基礎科学と臨床医学の架け橋として
新しい医療を確立する。

免疫学、分子生物学、細胞生物学、発生工学など、基礎科学の知識や方法論を臨床医学と結びつけることにより、新しい病気の発見、病態の解明、治療法の開発など、先端医療の確立に貢献することを目指しています。

最新のお知らせ一覧

2019/09/03

AMED再生医療研究交流会に参加しました

詳しくはこちら

2019/08/22

日経新聞電子版に記事が掲載されました

詳しくはこちら

2019/08/19

朝日新聞科学の扉に記事が掲載されました

詳しくはこちら

2019/05/29

Natureに論文が掲載されました

詳しくはこちら

2018/03/05

Stanford Medicine Magazineにinterviewが掲載されました

詳しくはこちら

最近の研究実績一覧

Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.
Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.
Stem Cell Reports. 2019 Aug

Abstract on PubMed

Villanueva J, Nishimura T, Nakauchi H.
Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.
Methods Mol Biol. 2019

Abstract on PubMed

Nishimura T, Murmann Y, Nakauchi H.
Human iPSC Generation from Antigen-Specific T Cells.
Methods Mol Biol. 2019

Abstract on PubMed

Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
Development. 2019 Aug

Abstract on PubMed

Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun. 2019 Jul

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica. 2019 Jul y

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Sci Rep. 2019 May

Abstract on PubMed

Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.

Stem Cell. 2019 May

Abstract on PubMed

Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.

Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.

J Hepatol. 2019 Mar

Abstract on PubMed

Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.

Sci Rep. 2019 Feb

Abstract on PubMed

Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.

Nat Commun. 2019 Feb

Abstract on PubMed

Nishimura T, Nakauchi H.

Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.

Methods Mol Biol. 2019

Abstract on PubMed

Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH.

Efficient scarless genome editing in human pluripotent stem cells.

Nat Methods. 2018 Dec

Abstract on PubMed

Mizuno N, Mizutani E, Sato H, Kasai M, Ogawa A, Suchy F, Yamaguchi T, Nakauchi H.

Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector.

iScience. 2018 Nov

Abstract on PubMed

Yamamoto R, Wilkinson AC, Nakauchi H.

hanging concepts in hematopoietic stem cells.

Science. 2018 Nov

Abstract on PubMed

Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.

Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.

Biomaterials. 2018 Nov

Abstract on PubMed

van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

Cell Rep. 2018 Oct

Abstract on PubMed

Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.

Sci Rep. 2018 Oct

Abstract on PubMed

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.

An interspecies barrier to tetraploid complementation and chimera formation.

Sci Rep. 2018 Oct

Abstract on PubMed

Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ.

Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep.

Transgenic Res. 2018 Oct

Abstract on PubMed

Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.

Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.

Stem Cell Reports. 2018 Sep

Abstract on PubMed

Higaki K, Hirao M, Kawana-Tachikawa A, Iriguchi S, Kumagai A, Ueda N, Bo W, Kamibayashi S, Watanabe A, Nakauchi H, Suzuki K, Kaneko S.

Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA.

Mol Ther Nucleic Acids. 2018 Aug

Abstract on PubMed

Ando M, Nakauchi H, Komatsu N.

[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].

Rinsho Ketsueki. 2018

Abstract on PubMed

Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.

Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

ACS Synth Biol. 2018 Jul

Abstract on PubMed

Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.

Chimeric liver transplantation reveals interspecific graft remodelling.

J Hepatol. 2018 Jul

Abstract on PubMed

Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.

Author Correction: Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.

Sci Rep. 2018 Jun

Abstract on PubMed

Suchy F, Nakauchi H.

Interspecies chimeras.

Curr Opin Genet Dev. 2018 May

Abstract on PubMed

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Cell Stem Cell. 2018 May

Abstract on PubMed

Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.

Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.

Exp Hematol. 2018 Apr

Abstract on PubMed

Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Cell Stem Cell.2018 Apr

Abstract on PubMed

Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y.

In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects.

Europace. 2018 Mar

Abstract on PubMed