK., Kimura K., Yagi T., Saito Y., Fushiki T., Inoue H., Matsumoto M. Nabeshima Y*. Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice. FASEB J. 30: 849-862. 2016.
  12. Inada A＊., Fujii NL, Inada O., Higaki Y., Nabeshima Y. Effects of 17β-estradiol and androgen on glucose metabolism in skeletal muscle. Endocrinology. 157: 4691-4705. 2016.
  13. Karigane D, #Kobayashi H, # Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, *Takubo K. (2016). p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling. Cell Stem Cell. 19:192-204. (#equal contribution)
  14. Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, *Keller JR. (2016). Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. Stem Cells. 34:1068-1082.
  15. Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, *Ozawa Y. (2016). Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration. J Biol Chem. 291:7373-7385.
  16. Ishii A, Kimura T, Sadahiro H, Kawano H, Takubo K, Suzuki M, *Ikeda E. (2016). Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma. PLoS One. 11:e0147366.
  17. Ikeda K, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L, Honda Z, Ichinohe T, Matsubara A, Suda T, Inaba T, *Honda H. (2016) Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency. Sci Rep. 6:29454.
  18. Fujita N, Suzuki S, Watanabe K, Ishii K, Watanabe R, Shimoda M, Takubo K, Tsuji T, Toyama Y, Miyamoto T, Horiuchi K, Nakamura M, Matsumoto M. (2016) Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells. J Orthop Res. 34:1341-1350.
【公募班】
  1. Liu J, Guo YM, Onai N, Ohyagi H, Hirokawa M, Takahashi N, Tagawa H, Ubukawa K, Kobayashi I, Tezuka H, Minamiya Y, Ohteki T, Sawada K. (2016). Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 22:627-36.
  2. Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N. (2016). MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 127:2607-17.
  3. MatsushitaT, Huu DL, Hamaguchi Y, Hasegawa M, Naka K, Hirao A, Muramatsu M, Takehara K, Fujimoto M. (2016). The PI3K-Akt pathway controls IL-10-producing regulatory B cells. J Allergy Clin Immunol. 138:1170-1182.
  4. Naka K, Ishihara K, Jomen Y, Jin CH, Kim DH, Gu YK, Jeong ES, Li S, Krause DS, Kim DW, Bae E, Takihara Y, Hirao A, Oshima H, Oshima M, Ooshima A, Sheen YY, Kim SJ, Kim DK. (2016). Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells. Cancer Sci. 107:140-8.
  5. Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, *Hirao A. (2016). Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance. J Biol Chem. 291:21496-21509.
  6. Kanatsu-Shinohara M, Morimoto H, *Shinohara T. (2016). Fertility of male germline stem cells following spermatogonial transplantation in infertile mouse models. Biol Reprod. 94:112.
  7. Kanatsu-Shinohara M, Morimoto H, *Shinohara T. (2016). Enrichment of mouse spermatogonial stem cells by the stem cell dye CDy1. Biol Reprod. 94:13.
  8. #Kanatsu-Shinohara M., #Tanaka T., Ogonuki N., Ogura A., Morimoto H., Cheng PF., Eisenman RN., Trumpp A., *Shinohara T. (2016). Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Genes Dev. 30:2637-2648. (#equal contribution)
  9. Yasuko Inaba, Kyosuke Shinohara, Yanick Botilde, Ryo Nabeshima, Katsuyoshi Takaoka, Rieko Ajima, Lynda Lamri, Hiroyuki Takeda, Yumiko Saga, Tetsuya Nakamura and *Hiroshi Hamada. Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Gene to cells. 21:728-39.
  10. Kadono M, Kanai A, Nagamachi A, Shinriki S, Kawata J, Iwato K, Kyo T, Oshima K, Yokoyama A, Kawamura T, Nagase R, Inoue D, Kitamura T, Inaba T, Ichinohe T, *Matsui H. (2016) Biological implication of somatic DDX41 p.R525H mutation in acute myeloid leukemia. Exp. Hematol. 44: 745-754, 2016.
  11. Yamashita T, Ueda M, Saga N, Nanto K, Tasaki M, Masuda T, Misumi Y, Oda S, Fujimoto A, Amano T, Takamatsu K, Yamashita S, Obayashi K, Matsui H, Ando Y. Hereditary amyloidosis with cardiomyopathy caused by the novel variant transthyretin A36D. Amyloid. 23:207-208.
  12. Kovtonyuk LV, Markus G. *Manz, *Takizawa H. Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo. Blood. 2016. in press.
  13. Ziegler P, Boettcher S, Takizawa H, Manz MG, *Brümmendorf TH. LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance. Ann Hematol. 2016. 95:173-8.
  14. Rauch PJ, Ellegast JM, Widmer CC, Fritsch K, Goede JS, Valk PJ, Löwenberg B, Takizawa H, ＊Manz MG. MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia. Blood. 128:2253-2257. 2016.
  15. Kobayashi N, Okae H, Hiura H, Chiba H, Shirakata Y, Hara K, Tanemura K, *Arima T. Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa. PLoS One. 11:e0167127.
  16. Umezu K, Hiradate Y, Oikawa T, Ishiguro H, Numabe T, Hara K, *Tanemura K. (2016) Exogenous neurotensin modulates sperm function in Japanese Black cattle. J Reprod Dev. 62:409-14.
  17. Noguchi H, Kimura A, Murao N, Namihira M. *Nakashima K. (2016). Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood. Neurogenesis (Austin) 3: e1232679.
  18. Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K. (2016). Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature. 539: 299-303.
  19. Morita S., Noguchi H., Horii T., Nakabayashi K., Kimura M., Okamura K., Sakai A., Nakashima H, Hata K, Nakashima K. *Hatada I. (2016). Targeted manipulation of DNA methylation in vivo using CRISPR/Cas9 and a repeating peptide array-based amplification. Nat Biotechnol. 34: 1060-1065.
  20. Irie K, *Tsujimura K, Nakashima H, *Nakashima K. (2016). MicroRNA-214 promotes dendritic development by targeting the schizophrenia-associated gene Quaking. J Biol Chem. 291: 13891-13904. (*shared correspondence)
  21. Murao N, Noguchi H, *Nakashima K. (2016). Epigenetic regulation of neural stem cell property from embryo to adult. Neuroepigenetics. 5: 1-10.
  22. Noguchi H, Murao N, Kimura A, Matsuda T, Namihira M, *Nakashima K. (2016). DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus. J Neurosci. 36: 6050-6068.
  23. Yamamoto N, Agata K, Nakashima K, *Imamura T. (2016).Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells. Nucleic Acids Res. 44: 5105-5122.
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