主要原著論文,
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1.Kajikawa, S., Taguchi, Y., Hayata, T., Ezura, Y., Ueta, R., Arimura, S., Inoue, J., Noda, M., and Yamanashi, Y. Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia. Biochem. Biophys. Res. Commun. 498: 967-974 (2018)
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2.Miyoshi, S., Tezuka, T., Arimura, S., Tomono, T., Okada, T., and Yamanashi, Y. DOK7 gene therapy enhances motor activity and life span in ALS model mice. EMBO Mol. Med. Published online e201607298 (2017) [Full Text] [PDF]
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3.Waseda, M., Arimura, S., Shimura, E., Nakae, S., and Yamanashi, Y. Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22. Biochem. Biophys. Res. Commun. 478: 135-142 (2016)
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4.Eguchi, T., Tezuka, T., Miyoshi, S., and Yamanashi, Y. Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology. Genes Cells 21: 670-676 (2016)
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5.Tezuka, T., Inoue, A., Hoshi T., Weatherbee, S.D., Burgess, R.W., Ueta, R., and Yamanashi, Y. The MuSK actvator agrin has a separate role essential for a postnatal maintenance of neuromuscular synapses. Proc. Natl. Acad. Sci. USA. 111, 16556-16561 (2014) [Full Text][PDF]
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6.Arimura, S., Okada, T., Tezuka, T., Chiyo, T., Kasahara, Y., Yoshimura, T., Motomura, M., Yoshida, N., Beeson, D., Takeda, S., and Yamanashi, Y. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction. Science 345: 1505-1508 (2014) [Full Text][PDF]
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7.Hoshi, T., Tezuka, T., Yokoyama, K., Iemura, S., Natsume, T., and Yamanashi, Y. Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes. FEBS Lett. 587: 3749-3754 (2013)
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8.Mashima, R., Arimura, S., Kajikawa, S., Oda, H., Nakae, S., and Yamanashi,Y. Dok adaptors play anti-inflammatory roles in pulmonary homeostasis. Genes Cells 18: 56-65 (2013)
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9.Higuchi, O., Hamuro J., Motomura, M. and Yamanashi, Y. Autoantibodies to LDL receptor-related protein 4 in myasthenia gravis. Annals of Neurology 69: 418-422 (2011)
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10.Mashima, R., Honda, K., Yang, Y., Morita, Y., Inoue, A., Arimura, S., Nishina, H., Ema, H., Nakauchi, H., Seed, B., Oda, H., and Yamanashi, Y. Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab. Investigation 90: 1357-1364 (2010)
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11.Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y. Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation. Science Signaling 2: ra7 (2009) [Full Text]
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12.Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, & Yamanashi Y. Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7. J. Biol. Chem. 283: 5518-5524 (2008)
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13.Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H, Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda T, Lazar M, Yamanashi Y, & Kasuga M. Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARγ phosphorylation. Nature Med. 14: 188-193 (2008)
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14.Palace J, Lashley D, Newsom-Davis J, Cossins J, Maxwell S, Kennett R, Jayawant S, Yamanashi Y, & Beeson D. Clinical features of the DOK7 neuromuscular junction synaptopathy. Brain 130: 1507-1515 (2007)
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15.Beeson D, Higuchi O, Palace J, Cossins J, Spearman H, Maxwell S, Newsom-Davis J, Burke G, Fawcett P, Motomura M, Muller J, Lochmuller H, Slater C, Vincent A, & Yamanashi Y. Dok-7 mutations underlie a neuromuscular junction synaptopathy. Science 313: 1975-1978 (2006)
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16.Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, & Yamanashi Y. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312: 1802-1805 (2006)
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17.Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K & Yamanashi Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J. Exp. Med. 201: 333-339 (2005)
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18.Yasuda T, Shirakata M, Iwama A, Ishii A, Ebihara Y, Osawa M, Honda K, Shinohara H, Sudo K, Tsuji K, Nakauchi H, Iwakura Y, Hirai H, Oda H, Yamamoto T, & Yamanashi Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med. 200: 1681-1687 (2004)
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19.Imadome K, Shirakata M, Shimizu N, Nonoyama S, & Yamanashi Y. CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation. Proc. Natl. Acad. Sci. USA. 100: 7836-7840 (2003)
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20.Songyang Z*, Yamanashi Y*, Liu D, & Baltimore D. (*equally contributed authors) Domain-dependent function of the rasGAP-binding protein p62dok in cell signaling. J. Biol. Chem. 276: 2459-2465 (2001)
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21.Yamanashi Y, Tamura T, Kanamori T, Yamane H, Nariuchi H, Yamamoto T, & Baltimore D. Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling. Genes Dev. 14: 11-16. (2000)
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22.Yamanashi Y, Fukuda T, Nishizumi H, Inazu T, Higashi K, Kitamura D, Ishida T, Yamamura H, Watanabe T, & Yamamoto T. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J. Exp. Med. 185: 1387-1392 (1997)
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23.Yamanashi Y & Baltimore D. Identification of Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88: 205-211 (1997)
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24.Yamanashi Y, Okada M, Semba T, Yamori T, Umemori H, Tsunasawa S, Toyoshima K, Kitamura D, Watanabe T, & Yamamoto T. Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA. 90: 631-3635 (1993)
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25.Yamanashi Y, Fukui Y, Wongsasant B, Kinoshita Y, Ichimori Y, Toyoshima K, & Yamamoto T. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidy-linositol-3 kinase upon B cell antigen receptor-mediated signalling. Proc. Natl. Acad. Sci. USA. 89: 1118-1122 (1992)
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26.Yamanashi Y, Miyasaka M, Takeuchi M, Ilic D, Mizuguchi J, & Yamamoto T. Differential response of p561yn and p531yn, products of alternatively spliced lyn mRNA, on stimulation of B cell antigen receptor. Cell Regulation (currently Molec. Biol. Cell) 2: 979-987 (1991)
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27.Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, & Toyoshima K. Association of B cell antigen receptor with protein-tyrosine kinase Lyn. Science 251: 192-194 (1991)
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28.Yamanashi Y, Mori S, Yoshida M, Kishimoto T, Inoue K, Yamamoto T, & Toyoshima K. Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc. Natl. Acad. Sci. USA. 86: 6538-6542 (1989)
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29.Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, & Toyoshima K. The yes-related cellular gene, lyn, encodes a possible tyrosine kinase similar to p56lck. Molec. Cell. Biol. 7: 237-243 (1987)
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30.Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, & Toyoshima K. Location of the c-yes gene on the human chromosome and its expression in various tissues. Science 227: 1038-1040 (1985)