"Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging"
Nature Communications Online 6 April 2026 doi:10.1038/s41467-026-71060-4
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging
Description
Published Article
Yuta Yamada1,2, Jinjing Yang2, Akiho Saiki-Tsuchiya2, Yuji Watanabe3, Shuhei Koide2, Shin Murai4, Yuriko Sorimachi5, Yu Fukuda1, Kenta Sumiyama6, Hiroshi Sagara3, Hiroyasu Nakano7,8, Keiyo Takubo5,9, Atsushi Iwama2,10, and Masayuki Yamashita1,2
1Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Research Hospital, USA
2Division of Stem Cell and Molecular Medicine, Centre for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
3Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Japan
4Department of Biochemistry, Faculty of Medicine, Toho University, Japan
5Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security, Japan
6Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
7Unit of Host Defense, Faculty of Medicine, Toho University, Japan
8Research Administration Organization, Toho University, Japan
9Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Japan
10Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
1Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Research Hospital, USA
2Division of Stem Cell and Molecular Medicine, Centre for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
3Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Japan
4Department of Biochemistry, Faculty of Medicine, Toho University, Japan
5Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security, Japan
6Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
7Unit of Host Defense, Faculty of Medicine, Toho University, Japan
8Research Administration Organization, Toho University, Japan
9Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Japan
10Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
