"Herpes simplex virus-1 evades APOBEC1-mediated immunity via its uracil DNA glycosylase in mice"
Nature Microbiology Online 3 June 2025 doi:10.1038/s41564-025-02026-3
Targeting Viral Enzymes to Strengthen Brain Immunity Against HSV-1
Description
Published Article
Akihisa Kato1, 2, 3, 4, Hayato Harima 17,18, Yuji Tsunekawa5, Manabu Igarashi6, 7, Kouichi Kitamura8, Kousho Wakae8, Tomoaki Nishiyama9, 10, Satoru Morimoto11, Toru Suzuki12, Hiroko Kozuka-Hata13, Masaaki Oyama13, Daisuke Motooka14, Mizuki Watanabe18, Kousuke Takeshima1, Yuhei Maruzuru1, 2, 3, Naoto Koyanagi1, 2, 3, Hideyuki Okano11, Toshifumi Inada12, Takashi Okada5, Masamichi Muramatsu8, 15, and Yasushi Kawaguchi1, 2, 3, 16
1 Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
2 Department of Infectious Disease Control, The Institute of Medical Science, The University of Tokyo, Japan
3 Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Japan
4 PRESTO, Japan Science and Technology Agency, Japan
5 Division of Molecular and Medical Genetics, The Institute of Medical Science, The University of Tokyo, Japan
6 Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Japan
7 International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Japan
8 Department of Virology II, National Institute of Infectious Diseases, Japan
9 Research Center for Experimental Modeling of Human Disease, Kanazawa University, Japan
10 School of Science, University of Toyama, Japan
11 Keio University Regenerative Medicine Research Center, Keio University, Japan
12 Division of RNA and Gene Regulation, The Institute of Medical Science, The University of Tokyo, Japan
13 Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Japan
14 Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Japan
15 Department of Infectious Disease Research, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Japan
16 Pandemic Preparedness, Infection and Advanced Research Center, The University of Tokyo, Japan
17 Laboratory of Veterinary Public Health, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan
18 Pathology, Immunology and Microbiology, Graduate School of Medicine, The University of Tokyo, Japan
