Malaria affects host immunity by modulating the bone marrow B cell niche. Details arehere.

Lee MSJ, Matsuo Dapaah J, Del Rosario Zorrilla C, Omatsu Y, Nagasawa T, Uemura S, Iwama A, Ishii KJ, Coban C.

Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells.https://doi.org/10.1093/intimm/dxae012.

We performed brain imaging of mouse cerebral malaria after CUBIC clearance and found thatP. bergheiANKA parasites accumulate in olfactory bulb of mouse.

What would happen if olfactory bulb is removed? See below.

Details can be found at:
Matsuo-Dapaah J, Lee MSJ, Ishii KJ, Tainaka K, Coban C. Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria. International Immunology, 2021, dxab060
Link:https://doi.org/10.1093/intimm/dxab060

https://immunology.sciencemag.org/content/2/12/eaam8093.long

Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C.Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria. Cell Host Microbe, 2014, 15(5): 551-63. DO I: 10.1016/j.chom.2014.04.008