Tissue Macrophage Heterogeneity
国際共・共拠点セミナー
開催情報
開催日時 | 2023年9月1日(金)16:00~17:00 |
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開催場所 | 総合研究棟8階 大セミナー室/ General research buldg. 8F, Large seminar room |
演者 | Florent Ginhoux |
所属・職名 | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR), Senior PI |
国名 | Singapore |
演題 | Tissue Macrophage Heterogeneity |
使用言語 | English |
世話人 | Kenta Nakai (Laboratory of functional analysis in silico), Ken Ishii(Division of Vaccine Science) |
概要
Macrophages have a broad spectrum of immune- and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering macrophage heterogeneity that organizes the factors shaping their identity within four cardinal points: (1) ontogeny and the view that adult macrophage populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We will especially discuss how to transpose these concepts to disease to better understand macrophage heterogeneity.