主な業績
研究室の主な業績：1998-2020年に発表した約230論文より抜粋(reviewを除く)。
筆頭著者あるいはco-first author*が
・大学院生または学位論文の場合は二重下線
・博士研究員の場合は太字
・スタッフの場合は下線
で記載されています。
大学院生が筆頭著者の論文については下記リンクを参照してください。
大学院生が筆頭著者の論文と学位論文
2021
Yamamoto, K., Goyama, S., Asada, S., Fujino, T., Yonezawa, T., Sato, N., Takeda, R., Tsuchiya, A., Fukuyama, T., Tanaka, Y., Yokoyama, A., Toya, H., Kon, A., Nannya, Y., Onoguchi-Mizutani, R., Nakagawa, S, Hirose, T., Ogawa, S., Akimitsu, N., and Kitamura, T. A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells. Cell Rep. 24;36(8):109576. pubmed
Fujino, T., Goyama, S., Sugiura, Y., Inoue, D., Asada, S., Yamasaki, S., Matsumoto, A., Tsuchiya, A., Shikata, S., Sato N., Morinaga, H., Fukuyama, T., Tanaka, Y., Fukushima, T., Takeda, R., Yamamoto, K., Honda, H., Nishimura, E.K., Shibata, T., Abdel-Wahab, Omar., Suematsu, M., and Kitamura, T. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cell through activation of Akt/mTOR pathway. Nat Commun. 12:1826 pubmed
Oki, T., Mercier, F., Kato, H., Jung, Y., McDonald, T., Spencer, J., Mazzola, M., Gastel, N.V., Lin, C., Michor, F., Kitamura, T., and Scaden, D. Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML. Nat Commun. 12:245 pubmed
2020
Tanaka, Y., Fukushima, T., Mikami, K., Adachi, K., Fukuyama, T., Goyama, S., and Kitamura, T. Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells. Exp Hematol. 90:46-51 pubmed
Inoue, T., Shinnakasu, R., Kawai, C., Ersching, J., Ise, W., Kawakami, E., Sax, N., Oki, T., Kitamura, T., Yamashita, K., Fukuyama, H., Victora, G.D., and Kurosaki, T. Exit from the germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal. J Exp Med. 218: e20200866. pubmed
Hayashi, Y., Kawabata, K.C., Tanaka, Y., Uehara, Y., Kiryu, S., Ota, Y., Yoshioka, Y., Mabuchi, Y., Sugiyama, T., Mikami, K., Tamura, M., Fukushima, T., Asada, S., Takeda, R., Kunisaki, Y., Fukuyama, T., Goyama, S., Yokoyama, K., Tojo, A., Katayama, Y., Arai, F., Nagasawa, T., Ochiya, T., Inoue, D., and Kitamura, T. Impaired osteoblastic differentiation of MSCs suppresses normal hematopoiesis in MDS. Cell Stem Cell in revise.
Miyamoto, R., Okuda, H., Kanai, A., Takahashi, S., Kawamura, T., Matsui, H., Kitamura, T., Kitabayashi, I., Inaba, T., and Yokoyama, A. Activation of CpG-rich promoters mediated by MLL drives MOZ-rearranged Leukemia. Cell Rep. 32:108200. pubmed
Takeda, R., Asada, S. , Park, SJ., Yokoyama, A., Becker, HJ., Kanai, A., Visconte, V., Hershberger, C., Hayashi, Y., Yonezawa, T., Tamura, M., Fukushima, T., Tanaka, Y., Fukuyama, Matsumoto, A., Yamasaki, S., Nakai, K., Yamazaki, S., Inaba, T., Shibata, T., Inoue, D., Honda, H., Goyama, S., Maciejewski, JP., and Kitamura, T. HHEX promotes myeloid transformation in cooperation with mutant ASXL1. Blood 136:1670-1684. pubmed
Kawashima, M., Carreras, J., Higuchi, H., Kotani, R., Hoshina, T., Okuyama, K., Suzuki, N., Kakizaki, M., Miyatake, Y., Ando, K., Nakayama, M., Umezu, S., Horie, R., Higuchi, Y., Katagiri, K., Goyama, S., Kitamura, T., Chamoto, K., Yano, S., Nakamura, N., and Kotani, A. PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma. Leukemia 34:2405-2417. pubmed
Fujino, T. and Kitamura, T. ASXL1 mutation in clonal hematopoiesis. Exp Hematol. 83:74-84. Review. pubmed
2019
Fukushima, T., Tanaka, Y., Hamey, F.K., Chang, C.H., Oki, T., Asada, S., Hayashi, Y., Fujino, T., Yonezawa, T., Takeda, R., Kawabata, K.C., Fukuyama, T., Umemoto, T., Takubo, K., Takizawa, H., Goyama, S., Ishihama, Y., Honda, H., G?ttgens, B. and Kitamura, T. Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 29:4144-4158. pubmed
Hayashi, Y., Goyama, S., Liu, X., Tamura, M., Asada, S., Tanaka, Y., Fukuyama, T., Wunderlich, M., O'Brien, E., Mizukawa, B., Yamazaki, S., Matsumoto, A., Yamasaki, S., Shibata, T., Matsuda, K., Sashida, G., Takizawa, H. and Kitamura, T. Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. Nat Commun. 10:4869. pubmed
Tamura, M., Yonezawa, T., Liu, X., Asada, S., Hayashi, Y., Fukuyama, T., Tanaka, Y., Kitamura, T. and Goyama, S. Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Sci Rep. 9:8171. pubmed
Asada, S., Fujino, T., Goyama, S. and Kitamura, T. The role of ASXL1 in hematopoiesis and myeloid malignancies. Cell Mol Life Sci. 76:2511-2523. Review. pubmed
Asada, S. and Kitamura, T. Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms. Int J Hematol. 110:179-186. Review. pubmed
Inoue, D., Fujino, T. and Kitamura, T. ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells. Oncotarget. 9:35203-35204. pubmed
2018
Saika, M., Inoue, D., Nagase, R., Sato, N., Tsuchiya, A., Yabushita, T., Kitamura, T. and Goyama, S. ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation. Sci Rep. 8:15873. pubmed
Yonezawa, T., Takahashi, H., Shikata, S., Sawasaki, T., Kitamura, T. and Goyama, S. The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program. Biochem Biophys Res Commun. 505:905-909. pubmed
Asada, S., Goyama, S., Inoue, D., Shikata, S., Takeda, R., Fukushima, T., Yonezawa, T., Fujino, T., Hayashi, Y., Kawabata, K.C., Fukuyama, T., Tanaka, Y., Yokoyama, A., Yamazaki, S., Kozuka-Hata, H., Oyama, M., Kojima, S., Kawazu, M., Mano, H. and Kitamura, T. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat Commun. 9:2733. pubmed
Nagase, R., Inoue, D., Pastre, A., Fujino, T., Hou, H-A, Yamasaki,N., Goyama, S., Saika, M., Kanai, A., Sera, Y., Horikawa, S., Ota, Y., Asada, S., Hayashi, Y., Kwabata, K.C., Takeda, R., Tien, H.F., Honda, H., Abdel-Wahab, O. and Kitamura, T. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 215:1729-1747. pubmed
Inoue, D., Fujino, T., Sheridan, P., Zhang, Y-Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K.C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C., Oyama, M. and Kitamura, T. A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. Leukemia. 32:1327-1337. pubmed
Isobe, M., Izawa, K., Sugiuchi, M., Sakanishi, T., Kaitani, A., Takamori, A., Maehara, A., Matsukawa, T., Takahashi, M., Yamanishi, Y., Oki, T., Uchida, S., Uchida, K., Ando, T., Maeda, K., Nakano, N., Yagita, H., Takai, T., Ogawa, H., Okumura, K., *Kitamura, T. and *Kitaura, J. The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805. pubmed
Maehara, A., Kaitani, A., Izawa, K., Shiba, E., Nagamine, M., Takamori, A., Isobe, M., Uchia, S., Uchida, K., Ando, T., Keiko, M., Nakano, N., Voehringer, D., Roers, A., Shimizu, T., Ogawa, H., Okumura, K., Kitamura, T. and Kitaura, J. Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections. J Invest Dermatol. 138:1221-1224. pubmed
Kitamura, T. ASXL1 mutations gain a function. Blood. 131:274-275. pubmed
Miyashita, K., Kitajima, K., Goyama, S., Kitamura, T. and Hara, T. Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochem. Biophys. Res. Commun. 495:2310-2316. pubmed
Kawabata, K.C., Hayashi, Y., Inoue, D., Meguro, H., Sakurai, H., Fukuyama, T., Tanaka, Y., Asada, S., Fukushima, T., Nagase, R., Takede, R., Harada, Y., Kitaura, J., Goyama, S., Harada, H., Aburatani, H. and Kitamura, T. High expression of ABC-G2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis. Leukemia. 32:419-428. pubmed
2017
Izawa, K., Maehara, A., Isobe, M., Yasuda, Y., Urai, M., Hoshino, Y., Ueno, K., Matsukawa, T., Takahashi, M., Kaitani, A., Shiba, E., Takamori, A., Uchida, S., Uchida, K., Maeda, K., Nakano, N., Yamanishi, Y., Oki, T., Voehringer, D., Roers, A., Nakae, S., Ishikawa, J., Kinjo, Y., Shimizu, T., Ogawa, H., Okumura, K., Kitamura, T. and Kitaura, J. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci. Rep. 7:4298. pubmed
Yonezawa, T., Takahashi, H., Shikata, S., Liu, X., Tamura, M., Asada, S., Fukushima, T., Fukuyama, T., Tanaka, Y., Sawasaki, T., Kitamura, T. and Goyama, S. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J. Biol. Chem. 292:12528-12541. pubmed
Goyama, S., Shrestha, M., Schibler, J., Rosenfeldt, L., Miller, W., O'Brien, E., Mizukawa, B., Kitamura, T., Palumbo, JS. and Mulloy, J.C. Protease-activated receptor 1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia. Oncogene. 36:2589-2598. pubmed
Shiba, E., Izawa, K., Kaitani, A., Isobe, M., Maehara, A., Uchida, K., Maeda, K., Nakano, N., Ogawa, H., Okumura, K., Kitamura, T., Shimizu, T. and Kitaura, J. Ceramide-CD300f binding inhibits lipopolysaccharide-induced skin inflammation. J. Biol. Chem. 292:2924-2932. pubmed
2016
Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T. Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels. Exp. Hematol. 44:172-176. pubmed
Goyama, S.,, Schbler, J., Gasilina, A., Shestha, M., Lin, S., Link, K.A., Chen, J., Whitman, S.P., Bloomfield, C.D., Nicolet, D., Assi, S.A., Ptasinska, A., Heidenreich, O., Bonifer, C., Kitamura, T., Nassar, N.N. and Mulloy, J.C. UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. Leukemia. 30:728-739. pubmed
2015
Inoue, D., Nishimura, K., Kozuka-Hata, H., Oyama, M. and Kitamura, T. The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination. Leukemia. 29:2257-2260. pubmed
Matsukawa, T., Izawa, K., Isobe, M., Takahashi, M., Maehara, A., Yamanishi, Y., Kaitani, A., Okumura, K., Teshima, T., Kitamura, T. and Kitaura, J. Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65:777-787. pubmed journal
Togami, K., Kitaura, J., Uchida, T., Inoue, D., Nishimura, K., Kawabata, K.C., Nagase, R., Horikawa, S., Izawa, K., Fukuyama, T., Nakahara, F., Oki, T., Harada, Y., Harada, H., Aburatani, H. and Kitamura, T. A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm. Exp Hematol. 43:300-8 pubmed
Inoue, D., Kitaura, J., Matsui, H., Hou, H-A., Chou, W-C., Nagamachi, A., Kawabata, K.C., Togami, K., Nagase, R., Horikawa, S., Saika, M., Micol, J-P., Hayashi, Y., Harada, Y., Harada, H., Inaba, T., Tien, H-F., Abdel-Wahab, O. and Kitamura, T. SETBP1 mutations drive leukemic transformation in ASXL1-murtated MDS. Leukemia. 29:847-857.
2014
Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., Kitamura, T. and Kitaura, J. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast-cell activation. J Allergy Clin Immunol. 133:270-3.e1-7. pubmed journal
Uchida, T., Kitaura, J., Nakahara, F., Togami, K., Inoue, D., Maehara, A., Nishimura, K., Kawabata, K.C., Doki, N., Kakihana, K., Yoshioka, K., Izawa, K., Oki, T., Sada, A., Harada, Y., Ohashi, K., Katayama, Y., Matsui, T, Harada, H. and Kitamura, T. Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42:369-379. pubmed journal
Oki, T., Nishimura, K, Kitaura, J, Togami, K., Maehara, A., Izawa, K., Sakaue-Sawano, A., Niida, A., Miyano, S., Aburatani, H., Kiyonari, H., Miyawaki, A. and Kitamura, T. A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012. pubmed journal
Nakahara, F., Kitaura, J., Uchida, T., Nishida, C., Togami, K., Inoue, D., Matsukawa, T., Kagiyama, Y., Enomoto, Y., Kawabata, K.C., Chen-Yi, L., Komeno, Y., Izawa, K., Oki, T., Nagae, G., Harada, Y., Harada, H., Otsu, M., Aburatani, H., Heissig, B., Hattori, K. and Kitamura, T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123:3932-42. pubmed journal
Ishihara, J., Umemoto, T., Yamato, M., Shiratsuchi, Y., Takaki, S., Petrich, B.G., Nakauchi, H., Eto, K., Kitamura, T. and Okano, T. Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3. Int J Hematol. 99:393-406. pubmed journal
Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayashi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat Commun. 5:4177. pubmed journal
2013
Inoue, D., Kitaura, J., Togami, K., Nishimura, K., Enomoto, Y., Uchida, T., Kagiyama, Y., Kawabata, K.C., Nakahara, F., Izawa, K., Oki, T., Maehara, A., Isobe, M., Tsuchiya, A., Harada, Y., Harada, H., Ochiya, T., Aburatani, H., Kimura, H., Thol, F., Heuser, M., Levine, R.L., Abdel-Wahab, O. and Kitamura, T. Myelodysplastic syndromes are induced by histone methylation?altering ASXL1 mutations. J Clin Invest. 123:4627-40. pubmed journal
Nishimura, K., Oki, T., Kitaura, J., Kuninaka, S., Saya, H., Sakaue-Sawano, A., Miyawaki, A. and Kitamura, T. APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One. 8:e63001. pubmed journal
Harada, Y.*, Inoue, D.*, Ding, Y.*, Imagawa, J., Doki, N., Matsui, H., Yahata, T., Matsushita, H., Ando, K., Sashida, G., Iwama, A., Kitamura, T. and Harada H. Runx1/AML1 mutant collaborates with Bmi1 overexpression in the development of human and mouse myelodysplastic syndromes. Blood. 121:3434-46. pubmed journal
Takahashi, M., Izawa, K., Kashiwakura, J., Yamanishi, Y., Enomoto, Y., Kaitani, A., Maehara, A., Isobe, M., Ito, S., Matsukawa, T., Nakahara, F., Oki, T., Kajikawa, M., Ra, C., Okayama, Y., Kitamura, T. and Kitaura, J. Human CD300C delivers an Fc receptor-g-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. J. Biol. Chem. 288:7662-75. pubmed journal
2012
Izawa, K., Yamanishi, Y., Maehara, A., Takahashi, M., Isobe, M., Ito, S., Kaitani, A., Matsukawa, T., Matsuoka, T., Nakahara, F., Oki, T., Kiyonari, H., Abe, T., Okumura, K., Kitamura, T. and Kitaura, J. LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37:827-39. pubmed journal
Kagiyama, Y., Kitaura, J., Togami, K., Uchida, T., Inoue, D., Matsukawa, T., Izawa, K., Kawabata, K.C., Komeno, Y., Oki, T., Nakahara, F., Sato, K., Aburatani, H. and Kitamura, T. Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML-ETO-positive leukemia in mice. Int. J. Hematol. 96:638-48. pubmed journal
Yamanishi, Y., Takahashi, M., Izawa, K., Isobe, M., Ito, S., Tsuchiya, A., Maehara, A., Kaitani, A., Uchida, T., Togami, K., Enomoto, Y., Nakahara, F., Oki, T., Kajikawa, M., Kurihara, H., Kitamura, T. and Kitaura, J. A soluble form of LMIR5/CD300b amplifies lipppolisaccharide-induced lethal inflammation in sepsis. J. Immunol. 189:1773-9. pubmed journal
Doki, N., Kitaura, J., Uchida, T., Inoue, D., Kagiyama, Y., Togami, K., Isobe, M., Ito, S., Maehara, A., Izawa, K., Kato, N., Oki, T., Harada, Y., Nakahara, F., Harada, H. and Kitamura, T. Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int. J. Hematol. 95:167-75. pubmed journal
Nakamura, M., Kitaura, J., Enomoto, Y., Lu, Y., Nishimura, K., Isobe, M., Ozaki, K., Komeno, Y., Nakahara, F., Oki, T., Kume, H., Homma, Y. and Kitamura, T. TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis. Cancer Science. 103:26-33. pubmed journal
2011
Oki, T., Kitaura, T., Watanabe-Okochi, N., Nishimura, K., Maehara, A., Uchida, T., Komeno, Y., Nakahara, F., Harada, Y., Sonoki, T., Harada, H. and Kitamura, T. Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26:1038-1045 pubmed
Enomoto, Y., Kitaura, J., Hatakeyama, K., Watanuki, J., Akasaka, T., Kato, N., Shimanuki, M., Nishimura, K., Takahashi, M., Taniwaki, M., Haferlach, C,, Siebert, S., Dyer, M.J.S., Asou, N., Nakakuma, H., Kitamura, T. and Sonoki, T. Em/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25:1849-1856. pubmed
Kato, N., Kitaura, J., Doki, N., Komeno, Y., Watanabe-Okochi, N., Togami, K., Nakahara, F., Oki, T., Enomoto, Y., Fukuchi, Y., Nakajima, H., Harada, Y., Harada, H. and Kitamura, T. Two types of C/EBP-alpha mutations play distinct roles in leukemogenesis: Lessons from clinical data and BMT models. Blood. 117:221-233. pubmed
2010
Nakajima, H., Ito, M., Smookler, D.S., Shibata, F., Fukuchi, Y., Morikawa, Y., Ikeda, Y., Arai, F., Suda, T., Khokha, R. and Kitamura, T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood. 116:4474-4482. pubmed
Enomoto, Y., Yamanishi, Y., Izawa, K., Kaitani, A., Takahashi, M., Maehara, A., Oki, T., Kajikawa, M., Takai, T., Kitamura, T. and Kitaura, J. Characterization of leukocyte mono-Ig receptor 7 (LMIR7)/CLM3 as an activating receptor: Its similarities to and differences from LMIR4/CLM5. J. Biol. Chem. 285:35274-35283. pubmed
Minobe, K., Ono, R., Matsumine A, Shibata-Minoshima, F., Izawa, K., Oki, T., Kitaura, J., Iino, T., Takita, J., Iwamoto, S., Hori, H., Komada, Y., Uchida, A., Hayashi, Y., Kitamura, T. and Nosaka, T. Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37:569-81. pubmed
Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M., Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., Komori, T., Morikawa, Y., Kiyonari, H., Takai, T., Okumura, K. and Kitamura, T. TIM1 is an endogenous ligand for LMIR5/CD300b and LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J. Exp. Med. 207:1501-1511. pubmed
Nakahara, F., Sakata-Yanagimoto, M., Komeno, Y., Kato, N., Uchida, T., Haraguchi, K., Kumano, K., Harada, Y., Harada, H., Kitaura, J., Ogawa, S., Kurokawa, M., Kitamura, T. and Chiba, S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia. Blood. 115:2872-2881. pubmed
Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T. and Kitamura, T. AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia. 24:1018-1024. pubmed
2009
Islam, S.M., Shinmyo, Y., Okafuji, T., Su, Y., Naser, I.B., Ahmed, G., Zhang, S., Chen, S., Ohta, K., Kiyonari, H., Abe, T., Tanaka, S., Nishinakamura, R., Terashima, T., Kitamura, T. and Tanaka, H. Draxin, a novel repulsive guidance protein for spinal cord and forebrain commissures. Science. 323:388-393.
Komeno, Y., Kitaura, J. and Kitamura, T. Molecular bases of myelodysplastic syndromes: Lessons from animal models. J Cell. Physiol. 219:529-534. pubmed
Kawashima, T., Bao, Y.C., Minoshima, Y., Nomura, Y., Hatori, T., Hori, T., Fukagawa, T., Takahashi, N., Nosaka, T., Inoue, M., Sato, T., Kukimoto-Niino, M., Shirouzu, M., Yokoyama, S. and Kitamura, T. A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol. 29:1796-1813. pubmed
Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T. and Kitamura, T. An activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments LPS response through association with FcRg in mast cells. J. Immunol. 183:925-936. pubmed
Doki, N., Kawashima, T., Nomura, Y., Tsuchiya, A., Oneyama, C., Akagi, T., Nojima, Y. and Kitamura, T. Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells. Cancer Science. 100:1675-1679. pubmed
Oki, T., Eto, K, Izawa, K., Yamanishi, Y., Inagaki, N., Frampton, J., *Kitamura, T. and *Kitaura, J. Evidence that integrin alpha 2b beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J. Biol. Chem. 284:31463-31472. pubmed
Ono, R., Kumagai, H., Nakajima, H., Hishiya, A., Taki, T., Horikawa, K., Takatsu. K., Satoh, T., Hayashi, Y., Kitamura, T. and Nosaka T. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 23:2197-2209. pubmed
2008
Watanabe-Okochi, N., Kitaura, J., Ono, R., Harada, H., Harada, Y., Nakajima, H., Nosaka, T., Inaba, T. and Kitamura, T. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood. 111:4297-4308. pubmed
Yamanishi, Y., Kitaura, J., Izawa, K., Matsuoka, T., Oki, T., Lu, Y., Shibata, F., Yamazaki, S., Kumagai. H., Nakajima, H., Maeda-Yamamoto, M., Tybulewicz, V.L.J., Takai, T. and Kitamura, T. Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human. Blood. 111:688-698. pubmed
Kawashima, T. and Kitamura, T. Rac and Nuclear Translocation of STAT Transcription Factors. Methods in Enzymology. 431:171-180. pubmed
Hiwatari, M., Ono, R., Taki, T., Hishiya, A., Ishii, E., Kitamura, T., Hayashi, Y. and Nosaka, T. Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia. 22:2279-2280. pubmed
2007
Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Oki, T., Shibata, F., Kumagai, H., Nakajima, H., Maeda-Yamamoto, M., Hauchins, J.P., Tybulewicz, V.L.J., Takai, T. and Kitamura, T. Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3. J. Biol. Chem. 25:17997-18008. pubmed
Lu, Y., Kitaura, J., Oki, T., Komeno, Y., Ozaki, K., Kiyono, M., Kumagai, H., Nakajima, H., Aburatani, H. and Kitamura, T. Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21:2246-2257. pubmed
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T. and Nagata, S. Identification of TIM4 as a phosphatidylserine receptor for engulfment of apoptotic cells. Nature. 450:435-440. pubmed
2006
Oki, T., Kitaura, J., Eto, K., Maeda-Yamamoto, M., Inagaki, N., Nagai, H., Yamanishi, Y., Kumagai, H. and Kitamura, T. Integrin alpha-IIb-beta-3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J. Immunol. 176:52-60. pubmed
Nakajima, H., Shibata, F., Fukuchi, Y., Goto-Koshino, Y., Ito, M., Urano, A., Nakahata, T., Aburatani, H. and Kitamura, T. Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells. Biochem. Biophys. Res. Commun. 340:35-42. pubmed
Fukuchi, Y., Shibata, F., Ito, M., Goto-Koshino, Y., Sotomaru, Y., Ito, M., Kitamura, T. and Nakajima H. Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBP-alpha. EMBO J. 25:3398-3410. pubmed
Kawashima, T., Bao, Y.C., Nomura, Y., Moon, Y., Tonozuka, Y., Minoshima, Y., Hatori, T., Kiyono, M., Nosaka, T., Nakajima, H., Williams, D.A. and Kitamura, T. Rac1 and a GTPase activating protein MgcRacGAP are required for nuclear translocation of STAT transcription factors. J. Cell Biol. 175:937-946. pubmed
2005
Ono, R., Nakajima, H., Ozaki, K., Kumagai, H., Kawashima, T., Taki, T., Kitamura, T., Hayashi, Y. and Nosaka, T. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J. Clin. Invest. 115:919-929. pubmed
Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol. 15:6834-6845. pubmed
Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi. T., Hiraoka, Y., Bao, Y-C., Kawashima, T., *Kitamura, T. and *Fukagawa, T. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol. Cell. Biol. 25:10315-10328. pubmed
Ono, R., Ihara, M., Nakajima, H., Ozaki, K., Kataoka-Fujiwara, Y., Taki, T., Nagata, K., Inagaki, M., Yoshida, N., Kitamura, T., Hayashi, Y., Kinoshita, M. and Nosaka, T. Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4. Mol. Cell. Biol. 25:10965-10978. pubmed
2004
Tonozuka, Y., Minoshima, Y., Bao, Y.C., Moon, Y., Tsubono, Y., Hatori, T., Nakajima, H., Nosaka, T., Kawashima, T. and Kitamura, T. A GTPase activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and differentiation of a leukemic cell line. Blood. 104:3550-3557. pubmed
Ikeda, Y., Imai, Y., Kumagai, H., Nosaka, T., Morikawa, Y., Hisaoka, T., Manabe, I., Maemura, K., Nakaoka, T., Imamura, T., Miyazono, K., Komuro, I., Nagai, R. and Kitamura, T. Vasorin, a novel TGF-beta binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737. pubmed
2003
Ozawa, T., Sako, Y., Sato, M., Kitamura, T. and Umezawa, Y. A genetic approach to identifying mitochondrial proteins. Nat. Biotechnol. 21:287-293.
Kitamura, T., Koshino, Y., Shibata, F., Nakajima, H., Nosaka, T. and Kumagai, H. Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics. Exp. Hematol. 31:1007-1014. pubmed
Murata, K., Kumagai, H., Kawashima, T., Tamitsu, K., Irie, M., Nakajima, H., Suzu, S., Sibuya, M., Kamihira, S., Nosaka, T., Asano, S. and Kitamura, T. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J. Biol. Chem. 278:32892-32898. pubmed
Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y-C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S. Jr., Nosaka, T., Senba, K., Inoue, T., Satoh, T., Inagaki, M. and Kitamura, T. Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell. 4:549-560. pubmed
Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, E., Tsuji, K., Makishima, F., Yoshida, N. and Kitamura, T. Mammalian twisted gastulation is essential for skeleto-lymphogenesis. Mol. Cell. Biol. 23:2969-2980. pubmed
Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T. and Saito, M. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat. Immunol. 4:457-463. pubmed
Kumagai, H., Oki, T., Tamitsu, K., Feng, S-Z., Ono, M., Nakajima, H., Bao, Y-C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T. and Kitamura, T. Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem. Biophys. Res. Commun. 307:719-729. pubmed
2002
Tulin, E. E., Onoda, N., Hasegawa, M., Nosaka, T., Nomura, H. and Kitamura, T. Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation. Exp. Cell Res. 272:23-31. pubmed
Tulin, E. E., Onoda, N., Hasegawa, M., Nomura, H. and Kitamura, T. Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein. Oncogene. 21:844-848. pubmed
Nosaka, T. and Kitamura, T. Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp. Hematol. 30:697-702. pubmed
Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M. and Miyake, K. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667-672. pubmed
2001
Hirose, K., Kawashima, T., Iwamoto, I., Nosaka, T. and Kitamura, T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J. Biol. Chem. 276:5821-5828. pubmed
Kawashima, T., Murata, K., Akira, S., Tonozuka, Y., Minoshima, Y., Feng, S., Kumagai, H., Tsuruga, H., Ikeda, Y., Asano, S., Nosaka, T. and Kitamura, T. STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF- B p65. J. Immunol. 167:3652-3660. pubmed
Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M. and Kitamura, T. Molecular cloning of a human novel type I cytokine receptor related to Delta1. Cytogenetics and Cell Genetics. 93:23-25. pubmed
Tulin, E.E., Onoda, N., Maeda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S. and Kitamura, T. A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation. J. Biol. Chem. 276:27519-27526. pubmed
Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T. and Ikuta, K. The IL-7 receptor controls the accessbility of the TCR locus by Stat5 and histone acetylation. Immunity 15:813-823. pubmed
2000
Yamada, K., Ariyoshi, K., Onishi, M., Miyajima, A., Hayakawa, F., Towatari, M., Saito, H., Oka, Y., Asano, S., Nosaka, T. and Kitamura, T. Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int. J. Hematol. 71:46-54. pubmed
Fujio, K., Nosaka, T., Kojima, T., Kawashima, T., Yahata, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Yamamoto, K, Nishimura, T. and Kitamura, T. Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain. Blood. 95:2204-2210. pubmed
Misawa, K., >Nosaka, T., Kojima, T., Hirai, M. and Kitamura, T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenetics and Cell Genetics. 89:89-91. pubmed
Misawa, K., Nosaka, T., Morita, S., Kaneko, A., Nakahata, T., Asano, S. and Kitamura, T. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97:3062-3066. pubmed
Morita, S., Kojima, T. and Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Therapy. 7:1063-1066. pubmed
Tsuruga, H., Kumagai, H., Kojima, T. and Kitamura, T. Identification of novel membrane and secreted proteins upregulated during adipocyte differentiation. Biochem. Biophys. Res. Commun. 272:293-297. pubmed
Fujio, K., Misaki, Y., Setoguchi, K., Morita, S., Kawahata, K., Nosaka, T., Yamamoto, K. and Kitamura, T. Functional reconstitution of Class-II MHC-restricted T cell immunity mediated by retroviral transfer of the αβTCR complex. J. Immunol. 165:528-532. pubmed
Kojima, T., Morikawa, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Senba, E. and Kitamura, T. Troy, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275:20742-20747. pubmed
Ariyoshi, K., Nosaka, T., Yamada, K., Onishi, M., Miyajima, A. and Kitamura, T. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275:24407-24413. pubmed
Kawashima, T., Hirose, K., Satoh, T., Kaneko, A., Ikeda, Y., Kaziro, Y., Nosaka, T. and Kitamura, T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood. 96:2116-2124. pubmed
Schwaller, J., Parganas, E., Wang, D., Cain, D., Aster, J.C., Williams, I.R., Lee, C-K., Gerthner, R., Kitamura, T., Frantsve, J., Anastasiadou, E., Loh, M.L., Levy, D.E., Ihle, J.N. and Gilliland, D.G. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK. Mol. Cell. 6:693-704. pubmed
Sugiyama, T., Kumagai, H., Morikawa, Y., Wada, Y., Sugiyama, A., Yasuda, K., Yokoi, N., Kojima, T., Nosaka, T., Senba, E., Kimura, S., Kadowaki, T., Kodama, T. and Kitamura, T. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Biochemistry. 39:15817-15825. pubmed
1999
Yang, Y-L., Lei, G., Xu, S., Holland, C.A., Kitamura, T., Hunter, K. and Cunningham, J.M. Receptors for polytropic and xenotropic murine leukemia viruses encoded by a single gene at Rmc1. Nature Genetics. 21:216-219. pubmed
Kojima, T. and Kitamura, T. A signal sequence trap based on a constitutively active cytokine receptor. Nature Biotechnol. 17:487-490. pubmed
Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A.L.F. and Kitamura, T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18:4754-4765. pubmed
Ye, S.K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I.L., Honjo, T. and Ikuta, K. Induction of germline transcription in the TCRg locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity. 11:213-223. pubmed
1998
Onishi, M., Nosaka, T. and Kitamura, T. Cytokine receptors: Structures and signal transduction. Int. Rev. Immunol. 16:617-634. pubmed
Morikawa, Y., Nishida, H., Misawa, K., Nosaka, T., Miyajima, A., Senba, E. and Kitamura, T. Induction of synaptosomal-associated protein-23kd (SNAP-23) by various cytokines. Blood. 92:129-135. pubmed
Onishi, M., Nosaka, T., Misawa, K., Mui, A.L.-F., Gorman, D., McMahon, M., Miyajima, A. and Kitamura, T. Identification and characterization of a constitutive active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18:3871-3879. pubmed