Division of Protein Metabolism

The ubiquitin-proteasome system and lysosomes are the major proteolytic pathways and play a fundamental role in cellular protein homeostasis (proteostasis). Their dysregulation causes a plethora of diseases, including neurodegenerative disorders, but the detailed pathogenic mechanisms remain largely unknown. Our goal is to elucidate the basic molecular mechanisms governing proteostasis-related diseases by analyzing the regulation of protein metabolism, thereby providing the basis for therapeutic strategies.