全ゲノムシークエンス解析により乾癬の新規関連遺伝子を発見 ――見逃されてきた希少変異と構造変異の関与を解明――

"Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene"

Cell Genomics オンライン版 2025年8月22日 doi:10.1016/j.xgen.2025.100978

Kyuto Sonehara*, Rei Watanabe, Yutaka Matsumura, Yuichi Mitsui, Yosuke Ogawa, Kaori Odomari, Saori Sakaue, Shinichi Namba, Mariko Komuro, Mio Edamoto, Junya Watanabe, Tomomitsu Hirota, Noriko Arase, Yuumi Nakamura, Kimiko Nakajima, Takashi Okamoto, Rika Nishikawa, Kenichi Yamamoto, Ken Suzuki, Toshihiro Kishikawa, Ryuya Edahiro, Yuya Shirai, Tatsuhiko Naito, Noah Sasa, Yosuke Ishitsuka, Junichi Furuta, Kayo Kunimoto, Ikko Kajihara, Satoshi Fukushima, Hideaki Miyachi, Hiroyuki Matsue, Masahiro Kamata, Mami Momose, Ippei Miyagawa, Hiroaki Tanaka, Masanobu Ueno, Toshinori Bito, Hiroshi Nagai, Tetsuya Ikeda, Tatsuya Horikawa, Atsuko Adachi, Tsukasa Matsubara, Emi Nishida, Biobank Japan Project, Koichi Matsuda, Nobuhiro Shojima, Ikuma Nakagawa, Yoshihide Asano, Shinichi Sato, Shinichi Imafuku, Yayoi Tada, Chikako Nishigori, Masatoshi Jinnin, Hironobu Ihn, Akihiko Asahina, Hidehisa Saeki, Toshimasa Yamauchi, Takashi Kadowaki, Tatsuyoshi Kawamura, Shinji Shimada, Ichiro Katayama, Koichiro Higasa, Emiko Noguchi, Shigetoshi Sano, Yoshiya Tanaka, Fumihiko Matsuda, Atsushi Kumanogoh, Mayumi Tamari, Takashi Satoh, Manabu Fujimoto, Akimichi Morita, Yukinori Okada*
*責任著者