東京大学医科学研究所
システム疾患モデル研究センター
先進モデル動物作製コア

小沢チーム

研究業績

*Correspondence, †Equally contributed

1) 論文

  1. Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y. Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience 2024;27:108997.
  2. Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, Okuzaki D, Shimada K, Miyata H, Shimada K, Kodani M, Ishikawa-Yamauchi Y, Motooka D, Hara E, Ikawa M. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice. Commun Biol 2024;7:16.
  3. Ozawa M*, Mori H, Endo T, Ishikawa-Yamauchi Y, Motooka D, Emori C, Ikawa M. Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice. iScience 2023;26:108456.
  4. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med 2023;220:e20230054.
  5. Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M. LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits. Nat Aging 2023;3:1001-1019.
  6. Hoang T, Kim DW, Appel H, Ozawa M, Zheng S, Kim J, Blackshaw S. Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature 2023;618:E1-E7.
  7. Iwagawa T, Fukushima M, Takeuchi S, Kawamura Y, Aihara Y, Ozawa M, Yakushiji-Kaminatsui N, Aihara M, Koseki H, Suzuki Y, Watanabe S. The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types. Genes Cells 2023;28:482-495.
  8. Ozawa M*, Taguchi J†, Katsuma K, Ishikawa-Yamauchi Y, Kikuchi M, Sakamoto R, Yamada Y, Ikawa M. Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice. Sci Rep 2022;12: 21558.
  9. Ozawa M*, Emori C, Ikawa M. CRISPR/Cas9-mediated highly efficient gene targeting in embryonic stem cells for developing gene-manipulated mouse models. J Vis Exp 2022;186.
  10. Hensel JA, Nicholas SE, Jellison ER, Kimble AL, Menoret A, Ozawa M, Rodriguez-Oquendo A, Vella AT, Murphy PA. Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions. Proc Natl Acad Sci U S A 2022;119:e2122227119.
  11. Hoang T, Kim DW, Appel H, Pannullo NA, Ozawa M, Zheng S, Yu M, Peachey NS, Kim J, Blackshaw S. Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina. Cell Reports 2022;39:110849.
  12. Hirano M, So Y, Tsunekawa S, Kabata M, Ohta S, Sagara H, Sankoda N, Taguchi J, Yamada Y, Ukai T, Kato M, Nakamura J, Ozawa M, Yamamoto T, Yamada Y. MYCL-mediated reprogramming expands pancreatic insulin-producing cells. Nat Metab 2022;4:254-268.
  13. Shimada-Takayama Y, Yasuda T, Ukai T, Taguchi J, Ozawa M, Sankoda N, Ohta S, Yamada Y. Generation of mice for evaluating endogenous p16Ink4a protein expression. Biochem Biophys Res Commun 2022;599:43-50
  14. Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka S, Yamasawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency. Nat Commun 2021;12:5041.
  15. Liu K, Sato R, Shibata T, Hiranuma R, Reuter T, Fukui R, Zhang Y, Ichinohe T, Ozawa M, Yoshida N, Latz E, Miyake K. Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages. Int Immunol 2021;33:479-490.
  16. Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T. Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS Genetics 2021;17(8):e1009688.
  17. Omori S, Wang TW, Johmura1 Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Miyoshi C, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, NakanishiN M. Generation of a p16 reporter mouse and its use to characterize and target p16 high cells in vivo. Cell Metab 2020;32:814-828.e6
  18. Senoo M, Hozoji H, Ishikawa-Yamauchi Y, Takijiri T, Ohta S, Ukai T, Kabata M, Yamamoto T, Yamada Y, Ikawa M, Ozawa M*. RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3. J Reprod Dev 2020;66:459-467.
  19. Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K, Kodani M, Kohda T, Fujihara Y, Ozawa M, Yu Z, Miklossy G, Bohren KM, Horie M, Okabe M, Matzuk MM, Ikawa M. NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science 2020;368:1132-1135.
  20. Senoo M, Takijiri T, Yoshida N, Ozawa M*, Ikawa M. PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia. J Reprod Dev 2019;65:37–46.
  21. Komura S, Ito K, Ohta S, Ukai T, Kabata M, Itakura F, Semi F, Matsuda Y, Hashimoto K, Shibata H, Sone M, Jo N, Sekiguchi K, Ohno T, Akiyama H, Shimizu K, Woltjen K, Ozawa M, Toguchida J, Yamamoto T, Yamada Y. Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas. Nat Commun 2019;10:3999.
  22. Sasanuma H, Ozawa M, Yoshida N. RNA binding protein Ptbp1 is essential for BCR-mediated antibody production. Int Immunol 2019;31:158-166.
  23. Tribulo P, Moss JI, Ozawa M, Jiang Z, Tian X, Hansen PJ. WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB1. Reproduction 2017;153:405-419.
  24. Zhang X, Chen H, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell 2016;166:1147-1162.
  25. Ozawa M, Sakatani M†, Dobbs K, Kannampuzha-Francis J, Hansen PJ. Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2. BMC Research Notes 2016;9:250.
  26. Ozawa M*, Fukuda T, Sakamoto R, Honda H, Yoshida N. The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice. Biol Reprod 2016; 94:1-11.
  27. Yang QE, Ozawa M, Zhang K, Johnson S, Ealy AD. The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. Reprod Fertil Dev 2016;28:482-490.
  28. Ozawa M*, Kawakami E, Sakamoto R, Shibasaki T, Goto A, Yoshida N. Development of FGF2-dependent pluripotent stem cells showing naive state characteristics from murine preimplantation inner cell mass. Stem Cell Res 2014;13:75-87.
  29. Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N. The histone demethylases Fbxl11 plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Devel 2014;135:31-42.
  30. Nakai M, Ozawa M, Maedomari N, Noguchi J, Kaneko H, Ito J, Onishi A, Kashiwazaki N, Kikuchi K. Delay in cleavage of porcine embryos after intracytoplasmic sperm injection (ICSI) shows poorer embryonic development. J Reprod Dev 2014;60:256-259.
  31. Ozawa M, Yang QE, Ealy AD. The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro. Reproduction 2013;145:191-201.
  32. Sakatani M, Bonilla L, Dobbs KB, Block J, Ozawa M, Shanker S, Yao J, Hansen PJ. Changes in the transcriptome of morula-stage bovine embryos caused by heat shock: relationship to developmental acquisition of thermotolerance. Reprod Biol Endocrinol 2013;11:3.
  33. Dobbs KB, Khan FA, Sakatani M, Moss JI, Ozawa M, Ealy AD, Hansen PJ. Regulation of pluripotency of inner cell mass and growth and differentiation of trophectoderm of the bovine embryo by colony stimulating factor 2. Biol Reprod 2013;89:1-10.
  34. Ozawa M, Sakatani M, Yao J, Shanker S, Yu F, Yamashita R, Wakabayashi S, Nakai K, Dobbs KB, Sudano MJ, Farmerie WG, Hansen PJ. Global gene expression of the inner cell mass and trophectoderm of the bovine blastocyst. BMC Dev Biol 2012;12:33.
  35. Ozawa M, Sakatani M, Hankowski KE, Terada N, Dobbs KB, Hansen PJ. Importance of culture conditions during the morula-to-blastocyst period on capacity of inner cell-mass cells of bovine blastocysts for establishment of self-renewing pluripotent cells. Theriogenology 2012;78:1243-1251.
  36. Dong Y., Kobayashi S, Tian Y, Ozawa M, Hiramoto T, Izawa K, Bai Y, Soda Y, Sasaki E, Itoh T, Maru Y, Oyaizu N, Tojo A, Kai C, Tani K. Leukemogenic fusion gene (p190 BCR-ABL) transduction into hematopoietic stem/progenitor cells in the common marmoset. Open J Blood Dis. 2012;2: 1-10.
  37. Nunomura S, Shimada S, Kametani Y, Yamada Y, Yoshioka M, Suemizu H, Ozawa M, Itoh T, Kono A, Suzuki R, Tani K, Ando K, Yagita H, Ra C, Habu S, Satake M, Sasaki E. Double expression of CD34 and CD117 on bone marrow progenitors is a hallmark of the development of functional mast cell of Callithrix jacchus (common marmoset). Int Immunol 2012;24:593-603.
  38. Bonilla AQ, Oliveira LJ, Ozawa M, Newsom EM, Lucy MC. Hansen PJ. Developmental changes in thermoprotective actions of insulin-like growth factor-1 on the preimplantation bovine embryo. Mol Cell Endocrinol 2011;332:170-179.
  39. Bonilla AQ, Ozawa M, Hansen PJ. Timing and dependence upon mitogen-activated protein kinase signaling for pro-developmental actions of insulin-like growth factor 1 on the preimplantation bovine embryo. Growth Horm IGF Res 2011;2,107-111.
  40. Ozawa M, Hansen PJ. A novel method for purification of inner cell mass and trophectoderm cells from blastocysts using magnetic activated cell sorting. Fertil Steril 2011;95;799-802.
  41. Thompson IM, Ozawa M, Bubolz JW, Yang Q, Dahl GE. Bovine luteal prolactin receptor expression: potential involvement in regulation of progesterone during the estrous cycle and pregnancy. J Anim Sci 2011;89:1338-1346.
  42. Yang QE, Fields SD, Zhang K, Ozawa M, Johnson SE, Ealy AD. Fibroblast Growth Factor 2 Promotes Primitive Endoderm Development in Bovine Blastocyst Outgrowths. Biol Reprod 2011;85:946-953.
  43. Dang-Nguyen TQ, Kikuchi K, Somfai, Ozawa M, Nakai M, Maedomari Viet-Linh N, Kanai Y, Nguyen BX, Nagai T. Evaluation of developmental competence of in vitro-produced porcine embryos based on the timing, pattern and evenness of the first cleavage and the onset of the second cleavage. J Reprod Dev 2010;56:593-600.
  44. Maedomari N, Kikuchi K, Nagai T, Fahrudin M, Kaneko H, Noguchi J, Nakai M, Ozawa M, Somfai T, Nguyen LV, Ito J, Kashiwazaki N. Nuclear Replacement of In Vitro-Matured Porcine Oocytes by a Serial Centrifugation and Fusion Method. Reprod Domest Anim 2010;45:659-665.
  45. Nakai M, Kaneko H, Somfai T, Maedomari N, Ozawa M, Noguchi J, Ito J, Kashiwazaki N, Kikuchi K. Production of viable piglets for the first time using sperm derived from ectopic testicular xenografts. Reproduction 2010;139:331–335.
  46. Ozawa M, Nagai T, Somfai T, Nakai M, Maedomari N, Miyazaki H, Kaneko H, Noguchi J, Kikuchi K. Cumulus cell-enclosed oocytes acquire a capacity to synthesize GSH by FSH stimulation during in vitro maturation in pigs. J Cell Physiol 2010;222:294-301.
  47. Somfai T, Noguchi J, Kaneko H, Nakai M, Ozawa M, Kashiwazaki N, Egerszegi I, Rátky J, Nagai T, Kikuchi K. Production of good-quality porcine blastocysts by in vitro fertilization of follicular oocytes vitrified at the germinal vesicle stage. Theriogenology 2010;73:147-156.
  48. Kametani Y, Suzuki D, Kohu K, Satake M, Suemizu H, Sasaki E, Ito T, Tamaoki N, Mizushima T, Ozawa M, Tani K, Kito M, Arai H, Koyanagi A, Yagita H, Habu S. Development of Monoclonal Antibodies for Analyzing Immune and Hematopoietic Systems of Common Marmoset. Exp Hematol 2009;37:1318-1329.
  49. Nakai M, Kaneko H, Somfai T, Maedomari N, Ozawa M, Noguchi J, Kashiwazaki N, Kikuchi K. Generation of porcine diploid blastocysts after injection of spermatozoa grown in nude mice. Theriogenology 2009;72: 2-9.
  50. Sakamoto N, Ozawa M†, Yokotani-Tomita K, Morimoto A, Ijiri D, Hirabayashi M, Ushitani A, Kanai Y. Administration of DL-a-tocopherol acetate mitigates maternal hyperthermia-induced preimplantation embryonic death accompanied with reduction of oxidative stress in mice. Reproduction 2009;135:489-496.
  51. Somfai T, Ozawa M, Noguchi J, Kaneko H, Nakai M, Maedomari N, Ito J, Kashiwazaki N, Nagai T & Kikuchi K. Live piglets derived from in vitro-produced zygotes vitrified at the pronuclear stage. Biol Reprod 2009;80:42-49.
  52. Noguchi J, Ozawa M, Nakai M, Somfai T, Kikuchi K, Kaneko H, Kunieda T. Affected homologous chromosome pairing and phosphorylation of testis specific histone, H2AX, in male meiosis under FKBP6 deficiency. J Reprod Dev 2008;54:203-207.
  53. Ozawa M, Nagai T, Somfai T, Nakai M, Maedomari N, Fahrudin M, Karja NWK, Kaneko H, Noguchi J, Ohnuma K, Noriko Yoshimi, Miyazaki H, Kikuchi K. Comparison between effects of 3-isobutyl-1-methylxanthine and FSH on gap junctional communication, LH receptor expression, and meiotic maturation of cumulus-oocyte complexes in pigs. Mol Reprod Dev 2008;75:857-866.
  54. Somfai T, Kashiwazaki N, Ozawa M, Nakai M, Maedomari N, Noguchi J, Kaneko H, Nagai T, Kikuchi K. Effect of centrifugation treatment before vitrification on the viability of porcine mature oocytes and zygotes produced in vitro. J Reprod Dev 2008;54:149-155.
  55. Somfai T, Ozawa M, Noguchi J, Kaneko H, Karja NWK, Fahrudin M, Nakai M, Maedomari N, Dinnyés A, Nagai T, Kikuchi K. In vitro development of polyspermic porcine oocytes: Relationship between early fragmentation and excessive number of penetrating spermatozoa. Anim Reprod Sci 2008;107:131-147.
  56. Fahrudin M, Kikuchi K, Karja NWK, Ozawa M, Somfai T, Ohnuma K, Noguchi J, Kaneko H, Nagai T. Development to the blastocyst stage of porcine somatic cell nuclear transfer embryos reconstructed by the fusion of cumulus cells and cytoplasts prepared by gradient centrifugation. Cloning Stem Cells 2007;9:216-228.
  57. Ohnuma K, Kaneko H, Noguchi J, Kikuchi K, Ozawa M, Hasegawa Y. Isolation and identification of F-spondin in boar testis and its production during testis growth. J Reprod Dev 2007;53:151-158.
  58. Ohnuma K, Kaneko H, Noguchi J, Kikuchi K, Ozawa M, Hasegawa Y. Production of inhibin A and inhibin B in boars: changes in testicular and circulating levels of dimeric inhibins and characterization of inhibin forms during testis growth. Domest Anim Endocrinol 2007;33:410-421.
  59. Somfai T, Ozawa M, Noguchi J, Kaneko H, Ohnuma K, Karja NWK, Fahrudin M, Maedomari N, Dinnyés A, Nagai T, Kikuchi K. Developmental competence of in vitro fertilized porcine oocytes after in vitro maturation and Solid Surface Vitrification: the effect of cryopreservation on oocyte antioxidative system. Cryobiology 2007;55:115-126.
  60. Kaneko H, Kikuchi K, Noguchi J, Ozawa M, Ohnuma K, Maedomari N, Kashiwazaki N. Effects of gonadotropin treatments on meiotic and developmental competence of oocytes in porcine primordial follicles following xenografting to nude mice. Reproduction 2006;131:279-288.
  61. Kaneko H, Matsuzaki M, Noguchi J, Kikuchi K, Ohnuma K, Ozawa M. Changes in circulating and testicular levels of inhibin A and B during postnatal development in bulls. J Reprod Dev 2006;52:741-749.
  62. Karja NWK, Kikuchi K, Fahrudin M, Ozawa M, Somfai T, Ohnuma K, Noguchi J, Kaneko H, Nagai T. Development to the blastocyst stage, the oxidative state, and the quality of early developmental stage of porcine embryos cultured in alteration of glucose concentrations in vitro under different oxygen tensions. Reprod Biol Endocrinol 2006;4:5.
  63. Kikuchi K, Kaneko H, Nakai M, Noguchi J, Ozawa M, Ohnuma K, Kashiwazaki N. In vitro and in vivo developmental ability of oocytes derived from porcine primordial follicles xenografted into nude mice. J Reprod Dev 2006;52:51-57.
  64. Maedomari N, Kikuchi K, Ozawa M, Noguchi J, Kaneko H, Ohnuma K, Nakai M, Shino M, Nagai T, Kashiwazaki N. Cytoplasmic glutathione regulated by cumulus cells during porcine oocyte maturation affects fertilization and embryonic development in vitro. Theriogenology 2006;67:983-993.
  65. Nakai M, Kashiwazaki N, Takizawa A, Maedomari N, Ozawa M, Noguchi J, Kaneko H, Shino M, Kikuchi K. Morphological changes in boar sperm nuclei with reduced disulfide bonds in electrostimulated porcine oocytes. Reproduction 2006;131:603-611.
  66. Nakai M, Kashiwazaki N, Takizawa A, Maedomari N, Ozawa M, Noguchi J, Kaneko H, Shino M, Kikuchi K. Effects of chelating agents during freeze-drying of boar spermatozoa on DNA fragmentation and on developmental ability in vitro and in vivo after intracytoplasmic sperm head injection. Zygote 2006;15:15-24.
  67. Noguchi J, Ohnuma K, Ozawa M, Karja NWK, Fahrudin M, Somfai T, Kikuchi K, Kaneko H. Successful long term culture of immature porcine sertoli cells in the reconstructed testicular cell cord. J Reprod Dev 2006;52:383-389.
  68. Ozawa M, Nagai T, Fahrudin M, Karja NWK, Kaneko H, Noguchi J, Ohnuma K, Kikuchi K. Addition of glutathione or thioredoxin to culture medium reduces intracellular redox status of porcine IVM/IVF embryos, resulting in improved development to the blastocyst stage. Mol Reprod Dev 2006;73:998-1007.
  69. Ozawa M*, Nagai T, Kaneko H, Noguchi J, Ohnuma K, Kikuchi K. Successful pig embryonic development in vitro outside a CO2 gas-regulated incubator: effect of pH and osmolality. Theriogenology 2006;65:860-869.
  70. Somfai T, Dinnyés A, Sage D, Marosán M, Carnwath JW, Ozawa M, Kikuchi K, Niemann H. Development to the blastocyst stage of parthenogenetically activated in vitro matured porcine oocytes after solid surface vitrification (SSV). Theriogenology 2006;66:415-422.
  71. Somfai T, Ozawa M, Noguchi J, Ohnuma K, Karja NWK, Fahrudin M, Maedomari N, Dinnyés A, Nagai T, Kikuchi K. Diploid porcine parthenotes produced by inhibition of first polar body extrusion during in vitro maturation of follicular oocytes. Reproduction 2006;132:559-570.
  72. Suzuki M, Misumi K, Ozawa M, Noguchi J, Kaneko H, Ohnuma K, Fuchimoto D, Onishi A, Iwamoto M, Saito N, Nagai T, Kikuchi K. Successful piglet production by IVF of oocytes matured in vitro using NCSU-37 supplemented with fetal bovine serum. Theriogenology 2006;65:374-386.
  73. Matsuzuka T, Ozawa M, Nakamura A, Ushitani A, Hirabayashi M, Kanai Y. Effects of heat stress on the redox status in the oviduct and early embryonic development in mice. J Reprod Dev 2005;51:281-287.
  74. Matsuzuka T, Sakamoto N, Ozawa M, Ushitani A, Hirabayashi M, Kanai Y. Alleviation of maternal hyperthermia-induced early embryonic death by administration of melatonin to mice. J Pineal Res 2005;39:217-223.
  75. Ozawa M, Tabayashi D, Latief TA, Shimizu T, Oshima I, Kanai Y. Alterations in follicular dynamics and steroidogenic abilities induced by heat stress during follicular recruitment in goats. Reproduction 2005;129:621-630.
  76. Shimizu T, Ohshima I, Ozawa M, Takahashi S, Tajima A, Shiota M, Miyazaki H, Kanai Y. Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells. Reproduction 2005;129:463-472.
  77. Somfai T, Kikuchi K, Medvedev S, Ohnishi A, Iwamoto M, Fuchimoto D, Ozawa M, Noguchi J, Kaneko H, Ohnuma K, Sato E, Nagai T. Development to the blastocyst stage of immature pig oocytes arrested before the metaphase-II stage and fertilized in vitro. Anim Reprod Sci 2005;90:307-328.
  78. Matsuzuka T, Ozawa M, Hirabayashi M, Kanai Y. Effects of maternal heat stress during oocyte maturation and soon after fertilization on subsequent embryonic development. Anim Sci J 2004;75:117-123.
  79. Noguchi J, Kobayashi E, Akiyama K, Kawai Y, Ozawa M, Ohnuma K, Kikuchi K, Kaneko H, Kunieda T. Fine mapping of a region of rat chromosome 12 close to the aspermia (as) locus and comparison with the human orthologous regions. Exp Anim 2004;53:429-435.
  80. Ozawa M, Matsuzuka T, Hirabayashi M, Kanai Y. Redox status of the oviduct and Cdc2 activity in two-cell stage embryos in heat-stressed mice. Biol Reprod 2004;71:291-296.
  81. Todoroki J, Noguchi J, Kikuchi K, Ohnuma K, Ozawa M, Kaneko K. Plasma concentrations of inhibin A in cattle with follicular cysts: relationships between turnover of follicular waves and plasma levels of gonadotropins and steroid hormones. Domest Anim Endocrinol 2004;27:333-344.
  82. Ozawa M, Yamasaki Y, Hirabayashi M, Kanai Y. Viability of maternally heat-stressed mouse zygotes in vivo and in vitro. Anim Sci J 2003;74:181-185.
  83. Ozawa M, Hirabayashi M, Kanai Y. Developmental competence and oxidative state of murine zygotes heat stressed maternally or in vitro. Reproduction 2002;124:683-689.

2) 総説

  1. Taguchi J, Yamada Y. In vivo reprogramming for tissue regeneration and organismal rejuvenation. Curr Opin Genet Dev 2017;46:132-140.
  2. Taguchi J, Yamada Y. Unveiling the Role of Senescence-Induced Cellular Plasticity. Cell Stem Cell 2017;20:293-294.
  3. Nakai M, Kashiwazaki N, Ito J, Maedomari N, Ozawa M, Shino M, Noguchi J, Kaneko H, Kikuchi K. Factors affecting fertilization and embryonic development during intracytoplasmic sperm injection in pigs. J Reprod Dev. 2011;57:183-187.
  4. Dang-Nguyen TQ, Kikuchi K, Somfai T, Ozawa M, Nakai M, Maedomari N, Viet-Linh N, Kanai Y, Nguyen BX, Nagai T Evaluation of Developmental Competence of In Vitro-produced Porcine Embryos Based on the Timing, Pattern and Evenness of the First Cleavage and Onset of the Second Cleavage. J Reprod Dev. 2010;56,31-35.

3) 欧文著書

  1. Ozawa M*, Emori C, Ikawa M. Gene targeting in mouse embryonic stem cells via CRISPR/Cas9 ribonucleoprotein (RNP) mediated genome editing. In: Hatada I (ed) Genome Editing in Animals – Methods and Protocols 2nd edition. 2022

4) 和文著書

  1. 田口 純平, 山田 泰広. 発がんにおける細胞老化. 生命の寿命延長:老化・長寿命の基盤研究最前線　2022年3月; 第8章-第2節: p267-274
  2. 田口 純平, 小沢　学, 三小田 直, 山田 泰広. 遺伝子発現誘導システムを用いたマウスモデルの作製とその応用. マウス・ラットモデル作製・解析プロフェッショナル:あなたの研究をステップアップさせる最新・最適技術 (先端モデル動物支援プラットフォーム AdAMS)　2021年3月; 第1章-3: p31-43
  3. 平野 利忠, 田口 純平, 山田 泰広. 幹細胞性獲得とがん幹細胞. 病理と臨床 2018年12月; 36(12): p1148-1154
  4. 田口 純平, 山田 泰広. エピゲノム制御に基づいた炎症性発がん機構の理解. 実験医学 2018年11月; 36(18): p3075-3080
  5. 平野 利忠, 田口 純平, 山田 泰広. 細胞初期化技術を応用したがんエピゲノム研究. 医学のあゆみ 2017年12月; 263(11-12): p941-945
  6. 田口 純平, 山田 泰広. リプログラミング技術を応用したがん研究. 実験医学増刊号 2016年6月; 34(10): p1611-1616
  7. 田口 純平, 山田 泰広.　リプログラミング技術を使ったがんエピゲノム研究. がん分子標的治療 2015年7月; 13(2): p232-236
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