Y染色体がもたらす男性特異的な疾患リスク形成機構を解明 ――2型糖尿病リスクの性差につながる新たな因子の発見――

"Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes"

Nature Medicine オンライン版 2026年2月23日 doi:10.1038/s41591-026-04213-z

Go Sato#✝, Yuji Yamamoto#, Kyuto Sonehara, Ryunosuke Saiki, Takafumi Ojima, Masahiro Kanai, Aoxing Liu, Ryuya Edahiro, Yuya Shirai, Shinichi Namba, Ho Namkoong, Takanori Hasegawa, Yuriko N. Koyanagi, Yumiko Kasugai, Taiki Yamaji, Shiori Nakano, Giulio Genovese, Timo P. Sipilä, Awaisa Ghazal, Hiromu Tanaka, Shuhei Azekawa, Yoshifumi Uwamino, Kenichi Yamamoto, Ken Suzuki, Tsuyoshi Hata, Mamoru Uemura, Yoshito Takeda, Akinori Kanai, Shinichi Higashiue, Shuzo Kobayashi, Hisaaki Afuso, Kosho Matsuura, Yojiro Mitsumoto, Yasuhiko Fujita, FinnGen, the Japan COVID-19 Task Force, the Biobank Japan Project, Yoshiya Oda, Yutaka Suzuki, Takayuki Morisaki, Makoto Ishii, Yuko Kitagawa, Ryuji Koike, Akinori Kimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Jun Takayama, Motoki Iwasaki, Norie Sawada, Koichi Fukunaga, Keitaro Matsuo, Atsushi Kumanogoh, Yuichiro Doki, Hidetoshi Eguchi, Shigeki Nakagome, Gen Tamiya, Andrea Ganna, Aarno Palotie, Mark J. Daly, James F. Wilson, Masayuki Yamamoto, Koichi Matsuda, Seishi Ogawa, Toshimasa Yamauchi, Takashi Kadowaki, and Yukinori Okada✝
#同等貢献、✝責任著者