腹部放射線治療後に起こる腸線維症のメカニズムを解明 好酸球除去抗体による革新的治療法に期待
腹部放射線治療後に起こる腸線維症のメカニズムを解明 好酸球除去抗体による革新的治療法に期待
Science Translational Medicine オンライン版
Naoki Takemura1,2, Yosuke Kurashima3,4, Yuki Mori5, Kazuki Okada6, Takayuki Ogino7,8, Hideki Osawa7, Hirosih Matsuno7, Lamichhane Aayam3, Satoshi Kaneto3, E. J. Park3,9, Shintaro Sato3,10 Kouta Matsunaga2, Yusuke Tamura2, Yasuo Ouchi1, Yutaro Kumagai11, Daichi Kobayashi12,13, Yutaka Suzuki14, Yoshichika Yoshioka5, Junichi Nishimura7, Masaki Mori7, Ken J. Ishii15,16, Mark E. Rothenberg17, Hiroshi Kiyono3,4, Shizuo Akira18,19, and Satoshi Uematsu1,2
1Department of Mucosal Immunology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
2Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
3Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
4Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
5Laboratory of Biofunctional Imaging, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
6Immunology & Allergy R&D Unit, R&D Division, Kyowa Hakko Kirin Co., Ltd, 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan
7Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
8Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany
9Department of Molecular Pathobiology and Cell Adhesion Biology, Basic Medical Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
10Mucosal Vaccine Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
11Quantitative Immunology Research Unit, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
12Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
13Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
14Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8562, Japan
15Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, 7-6-8 Asagi Saito, Ibaraki, Osaka 567-0085, Japan
16Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
17Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
18Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
19Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, JapanEosinophil depletion suppresses radiation-induced small intestinal fibrosis
千葉大学大学院医学研究院粘膜免疫学／東京大学医科学研究所国際粘膜ワクチン開発研究センター自然免疫制御分野・植松智教授の研究グループは、これまで治療法のなかった腹部放射線治療後の重篤な合併症である腸線維症において、好酸球が重要な役割を果たすことを発見し、発症のメカニズムを解明しました。好酸球除去抗体の投与が、放射線照射後の線維化を著しく抑制したことから、新規治療法の開発につながることが考えられます。
この成果を報告した論文は、2018年2月21日（米国東部時間）発行の米国学術誌Science Translational Medicineオンライン版にて発表されます。なお、本研究は、AMED免疫アレルギー疾患等実用化研究事業(免疫アレルギー疾患実用化研究分野)における研究開発課題「腸管免疫統合的制御による炎症性腸疾患新規予防・治療戦略研究開発(研究開発代表者：清野宏)」の一環として行われました。