"Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats"
Communications Biology オンライン版 2022年3月30日 doi:10.1038/s42003-022-03241-y
がん耐性齧歯類ハダカデバネズミの 化学発がん物質への強い発がん耐性を証明 -炎症抑制を介したがん耐性機構の一端を解明-
解説
論文情報
Kaori Oka1,2†, Shusuke Fujioka1,2†, Yoshimi Kawamura1,2†, Yoshihiro Komohara3, Takeshi Chujo4, Koki Sekiguchi1, Yuki Yamamura1, Yuki Oiwa1,2, Natsuko Omamiuda-Ishikawa1, Shohei Komaki5, Yoichi Sutoh5, Satoko Sakurai6, Kazuhito Tomizawa4,7, Hidemasa Bono8, Atsushi Shimizu5,9, Kimi Araki7,10, Takuya Yamamoto6,11,12,13, Yasuhiro Yamada13,14, Hiroyuki Oshiumi15, and Kyoko Miura1,2,7*
1 Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-0811, Japan.
2 Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
3 Department of Cell Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
4 Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
5 Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate 028-3694, Japan.
6 Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
7 Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto 860-8556, Japan.
8 Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-0046, Japan.
9 Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
10 Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan.
11 Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan.
12 Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan.
13 AMED-CREST, AMED, Tokyo 100-0004, Japan.
14 Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
15 Department of Immunology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
†：共同第一著者、*：責任著者
1 Department of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-0811, Japan.
2 Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
3 Department of Cell Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
4 Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
5 Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate 028-3694, Japan.
6 Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
7 Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto 860-8556, Japan.
8 Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-0046, Japan.
9 Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate 028-3694, Japan.
10 Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan.
11 Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan.
12 Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan.
13 AMED-CREST, AMED, Tokyo 100-0004, Japan.
14 Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
15 Department of Immunology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
†：共同第一著者、*：責任著者
