Establish a New Frontier of Stem Cell Therapy by Connecting the Basic Science and Clinical Medicine.

We are working to uncover new diseases, elucidating the causes of disease and developing therapeutic modalities by connecting the knowledge and methodology of basic science such as immunology, molecular biology, cell biology and developmental engineering with clinical medicine.

Current NewsList

2019/11/13

PRESS:Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.

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2019/09/03

Participated of AMED再生医療研究交流会

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2019/08/01

AFP Article

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2019/07/30

Article on INDEPENDENT

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2019/07/26

Article on Nature

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2019/05/30

"Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation" was published in "Nature".

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PublicationsList

Honda T, Ando M, Ando J, Ishii M, Sakiyama Y, Ohara K, Toyota T, Ohtaka M, Masuda A, Terao Y, Nakanishi M, Nakauchi H, Komatsu N.
Sustainable Tumor-Suppressive Effect of iPSC-Derived Rejuvenated T Cells Targeting Cervical Cancers.
Mol Ther. 2020 Jul

Abstract on PubMed

Nishimura T, Xu H, Iwasaki M, Karigane D, Saavedra B, Takahashi Y, Suchy FP, Monobe S, Martin RM, Ohtaka M, Nakanishi M, Burrows SR, Cleary ML, Majeti R, Shibuya A, Nakauchi H.
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells.
Gene Ther. 2020 Jul

Abstract on PubMed

Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL.
Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
Cell Rep. 2020 Jul

Abstract on PubMed

Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H,Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T, Ohba S.
Hedgehog Activation Regulates Human Osteoblastogenesis.
Stem Cell Reports. 2020 Jul

Abstract on PubMed

Yamamoto R, Wilkinson AC, Nakauchi H.
In vivo and ex vivo haematopoietic stem cell expansion.
Curr Opin Hematol. 2020 Jul

Abstract on PubMed

Wilkinson AC, Nakauchi H.
Stabilizing hematopoietic stem cells in vitro.
Curr Opin Genet Dev. 2020 Jun

Abstract on PubMed

Wilkinson AC, Igarashi KJ, Nakauchi H.
Haematopoietic stem cell self-renewal in vivo and ex vivo.
Nat Rev Genet. 2020 May

Abstract on PubMed

Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki M, Nakauchi H, Asahina Y, Watanabe M.
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts.
Hepatol Commun. 2020 Feb

Abstract on PubMed

Kobayashi T, Kobayashi H, Goto T, Takashima T, Oikawa M, Ikeda H, Terada R, Yoshida F, Sanbo M, Nakauchi H, Kurimoto K, Hirabayashi M.
Germline development in rat revealed by visualization and deletion of Prdm14.
Development. 2020 Jan

Abstract on PubMed

Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S.
Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.
Regen Ther. 2020 Jan

Abstract on PubMed

Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan

Abstract on PubMed

Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H.
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation.
Stem Cell Reports. 2020 Jan

Abstract on PubMed

Mori M, Furuhashi K, Danielsson JA, Hirata Y, Kakiuchi M, Lin CS, Ohta M, Riccio P, Takahashi Y, Xu X, Emala CW, Lu C, Nakauchi H, Cardoso WV.
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells.
Nat Med. 2019 Nov

Abstract on PubMed

Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.
Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.
Stem Cell Reports. 2019 Aug

Abstract on PubMed

Villanueva J, Nishimura T, Nakauchi H.
Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.
Methods Mol Biol. 2019

Abstract on PubMed

Nishimura T, Murmann Y, Nakauchi H.
Human iPSC Generation from Antigen-Specific T Cells.
Methods Mol Biol. 2019

Abstract on PubMed

Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.
Development. 2019 Aug

Abstract on PubMed

Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Nat Commun. 2019 Jul

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica. 2019 Jul

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Sci Rep. 2019 May

Abstract on PubMed

Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.

Stem Cell. 2019 May

Abstract on PubMed