Hioki K, Hayashi T, Natsume-Kitatani Y, Kobiyama K, Temizoz B, Negishi H, Kawakami H, Fuchino H, Kuroda E, Coban C, Kawahara N, Ishii KJ. Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants. Front Immunol. 2022 May 19;13:847616. doi: 10.3389/fimmu.2022.847616. eCollection 2022.

Temizoz B, Hioki K, Kobari S, Jounai N, Kusakabe T, Lee MSJ, Coban C, Kuroda E, Ishii KJ. Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation. Int Immunol. 2022 Jul 4;34(7):353-364.doi: 10.1093/intimm/dxac012.

Lee MSJ, Inoue T, Ise W, Matsuo-Dapaah J, Wing JB, Temizoz B, Kobiyama K, Hayashi T, Patil A, Sakaguchi S, Simon AK, Bezbradica JS, Nagatoishi S, Tsumoto K, Inoue JI, Akira S, Kurosaki T, Ishii KJ, Coban C. December 16 2021. B cell intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice. Journal of Experimental Medicine. DOI: 10.1084/jem.20211336.
Link:https://doi.org/10.1084/jem.20211336👏Cover

Fischer FA, Mies LFM, Nizami S, Pantazi E, Danielli S, Demarco B, Ohlmeyer M, Lee MSJ, Coban C, Kagan JC, Di Daniel E, Bezbradica JS. TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation. Proc Natl Acad Sci U S A. 2021, September 21, 118 (38) e2009309118. doi.org/10.1073/pnas.2009309118. PMID: 34518217
Link:https://www.pnas.org/content/118/38/e2009309118

Matsuo-Dapaah J, Lee MSJ, Ishii KJ, Tainaka K, Coban C. Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria. International Immunology, 2021, dxab060
Link:https://doi.org/10.1093/intimm/dxab060

Coban C. The host targeting effect of chloroquine in malaria. Curr Opin Immunol. 2020 Aug 18;66:98-107. doi: 10.1016/j.coi.2020.07.005. PMID: 32823144
Link:https://www.sciencedirect.com/science/article/pii/S0952791520300741

Lelliott PM, Momota M, Shibahara T, Lee MSJ, Smith NI, Ishii KJ, Coban C. Heparin induces neutrophil elastase dependent vital and lytic NET formation. Int Immunol., 2019, Dec 27. pii: dxz084. doi: 10.1093/intimm/dxz084. [Epub ahead of print] PMID: 31879779
Link:https://academic.oup.com/intimm/article/doi/10.1093/intimm/dxz084/5687821

Momota M, Lelliott P, Kubo A, Kusakabe T, Kobiyama K, Kuroda E, Imai Y, Akira S, Coban C, Ishii KJ. ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity. Int Immunol., 2019, Oct 20. pii: dxz070. doi: 10.1093/intimm/dxz070.
Link:https://academic.oup.com/intimm/advance-article/doi/10.1093/intimm/dxz070/5601248

Ozasa K, Temizoz B, Kusakabe T, Kobari S, Momota M, Coban C, Ito S, Kobiyama K, Kuroda E and Ishii KJ. Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor. Front. Immunol, 2019, 10:2212. doi: 10.3389/fimmu.2019.02212.
Link:https://www.frontiersin.org/articles/10.3389/fimmu.2019.02212/full

Lee MSJ, Natsume‐Kitatani Y,Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, KobiyamaK, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C. B cell‐intrinsic MyD88 signaling controls IFN‐γ‐mediated early IgG2c class switching in mice in response to a particulate adjuvant. European Journal of Immunology, 14 May 2019
Link:http://doi.org/10.1002/eji.201848084

Lelliott PM, Momota M, Lee MSJ, Kuroda E, Iijima N, Ishii KJ, Coban C. Rapid quantification of NETs in vitro and in whole blood samples by imaging flow cytometry. Cytometry A, 2019, DOI: 10.1002/cyto.a.23767.
Contact:Cevayir COBAN

Hayashi T, Momota M, Kuroda E, Kusakabe T, Kobari S, Makisaka K, Ohno Y, Suzuki Y, Nakagawa F, Lee MSJ, Coban C, Onodera R, Higashi T, Motoyama K, Ishii KJ, Arima H. DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination. Front Immunol. 2018 Nov 20;9:2619. doi: 10.3389/fimmu.2018.02619. eCollection 2018. Link

Ekemen S, Uzay A, Bassullu N, Dikicioglu-Cetin E, Matsuda K, Ince U, Coban C. Does it take three to tango? An unsuspected multimorbidity of CD8+ T cell lymphoproliferative disorder, malaria, and EBV infection. Malar Journal, 2018 Oct 5;17(1):349. doi: 10.1186/s12936-018-2497-9.Link

Coban C, Lee MSJ, Ishii KJ. Tissue-specific immunopathology during malaria infection. Nature Reviews Immunology, 2018 doi:10.1038/nri.2017.138

Lee MSJ, Coban C. Unforeseen pathologies caused by malaria. International Immunology, 2017 Dec 28. doi: 10.1093/intimm/dxx076. [Epub ahead of print] PMID: 29300968

Lelliott PM, Huang HM, Dixon MW, Namvar A, Blanch AJ, Rajagopal V, Tilley L, Coban C, McMorran BJ, Foote SJ, Burgio G. Erythrocyte β spectrin can be genetically targeted to protect mice from malaria. Blood Advances, 2017 Dec 12;1(26):2624-2636. doi: 10.1182/bloodadvances.2017009274. eCollection 2017 Dec 12.

Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S. A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers. Proc Natl Acad Sci U S A. 2017 Jul 11. pii: 201705551. doi: 10.1073/pnas.1705551114. PMID: 28698369.

Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin JW, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C. Plasmodium products persist in the bone marrow and promote chronic bone loss. Science Immunology, 2017, June 2; 2 (12), pii: eaam8093. DOI: 10.1126/sciimmunol.aam8093👏Cover

Hubber A, Kubori T, Coban C, Matsuzawa T, Ogawa M, Kawabata T, Yoshimori T, Nagai H. Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis. Sci Rep. 2017 Mar 20;7: 44795.doi: 10.1038/srep44795. PMID: 28317932

Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity, 2016 Dec 20; 45(6):1299-1310. doi: 10.1016/j.immuni.2016.11.010. PMID: 28002730

Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines. EBioMedicine. 2016 Dec 1. pii: S2352-3964(16)30519-9. doi: 10.1016/j.ebiom.2016.11.015. PMID:27919753

Hayashi M, Aoshi T, Ozasa K, Kusakabe T, Momota M, Haseda Y, Kobari S, Kuroda E, Kobiyama K, Coban C, Ishii KJ. RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine. Sci Rep, 2016, Jul 4; 6: 29165. doi: 10.1038/srep29165. PMID: 27374884

Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ. Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells. Oncotarget, 2016, Jul 1. doi: 10.18632/oncotarget.10379. PMID: 27384490

Lelliott PM, Coban C. IFN-γ protects hepatocytes against Plasmodium vivax infection via LAP-like degradation of sporozoites. Commentary, Proc Natl Acad Sci U S A, 2016, Jun 10. pii: 201607007. [Epub ahead of print]

Lee MSJ, Igari Y, Tsukui T, Ishii KJ, Coban C. Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation. Review, Vaccine, 2016, available online 11 March 2016, doi:10.1016/j.vaccine.2016.02.064.

Aoshi T, Haseda Y, Kobiyama K, Narita H, Sato H, Nankai H, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Kuroda E, Coban C, Ishii KJ. Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use. Journal of Immunology Research, 2015, Volume 2015, Article ID 316364.

Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley DM, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ. Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen. Journal of Immunology, 2015, 194(6), 2673-2682.

Hobro AJ, Pavillon N, Fujita K, Ozkan M, Coban C, Smith NI. Label-free Raman imaging of the macrophage response to the malaria pigment hemozoin. Analyst, 2015, Feb 3. [Epub ahead of print] PMID: 25646175

Uraki R, Das SC, Hatta M, Kiso M, Iwatsuki-Horimoto K, Ozawa M, Coban C, Ishii KJ, Kawaoka Y. Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine. Vaccine, 2014, Aug 6. pii: S0264-410X(14)01046-9. doi: 10.1016/j.vaccine.2014.07.079. [Epub ahead of print] PMID: 25108216

Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C. Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria. Cell Host Microbe, 2014, 15(5): 551-63.

Onishi M, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Coban C, Ishii KJ. Hemozoin is a potent adjuvant for hemagglutinin split vaccine without pyrogenicity in ferrets. Vaccine, 2014, Apr 8.doi: 10.1016/j.vaccine.2014.03.072. [Epub ahead of print] PMID: 24721532

Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci U S A, 2014, Feb 25;111(8):3086-91. doi: 10.1073/pnas.1319268111. Epub 2014 Feb 10. PMID: 24516163.

Coban C, Kobiyama K, Jounai N, Tozuka M, Ishii KJ. DNA vaccines: A simple DNA sensing matter? Review, Human Vaccines and Immunotherapeutics, 2013, Aug 2;9 (10). 23912600.
+ Selected as this journal cover.

Kobiyama K, Jounai N, Aoshi T, Tozuka M, Takeshita F, Coban C, Ishii KJ. Innate Immune Signaling by Genetic Adjuvants for DNA Vaccination. Review, Vaccines, 2013, 1, 278-292; doi:10. 3390/vaccines1030278.

Kuroda E, Coban C, Ishii KJ. Particulate adjuvant and innate immunity: past achievements, present findings and future prospects. Review, International Reviews of Immunology, 2013, 32(2):209-20. doi: 10.3109/08830185.2013.773326. PDF

Hobro AJ, Konishi A, Coban C, Smith NI. Raman spectroscopic analysis of malaria disease progression via blood and plasma samples. Analyst, 2013, Mar 26. [Epub ahead of print] PMID: 23529513.
+ Selected as one of the HOT papers in Analyst and openly accessed.

Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C, Ishii KJ. The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant. PLOS ONE, 2013, 8(3): e60038. doi:10.1371/journal.pone.0060038. PDF

Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T. TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Human Vaccines and Immunotherapeutics, 2013, Jan 4; 9(2). PMID: 23291928

Kim W, Ozdemir SK, Zhu J, Faraz M, Coban C, Yang L. Detection and size measurement of individual hemozoin nanocrystals in aquatic environment using a whispering gallery mode resonator. Optics Express, 2012, Dec 31; 20(28):29426-46. doi: 10.1364/OE.20.029426. PDF
+Selected as featured article in Virtual Journal for Biomedical Optics (VJBO).

Hong Z, Konishi A, Fujita Y, Yagi M, Ohata K, Aoshi T, Itagaki S, Sato S, Narita H, Abdelgelil NH, Inoue M, Culleton R, Kaneko O, Nakagawa A, Horii T, Akira S, Ishii KJ, Coban C. Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe, 2012, 12(5):705-16. doi: 10.1016/j.chom.2012.10.010.PMID: 23159059.
+ Chosen as featured article at Malaria Nexus (Elsevier’s global malaria resource) network.

Culleton R, Coban C, Yildiz Zeyrek F, Cravo P, Kaneko A, Randrianarivelojosia M, Andrianaranjaka V, Kano S, Farnert A, Arez A, Sharp PM , Carter R, Tanabe K. The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing. PLOS ONE, 2011, 6(12): e29137. DOI:10.1371/journal.pone.0029137 PDF

Yildiz Zeyrek F, Palacpac N, Yuksel F, Yagi M, Honjo K, Fujita Y, Arisue N, Takeo S, Tanabe K, Horii T, Tsuboi T, Ishii KJ, Coban C. Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax. PLOS ONE, 2011, 6(11): e28126. DOI:10.1371/journal.pone.0028126. PDF

Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ. Novel Strategies to Improve DNA Vaccine Immunogenicity. Review, Current Gene Therapy, 2011, Dec; 11(6):479-484. PMID: 22023477. PDF

Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ. DNA released from dying host cells mediates aluminum adjuvant activity. Nature Medicine, 2011, Jul 17; 17(8):996-1002. DOI: 10.1038/nm.2403.

Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y. Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms. Immunity, 2011, 34(4):514-526. DOI:10.1016/j.immuni.2011.03.019

Yildiz Zeyrek F, Tachibana S, Yuksel F, Doni N, Palacpac N, Arisue N, Horii T, Coban C, Tanabe K. Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey. American Journal of Tropical Medicine and Hygiene, 2010, 83(6):1230-1237.

Coban C, Horii T, Akira S, Ishii KJ. TLR9 and Endogenous Adjuvants of the Whole Blood-stage Malaria Vaccine. Review, Expert Review of Vaccines, 2010, 9(7):775-84.

Shokouhi B, Coban C, Hasirci V, Aydin E, Dhanasingh A, Shi N, Koyama S, Akira S, Zenke M, Sechi AS. Biomedical polymers subvert dendritic cell function and adhesion through the activation of multiple Toll-like receptor signaling cascades. Biomaterials, 2010, 31(22):5759-5771.

Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ. Plasmocytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Science Translational Medicine, 2010, Vol. 2, Issue 25, p. 25ra24.

Coban C, Yagi M, Ohata K, Igari Y, Tsukui T, Horii T, Ishii KJ, Akira S. The malarial metabolite hemozoin and its potential use as s vaccine adjuvant. Review, Allergology International, 2010, 59(2): 115-124. DOI: 10.2332_allergolint.10-RAI-0194. PDF

Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nuñez G, Ishii KJ, Akira S. Immunogenicity of Whole Parasite Vaccines Against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9. Cell Host and Microbe, 2010, 7(1):50-61.
+ This paper is previewed (by Prof. Herman Wagner) and published as Featured Article, + Chosen by F1000 Biology.
+ This paper has been selected in the Research Highlights of Nature Immunology, April 2010 issue. Nature Immunology 11, 287 (2010)doi:10.1038/ni0410-287.

Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Núñez G. Experimental Cerebral Malaria Progresses Independently of the Nlrp3 Inflammasome. European Journal of Immunology, 2010, 40(3):764-9.