主な業績

研究室の主な業績:1998-2020年に発表した約230論文より抜粋(reviewを除く)。
筆頭著者あるいはco-first author*が
・大学院生または学位論文の場合は二重下線
・博士研究員の場合は太字
・スタッフの場合は下線
で記載されています。
大学院生が筆頭著者の論文については下記リンクを参照してください。
大学院生が筆頭著者の論文と学位論文



2020

Fujino, T. and Kitamura, T. ASXL1 mutation in clonal hematopoiesis. Exp Hematol. 83:74-84. Review. pubmed




2019

Fukushima, T., Tanaka, Y., Hamey, F.K., Chang, C.H., Oki, T., Asada, S., Hayashi, Y., Fujino, T., Yonezawa, T., Takeda, R., Kawabata, K.C., Fukuyama, T., Umemoto, T., Takubo, K., Takizawa, H., Goyama, S., Ishihama, Y., Honda, H., G?ttgens, B. and Kitamura, T. Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 29:4144-4158. pubmed


Hayashi, Y., Goyama, S., Liu, X., Tamura, M., Asada, S., Tanaka, Y., Fukuyama, T., Wunderlich, M., O'Brien, E., Mizukawa, B., Yamazaki, S., Matsumoto, A., Yamasaki, S., Shibata, T., Matsuda, K., Sashida, G., Takizawa, H. and Kitamura, T. Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. Nat Commun. 10:4869. pubmed


Tamura, M., Yonezawa, T., Liu, X., Asada, S., Hayashi, Y., Fukuyama, T., Tanaka, Y., Kitamura, T. and Goyama, S. Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Sci Rep. 9:8171. pubmed


Asada, S., Fujino, T., Goyama, S. and Kitamura, T. The role of ASXL1 in hematopoiesis and myeloid malignancies. Cell Mol Life Sci. 76:2511-2523. Review. pubmed


Asada, S. and Kitamura, T. Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms. Int J Hematol. 110:179-186. Review. pubmed


Inoue, D., Fujino, T. and Kitamura, T. ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells. Oncotarget. 9:35203-35204. pubmed




2018

Saika, M., Inoue, D., Nagase, R., Sato, N., Tsuchiya, A., Yabushita, T., Kitamura, T. and Goyama, S. ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation. Sci Rep. 8:15873. pubmed


Yonezawa, T., Takahashi, H., Shikata, S., Sawasaki, T., Kitamura, T. and Goyama, S. The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program. Biochem Biophys Res Commun. 505:905-909. pubmed


Asada, S., Goyama, S., Inoue, D., Shikata, S., Takeda, R., Fukushima, T., Yonezawa, T., Fujino, T., Hayashi, Y., Kawabata, K.C., Fukuyama, T., Tanaka, Y., Yokoyama, A., Yamazaki, S., Kozuka-Hata, H., Oyama, M., Kojima, S., Kawazu, M., Mano, H. and Kitamura, T. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat Commun. 9:2733. pubmed


Nagase, R., Inoue, D., Pastre, A., Fujino, T., Hou, H-A, Yamasaki,N., Goyama, S., Saika, M., Kanai, A., Sera, Y., Horikawa, S., Ota, Y., Asada, S., Hayashi, Y., Kwabata, K.C., Takeda, R., Tien, H.F., Honda, H., Abdel-Wahab, O. and Kitamura, T. Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 215:1729-1747. pubmed


Inoue, D., Fujino, T., Sheridan, P., Zhang, Y-Z., Nagase, R., Horikawa, S., Li, Z., Matsui, H., Kanai, A., Saika, M., Yamaguchi, R., Kozuka-Hata, H., Kawabata, K.C., Yokoyama, A., Goyama, S., Inaba, T., Imoto, S., Miyano, S., Xu, M., Yang, F-C., Oyama, M. and Kitamura, T. A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. Leukemia. 32:1327-1337. pubmed


Isobe, M., Izawa, K., Sugiuchi, M., Sakanishi, T., Kaitani, A., Takamori, A., Maehara, A., Matsukawa, T., Takahashi, M., Yamanishi, Y., Oki, T., Uchida, S., Uchida, K., Ando, T., Maeda, K., Nakano, N., Yagita, H., Takai, T., Ogawa, H., Okumura, K., *Kitamura, T. and *Kitaura, J. The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805. pubmed


Maehara, A., Kaitani, A., Izawa, K., Shiba, E., Nagamine, M., Takamori, A., Isobe, M., Uchia, S., Uchida, K., Ando, T., Keiko, M., Nakano, N., Voehringer, D., Roers, A., Shimizu, T., Ogawa, H., Okumura, K., Kitamura, T. and Kitaura, J. Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections. J Invest Dermatol. 138:1221-1224. pubmed


Kitamura, T. ASXL1 mutations gain a function. Blood. 131:274-275. pubmed


Miyashita, K., Kitajima, K., Goyama, S., Kitamura, T. and Hara, T. Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochem. Biophys. Res. Commun. 495:2310-2316. pubmed


Kawabata, K.C., Hayashi, Y., Inoue, D., Meguro, H., Sakurai, H., Fukuyama, T., Tanaka, Y., Asada, S., Fukushima, T., Nagase, R., Takede, R., Harada, Y., Kitaura, J., Goyama, S., Harada, H., Aburatani, H. and Kitamura, T. High expression of ABC-G2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis. Leukemia. 32:419-428. pubmed




2017

Izawa, K., Maehara, A., Isobe, M., Yasuda, Y., Urai, M., Hoshino, Y., Ueno, K., Matsukawa, T., Takahashi, M., Kaitani, A., Shiba, E., Takamori, A., Uchida, S., Uchida, K., Maeda, K., Nakano, N., Yamanishi, Y., Oki, T., Voehringer, D., Roers, A., Nakae, S., Ishikawa, J., Kinjo, Y., Shimizu, T., Ogawa, H., Okumura, K., Kitamura, T. and Kitaura, J. Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci. Rep. 7:4298. pubmed


Yonezawa, T., Takahashi, H., Shikata, S., Liu, X., Tamura, M., Asada, S., Fukushima, T., Fukuyama, T., Tanaka, Y., Sawasaki, T., Kitamura, T. and Goyama, S. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J. Biol. Chem. 292:12528-12541. pubmed


Goyama, S., Shrestha, M., Schibler, J., Rosenfeldt, L., Miller, W., O'Brien, E., Mizukawa, B., Kitamura, T., Palumbo, JS. and Mulloy, J.C. Protease-activated receptor 1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia. Oncogene. 36:2589-2598. pubmed


Shiba, E., Izawa, K., Kaitani, A., Isobe, M., Maehara, A., Uchida, K., Maeda, K., Nakano, N., Ogawa, H., Okumura, K., Kitamura, T., Shimizu, T. and Kitaura, J. Ceramide-CD300f binding inhibits lipopolysaccharide-induced skin inflammation. J. Biol. Chem. 292:2924-2932. pubmed




2016

Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T. Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels. Exp. Hematol. 44:172-176. pubmed


Goyama, S.,, Schbler, J., Gasilina, A., Shestha, M., Lin, S., Link, K.A., Chen, J., Whitman, S.P., Bloomfield, C.D., Nicolet, D., Assi, S.A., Ptasinska, A., Heidenreich, O., Bonifer, C., Kitamura, T., Nassar, N.N. and Mulloy, J.C. UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. Leukemia. 30:728-739. pubmed




2015

Inoue, D., Nishimura, K., Kozuka-Hata, H., Oyama, M. and Kitamura, T. The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination. Leukemia. 29:2257-2260. pubmed


Matsukawa, T., Izawa, K., Isobe, M., Takahashi, M., Maehara, A., Yamanishi, Y., Kaitani, A., Okumura, K., Teshima, T., Kitamura, T. and Kitaura, J. Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65:777-787. pubmed journal


Togami, K., Kitaura, J., Uchida, T., Inoue, D., Nishimura, K., Kawabata, K.C., Nagase, R., Horikawa, S., Izawa, K., Fukuyama, T., Nakahara, F., Oki, T., Harada, Y., Harada, H., Aburatani, H. and Kitamura, T. A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm. Exp Hematol. 43:300-8 pubmed


Inoue, D., Kitaura, J., Matsui, H., Hou, H-A., Chou, W-C., Nagamachi, A., Kawabata, K.C., Togami, K., Nagase, R., Horikawa, S., Saika, M., Micol, J-P., Hayashi, Y., Harada, Y., Harada, H., Inaba, T., Tien, H-F., Abdel-Wahab, O. and Kitamura, T. SETBP1 mutations drive leukemic transformation in ASXL1-murtated MDS. Leukemia. 29:847-857.




2014

Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., Kitamura, T. and Kitaura, J. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast-cell activation. J Allergy Clin Immunol. 133:270-3.e1-7. pubmed journal


Uchida, T., Kitaura, J., Nakahara, F., Togami, K., Inoue, D., Maehara, A., Nishimura, K., Kawabata, K.C., Doki, N., Kakihana, K., Yoshioka, K., Izawa, K., Oki, T., Sada, A., Harada, Y., Ohashi, K., Katayama, Y., Matsui, T, Harada, H. and Kitamura, T. Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42:369-379. pubmed journal


Oki, T., Nishimura, K, Kitaura, J, Togami, K., Maehara, A., Izawa, K., Sakaue-Sawano, A., Niida, A., Miyano, S., Aburatani, H., Kiyonari, H., Miyawaki, A. and Kitamura, T. A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012. pubmed journal


Nakahara, F., Kitaura, J., Uchida, T., Nishida, C., Togami, K., Inoue, D., Matsukawa, T., Kagiyama, Y., Enomoto, Y., Kawabata, K.C., Chen-Yi, L., Komeno, Y., Izawa, K., Oki, T., Nagae, G., Harada, Y., Harada, H., Otsu, M., Aburatani, H., Heissig, B., Hattori, K. and Kitamura, T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123:3932-42. pubmed journal


Ishihara, J., Umemoto, T., Yamato, M., Shiratsuchi, Y., Takaki, S., Petrich, B.G., Nakauchi, H., Eto, K., Kitamura, T. and Okano, T. Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3. Int J Hematol. 99:393-406. pubmed journal


Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayashi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat Commun. 5:4177. pubmed journal




2013

Inoue, D., Kitaura, J., Togami, K., Nishimura, K., Enomoto, Y., Uchida, T., Kagiyama, Y., Kawabata, K.C., Nakahara, F., Izawa, K., Oki, T., Maehara, A., Isobe, M., Tsuchiya, A., Harada, Y., Harada, H., Ochiya, T., Aburatani, H., Kimura, H., Thol, F., Heuser, M., Levine, R.L., Abdel-Wahab, O. and Kitamura, T. Myelodysplastic syndromes are induced by histone methylation?altering ASXL1 mutations. J Clin Invest. 123:4627-40. pubmed journal


Nishimura, K., Oki, T., Kitaura, J., Kuninaka, S., Saya, H., Sakaue-Sawano, A., Miyawaki, A. and Kitamura, T. APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One. 8:e63001. pubmed journal


Harada, Y.*, Inoue, D.*, Ding, Y.*, Imagawa, J., Doki, N., Matsui, H., Yahata, T., Matsushita, H., Ando, K., Sashida, G., Iwama, A., Kitamura, T. and Harada H. Runx1/AML1 mutant collaborates with Bmi1 overexpression in the development of human and mouse myelodysplastic syndromes. Blood. 121:3434-46. pubmed journal


Takahashi, M., Izawa, K., Kashiwakura, J., Yamanishi, Y., Enomoto, Y., Kaitani, A., Maehara, A., Isobe, M., Ito, S., Matsukawa, T., Nakahara, F., Oki, T., Kajikawa, M., Ra, C., Okayama, Y., Kitamura, T. and Kitaura, J. Human CD300C delivers an Fc receptor-g-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. J. Biol. Chem. 288:7662-75. pubmed journal




2012

Izawa, K., Yamanishi, Y., Maehara, A., Takahashi, M., Isobe, M., Ito, S., Kaitani, A., Matsukawa, T., Matsuoka, T., Nakahara, F., Oki, T., Kiyonari, H., Abe, T., Okumura, K., Kitamura, T. and Kitaura, J. LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37:827-39. pubmed journal


Kagiyama, Y., Kitaura, J., Togami, K., Uchida, T., Inoue, D., Matsukawa, T., Izawa, K., Kawabata, K.C., Komeno, Y., Oki, T., Nakahara, F., Sato, K., Aburatani, H. and Kitamura, T. Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML-ETO-positive leukemia in mice. Int. J. Hematol. 96:638-48. pubmed journal


Yamanishi, Y., Takahashi, M., Izawa, K., Isobe, M., Ito, S., Tsuchiya, A., Maehara, A., Kaitani, A., Uchida, T., Togami, K., Enomoto, Y., Nakahara, F., Oki, T., Kajikawa, M., Kurihara, H., Kitamura, T. and Kitaura, J. A soluble form of LMIR5/CD300b amplifies lipppolisaccharide-induced lethal inflammation in sepsis. J. Immunol. 189:1773-9. pubmed journal


Doki, N., Kitaura, J., Uchida, T., Inoue, D., Kagiyama, Y., Togami, K., Isobe, M., Ito, S., Maehara, A., Izawa, K., Kato, N., Oki, T., Harada, Y., Nakahara, F., Harada, H. and Kitamura, T. Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int. J. Hematol. 95:167-75. pubmed journal


Nakamura, M., Kitaura, J., Enomoto, Y., Lu, Y., Nishimura, K., Isobe, M., Ozaki, K., Komeno, Y., Nakahara, F., Oki, T., Kume, H., Homma, Y. and Kitamura, T. TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis. Cancer Science. 103:26-33. pubmed journal




2011

Oki, T., Kitaura, T., Watanabe-Okochi, N., Nishimura, K., Maehara, A., Uchida, T., Komeno, Y., Nakahara, F., Harada, Y., Sonoki, T., Harada, H. and Kitamura, T. Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26:1038-1045 pubmed


Enomoto, Y., Kitaura, J., Hatakeyama, K., Watanuki, J., Akasaka, T., Kato, N., Shimanuki, M., Nishimura, K., Takahashi, M., Taniwaki, M., Haferlach, C,, Siebert, S., Dyer, M.J.S., Asou, N., Nakakuma, H., Kitamura, T. and Sonoki, T. Em/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25:1849-1856. pubmed


Kato, N., Kitaura, J., Doki, N., Komeno, Y., Watanabe-Okochi, N., Togami, K., Nakahara, F., Oki, T., Enomoto, Y., Fukuchi, Y., Nakajima, H., Harada, Y., Harada, H. and Kitamura, T. Two types of C/EBP-alpha mutations play distinct roles in leukemogenesis: Lessons from clinical data and BMT models. Blood. 117:221-233. pubmed




2010

Nakajima, H., Ito, M., Smookler, D.S., Shibata, F., Fukuchi, Y., Morikawa, Y., Ikeda, Y., Arai, F., Suda, T., Khokha, R. and Kitamura, T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood. 116:4474-4482. pubmed


Enomoto, Y., Yamanishi, Y., Izawa, K., Kaitani, A., Takahashi, M., Maehara, A., Oki, T., Kajikawa, M., Takai, T., Kitamura, T. and Kitaura, J. Characterization of leukocyte mono-Ig receptor 7 (LMIR7)/CLM3 as an activating receptor: Its similarities to and differences from LMIR4/CLM5. J. Biol. Chem. 285:35274-35283. pubmed


Minobe, K., Ono, R., Matsumine A, Shibata-Minoshima, F., Izawa, K., Oki, T., Kitaura, J., Iino, T., Takita, J., Iwamoto, S., Hori, H., Komada, Y., Uchida, A., Hayashi, Y., Kitamura, T. and Nosaka, T. Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37:569-81. pubmed


Yamanishi, Y., Kitaura, J., Izawa, K., Kaitani, A., Komeno, Y., Nakamura, M., Yamazaki, S., Enomoto, Y., Oki, T., Akiba, H., Komori, T., Morikawa, Y., Kiyonari, H., Takai, T., Okumura, K. and Kitamura, T. TIM1 is an endogenous ligand for LMIR5/CD300b and LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J. Exp. Med. 207:1501-1511. pubmed


Nakahara, F., Sakata-Yanagimoto, M., Komeno, Y., Kato, N., Uchida, T., Haraguchi, K., Kumano, K., Harada, Y., Harada, H., Kitaura, J., Ogawa, S., Kurokawa, M., Kitamura, T. and Chiba, S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia. Blood. 115:2872-2881. pubmed


Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T. and Kitamura, T. AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia. 24:1018-1024. pubmed




2009

Islam, S.M., Shinmyo, Y., Okafuji, T., Su, Y., Naser, I.B., Ahmed, G., Zhang, S., Chen, S., Ohta, K., Kiyonari, H., Abe, T., Tanaka, S., Nishinakamura, R., Terashima, T., Kitamura, T. and Tanaka, H. Draxin, a novel repulsive guidance protein for spinal cord and forebrain commissures. Science. 323:388-393.


Komeno, Y., Kitaura, J. and Kitamura, T. Molecular bases of myelodysplastic syndromes: Lessons from animal models. J Cell. Physiol. 219:529-534. pubmed


Kawashima, T., Bao, Y.C., Minoshima, Y., Nomura, Y., Hatori, T., Hori, T., Fukagawa, T., Takahashi, N., Nosaka, T., Inoue, M., Sato, T., Kukimoto-Niino, M., Shirouzu, M., Yokoyama, S. and Kitamura, T. A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol. 29:1796-1813. pubmed


Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T. and Kitamura, T. An activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments LPS response through association with FcRg in mast cells. J. Immunol. 183:925-936. pubmed


Doki, N., Kawashima, T., Nomura, Y., Tsuchiya, A., Oneyama, C., Akagi, T., Nojima, Y. and Kitamura, T. Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells. Cancer Science. 100:1675-1679. pubmed


Oki, T., Eto, K, Izawa, K., Yamanishi, Y., Inagaki, N., Frampton, J., *Kitamura, T. and *Kitaura, J. Evidence that integrin alpha 2b beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J. Biol. Chem. 284:31463-31472. pubmed


Ono, R., Kumagai, H., Nakajima, H., Hishiya, A., Taki, T., Horikawa, K., Takatsu. K., Satoh, T., Hayashi, Y., Kitamura, T. and Nosaka T. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 23:2197-2209. pubmed




2008

Watanabe-Okochi, N., Kitaura, J., Ono, R., Harada, H., Harada, Y., Nakajima, H., Nosaka, T., Inaba, T. and Kitamura, T. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood. 111:4297-4308. pubmed


Yamanishi, Y., Kitaura, J., Izawa, K., Matsuoka, T., Oki, T., Lu, Y., Shibata, F., Yamazaki, S., Kumagai. H., Nakajima, H., Maeda-Yamamoto, M., Tybulewicz, V.L.J., Takai, T. and Kitamura, T. Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human. Blood. 111:688-698. pubmed


Kawashima, T. and Kitamura, T. Rac and Nuclear Translocation of STAT Transcription Factors. Methods in Enzymology. 431:171-180. pubmed


Hiwatari, M., Ono, R., Taki, T., Hishiya, A., Ishii, E., Kitamura, T., Hayashi, Y. and Nosaka, T. Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia. 22:2279-2280. pubmed




2007

Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Oki, T., Shibata, F., Kumagai, H., Nakajima, H., Maeda-Yamamoto, M., Hauchins, J.P., Tybulewicz, V.L.J., Takai, T. and Kitamura, T. Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3. J. Biol. Chem. 25:17997-18008. pubmed


Lu, Y., Kitaura, J., Oki, T., Komeno, Y., Ozaki, K., Kiyono, M., Kumagai, H., Nakajima, H., Aburatani, H. and Kitamura, T. Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21:2246-2257. pubmed


Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T. and Nagata, S. Identification of TIM4 as a phosphatidylserine receptor for engulfment of apoptotic cells. Nature. 450:435-440. pubmed




2006

Oki, T., Kitaura, J., Eto, K., Maeda-Yamamoto, M., Inagaki, N., Nagai, H., Yamanishi, Y., Kumagai, H. and Kitamura, T. Integrin alpha-IIb-beta-3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J. Immunol. 176:52-60. pubmed


Nakajima, H., Shibata, F., Fukuchi, Y., Goto-Koshino, Y., Ito, M., Urano, A., Nakahata, T., Aburatani, H. and Kitamura, T. Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells. Biochem. Biophys. Res. Commun. 340:35-42. pubmed


Fukuchi, Y., Shibata, F., Ito, M., Goto-Koshino, Y., Sotomaru, Y., Ito, M., Kitamura, T. and Nakajima H. Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBP-alpha. EMBO J. 25:3398-3410. pubmed


Kawashima, T., Bao, Y.C., Nomura, Y., Moon, Y., Tonozuka, Y., Minoshima, Y., Hatori, T., Kiyono, M., Nosaka, T., Nakajima, H., Williams, D.A. and Kitamura, T. Rac1 and a GTPase activating protein MgcRacGAP are required for nuclear translocation of STAT transcription factors. J. Cell Biol. 175:937-946. pubmed




2005

Ono, R., Nakajima, H., Ozaki, K., Kumagai, H., Kawashima, T., Taki, T., Kitamura, T., Hayashi, Y. and Nosaka, T. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J. Clin. Invest. 115:919-929. pubmed


Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol. 15:6834-6845. pubmed


Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi. T., Hiraoka, Y., Bao, Y-C., Kawashima, T., *Kitamura, T. and *Fukagawa, T. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol. Cell. Biol. 25:10315-10328. pubmed


Ono, R., Ihara, M., Nakajima, H., Ozaki, K., Kataoka-Fujiwara, Y., Taki, T., Nagata, K., Inagaki, M., Yoshida, N., Kitamura, T., Hayashi, Y., Kinoshita, M. and Nosaka, T. Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4. Mol. Cell. Biol. 25:10965-10978. pubmed




2004

Tonozuka, Y., Minoshima, Y., Bao, Y.C., Moon, Y., Tsubono, Y., Hatori, T., Nakajima, H., Nosaka, T., Kawashima, T. and Kitamura, T. A GTPase activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and differentiation of a leukemic cell line. Blood. 104:3550-3557. pubmed


Ikeda, Y., Imai, Y., Kumagai, H., Nosaka, T., Morikawa, Y., Hisaoka, T., Manabe, I., Maemura, K., Nakaoka, T., Imamura, T., Miyazono, K., Komuro, I., Nagai, R. and Kitamura, T. Vasorin, a novel TGF-beta binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737. pubmed




2003

Ozawa, T., Sako, Y., Sato, M., Kitamura, T. and Umezawa, Y. A genetic approach to identifying mitochondrial proteins. Nat. Biotechnol. 21:287-293.


Kitamura, T., Koshino, Y., Shibata, F., Nakajima, H., Nosaka, T. and Kumagai, H. Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics. Exp. Hematol. 31:1007-1014. pubmed


Murata, K., Kumagai, H., Kawashima, T., Tamitsu, K., Irie, M., Nakajima, H., Suzu, S., Sibuya, M., Kamihira, S., Nosaka, T., Asano, S. and Kitamura, T. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J. Biol. Chem. 278:32892-32898. pubmed


Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y-C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S. Jr., Nosaka, T., Senba, K., Inoue, T., Satoh, T., Inagaki, M. and Kitamura, T. Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell. 4:549-560. pubmed


Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, E., Tsuji, K., Makishima, F., Yoshida, N. and Kitamura, T. Mammalian twisted gastulation is essential for skeleto-lymphogenesis. Mol. Cell. Biol. 23:2969-2980. pubmed


Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T. and Saito, M. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat. Immunol. 4:457-463. pubmed


Kumagai, H., Oki, T., Tamitsu, K., Feng, S-Z., Ono, M., Nakajima, H., Bao, Y-C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T. and Kitamura, T. Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem. Biophys. Res. Commun. 307:719-729. pubmed




2002

Tulin, E. E., Onoda, N., Hasegawa, M., Nosaka, T., Nomura, H. and Kitamura, T. Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation. Exp. Cell Res. 272:23-31. pubmed


Tulin, E. E., Onoda, N., Hasegawa, M., Nomura, H. and Kitamura, T. Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein. Oncogene. 21:844-848. pubmed


Nosaka, T. and Kitamura, T. Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp. Hematol. 30:697-702. pubmed


Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M. and Miyake, K. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667-672. pubmed




2001

Hirose, K., Kawashima, T., Iwamoto, I., Nosaka, T. and Kitamura, T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J. Biol. Chem. 276:5821-5828. pubmed


Kawashima, T., Murata, K., Akira, S., Tonozuka, Y., Minoshima, Y., Feng, S., Kumagai, H., Tsuruga, H., Ikeda, Y., Asano, S., Nosaka, T. and Kitamura, T. STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF- B p65. J. Immunol. 167:3652-3660. pubmed


Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M. and Kitamura, T. Molecular cloning of a human novel type I cytokine receptor related to Delta1. Cytogenetics and Cell Genetics. 93:23-25. pubmed


Tulin, E.E., Onoda, N., Maeda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S. and Kitamura, T. A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation. J. Biol. Chem. 276:27519-27526. pubmed


Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T. and Ikuta, K. The IL-7 receptor controls the accessbility of the TCR locus by Stat5 and histone acetylation. Immunity 15:813-823. pubmed




2000

Yamada, K., Ariyoshi, K., Onishi, M., Miyajima, A., Hayakawa, F., Towatari, M., Saito, H., Oka, Y., Asano, S., Nosaka, T. and Kitamura, T. Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int. J. Hematol. 71:46-54. pubmed


Fujio, K., Nosaka, T., Kojima, T., Kawashima, T., Yahata, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Yamamoto, K, Nishimura, T. and Kitamura, T. Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain. Blood. 95:2204-2210. pubmed


Misawa, K., >Nosaka, T., Kojima, T., Hirai, M. and Kitamura, T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenetics and Cell Genetics. 89:89-91. pubmed


Misawa, K., Nosaka, T., Morita, S., Kaneko, A., Nakahata, T., Asano, S. and Kitamura, T. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97:3062-3066. pubmed


Morita, S., Kojima, T. and Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Therapy. 7:1063-1066. pubmed


Tsuruga, H., Kumagai, H., Kojima, T. and Kitamura, T. Identification of novel membrane and secreted proteins upregulated during adipocyte differentiation. Biochem. Biophys. Res. Commun. 272:293-297. pubmed


Fujio, K., Misaki, Y., Setoguchi, K., Morita, S., Kawahata, K., Nosaka, T., Yamamoto, K. and Kitamura, T. Functional reconstitution of Class-II MHC-restricted T cell immunity mediated by retroviral transfer of the αβTCR complex. J. Immunol. 165:528-532. pubmed


Kojima, T., Morikawa, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Senba, E. and Kitamura, T. Troy, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275:20742-20747. pubmed


Ariyoshi, K., Nosaka, T., Yamada, K., Onishi, M., Miyajima, A. and Kitamura, T. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275:24407-24413. pubmed


Kawashima, T., Hirose, K., Satoh, T., Kaneko, A., Ikeda, Y., Kaziro, Y., Nosaka, T. and Kitamura, T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood. 96:2116-2124. pubmed


Schwaller, J., Parganas, E., Wang, D., Cain, D., Aster, J.C., Williams, I.R., Lee, C-K., Gerthner, R., Kitamura, T., Frantsve, J., Anastasiadou, E., Loh, M.L., Levy, D.E., Ihle, J.N. and Gilliland, D.G. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK. Mol. Cell. 6:693-704. pubmed


Sugiyama, T., Kumagai, H., Morikawa, Y., Wada, Y., Sugiyama, A., Yasuda, K., Yokoi, N., Kojima, T., Nosaka, T., Senba, E., Kimura, S., Kadowaki, T., Kodama, T. and Kitamura, T. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Biochemistry. 39:15817-15825. pubmed




1999

Yang, Y-L., Lei, G., Xu, S., Holland, C.A., Kitamura, T., Hunter, K. and Cunningham, J.M. Receptors for polytropic and xenotropic murine leukemia viruses encoded by a single gene at Rmc1. Nature Genetics. 21:216-219. pubmed



Kojima, T. and Kitamura, T. A signal sequence trap based on a constitutively active cytokine receptor. Nature Biotechnol. 17:487-490. pubmed


Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A.L.F. and Kitamura, T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18:4754-4765. pubmed


Ye, S.K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I.L., Honjo, T. and Ikuta, K. Induction of germline transcription in the TCRg locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity. 11:213-223. pubmed




1998

Onishi, M., Nosaka, T. and Kitamura, T. Cytokine receptors: Structures and signal transduction. Int. Rev. Immunol. 16:617-634. pubmed


Morikawa, Y., Nishida, H., Misawa, K., Nosaka, T., Miyajima, A., Senba, E. and Kitamura, T. Induction of synaptosomal-associated protein-23kd (SNAP-23) by various cytokines. Blood. 92:129-135. pubmed


Onishi, M., Nosaka, T., Misawa, K., Mui, A.L.-F., Gorman, D., McMahon, M., Miyajima, A. and Kitamura, T. Identification and characterization of a constitutive active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18:3871-3879. pubmed


2019

Takahashi, M., Izawa, K., Urai, M., Yamanishi, Y., Maehara, A., Isobe, M., Matsukawa, T., Kaitani, A., Takamori, A., Uchida, S., Yamada, H., Nagamine, M., Ando, T., Shimizu, T., Ogawa, H., Okumura, K., Kinjo, Y., Kitamura, T., Kitaura, J. The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12(564). pubmed


2018

Kaitani, A., Izawa, K., Maehara, A., Isobe, M., Takamori, A., Matsukawa, T., Takahashi, M., Yamanishi, Y., Oki, T., Yamada, H., Nagamine, M., Uchida, S., Uchida, K., Ando, T., Maeda, K., Nakano, N., Shimizu, T., Takai, T., Ogawa, H., Okumura, K., Kitamura, T., Kitaura, J. Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8(1):8259. pubmed