“Intracellular Protein Degradation” for Health

We aim to elucidate the molecular mechanisms underlying
intracellular protein degradation pathways and understand how their
abnormalities contribute to the pathogenesis of various diseases.

The ubiquitin-proteasome system and lysosome play critical roles in breaking down unwanted or aberrant proteins within cells. Their functions are essential for maintaining protein homeostasis (proteostasis) and regulating various cellular processes.

In recent years, abnormalities in these protein degradation systems have been implicated in various pathological conditions, including cancer, neurodegenerative diseases, inflammatory disorders, and aging. However, the precise molecular mechanisms remain largely elusive.

Our laboratory employs a comprehensive approach using techniques such as proteomics analysis and mouse genetics, to unravel the molecular details by which these protein degradation pathways control cellular functions. Our ultimate goal is to gain a precise understanding of the disease pathogenesis and develop effective therapeutic strategies based on these insights.