Ex vivo haematopoietic stem cell expansion technologies



開催日時 2022年10月21日(金)16:30~18 : 00
開催場所 1号館講堂
演者 Adam Wilkinson
所属・職名 Associate professor, Stem Cell Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
国名 UK
演題 Ex vivo haematopoietic stem cell expansion technologies
使用言語 English
世話人 岩間 厚志


Self-renewing multipotent haematopoietic stem cells (HSCs) are a rare bone marrow cell type that can reconstitute the entire blood and immune systems following transplantation. HSC transplantation is used clinically as a curative therapy for a range of blood diseases. However, despite clinical importance of this cell type, it has long been challenging to expand HSCs ex vivo. We recently developed a novel polymer-based long-term ex vivo expansion culture system for mouse HSCs. I will discuss recent improvements in this technology as well as its application to investigate the biological mechanisms regulating HSC activity.