Publications
2022
Yamazaki K, Kubara K, Ishii S, Li P, Dairiki R, Hihara T, Ishizuka Y, Izumi Y, Kumai M, Kamisako T, Ishizaki H, Sato H, Masaki H, Mizuno N, Mitsuhashi K, Ito M, Hamanaka S, Yamaguchi T, Watanabe M, Sugiyama F, Nakauchi H.
In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation.
Sci Rep. 2022 Feb
Toral MA, Charlesworth CT, Ng B, Chemudupati T, Homma S, Nakauchi H, Bassuk AG, Porteus MH, Mahajan VB.
Investigation of Cas9 antibodies in the human eye.
Nat Commun. 2022 Feb
Oikawa M, Nagae M, Mizuno N, Iwatsuki K, Yoshida F, Inoue N, Uenoyama Y, Tsukamura H, Nakauchi H, Hirabayashi M, Kobayashi T.
Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting.
Mol Reprod Dev. 2022 Feb
Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N.
Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma.
Mol Ther. 2022 Feb
Furukawa Y, Hamano Y, Shirane S, Kinoshita S, Azusawa Y, Ando J, Nakauchi H, Ando M.
Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing.
Cells. 2022 Jan
Watanabe M, Umeyama K, Nakano K, Matsunari H, Fukuda T, Matsumoto K, Tajiri S, Yamanaka S, Hasegawa K, Okamoto K, Uchikura A, Takayanagi S, Nagaya M, Yokoo T, Nakauchi H, Nagashima H.
Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation.
Lab Invest. 2022 Jan
2021
Kinoshita M, Kobayashi T, Planells B, Klisch D, Spindlow D, Masaki H, Bornelöv S, Stirparo GG, Matsunari H, Uchikura A, Lamas-Toranzo I, Nichols J, Nakauchi H, Nagashima H, Alberio R, Smith A.
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.
Development. 2021 Dec
Kobayashi T, Castillo-Venzor A, Penfold CA, Morgan M, Mizuno N, Tang WWC, Osada Y, Hirao M, Yoshida F, Sato H, Nakauchi H, Hirabayashi M, Surani MA.
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells.
Cell Rep. 2021 Oct
Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M.
iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma.
Cancer Immunol Res. 2021 Oct
Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N
Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma.
Mol Ther. 2021 Oct
Sudo K, Yamazaki S, Wilkinson AC, Nakauchi H, Nakamura Y.
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem Cell Res. 2021 Oct
Bouchareychas L, Duong P, Phu TA, Alsop E, Meechoovet B, Reiman R, Ng M, Yamamoto R, Nakauchi H, Gasper WJ, Van Keuren-Jensen K, Raffai RL.
High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
iScience. 2021 Jul
Nagaya M, Hasegawa K, Uchikura A, Nakano K, Watanabe M, Umeyama K, Matsunari H, Osafune K, Kobayashi E, Nakauchi H, Nagashima H.
Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes.
World J Diabetes. 2021 Apr
Kobayashi T, Goto T, Oikawa M, Sanbo M, Yoshida F, Terada R, Niizeki N, Kajitani N, Kazuki K, Kazuki Y, Hochi S, Nakauchi H, Surani MA, Hirabayashi M.
Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats.
Nat Commun. 2021 Feb
Wilkinson AC, Dever DP, Baik R, Camarena J, Hsu I, Charlesworth CT, Morita C, Nakauchi H, Porteus MH.
Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice.
Nat Commun. 2021 Jan
Nishimura T, Suchy FP, Bhadury J, Igarashi KJ, Charlesworth CT, Nakauchi H.
Generation of Functional Organs Using a Cell-Competitive Niche in Intra-and Inter-species Rodent Chimeras.
Cell Stem Cell. 2021 Jan
2020
Nagaya M, Hasegawa K, Watanabe M, Nakano K, Okamoto K, Yamada T, Uchikura A, Osafune K, Yokota H, Nagaoka T, Matsunari H, Umeyama K, Kobayashi E, Nakauchi H, Nagashima H.
Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes.
BMJ Open Diabetes Res Care. 2020 Nov
Yamamoto R, Nakauchi H.
In vivo clonal analysis of aging hematopoietic stem cells.
Mech Ageing Dev. 2020 Oct
Wilkinson AC, Igarashi KJ, Nakauchi H.
Haematopoietic stem cell self-renewal in vivo and ex vivo.
Nat Rev Genet. 2020 Sep
Honda T, Ando M, Ando J, Ishii M, Sakiyama Y, Ohara K, Toyota T, Ohtaka M, Masuda A, Terao Y, Nakanishi M, Nakauchi H, Komatsu N.
Sustainable Tumor-Suppressive Effect of iPSC-Derived Rejuvenated T Cells Targeting Cervical Cancers.
Mol Ther. 2020 Jul
Nishimura T, Xu H, Iwasaki M, Karigane D, Saavedra B, Takahashi Y, Suchy FP, Monobe S, Martin RM, Ohtaka M, Nakanishi M, Burrows SR, Cleary ML, Majeti R, Shibuya A, Nakauchi H.
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells.
Gene Ther. 2020 Jul
Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL.
Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
Cell Rep. 2020 Jul
Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H,Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T, Ohba S.
Hedgehog Activation Regulates Human Osteoblastogenesis.
Stem Cell Reports. 2020 Jul
Yamamoto R, Wilkinson AC, Nakauchi H.
In vivo and ex vivo haematopoietic stem cell expansion.
Curr Opin Hematol. 2020 Jul
Wilkinson AC, Nakauchi H.
Stabilizing hematopoietic stem cells in vitro.
Curr Opin Genet Dev. 2020 Jun
Wilkinson AC, Igarashi KJ, Nakauchi H.
Haematopoietic stem cell self-renewal in vivo and ex vivo.
Nat Rev Genet. 2020 May
Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki M, Nakauchi H, Asahina Y, Watanabe M.
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts.
Hepatol Commun. 2020 Feb
Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.
Germline development in rat revealed by visualization and deletion of Prdm14.
Development. 2020 Jan
Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S.
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Regen Ther. 2020 Jan
Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan
Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H.
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation.
Stem Cell Reports. 2020 Jan
2019
Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV.
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.
Nat Med. 2019 Nov
Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.
Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.
Stem Cell Reports. 2019 Aug
Villanueva J, Nishimura T, Nakauchi H.
Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.
Methods Mol Biol. 2019
Nishimura T, Murmann Y, Nakauchi H.
Human iPSC Generation from Antigen-Specific T Cells.
Methods Mol Biol. 2019
Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
Development. 2019 Aug
Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun. 2019 Jul
Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica. 2019 Jul y
Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May
Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Sci Rep. 2019 May
Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.
Stem Cell. 2019 May
Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.
Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.
J Hepatol. 2019 Mar
Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.
Sci Rep. 2019 Feb
Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.
Nat Commun. 2019 Feb
Nishimura T, Nakauchi H.
Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.
Methods Mol Biol. 2019
2018
Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH.
Efficient scarless genome editing in human pluripotent stem cells.
Nat Methods. 2018 Dec
Mizuno N, Mizutani E, Sato H, Kasai M, Ogawa A, Suchy F, Yamaguchi T, Nakauchi H.
Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector.
iScience. 2018 Nov
Yamamoto R, Wilkinson AC, Nakauchi H.
hanging concepts in hematopoietic stem cells.
Science. 2018 Nov
Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.
Biomaterials. 2018 Nov
van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.
Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.
Cell Rep. 2018 Oct
Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.
Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.
Sci Rep. 2018 Oct
Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.
An interspecies barrier to tetraploid complementation and chimera formation.
Sci Rep. 2018 Oct
Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ.
Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep.
Transgenic Res. 2018 Oct
Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem Cell Reports. 2018 Sep
Higaki K, Hirao M, Kawana-Tachikawa A, Iriguchi S, Kumagai A, Ueda N, Bo W, Kamibayashi S, Watanabe A, Nakauchi H, Suzuki K, Kaneko S.
Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA.
Mol Ther Nucleic Acids. 2018 Aug
Ando M, Nakauchi H, Komatsu N.
[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].
Rinsho Ketsueki. 2018
Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.
Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.
ACS Synth Biol. 2018 Jul
Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.
Chimeric liver transplantation reveals interspecific graft remodelling.
J Hepatol. 2018 Jul
Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.
Author Correction: Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.
Sci Rep. 2018 Jun
Suchy F, Nakauchi H.
Interspecies chimeras.
Curr Opin Genet Dev. 2018 May
Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell. 2018 May
Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.
Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.
Exp Hematol. 2018 Apr
Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell Stem Cell.2018 Apr
Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y.
In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects.
Europace. 2018 Mar
Ong J, Serra MP, Segal J, Cujba AM, Ng SS, Butler R, Millar V, Hatch S, Zimri S, Koike H, Chan K, Bonham A, Walk M, Voss T, Heaton N, Mitry R, Dhawan A, Ebner D, Danovi D, Nakauchi H, Rashid ST
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications
Stem Cell Reports.. :,2018 Mar.
Aihara A, Koike T, Abe N, Nakamura S, Sawaguchi A, Nakamura T, Sugimoto N, Nakauchi H, Nishino T, Eto K
Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells
Blood Adv. :,2018 Feb.
Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S
Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
Blood. :,2018 Feb.
Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakavuchi H, Nagashima H
Modeling lethal X-linked genetic disorders in pigs with ensured fertility
Proc Natl Acad Sci USA. :,2018 Jan.
Suchy F, Yamaguchi T, Nakauchi H
iPSC-Derived Organs In Vivo: Challenges and Promise
Cell Stem Cell. :,2018 Jan.
2017
Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan S, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ
CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep
Sci Rep. :,2017 Dec.
Wilkinson AC, Nakauchi H, Göttgens B
Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity
Cell Syst. :,2017 Oct.
Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.
Establishment of mouse expanded potential stem cells.
Nature.. :,2017 Oct.
Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.
A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.
Sci Rep.. :,2017 Oct.
Saka K, Lai CY, Nojima M, Kawahara M, Otsu M, Nakauchi H, Nagamune T.
Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.
Stem Cell Rev. . :,2017 Sep.
Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports.. :,2017 Oct.
Tachikawa S, Nishimura T, Nakauchi H, Ohnuma K.
Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells.
In Vitro Cell Dev Biol Anim. . :,2017 Aug.
Hirabayashi M, Hara H, Goto T, Takizawa A, Dwinell MR, Yamanaka T, Hochi S, Nakauchi H.
Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts.
J Reprod Dev.. :,2017 Aug.
Suchy F, Nakauchi H
Lessons from Interspecies Mammalian Chimeras.
Annu Rev Cell Dev Biol. . :,2017 Aug.
Masaki H, Nakauchi H.
Interspecies chimeras for human stem cell research.
Development. . :,2017 Jul.
Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H, Yamazaki S.
An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors.
Stem Cell Reports.. :,2017 Feb.
Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H.
Interspecies organogenesis gererates autologous functional islets.
Nature,. :,2017 Jan.
Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S.
Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.
Sci Rep.. :,2017 Jan.
2016
Taya Y, Ota Y, Wilkinson A, Kanezawa A, Watarai H, Kasai M, Nakauchi H, Yamazaki S.
Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.
Science.. :,2016 Dec.
Tarusawa E, Sanbo M, Okayama A, Miyashita T, Kitsukawa T, Hirayama T, Hirabayashi T, Hasegawa S, Kaneko R, Toyoda S, Kobayashi T, Kato-Itoh M, Nakauchi H, Hirabayashi M, Yagi T, Yoshimura Y.
Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.
BMC Biol.. :,2016 Dec.
Wu J, Greely H, Jaenisch R, Nakauchi H, Rossant J, Izpisua Belmonte J.
Stem Cells and Interspecies Chimeras: Past, Present, Future.
Nature.. :,2016 Dec.
Ando M, Nakauchi H.
'Off-the-shelf' immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes.
Exp Hematol.. :,2016 Nov.
Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.
Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.
Cell Stem Cell.. :,2016 Nov.
Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, Sato T, Ohteki T, Otsu M, Nakauchi H, Ida H, Ohashi T.
Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.
Mol Genet Metab.. :,2016 Nov.
Lin HT, Okumura T, Yatsuda Y, Ito S, Nakauchi H, Otsu M.
Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy.
Hum Gene Ther Methods.. :,2016 Oct.
Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.
Stem Cells.. :,2016 Oct.
Ishida T, Takahashi S, Lai CY, Nojima M, Yamamoto R, Takeuchi E, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.
J Exp Med. :,2016 Aug.
Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A.
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
Blood.. :,2016 Aug.
Goto T, Hara H, Nakauchi H, Hochi S, Hirabayashi M.
Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.
Transgenic Res.. :,2016 Aug.
Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K, Heissig B.
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood. :,2016 Aug.
Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A.
Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice.
Hepatol Res.. :,2016 Jul.
Ueno K, Iwagawa T, Kuribayashi H, Baba Y, Nakauchi H, Murakami A, Nagasaki M, Suzuki Y, Watanabe S.
Transition of differential histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation.
Sci Rep. :,2016 Jul.
Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T, Watanabe M.
Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.
Sci Rep.. :,2016 Jul.
Durruthy-Durruthy J, Wossidlo M, Pai S, Takahashi Y, Kang G, Omberg L, Chen B, Nakauchi H, Reijo Pera R, Sebastiano V.
Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency.
Dev Cell.. :,2016 Jul.
Noguchi Y, Kawashima Y, Kawara H, Kaneko M, Nakauchi H, Tokuyama Y.
[An Undeniable Case of Optic Neuropathy Due to Cabazitaxel].
Gan To Kagaku Ryoho. . :,2016 Jun.
Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.
Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting.
Mol Reprod Dev.. :,2016 Jun.
Hara H, Goto T, Takizawa A, Sanbo M, Jacob HJ, Kobayashi T, Nakauchi H, Hochi S, Hirabayashi M.
Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.
Cell Reprogram.. :, 2016 Apr.
Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.
Nature.. :,2016 Feb.
Yanagida A, Nakauchi H, Kamiya A.
Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells.
Methods Mol Biol.. :,2016 Feb.
Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.
Biochem Biophys Res Commun.. :,2016 Jan.
Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.
Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.
Stem Cell Reports.. :,2016 Jan.
2015
Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.
A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T-Cell Therapy.
Stem Cell Reports. :,2015 Aug.
Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama K, Nakauchi H, Kamiya A.
Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.
Developmental Biology. :,2015 Jul.
2014
2013
Mochizuki Y, Iida A, Lyons E, Kageyama R, Nakauchi H, Murakami A, Watanabe S.
Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development.
Dev Neurobiol. . :,2013 Oct 1..
Akiyama K, Shimada Y, Higuchi T, Ohtsu M, Nakauchi H, Kobayashi H, Fukuda T, Ida H, Eto Y, Crawford BE, Brown JR, Ohashi T.
Enzyme augmentation therapy enhances the therapeutic efficacy of bone marrow transplantation in mucopolysaccharidosis type II mice.
Mol Genet Metab. . (13):S1096-7192,2013 Sep 21..
Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns.
PLoS One. . 8(9):,2013 Sep 23.
Saka K, Kawahara M, Teng J, Otsu M, Nakauchi H, Nagamune T.
Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.
J Biotechnol. . :S0168-1656,2013 Sep 23.
Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H.
Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation.
PLoS One. . 8(9):,2013 Sep 16.
Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL.
Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?
Stem Cell Reports. 1(2)::198-208.,2013 Jul 24.
Hirabayashi M, Goto T, Tamura C, Sanbo M, Hara H, Kato-Itoh M, Sato H, Kobayashi T, Nakauchi H, Hochi S.
Derivation of Embryonic Stem Cell Lines From Parthenogenetically Developing Rat Blastocysts.
Stem Cells Dev. . :,2013 Sep 6. .
Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell. . 154(5):1112-26.,2013 Aug 29.
Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A.
An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.
PLoS One. . 8(7):e67541:,2013 Jul 25.
Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K.
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.
J Clin Invest. . :,2013 Aug 1.
Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H.
Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.
Biochem Biophys Res Commun. . 435(4):586-91,2013 Jun 14.
Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.
Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.
Mol Ther.. 21(7):1424-31,2013 Jul.
Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K.
Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.
Exp Hematol. . 41(8):742-8,2013 Aug.
Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H.
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs.
Proc Natl Acad Sci U S A.. 110(12):4557-62, 2013 Mar 19.
Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M.
Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.
Hepatology. 57(6):2502-13,2013 Jun.
Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Nariai N, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K.
Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.
Proc Natl Acad Sci U S A.. 110(8):3023-8,2013 Feb 19.
Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S.
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
Development. 140(4):740-50, 2013 Jan 14.
2012
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Cell Stem Cell. . 12(1):114-26,.2012.11.
Matsunari H, Nakano K, Kanai T, Sakai R, Watanabe M, Umeyama K, Kobayashi T, Yamaguchi T, Shiota A, Nagaya M, Nakauchi H, Nagashima H.
326 generation of a double-transgenic pig with pancreas-specific green and liver-specific red fluorescence.
Reprod Fertil Dev. . 25(1):311:,2012 Dec;25.
Honda K, Takeuchi Y, Matsuda T, Kanai T, Kuramoto M, Maehara M, Matsunari H, Nakano K, Umeyama K, Watanabe M, Nakauchi H, Nagashima H.
324 production of genetically modified pigs by artificial reproductive technologies using frozen epididymal sperm.
Reprod Fertil Dev. . :309-10.,2012 Dec;25.
Oikawa T, Kamiya A, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM, Nakauchi H.
SALL4, a stem cell biomarker in liver cancers.
Hepatology. hep.26159.:,2012 Nov 23..
Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood. . :,2012 Nov 20..
Lin HT, Otsu M, Nakauchi H.
Stem cell therapy: an exercise in patience and prudence.
Philos Trans R Soc Lond B Biol Sci. . 368:,2013 Jan 5.
Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S.
Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation.
Br J Haematol.. :,2012 Nov 1. .
Kamiya A, Nakauchi H.
Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development.
Methods Mol Biol. . 2013;945:273-86.,2013.
Hirabayashi M, Tamura C, Sanbo M, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
A retrospective analysis of germline competence in rat embryonic stem cell lines.
Transgenic Res. . :,2012 Aug 9..
Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PLoS One. . 7(7):e41007.:,2012 Jul 18..
Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PLoS One. . 2012;7(5):,2012 May 11..
Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M.
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood. . 2012 Jun 28;119(26):6234-42, 2012 May 16..
Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Blood. . 2012 Jun 28;119(26):6382-93, 2012 May 9..
Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H.
Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells.
Transplant Proc.. 2012 May;44(4):1127-9.,2012.
Kobayashi T, Kato-Itoh M, Yamaguchi T, Tamura C, Sanbo M, Hirabayashi M, Nakauchi H.
Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
Stem Cells Dev. . 2012 Jun 11.:,2012.
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Blood. . 2012 Jun 7;119(23):5405-16,2012 Apr 27..
Usui J, Kobayashi T, Yamaguchi T, Knisely AS, Nishinakamura R, Nakauchi H.
Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation.
Am J Pathol. . 2012 Jun;180(6):2417-26, 2012 Apr 14..
Hirabayashi M, Tamura C, Sanbo M, Goto T, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.
Mol Reprod Dev.. 2012 Jun;79(6):402-12,2012 May 4..
Ghosn EE, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA.
Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.
Proc Natl Acad Sci U S A.. 2012 Apr 3.109(14):5394-8,2012 Mar 19..
Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell.. 148(5):1001-14.,2012 .
Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
J Exp Med. . :,2012 Feb 20..
Ito H, Kamiya A, Ito K, Yanagida A, Okada K, Nakauchi H.
In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
Liver Int.. :,2012 Jan 4..
2011
Takayama N, Eto K, Nakauchi H.
Potential usefulness of human iPS cells on the generation of platelets
Nihon Rinsho.. :,2011 Dec.
Kobayashi T, Nakauchi H.
From cell therapy to organ regeneration therapy: generation of functional organs from pluripotent stem cells
Nihon Rinsho.. :,2011 Dec.
Umeyama K, Saito H, Kurome M, Matsunari H, Watanabe M, Nakauchi H, Nagashima H.
Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs.
Mol Reprod Dev.. :218-28,2011 Dec 29..
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H.
Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Cell.. 147(5):1146-58., 2011 Nov 23.
Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, Takaki S.
Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL.
Exp Hematol. . :,2011 Nov 17..
Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T.
Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.
Blood. . :, 2011 Nov 16. .
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Blood. . :,2011 Nov 16..
Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B.
Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.
Exp Hematol. . :, 2011 Nov 3..
Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, Shiota A, Nakauchi H, Nagashima H.
The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer.
Transgenic Res. . :,2011 Oct 25..
Watabe Y, Baba Y, Nakauchi H, Mizota A, Watanabe S.
The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.
Biochem Biophys Res Commun. . :415(1):42-7., 2011 Nov 11.
Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Okaji Y, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment.
Leukemia. . :,2011 Sep 20..
Saito R, Nakauchi H, Watanabe S.
Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.
Cancer Sci. . :,2011 Sep 16..
Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.
Frequent pathway mutations of splicing machinery in myelodysplasia.
Nature.. 478: 64–69, 2011 Sep 11.
Okada K, Kamiya A, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H.
Prospective isolation and characterization of bi-potent progenitor cells in early mouse liver development.
Stem Cells Dev. . :,2011 Aug 23.
Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H.
Generation of germline-competent rat induced pluripotent stem cells.
PLoS One. :, 2011 Jul 15.
Kawahara M, Chen J, Sogo T, Teng J, Otsu M, Onodera M, Nakauchi H, Ueda H, Nagamune T.
Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera
Cytokine. Volume 55:Pages 402-408,September 2011.
Yokoi T, Kobayashi H, Shimada Y, Higuchi T, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T.
Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease.
J Gene Med. . :,2011 Apr 25.
Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.
Biochem Biophys Res Commun. . 406(1):134-40,2011 Mar 4.
Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK.
Hair follicle stem cells provide a functional niche for melanocyte stem cells.
Cell Stem Cell. . 8(2):177-87.,2011 Feb 4.
Morita Y, Iseki A, Okamura S, Suzuki S, Nakauchi H, Ema H.
Functional characterization of hematopoietic stem cells in the spleen.
Exp Hematol. . 39(3):351-359.,2011 Mar.
2010
Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
J Biol Chem.. 286(6):4760-71,2010 Dec 7..
Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PLoS One. . 5(11):,2010 Nov.
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med. . 207(13):2817-30,2010 Nov 22..
Watanabe M, Umeyama K, Matsunari H, Takayanagi S, Haruyama E, Nakano K, Fujiwara T, Ikezawa Y, Nakauchi H, Nagashima H.
Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases.
Biochem Biophys Res Commun.. 402(1):14-8,2010 Sep 26..
Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A.
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Exp Hematol. . 38(8):696-706,2010 Aug.
Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J Exp Med.. 207(7):1501-11,2010 Jun 21.
Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Hepatology. 52:1111-1123,September 2010.
Kaneko S, Otsu M, Nakauchi H.
Reprogramming adult hematopoietic cells.
Curr Opin Hematol. 17(4):271-5,Jul 2010.
Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y.
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest.. 90(9):1357-64,2010 Sep.
Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clin Cancer Res.. 16(15):3825-31.,2010 Aug 1.
Nakahata S, Yamazaki S, Nakauchi H, Morishita K.
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.
Oncogene. 29(29):4157-69.,2010 Jul 22.
Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Blood. 115(21):4302-12,2010 May 27.
Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.
Mol Reprod Dev.. 77(6):474,Jun 2010.
Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A.
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Cell Stem Cell. 6(3):279-86,2010.
2009
Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.
Mol Reprod Dev.. 77(6):474,Jun 2010.
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.
Lnk regulates integrin aIIbb3 outside-in signaling in m ouse platelets leading to stabilization of thrombus development in vivo.
J Clin Invest. 120:179-90,2009.
Liao CH, Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
J Clin Invest. 120:242-53,2009.
Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H.
Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency.
Mol Reprod Dev. in press:,2009 Nov 6.
Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.
Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.
Exp Hematol. in press:,2009 Sep 7.
Ishige I, Nagamura-Inoue T, Honda MJ, Harnprasopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A.
Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.
Int J Hematol. 90:261-69,2009.
Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T.
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Cancer Cell. 16:161-71,2009.
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature. 460:904-8,2009.
Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H.
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.
Blood. 114:1764-7,2009.
Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H.
Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mise.
Gastroenterology.. 137:1114-26,2009.
Yamazaki S, Nakauchi H
Insights into signaling and function of hematopoietic stem cells at the single-cell level.
Curr Opin Hematol. 16:255-8,2009.
Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H.
Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver.
J Hepatol. 51:127-38,2009.
M, atsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.
Stepwise development of hematopoietic stem cells from embryonic stem cells.
PLoS ONE. 4:e4820,2009.
Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T.
T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.
Cytokine. 46:127-36,2009.
Kakinuma S, Nakauchi H, Watanabe M.
Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.
J Gastroenterol. 44:167-72,2009.
Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N.
A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.
J Immunol Methods. 343:56-60,2009.
Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H.
Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.
Gastroenterology. 136:1000-11,2009.
Yashiro Y, Bannai H, Minowa T, Yabiku T, Miyano S, Osawa M, Iwama A, Nakauchi H.
Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.
Int J Hematol. 89:24-33,2009.
Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H.
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem Cells. 27:1120-1129,2009.
Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H.
TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.
Blood. 113:1250-1256,2009.
2008
Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ.
New ISSCR guidelines underscore major principles for responsible translational stem cell research.
Cell Stem Cell. 3:607-9,2008.
Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H.
Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.
Hepatology. 48:1964-78,2008.
Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.
Cancer Res. 68:7742-9,2008.
Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K.
Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.
Proc Natl Acad Sci U S A. 105:13087-92,2008.
Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H.
Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.
Hepatology. 48:252-64,2008.
Nishikii H, Eto K, Tamura N, Hattori1 K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H.
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.
J Exp Med. 205:1917-27,2008.
Watanabe N, Takahashi S, Ishige M, Ishii Y, Ooi J, Tomonari A, Tsukada N, Konuma T, Kato S, Sato A, Tojo A, Nakauchi H.
Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.
Biol Blood Marrow Transplant. 14:693-701,2008.
Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H.
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.
Blood. 111:5298-306,2008.
Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S.
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.
Exp Hematol. 36:897-906,2008.
Seita J, Asakawa M, Ooehara J, Takayanagi SI, Morita Y, Watanabe N, Fujita K, Kudo M, Mizuguchi J, Ema H, Nakauchi H, Yoshimoto Y.
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Blood. 111:1903-12,2008.
2007
Nabekura T, Nagasawa T, Nakauchi H, Onodera M.
An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.
Cancer Immunol Immunother. 57:611-22,2008.
Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Romer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Dano K, Hattori K.
The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.
Cell Stem Cell. 1:658-70,2007.
Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell Stem Cell. 1:101-12,2007.
Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H.
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.
Gastroenterology. 133:937-50,2007.
Yamazaki S, Iwama A, Morita Y, Eto K, Ema H, Nakauchi H.
Cytokine signaling, lipid raft clustering, and HSC hibernation.
Ann N Y Acad Sci. 1106:54-63,2007.
Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.
Blood. 110:3637-47,2007.
Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H.
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
J Exp Med. 204:715-22,2007.
Kato Y, Koseki H, Vidal M, Nakauchi H, Iwama A.
Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.
Int J Hematol. 85:179-81,2007.
Seita, J., Ema, H., Ooehara, J., Yamazaki, S., Tadokoro, Y., Yamazaki, A., Eto, K., Takaki, S., Takatsu, K., and Nakauchi H.
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.
Proc Natl Acad Sci USA. 104:2349-54,2007.
Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.
39. Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells.
Mol Ther. 15:560-5,2007.
Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iawama A.
Bmi1 cooperates with Dnmt1-assciated protein 1 in gene silencing.
Biochem Biophys Res Commun. 353:992-8,2007.
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Nature Genet. 39:99-105,2007 Epub, 2006.
2006
Ema H. Morita Y. Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.
Adult mouse hematopoietic stem cells: purification and single-cell assays.
Nature Protocols. 1:2979-87,2006.
Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H.
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
J Exp Med. 203:2247-53,2006.
Sakaguchi T, Nishimoto M, Miyagi S, Iwama A, Morita Y, Iwamori N, Nakauchi H, Kiyonari H, Muramatsu M, Okuda A.
Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.
Mol Cell Biol.. 26:6557-70,2006.
Yamazaki S, Iwama A, Takayanagi S, Morita Y, Eto K, Ema H, Nakauchi H.
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematpoetic stem cells.
EMBO J. 25:3515-3523,2006.
Morita Y, Ema H, Yamazaki S, Nakauchi H.
Non - sicde-population hematopoietic stem cells in mouse bone marrow.
Blood. 108:2850-2856,2006.
Chiba T, Kita K, Zheng YW, okosuka O, Saisho H, Iwama S, Nakauchi H, Taniguchi H.
Side p opulation purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.
Hepatology. 44:240-51,2006.
Furuta C, Ema H, takayanagi S, ogaeri T, Okamura D, Matsui Y, Nakauchi H.
Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo.
Development. 133:2771-9,2006.
Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H.
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proc Natl Acad Sci U S A. 103:7112-7,2006.
Takayanagi SI, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H.
Genet ic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell-surface protein with the thrombospondin-1 domain.
Blood. 107:4317-25,2006.
Nabekura T, Otsu M, Nagasawa T, Hakauchi H, Onodera M.
Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap.
Molecular Therapy. 13:301-09,2006.
2005
Usui J, Osawa M, Yamazaki S, Morita Y, Koyama A, Nakauchi H.
Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting.
Clin Exp Nephrol. 9:292-6,2005.
Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.
A role for PKCq in outside-in aIIbb3 signaling.
J Thromb Haemost. 4:658-55,2006.
Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestweber D, Nakauchi H.
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development.
J Exp Med. 202:1483-92,2005.
Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
J Exp Med. 202:169-79,2005.
Iseki H, Shimizukawa R, Sugiyama F, Kunita S, Iwama A, Onodera M, Nakauchi H, Yagami K.
Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.
J Virol. 79:8886-93,2005.
Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Ichiyanagi T, Kohike H, Komori T, Takahashi I, Takase O, Imai N, Yoshikawa M, Inowa T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.
Musculin/MyoR is expressed in kidney side population cells and can regulate their function.
J Cell Biol. 169:921-8,2005.
Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.
Dev Cell. 8:907-14,2005.
Iwama A, Oguro H, Negishi M, Kato Y, and Nakauchi H.
Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal by Polycomb Group Genes.
Int. Journal of Hematology. 81:294-300,2005.
Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Kohike H, Komori T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.
Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.
Biochem Biophys Res Commun.. 328:288-91,2005.
Almeida-Porada G, Crapnell K, Porada C, Benoit B, Nakauchi H, Quesenberry P, Zanjani ED.
In vivo haematopoietic potential of human neural stem cells.
Br J Haematol.. 130:276-83,2005.
Kaneko S, Nagasawa T, Nakauchi H, Onodera M.
An in vivo assay for retrovirally transduced human peripheral T lymphocytes using nonobese diabetic/severe combined immunodeficiency mice.
Exp Hematol. 33:35-41,2005.
selected
Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell. . 154(5):1112-26.,2013 Aug 29.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Cell Stem Cell. . 12(1):114-26,.2012.11.
Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell.. 148(5):1001-14.,2012 .
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H.
Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Cell.. 147(5):1146-58., 2011 Nov 23.
Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H.
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.
Cell. 142:787-99,Sep 2010.
Morita Y, Ema H, Nakauchi H.
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
J Exp Med. . 207:1173-1182,April 2010.
Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
Cell Cycle. 9(6).: 1051 - 1056,2010 Mar 23.
