"TLR7/8 stress response drives histiocytosis in SLC29A3 disorders"
Journal of Experimental Medicine Online 18 July 2023 doi:10.1084/jem.20230054
New Study Sheds Light on the Molecular Mechanisms Underlying SLC29A3 Disorders
Description
Published Article
Takuma Shibata1, Ryota Sato1, Masato Taoka2, Shin-Ichiroh Saitoh1, Mayumi Komine3, Kiyoshi Yamaguchi4, Susumu Goyama5, Yuji Motoi1, Jiro Kitaura6, Kumi Izawa6, Yoshio Yamauchi2, Yumiko Tsukamoto7, Takeshi Ichinohe8, Etsuko Fujita3, Ryosuke Hiranuma1, Ryutaro Fukui1, Yoichi Furukawa4, Toshio Kitamura9, Toshiyuki Takai10, Arinobu Tojo11, Mamitaro Ohtsuki3, Umeharu Ohto12, Toshiyuki Shimizu12, Manabu Ozawa13, Nobuaki Yoshida13, Toshiaki Isobe2, Eicke Latz14, Kojiro Mukai15, Tomohiko Taguchi15, Kensuke Miyake1
1 Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
2 Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa 1-1, Hachioji, Tokyo 192-0397, Japan.
3 Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
4 Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
5 Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan.
6 Atopy Research Center, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.
7 Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, 189-0002, Japan.
8 Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
9 Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan
10 Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
11 Department of Hematology and Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
12 Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan.
13 Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
14 Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
15 Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
1 Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
2 Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-Osawa 1-1, Hachioji, Tokyo 192-0397, Japan.
3 Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
4 Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
5 Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan.
6 Atopy Research Center, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.
7 Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, 189-0002, Japan.
8 Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
9 Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan
10 Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
11 Department of Hematology and Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
12 Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan.
13 Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
14 Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
15 Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
