主要原著論文

  1. 1.Higuchi, O., Hamuro J., Motomura, M. and Yamanashi, Y.  Autoantibodies to LDL receptor-related protein 4 in myasthenia gravis. Annals of Neurology: 69, 418-422, 2011


  3. 2.Mashima, R., Honda, K., Yang, Y., Morita, Y., Inoue, A., Arimura, S., Nishina, H., Ema, H., Nakauchi, H., Seed, B., Oda, H., and Yamanashi, Y. Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab. Investigation 90: 1357-1364, 2010


  5. 3.Inoue, A., Setoguchi, K., Matsubara, Y., Okada, K., Sato, N., Iwakura, Y., Higuchi, O., and Yamanashi, Y.   Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.  Science Signaling 2: ra7 (2009)    [Full Text]


  7. 4.Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, & Yamanashi Y. Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7. J. Biol. Chem. 283: 5518-5524 (2008)


  9. 5.Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H, Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda T, Lazar M, Yamanashi Y, & Kasuga M. Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARγ phosphorylation. Nature Med. 14: 188-193 (2008)


  11. 6.Palace J, Lashley D, Newsom-Davis J, Cossins J, Maxwell S, Kennett R, Jayawant S, Yamanashi Y, & Beeson D. Clinical features of the DOK7 neuromuscular junction synaptopathy. Brain 130: 1507-1515 (2007)


  13. 7.Beeson D, Higuchi O, Palace J, Cossins J, Spearman H, Maxwell S, Newsom-Davis J, Burke G, Fawcett P, Motomura M, Muller J, Lochmuller H, Slater C, Vincent A, & Yamanashi Y. Dok-7 mutations underlie a neuromuscular junction synaptopathy. Science 313: 1975-1978 (2006)


  15. 8.Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, & Yamanashi Y. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312: 1802-1805 (2006)


  17. 9.Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K & Yamanashi Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J. Exp. Med. 201: 333-339 (2005)


  19. 10.Yasuda T, Shirakata M, Iwama A, Ishii A, Ebihara Y, Osawa M, Honda K, Shinohara H, Sudo K, Tsuji K, Nakauchi H, Iwakura Y, Hirai H, Oda H, Yamamoto T, & Yamanashi Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med. 200: 1681-1687 (2004)


  21. 11.Imadome K, Shirakata M, Shimizu N, Nonoyama S, & Yamanashi Y. CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation. Proc. Natl. Acad. Sci. USA. 100: 7836-7840 (2003)


  23. 12.Songyang Z*, Yamanashi Y*, Liu D, & Baltimore D. (*equally contributed authors) Domain-dependent function of the rasGAP-binding protein p62dok in cell signaling. J. Biol. Chem. 276: 2459-2465 (2001)


  25. 13.Yamanashi Y, Tamura T, Kanamori T, Yamane H, Nariuchi H, Yamamoto T, & Baltimore D. Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling. Genes Dev. 14: 11-16. (2000)


  27. 14.Yamanashi Y, Fukuda T, Nishizumi H, Inazu T, Higashi K, Kitamura D, Ishida T, Yamamura H, Watanabe T, & Yamamoto T. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J. Exp. Med. 185: 1387-1392 (1997)


  29. 15.Yamanashi Y & Baltimore D. Identification of Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88: 205-211 (1997)


  31. 16.Yamanashi Y, Okada M, Semba T, Yamori T, Umemori H, Tsunasawa S, Toyoshima K, Kitamura D, Watanabe T, & Yamamoto T. Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA. 90: 631-3635 (1993)


  33. 17.Yamanashi Y, Fukui Y, Wongsasant B, Kinoshita Y, Ichimori Y, Toyoshima K, & Yamamoto T. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidy-linositol-3 kinase upon B cell antigen receptor-mediated signalling. Proc. Natl. Acad. Sci. USA. 89: 1118-1122 (1992)


  35. 18.Yamanashi Y, Miyasaka M, Takeuchi M, Ilic D, Mizuguchi J, & Yamamoto T. Differential response of p561yn and p531yn, products of alternatively spliced lyn mRNA, on stimulation of B cell antigen receptor. Cell Regulation (currently Molec. Biol. Cell) 2: 979-987 (1991)


  37. 19.Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, & Toyoshima K. Association of B cell antigen receptor with protein-tyrosine kinase Lyn. Science 251: 192-194 (1991)


  39. 20.Yamanashi Y, Mori S, Yoshida M, Kishimoto T, Inoue K, Yamamoto T, & Toyoshima K. Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc. Natl. Acad. Sci. USA. 86: 6538-6542 (1989)


  41. 21.Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, & Toyoshima K. The yes-related cellular gene, lyn, encodes a possible tyrosine kinase similar to p56lck. Molec. Cell. Biol. 7: 237-243 (1987)


  43. 22.Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, & Toyoshima K. Location of the c-yes gene on the human chromosome and its expression in various tissues. Science 227: 1038-1040 (1985)



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