研究実績

2020

Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.
Germline development in rat revealed by visualization and deletion of Prdm14.
Development. 2020 Jan

Abstract on PubMed

Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S.
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Regen Ther. 2020 Jan

Abstract on PubMed

Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan

Abstract on PubMed

Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H.
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation.
Stem Cell Reports. 2020 Jan

Abstract on PubMed

2019

Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.
Exp Hematol. 2019 Dec

Abstract on PubMed

Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV.
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.
Nat Med. 2019 Nov

Abstract on PubMed

Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.
Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.
Stem Cell Reports. 2019 Aug

Abstract on PubMed

Villanueva J, Nishimura T, Nakauchi H.
Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.
Methods Mol Biol. 2019

Abstract on PubMed

Nishimura T, Murmann Y, Nakauchi H.
Human iPSC Generation from Antigen-Specific T Cells.
Methods Mol Biol. 2019

Abstract on PubMed

Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
Development. 2019 Aug

Abstract on PubMed

Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun. 2019 Jul

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica. 2019 Jul y

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Sci Rep. 2019 May

Abstract on PubMed

Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.

Stem Cell. 2019 May

Abstract on PubMed

Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.

Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.

J Hepatol. 2019 Mar

Abstract on PubMed

Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.

Sci Rep. 2019 Feb

Abstract on PubMed

Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.

Nat Commun. 2019 Feb

Abstract on PubMed

Nishimura T, Nakauchi H.

Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.

Methods Mol Biol. 2019

Abstract on PubMed

2018

Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH.

Efficient scarless genome editing in human pluripotent stem cells.

Nat Methods. 2018 Dec

Abstract on PubMed

Mizuno N, Mizutani E, Sato H, Kasai M, Ogawa A, Suchy F, Yamaguchi T, Nakauchi H.

Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector.

iScience. 2018 Nov

Abstract on PubMed

Yamamoto R, Wilkinson AC, Nakauchi H.

hanging concepts in hematopoietic stem cells.

Science. 2018 Nov

Abstract on PubMed

Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.

Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.

Biomaterials. 2018 Nov

Abstract on PubMed

van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

Cell Rep. 2018 Oct

Abstract on PubMed

Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.

Sci Rep. 2018 Oct

Abstract on PubMed

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.

An interspecies barrier to tetraploid complementation and chimera formation.

Sci Rep. 2018 Oct

Abstract on PubMed

Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ.

Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep.

Transgenic Res. 2018 Oct

Abstract on PubMed

Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.

Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.

Stem Cell Reports. 2018 Sep

Abstract on PubMed

Higaki K, Hirao M, Kawana-Tachikawa A, Iriguchi S, Kumagai A, Ueda N, Bo W, Kamibayashi S, Watanabe A, Nakauchi H, Suzuki K, Kaneko S.

Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA.

Mol Ther Nucleic Acids. 2018 Aug

Abstract on PubMed

Ando M, Nakauchi H, Komatsu N.

[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].

Rinsho Ketsueki. 2018

Abstract on PubMed

Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.

Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

ACS Synth Biol. 2018 Jul

Abstract on PubMed

Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.

Chimeric liver transplantation reveals interspecific graft remodelling.

J Hepatol. 2018 Jul

Abstract on PubMed

Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.

Author Correction: Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.

Sci Rep. 2018 Jun

Abstract on PubMed

Suchy F, Nakauchi H.

Interspecies chimeras.

Curr Opin Genet Dev. 2018 May

Abstract on PubMed

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Cell Stem Cell. 2018 May

Abstract on PubMed

Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.

Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.

Exp Hematol. 2018 Apr

Abstract on PubMed

Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Cell Stem Cell.2018 Apr

Abstract on PubMed

Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y.

In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects.

Europace. 2018 Mar

Abstract on PubMed

Ong J, Serra MP, Segal J, Cujba AM, Ng SS, Butler R, Millar V, Hatch S, Zimri S, Koike H, Chan K, Bonham A, Walk M, Voss T, Heaton N, Mitry R, Dhawan A, Ebner D, Danovi D, Nakauchi H, Rashid ST

Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications

Stem Cell Reports.. :,2018 Mar.

Abstract on PubMed

Aihara A, Koike T, Abe N, Nakamura S, Sawaguchi A, Nakamura T, Sugimoto N, Nakauchi H, Nishino T, Eto K

Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells

Blood Adv. :,2018 Feb.

Abstract on PubMed

Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

Blood. :,2018 Feb.

Abstract on PubMed

Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakavuchi H, Nagashima H

Modeling lethal X-linked genetic disorders in pigs with ensured fertility

Proc Natl Acad Sci USA. :,2018 Jan.

Abstract on PubMed

Suchy F, Yamaguchi T, Nakauchi H

iPSC-Derived Organs In Vivo: Challenges and Promise

Cell Stem Cell. :,2018 Jan.

Abstract on PubMed

2017

Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan S, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ

CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep

Sci Rep. :,2017 Dec.

Abstract on PubMed

Wilkinson AC, Nakauchi H, Göttgens B

Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity

Cell Syst. :,2017 Oct.

Abstract on PubMed

Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.

Establishment of mouse expanded potential stem cells.

Nature.. :,2017 Oct.

Abstract on PubMed

Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.

A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.

Sci Rep.. :,2017 Oct.

Abstract on PubMed

Saka K, Lai CY, Nojima M, Kawahara M, Otsu M, Nakauchi H, Nagamune T.

Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.

Stem Cell Rev. . :,2017 Sep.

Abstract on PubMed

Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.

In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.

Stem Cell Reports.. :,2017 Oct.

Abstract on PubMed

Tachikawa S, Nishimura T, Nakauchi H, Ohnuma K.

Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells.

In Vitro Cell Dev Biol Anim. . :,2017 Aug.

Abstract on PubMed

Hirabayashi M, Hara H, Goto T, Takizawa A, Dwinell MR, Yamanaka T, Hochi S, Nakauchi H.

Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts.

J Reprod Dev.. :,2017 Aug.

Abstract on PubMed

Suchy F, Nakauchi H

Lessons from Interspecies Mammalian Chimeras.

Annu Rev Cell Dev Biol. . :,2017 Aug.

Abstract on PubMed

Masaki H, Nakauchi H.

Interspecies chimeras for human stem cell research.

Development. . :,2017 Jul.

Abstract on PubMed

Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H, Yamazaki S.

An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors.

Stem Cell Reports.. :,2017 Feb.

Abstract on PubMed

Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H.

Interspecies organogenesis gererates autologous functional islets.

Nature,. :,2017 Jan.

Abstract on PubMed

Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S.

Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.

Sci Rep.. :,2017 Jan.

Abstract on PubMed

2016

Taya Y, Ota Y, Wilkinson A, Kanezawa A, Watarai H, Kasai M, Nakauchi H, Yamazaki S.

Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.

Science.. :,2016 Dec.

Abstract on PubMed

Tarusawa E, Sanbo M, Okayama A, Miyashita T, Kitsukawa T, Hirayama T, Hirabayashi T, Hasegawa S, Kaneko R, Toyoda S, Kobayashi T, Kato-Itoh M, Nakauchi H, Hirabayashi M, Yagi T, Yoshimura Y.

Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.

BMC Biol.. :,2016 Dec.

Abstract on PubMed

Wu J, Greely H, Jaenisch R, Nakauchi H, Rossant J, Izpisua Belmonte J.

Stem Cells and Interspecies Chimeras: Past, Present, Future.

Nature.. :,2016 Dec.

Abstract on PubMed

Ando M, Nakauchi H.

'Off-the-shelf' immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes.

Exp Hematol.. :,2016 Nov.

Abstract on PubMed

Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.

Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.

Cell Stem Cell.. :,2016 Nov.

Abstract on PubMed

Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, Sato T, Ohteki T, Otsu M, Nakauchi H, Ida H, Ohashi T.

Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.

Mol Genet Metab.. :,2016 Nov.

Abstract on PubMed

Lin HT, Okumura T, Yatsuda Y, Ito S, Nakauchi H, Otsu M.

Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy.

Hum Gene Ther Methods.. :,2016 Oct.

Abstract on PubMed

Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.

Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.

Stem Cells.. :,2016 Oct.

Abstract on PubMed

Ishida T, Takahashi S, Lai CY, Nojima M, Yamamoto R, Takeuchi E, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.

Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.

J Exp Med. :,2016 Aug.

Abstract on PubMed

Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A.

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

Blood.. :,2016 Aug.

Abstract on PubMed

Goto T, Hara H, Nakauchi H, Hochi S, Hirabayashi M.

Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.

Transgenic Res.. :,2016 Aug.

Abstract on PubMed

Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K, Heissig B.

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.

Blood. :,2016 Aug.

Abstract on PubMed

Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A.

Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice.

Hepatol Res.. :,2016 Jul.

Abstract on PubMed

Ueno K, Iwagawa T, Kuribayashi H, Baba Y, Nakauchi H, Murakami A, Nagasaki M, Suzuki Y, Watanabe S.

Transition of differential histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation.

Sci Rep. :,2016 Jul.

Abstract on PubMed

Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T, Watanabe M.

Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.

Sci Rep.. :,2016 Jul.

Abstract on PubMed

Durruthy-Durruthy J, Wossidlo M, Pai S, Takahashi Y, Kang G, Omberg L, Chen B, Nakauchi H, Reijo Pera R, Sebastiano V.

Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency.

Dev Cell.. :,2016 Jul.

Abstract on PubMed

Noguchi Y, Kawashima Y, Kawara H, Kaneko M, Nakauchi H, Tokuyama Y.

[An Undeniable Case of Optic Neuropathy Due to Cabazitaxel].

Gan To Kagaku Ryoho. . :,2016 Jun.

Abstract on PubMed

Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.

Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting.

Mol Reprod Dev.. :,2016 Jun.

Abstract on PubMed

Hara H, Goto T, Takizawa A, Sanbo M, Jacob HJ, Kobayashi T, Nakauchi H, Hochi S, Hirabayashi M.

Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.

Cell Reprogram.. :, 2016 Apr.

Abstract on PubMed

Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.

Nature.. :,2016 Feb.

Abstract on PubMed

Yanagida A, Nakauchi H, Kamiya A.

Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells.

Methods Mol Biol.. :,2016 Feb.

Abstract on PubMed

Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.

Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.

Biochem Biophys Res Commun.. :,2016 Jan.

Abstract on PubMed

Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.

Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.

Stem Cell Reports.. :,2016 Jan.

Abstract on PubMed

2015

Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T-Cell Therapy.

Stem Cell Reports. :,2015 Aug.

Abstract on PubMed

Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama K, Nakauchi H, Kamiya A.

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.

Developmental Biology. :,2015 Jul.

Abstract on PubMed

2014

2013

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Mochizuki Y, Iida A, Lyons E, Kageyama R, Nakauchi H, Murakami A, Watanabe S.

Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development.

Dev Neurobiol. . :,2013 Oct 1..

Abstract on PubMed

Akiyama K, Shimada Y, Higuchi T, Ohtsu M, Nakauchi H, Kobayashi H, Fukuda T, Ida H, Eto Y, Crawford BE, Brown JR, Ohashi T.

Enzyme augmentation therapy enhances the therapeutic efficacy of bone marrow transplantation in mucopolysaccharidosis type II mice.

Mol Genet Metab. . (13):S1096-7192,2013 Sep 21..

Abstract on PubMed

Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.

Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns.

PLoS One. . 8(9):,2013 Sep 23.

Abstract on PubMed

Saka K, Kawahara M, Teng J, Otsu M, Nakauchi H, Nagamune T.

Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.

J Biotechnol. . :S0168-1656,2013 Sep 23.

Abstract on PubMed

Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H.

Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation.

PLoS One. . 8(9):,2013 Sep 16.

Abstract on PubMed

Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL.

Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?

Stem Cell Reports. 1(2)::198-208.,2013 Jul 24.

Abstract on PubMed

Hirabayashi M, Goto T, Tamura C, Sanbo M, Hara H, Kato-Itoh M, Sato H, Kobayashi T, Nakauchi H, Hochi S.

Derivation of Embryonic Stem Cell Lines From Parthenogenetically Developing Rat Blastocysts.

Stem Cells Dev. . :,2013 Sep 6. .

Abstract on PubMed

Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Cell. . 154(5):1112-26.,2013 Aug 29.

Abstract on PubMed

Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A.

An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.

PLoS One. . 8(7):e67541:,2013 Jul 25.

Abstract on PubMed

Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K.

Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.

J Clin Invest. . :,2013 Aug 1.

Abstract on PubMed

Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H.

Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.

Biochem Biophys Res Commun. . 435(4):586-91,2013 Jun 14.

Abstract on PubMed

Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.

Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.

Mol Ther.. 21(7):1424-31,2013 Jul.

Abstract on PubMed

Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K.

Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.

Exp Hematol. . 41(8):742-8,2013 Aug.

Abstract on PubMed

Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H.

Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs.

Proc Natl Acad Sci U S A.. 110(12):4557-62, 2013 Mar 19.

Abstract on PubMed

Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M.

Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.

Hepatology. 57(6):2502-13,2013 Jun.

Abstract on PubMed

Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Nariai N, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K.

Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.

Proc Natl Acad Sci U S A.. 110(8):3023-8,2013 Feb 19.

Abstract on PubMed

Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S.

The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.

Development. 140(4):740-50, 2013 Jan 14.

Abstract on PubMed

2012

Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.

Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Cell Stem Cell. . 12(1):114-26,.2012.11.

Abstract on PubMed

Matsunari H, Nakano K, Kanai T, Sakai R, Watanabe M, Umeyama K, Kobayashi T, Yamaguchi T, Shiota A, Nagaya M, Nakauchi H, Nagashima H.

326 generation of a double-transgenic pig with pancreas-specific green and liver-specific red fluorescence.

Reprod Fertil Dev. . 25(1):311:,2012 Dec;25.

Abstract on PubMed

Honda K, Takeuchi Y, Matsuda T, Kanai T, Kuramoto M, Maehara M, Matsunari H, Nakano K, Umeyama K, Watanabe M, Nakauchi H, Nagashima H.

324 production of genetically modified pigs by artificial reproductive technologies using frozen epididymal sperm.

Reprod Fertil Dev. . :309-10.,2012 Dec;25.

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Oikawa T, Kamiya A, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM, Nakauchi H.

SALL4, a stem cell biomarker in liver cancers.

Hepatology. hep.26159.:,2012 Nov 23..

Abstract on PubMed

Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.

Role of SOX17 in hematopoietic development from human embryonic stem cells.

Blood. . :,2012 Nov 20..

Abstract on PubMed

Lin HT, Otsu M, Nakauchi H.

Stem cell therapy: an exercise in patience and prudence.

Philos Trans R Soc Lond B Biol Sci. . 368:,2013 Jan 5.

Abstract on PubMed

Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S.

Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation.

Br J Haematol.. :,2012 Nov 1. .

Abstract on PubMed

Kamiya A, Nakauchi H.

Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development.

Methods Mol Biol. . 2013;945:273-86.,2013.

Abstract on PubMed

Hirabayashi M, Tamura C, Sanbo M, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.

A retrospective analysis of germline competence in rat embryonic stem cell lines.

Transgenic Res. . :,2012 Aug 9..

Abstract on PubMed

Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PLoS One. . 7(7):e41007.:,2012 Jul 18..

Abstract on PubMed

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.

PLoS One. . 2012;7(5):,2012 May 11..

Abstract on PubMed

Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M.

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.

Blood. . 2012 Jun 28;119(26):6234-42, 2012 May 16..

Abstract on PubMed

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.

Blood. . 2012 Jun 28;119(26):6382-93, 2012 May 9..

Abstract on PubMed

Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H.

Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells.

Transplant Proc.. 2012 May;44(4):1127-9.,2012.

Abstract on PubMed

Kobayashi T, Kato-Itoh M, Yamaguchi T, Tamura C, Sanbo M, Hirabayashi M, Nakauchi H.

Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.

Stem Cells Dev. . 2012 Jun 11.:,2012.

Abstract on PubMed

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

Blood. . 2012 Jun 7;119(23):5405-16,2012 Apr 27..

Abstract on PubMed

Usui J, Kobayashi T, Yamaguchi T, Knisely AS, Nishinakamura R, Nakauchi H.

Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation.

Am J Pathol. . 2012 Jun;180(6):2417-26, 2012 Apr 14..

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Hirabayashi M, Tamura C, Sanbo M, Goto T, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.

Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.

Mol Reprod Dev.. 2012 Jun;79(6):402-12,2012 May 4..

Abstract on PubMed

Ghosn EE, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA.

Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.

Proc Natl Acad Sci U S A.. 2012 Apr 3.109(14):5394-8,2012 Mar 19..

Abstract on PubMed

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.

Cell.. 148(5):1001-14.,2012 .

Abstract on PubMed

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.

J Exp Med. . :,2012 Feb 20..

Abstract on PubMed

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ito H, Kamiya A, Ito K, Yanagida A, Okada K, Nakauchi H.

In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.

Liver Int.. :,2012 Jan 4..

Abstract on PubMed

2011

Takayama N, Eto K, Nakauchi H.

Potential usefulness of human iPS cells on the generation of platelets

Nihon Rinsho.. :,2011 Dec.

Abstract on PubMed

Kobayashi T, Nakauchi H.

From cell therapy to organ regeneration therapy: generation of functional organs from pluripotent stem cells

Nihon Rinsho.. :,2011 Dec.

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Umeyama K, Saito H, Kurome M, Matsunari H, Watanabe M, Nakauchi H, Nagashima H.

Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs.

Mol Reprod Dev.. :218-28,2011 Dec 29..

Abstract on PubMed

Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H.

Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.

Cell.. 147(5):1146-58., 2011 Nov 23.

Abstract on PubMed

Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, Takaki S.

Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL.

Exp Hematol. . :,2011 Nov 17..

Abstract on PubMed

Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T.

Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.

Blood. . :, 2011 Nov 16. .

Abstract on PubMed

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.

Blood. . :,2011 Nov 16..

Abstract on PubMed

Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B.

Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.

Exp Hematol. . :, 2011 Nov 3..

Abstract on PubMed

Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, Shiota A, Nakauchi H, Nagashima H.

The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer.

Transgenic Res. . :,2011 Oct 25..

Abstract on PubMed

Watabe Y, Baba Y, Nakauchi H, Mizota A, Watanabe S.

The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.

Biochem Biophys Res Commun. . :415(1):42-7., 2011 Nov 11.

Abstract on PubMed

Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Okaji Y, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.

Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment.

Leukemia. . :,2011 Sep 20..

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Saito R, Nakauchi H, Watanabe S.

Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.

Cancer Sci. . :,2011 Sep 16..

Abstract on PubMed

Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.

Frequent pathway mutations of splicing machinery in myelodysplasia.

Nature.. 478: 64–69, 2011 Sep 11.

Abstract on PubMed

Okada K, Kamiya A, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H.

Prospective isolation and characterization of bi-potent progenitor cells in early mouse liver development.

Stem Cells Dev. . :,2011 Aug 23.

Abstract on PubMed

Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H.

Generation of germline-competent rat induced pluripotent stem cells.

PLoS One. :, 2011 Jul 15.

Abstract on PubMed

Kawahara M, Chen J, Sogo T, Teng J, Otsu M, Onodera M, Nakauchi H, Ueda H, Nagamune T.

Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera

Cytokine. Volume 55:Pages 402-408,September 2011.

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Yokoi T, Kobayashi H, Shimada Y, Higuchi T, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T.

Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease.

J Gene Med. . :,2011 Apr 25.

Abstract on PubMed

Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.

Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.

Biochem Biophys Res Commun. . 406(1):134-40,2011 Mar 4.

Abstract on PubMed

Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK.

Hair follicle stem cells provide a functional niche for melanocyte stem cells.

Cell Stem Cell. . 8(2):177-87.,2011 Feb 4.

Abstract on PubMed

Morita Y, Iseki A, Okamura S, Suzuki S, Nakauchi H, Ema H.

Functional characterization of hematopoietic stem cells in the spleen.

Exp Hematol. . 39(3):351-359.,2011 Mar.

Abstract on PubMed

2010

Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.

J Biol Chem.. 286(6):4760-71,2010 Dec 7..

Abstract on PubMed

Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.

Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.

PLoS One. . 5(11):,2010 Nov.

Abstract on PubMed

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.

J Exp Med. . 207(13):2817-30,2010 Nov 22..

Abstract on PubMed

Watanabe M, Umeyama K, Matsunari H, Takayanagi S, Haruyama E, Nakano K, Fujiwara T, Ikezawa Y, Nakauchi H, Nagashima H.

Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases.

Biochem Biophys Res Commun.. 402(1):14-8,2010 Sep 26..

Abstract on PubMed

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.

Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A.

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.

Exp Hematol. . 38(8):696-706,2010 Aug.

Abstract on PubMed

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.

TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.

J Exp Med.. 207(7):1501-11,2010 Jun 21.

Abstract on PubMed

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Hepatology. 52:1111-1123,September 2010.

Abstract on PubMed

Reprogramming adult hematopoietic cells.

Kaneko S, Otsu M, Nakauchi H.

Reprogramming adult hematopoietic cells.

Curr Opin Hematol. 17(4):271-5,Jul 2010.

Abstract on PubMed

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y.

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.

Lab Invest.. 90(9):1357-64,2010 Sep.

Abstract on PubMed

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Clin Cancer Res.. 16(15):3825-31.,2010 Aug 1.

Abstract on PubMed

Nakahata S, Yamazaki S, Nakauchi H, Morishita K.

Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.

Oncogene. 29(29):4157-69.,2010 Jul 22.

Abstract on PubMed

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Blood. 115(21):4302-12,2010 May 27.

Abstract on PubMed

Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.

Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.

Mol Reprod Dev.. 77(6):474,Jun 2010.

Abstract on PubMed

Oguro-Cell Stem Cell

Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A.

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

Cell Stem Cell. 6(3):279-86,2010.

Abstract on PubMed

2009

Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.

Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.

Mol Reprod Dev.. 77(6):474,Jun 2010.

Abstract on PubMed

Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.

Lnk regulates integrin aIIbb3 outside-in signaling in m ouse platelets leading to stabilization of thrombus development in vivo.

J Clin Invest. 120:179-90,2009.

Abstract on PubMed

Liao CH, Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I

Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts

J Clin Invest. 120:242-53,2009.

Abstract on PubMed

Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H.

Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency.

Mol Reprod Dev. in press:,2009 Nov 6.

Abstract on PubMed

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

Exp Hematol. in press:,2009 Sep 7.

Abstract on PubMed

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.

Ishige I, Nagamura-Inoue T, Honda MJ, Harnprasopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A.

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.

Int J Hematol. 90:261-69,2009.

Abstract on PubMed

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T.

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Cancer Cell. 16:161-71,2009.

Abstract on PubMed

Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

Nature. 460:904-8,2009.

Abstract on PubMed

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.

Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H.

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.

Blood. 114:1764-7,2009.

Abstract on PubMed

Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H.

Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mise.

Gastroenterology.. 137:1114-26,2009.

Abstract on PubMed

Insights into signaling and function of hematopoietic stem cells at the single-cell level.

Yamazaki S, Nakauchi H

Insights into signaling and function of hematopoietic stem cells at the single-cell level.

Curr Opin Hematol. 16:255-8,2009.

Abstract on PubMed

Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H.

Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver.

J Hepatol. 51:127-38,2009.

Abstract on PubMed

M, atsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.

Stepwise development of hematopoietic stem cells from embryonic stem cells.

PLoS ONE. 4:e4820,2009.

Abstract on PubMed

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.

Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T.

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.

Cytokine. 46:127-36,2009.

Abstract on PubMed

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.

Kakinuma S, Nakauchi H, Watanabe M.

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.

J Gastroenterol. 44:167-72,2009.

Abstract on PubMed

Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N.

A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.

J Immunol Methods. 343:56-60,2009.

Abstract on PubMed

Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H.

Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.

Gastroenterology. 136:1000-11,2009.

Abstract on PubMed

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.

Yashiro Y, Bannai H, Minowa T, Yabiku T, Miyano S, Osawa M, Iwama A, Nakauchi H.

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.

Int J Hematol. 89:24-33,2009.

Abstract on PubMed

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H.

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Stem Cells. 27:1120-1129,2009.

Abstract on PubMed

TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.

Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H.

TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.

Blood. 113:1250-1256,2009.

Abstract on PubMed

2008

New ISSCR guidelines underscore major principles for responsible translational stem cell research.

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ.

New ISSCR guidelines underscore major principles for responsible translational stem cell research.

Cell Stem Cell. 3:607-9,2008.

Abstract on PubMed

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.

Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H.

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.

Hepatology. 48:1964-78,2008.

Abstract on PubMed

Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.

The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.

Cancer Res. 68:7742-9,2008.

Abstract on PubMed

Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K.

Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.

Proc Natl Acad Sci U S A. 105:13087-92,2008.

Abstract on PubMed

Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.

Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H.

Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.

Hepatology. 48:252-64,2008.

Abstract on PubMed

Nishikii H, Eto K, Tamura N, Hattori1 K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H.

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.

J Exp Med. 205:1917-27,2008.

Abstract on PubMed

Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.

Watanabe N, Takahashi S, Ishige M, Ishii Y, Ooi J, Tomonari A, Tsukada N, Konuma T, Kato S, Sato A, Tojo A, Nakauchi H.

Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.

Biol Blood Marrow Transplant. 14:693-701,2008.

Abstract on PubMed

Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H.

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.

Blood. 111:5298-306,2008.

Abstract on PubMed

Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S.

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.

Exp Hematol. 36:897-906,2008.

Abstract on PubMed

Seita J, Asakawa M, Ooehara J, Takayanagi SI, Morita Y, Watanabe N, Fujita K, Kudo M, Mizuguchi J, Ema H, Nakauchi H, Yoshimoto Y.

Interleukin-27 directly induces differentiation in hematopoietic stem cells.

Blood. 111:1903-12,2008.

Abstract on PubMed

2007

An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.  Cancer Immunol Immunother.

Nabekura T, Nagasawa T, Nakauchi H, Onodera M.

An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.

Cancer Immunol Immunother. 57:611-22,2008.

Abstract on PubMed

The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.

Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Romer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Dano K, Hattori K.

The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.

Cell Stem Cell. 1:658-70,2007.

Abstract on PubMed

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Cell Stem Cell. 1:101-12,2007.

Abstract on PubMed

Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H.

Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

Gastroenterology. 133:937-50,2007.

Abstract on PubMed

Cytokine signaling, lipid raft clustering, and HSC hibernation.

Yamazaki S, Iwama A, Morita Y, Eto K, Ema H, Nakauchi H.

Cytokine signaling, lipid raft clustering, and HSC hibernation.

Ann N Y Acad Sci. 1106:54-63,2007.

Abstract on PubMed

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.

Blood. 110:3637-47,2007.

Abstract on PubMed

Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H.

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.

J Exp Med. 204:715-22,2007.

Abstract on PubMed

Kato Y, Koseki H, Vidal M, Nakauchi H, Iwama A.

Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.

Int J Hematol. 85:179-81,2007.

Abstract on PubMed

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita, J., Ema, H., Ooehara, J., Yamazaki, S., Tadokoro, Y., Yamazaki, A., Eto, K., Takaki, S., Takatsu, K., and Nakauchi H.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Proc Natl Acad Sci USA. 104:2349-54,2007.

Abstract on PubMed

Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.

39. Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells.

Mol Ther. 15:560-5,2007.

Abstract on PubMed

Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iawama A.

Bmi1 cooperates with Dnmt1-assciated protein 1 in gene silencing.

Biochem Biophys Res Commun. 353:992-8,2007.

Abstract on PubMed

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Nature Genet. 39:99-105,2007 Epub, 2006.

Abstract on PubMed

2006

Ema H. Morita Y. Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.

Adult mouse hematopoietic stem cells: purification and single-cell assays.

Nature Protocols. 1:2979-87,2006.

Abstract on PubMed

Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H.

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.

J Exp Med. 203:2247-53,2006.

Abstract on PubMed

Sakaguchi T, Nishimoto M, Miyagi S, Iwama A, Morita Y, Iwamori N, Nakauchi H, Kiyonari H, Muramatsu M, Okuda A.

Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.

Mol Cell Biol.. 26:6557-70,2006.

Abstract on PubMed

Yamazaki S, Iwama A, Takayanagi S, Morita Y, Eto K, Ema H, Nakauchi H.

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematpoetic stem cells.

EMBO J. 25:3515-3523,2006.

Abstract on PubMed

Morita Y, Ema H, Yamazaki S, Nakauchi H.

Non - sicde-population hematopoietic stem cells in mouse bone marrow.

Blood. 108:2850-2856,2006.

Abstract on PubMed

Side p opulation purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.

Chiba T, Kita K, Zheng YW, okosuka O, Saisho H, Iwama S, Nakauchi H, Taniguchi H.

Side p opulation purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.

Hepatology. 44:240-51,2006.

Abstract on PubMed

Furuta C, Ema H, takayanagi S, ogaeri T, Okamura D, Matsui Y, Nakauchi H.

Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo.

Development. 133:2771-9,2006.

Abstract on PubMed

Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H.

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.

Proc Natl Acad Sci U S A. 103:7112-7,2006.

Abstract on PubMed

Takayanagi SI, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H.

Genet ic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell-surface protein with the thrombospondin-1 domain.

Blood. 107:4317-25,2006.

Abstract on PubMed

Nabekura T, Otsu M, Nagasawa T, Hakauchi H, Onodera M.

Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap.

Molecular Therapy. 13:301-09,2006.

Abstract on PubMed

2005

Usui J, Osawa M, Yamazaki S, Morita Y, Koyama A, Nakauchi H.

Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting.

Clin Exp Nephrol. 9:292-6,2005.

Abstract on PubMed

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.

A role for PKCq in outside-in aIIbb3 signaling.

J Thromb Haemost. 4:658-55,2006.

Abstract on PubMed

Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestweber D, Nakauchi H.

Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development.

J Exp Med. 202:1483-92,2005.

Abstract on PubMed

Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.

J Exp Med. 202:169-79,2005.

Abstract on PubMed

Iseki H, Shimizukawa R, Sugiyama F, Kunita S, Iwama A, Onodera M, Nakauchi H, Yagami K.

Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.

J Virol. 79:8886-93,2005.

Abstract on PubMed

Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Ichiyanagi T, Kohike H, Komori T, Takahashi I, Takase O, Imai N, Yoshikawa M, Inowa T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.

Musculin/MyoR is expressed in kidney side population cells and can regulate their function.

J Cell Biol. 169:921-8,2005.

Abstract on PubMed

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.

Dev Cell. 8:907-14,2005.

Abstract on PubMed

Iwama A, Oguro H, Negishi M, Kato Y, and Nakauchi H.

Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal by Polycomb Group Genes.

Int. Journal of Hematology. 81:294-300,2005.

Abstract on PubMed

Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Kohike H, Komori T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.

Biochem Biophys Res Commun.. 328:288-91,2005.

Abstract on PubMed

Almeida-Porada G, Crapnell K, Porada C, Benoit B, Nakauchi H, Quesenberry P, Zanjani ED.

In vivo haematopoietic potential of human neural stem cells.

Br J Haematol.. 130:276-83,2005.

Abstract on PubMed

Kaneko S, Nagasawa T, Nakauchi H, Onodera M.

An in vivo assay for retrovirally transduced human peripheral T lymphocytes using nonobese diabetic/severe combined immunodeficiency mice.

Exp Hematol. 33:35-41,2005.

Abstract on PubMed

selected

Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Cell. . 154(5):1112-26.,2013 Aug 29.

Abstract on PubMed

Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.

Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

Cell Stem Cell. . 12(1):114-26,.2012.11.

Abstract on PubMed

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.

Cell.. 148(5):1001-14.,2012 .

Abstract on PubMed

Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H.

Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.

Cell.. 147(5):1146-58., 2011 Nov 23.

Abstract on PubMed

Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H.

Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.

Cell. 142:787-99,Sep 2010.

Abstract on PubMed

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

Morita Y, Ema H, Nakauchi H.

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

J Exp Med. . 207:1173-1182,April 2010.

Abstract on PubMed

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

Cell Cycle. 9(6).: 1051 - 1056,2010 Mar 23.

Abstract on PubMed