"Brca1L63X/+ rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation-induced mammary cancer"
Cancer Science オンライン版 2022年8月22日 doi:10.1111/cas.15485
遺伝性乳がんの新しい動物モデルの作製に成功 ‐遺伝性乳がんが出やすくなる仕組みの解明や、予防法の研究開発への応用に期待‐
解説
論文情報
Yuzuki Nakamura1,2*, Jo Kubota1,2*, Yukiko Nishimura1, Kento Nagata1, Mayumi Nishimura1, Kazuhiro Daino1, Atsuko Ishikawa1, Takehito Kaneko3,4, Tomoji Mashimo4,5, Toshiaki Kokubo6, Masaru Takabatake1,2, Kazumasa Inoue2, Masahiro Fukushi2, Masami Arai7, Mitsue Saito8, Yoshiya Shimada1,2, Shizuko Kakinuma1,2, Tatsuhiko Imaoka1,2 (*YNa and JK contributed equally to this work.)
1. Department of Radiation Effects Research, National Institute of Radiological Sciences, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan
2. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
3. Division of Fundamental and Applied Sciences, Graduate School of Science and Engineering, Iwate University, Japan
4. Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
5. Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
6. Laboratory Animal and Genome Sciences Section, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan
7. Department of Clinical Genetics, Graduate School of Medicine, Juntendo University, Tokyo, Japan
8. Department of Breast Oncology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
1. Department of Radiation Effects Research, National Institute of Radiological Sciences, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan
2. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan
3. Division of Fundamental and Applied Sciences, Graduate School of Science and Engineering, Iwate University, Japan
4. Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
5. Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
6. Laboratory Animal and Genome Sciences Section, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan
7. Department of Clinical Genetics, Graduate School of Medicine, Juntendo University, Tokyo, Japan
8. Department of Breast Oncology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
