基礎科学と臨床医学の架け橋として
新しい医療を確立する。
免疫学、分子生物学、細胞生物学、発生工学など、基礎科学の知識や方法論を臨床医学と結びつけることにより、新しい病気の発見、病態の解明、治療法の開発など、先端医療の確立に貢献することを目指しています。
最新のお知らせ一覧
最近の研究実績一覧
Nagaya M, Hasegawa K, Watanabe M, Nakano K, Okamoto K, Yamada T, Uchikura A, Osafune K, Yokota H, Nagaoka T, Matsunari H, Umeyama K, Kobayashi E, Nakauchi H, Nagashima H.
Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes.
BMJ Open Diabetes Res Care. 2020 Nov
Yamamoto R, Nakauchi H.
In vivo clonal analysis of aging hematopoietic stem cells.
Mech Ageing Dev. 2020 Oct
Wilkinson AC, Igarashi KJ, Nakauchi H.
Haematopoietic stem cell self-renewal in vivo and ex vivo.
Nat Rev Genet. 2020 Sep
Honda T, Ando M, Ando J, Ishii M, Sakiyama Y, Ohara K, Toyota T, Ohtaka M, Masuda A, Terao Y, Nakanishi M, Nakauchi H, Komatsu N.
Sustainable Tumor-Suppressive Effect of iPSC-Derived Rejuvenated T Cells Targeting Cervical Cancers.
Mol Ther. 2020 Jul
Nishimura T, Xu H, Iwasaki M, Karigane D, Saavedra B, Takahashi Y, Suchy FP, Monobe S, Martin RM, Ohtaka M, Nakanishi M, Burrows SR, Cleary ML, Majeti R, Shibuya A, Nakauchi H.
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells.
Gene Ther. 2020 Jul
Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL.
Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
Cell Rep. 2020 Jul
Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H,Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T, Ohba S.
Hedgehog Activation Regulates Human Osteoblastogenesis.
Stem Cell Reports. 2020 Jul
Yamamoto R, Wilkinson AC, Nakauchi H.
In vivo and ex vivo haematopoietic stem cell expansion.
Curr Opin Hematol. 2020 Jul
Wilkinson AC, Nakauchi H.
Stabilizing hematopoietic stem cells in vitro.
Curr Opin Genet Dev. 2020 Jun
Wilkinson AC, Igarashi KJ, Nakauchi H.
Haematopoietic stem cell self-renewal in vivo and ex vivo.
Nat Rev Genet. 2020 May
Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki M, Nakauchi H, Asahina Y, Watanabe M.
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts.
Hepatol Commun. 2020 Feb
Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.
Germline development in rat revealed by visualization and deletion of Prdm14.
Development. 2020 Jan
Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S.
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Regen Ther. 2020 Jan
Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan
Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H.
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation.
Stem Cell Reports. 2020 Jan
Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.
Exp Hematol. 2019 Dec
Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV.
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.
Nat Med. 2019 Nov
Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.
Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.
Stem Cell Reports. 2019 Aug
Villanueva J, Nishimura T, Nakauchi H.
Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.
Methods Mol Biol. 2019
Nishimura T, Murmann Y, Nakauchi H.
Human iPSC Generation from Antigen-Specific T Cells.
Methods Mol Biol. 2019
Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
Development. 2019 Aug
Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun. 2019 Jul
Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica. 2019 Jul y
Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May
Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Sci Rep. 2019 May
Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.
Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.
Stem Cell. 2019 May
Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.
Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.
J Hepatol. 2019 Mar
Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.
Sci Rep. 2019 Feb
Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.
Nat Commun. 2019 Feb
Nishimura T, Nakauchi H.
Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.
Methods Mol Biol. 2019
Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH.
Efficient scarless genome editing in human pluripotent stem cells.
Nat Methods. 2018 Dec
Mizuno N, Mizutani E, Sato H, Kasai M, Ogawa A, Suchy F, Yamaguchi T, Nakauchi H.
Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector.
iScience. 2018 Nov
Yamamoto R, Wilkinson AC, Nakauchi H.
hanging concepts in hematopoietic stem cells.
Science. 2018 Nov
Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.
Biomaterials. 2018 Nov
van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.
Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.
Cell Rep. 2018 Oct
Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.
Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.
Sci Rep. 2018 Oct
Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.
An interspecies barrier to tetraploid complementation and chimera formation.
Sci Rep. 2018 Oct
Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ.
Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep.
Transgenic Res. 2018 Oct
Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem Cell Reports. 2018 Sep
Higaki K, Hirao M, Kawana-Tachikawa A, Iriguchi S, Kumagai A, Ueda N, Bo W, Kamibayashi S, Watanabe A, Nakauchi H, Suzuki K, Kaneko S.
Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA.
Mol Ther Nucleic Acids. 2018 Aug
Ando M, Nakauchi H, Komatsu N.
[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].
Rinsho Ketsueki. 2018
Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.
Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.
ACS Synth Biol. 2018 Jul
Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.
Chimeric liver transplantation reveals interspecific graft remodelling.
J Hepatol. 2018 Jul
Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.
Author Correction: Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.
Sci Rep. 2018 Jun
Suchy F, Nakauchi H.
Interspecies chimeras.
Curr Opin Genet Dev. 2018 May
Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell. 2018 May
Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.
Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.
Exp Hematol. 2018 Apr
Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell Stem Cell.2018 Apr
Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y.
In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects.
Europace. 2018 Mar
