Novel Microenvironment-Targeted Therapy for Bone Marrow Recovery After Injury

Description

Published Article

"Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration"

Blood Online 22 June 2026 doi:10.1182/blood.2025030831

Shun Uemura¹, Masayuki Yamashita^1,2, Takako Yokomizo-Nakano¹, Ayako Aihara³, Takumi Iwawaki³, Shuhei Koide¹, Yaeko Nakajima-Takagi¹, Motohiko Oshima¹, Yoshiki Omatsu^4,5,6, Yuki Matsumoto⁷, Yoshiaki Kubota⁷, Bahityar Rahmutulla⁸, Atsushi Kaneda^8,9, Miki Nishio¹⁰, Akira Suzuki¹⁰, Takashi Nagasawa^4,5,6, Kenta Kagaya³, Taito Nishino¹¹, and Atsushi Iwama^1,12,13

1. Division of Stem Cell and Molecular Medicine, The University of Tokyo, Japan

2. Division of Experimental Hematology, St. Jude Children’s Research Hospital, USA

3. Biological Research Laboratories, Nissan Chemical Corporation, Japan

4. Laboratory of Stem Cell Biology and Developmental Immunology, Osaka University, Japan

5. Graduate School of Medicine, Osaka University, Japan

6. Immunology Frontier Research Center (WPI-IFReC), Osaka University, Japan

7. Department of Anatomy, Keio University School of Medicine, Japan

8. Department of Molecular Oncology, Chiba University, Japan

9. Health and Disease Omics Center, Chiba University, Japan

10. Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Japan

11. Head Office, Nissan Chemical Corporation, Japan

12. Laboratory of Cellular and Molecular Chemistry, The University of Tokyo, Japan

13. The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Japan

Blood