"Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome"
Nature Communications Online 28 November 2025 doi:10.1038/s41467-025-65753-5
Chromatin Accessibility Maps Reveal How Stem Cells Drive Myelodysplastic Progression
Description
Published Article
Motohiko Oshima1, Naoya Takayama2, Yaeko Nakajima-Takagi1, Daisuke Shinoda1, Naoki Itokawa1, Shuhei Kurosawa1, Satoshi Kaito1, Takahiro Kamiya1, Yuta Yamada1, Shohei Andoh1, Kensuke Kayamori1,3, Sudip Kumar Paul2, Maria Alejandra Kanashiro2, Tomoya Muto3, Shokichi Tsukamoto3, Emiko Sakaida3, Eriko Sato4, Nozomi Yusa5, Kazuaki Yokoyama5, Yasuhito Nannya5, Seiya Imoto6, Bahityar Rahmutulla7, Atsushi Kaneda7,8, Kiyoshi Yamaguchi9, Yoichi Furukawa9, Noriko Doki10, Koji Eto2, Kei Nishikawa11, Ye Ding11, Tomohiro Myojo11, Yuka Harada12, Hironori Harada13, and Atsushi Iwama1,14
1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
2Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Japan
3Department of Hematology, Chiba University Hospital, Japan
4Department of Hematology, Juntendo University Nerima Hospital, Japan
5Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Japan
6Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Japan
7Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan
8Health and Disease Omics Center, Chiba University, Japan
9Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan
10Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan
11Department of Oncology and Hematology, Edogawa Hospital, Japan
12Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan
13Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Japan
14Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
2Department of Regenerative Medicine, Graduate School of Medicine, Chiba University, Japan
3Department of Hematology, Chiba University Hospital, Japan
4Department of Hematology, Juntendo University Nerima Hospital, Japan
5Department of Hematology/Oncology, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Japan
6Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Japan
7Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Japan
8Health and Disease Omics Center, Chiba University, Japan
9Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Japan
10Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan
11Department of Oncology and Hematology, Edogawa Hospital, Japan
12Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Japan
13Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Japan
14Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
