大学院生が筆頭著者の論文と学位論文

大学院生が研究室に残り博士研究員/助教として発表した論文も含む。

Fukushima, T. et al. (2019) Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell Rep. 29:4144-4158.


Hayashi, Y. et al. (2019) Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. Nat Commun. 10:4869.


Tamura, M. et al. (2019) Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Sci Rep. 9:8171.


Saika, M. et al. (2018) ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation. Sci Rep. 8:15873.


Yonezawa, T. et al. (2018) The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program. Biochem Biophys Res Commun. 505:905-909.


Asada, S. et al. (2018) Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat Commun. 9:2733.


Nagase, R. et al. (2018) Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 215:1729-1747.


Inoue, D. et al. (2018) A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies. Leukemia. 32:1327-1337.


Isobe, M. et al. (2018) The CD300e molecule in mice is an immune-activating receptor. J. Biol. Chem. 293:3793-3805.


Maehara, A. et al. (2018) Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J. Invest. Dermatol. 138:1221-1224.


Miyashita, K. et al. (2018) Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochem. Biophys. Res. Commun. 495:2310-2316.


Izawa, K. et al. (2017) Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci. Rep. 7:4298.


Yonezawa, T. et al. (2017) The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J. Biol. Chem. 292:12528-12541.


Shiba, E. et al. (2017) Ceramide-CD300f binding inhibits lipopolysaccharide-induced skin inflammation. J. Biol. Chem. 292:2924-2932.


Inoue, D. et al. (2016) Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels. Exp. Hematol. 44:172-176.


Inoue, D. et al. (2015) UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO. Leukemia.29:847-857.


Matsukawa, T. et al. (2015) Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65:777-787.


Togami, K. et al. (2015) A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm. Exp. Hematol. 43:300-308.


Inoue, D. et al. (2015) SETBP1 mutations drive leukemic transformation in ASXL1-murtated MDS. Leukemia. 29:2257-2260.


Izawa, K. et al. (2014) Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast-cell activation. J Allergy Clin Immunol. 133:270-3.e1-7.


Uchida, T. et al. (2014) Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp. Hematol. 42:369-379.


Oki, T. et al. (2014) A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012.


Nakahara, F. et al. (2014) Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123:3932-3942.


Ishihara, J. et al. (2014) Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3. Int J Hematol. 99:393-406.


Inoue, D. et al. (2013) Myelodysplastic syndromes are induced by histone methylation?altering ASXL1 mutations. J. Clin. Invest.123:4627-4640.


Nishimura, K. et al. (2013) APCCDH1 targets MgcRacGAP for destruction in the late M phase. Plos One. 8:e63001.


Takahashi, M. et al. (2013) Human CD300C delivers an Fc receptor-g-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. J. Biol. Chem. 288:7662-6775.


Izawa, K. et al. (2012) LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37:827-839.


Kagiyama, Y. et al. (2012) Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML-ETO-positive leukemia in mice. Int. J. Hematol. 96:638-48.


Yamanishi, Y. et al. (2012) A soluble form of LMIR5/CD300b amplifies lipppolisaccharide-induced lethal inflammation in sepsis. J. Immunol. 189:1773-9.


Doki, N. et al. (2012) Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int. J. Hematol. 95:167-75.


Nakamura, M. et al. (2012) TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis. Cancer Science. 103:26-33.


Oki, T. et al. (2011) Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26:1038-1045.


Enomoto, Y. et al. (2011) Em/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25:1849-1856.


Enomoto, Y. et al. (2010) Characterization of leukocyte mono-Ig receptor 7 (LMIR7)/CLM3 as an activating receptor: Its similarities to and differences from LMIR4/CLM5. J. Biol. Chem. 285:35274-35283.


Minobe, K. et al. (2010) Expression of ADAMTS4 in Ewing's sarcoma.Int J Oncol. 37:569-81.


Yamanishi, Y. et al. (2010) TIM1 is an endogenous ligand for LMIR5/CD300b and LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J. Exp. Med. 207:1501-1511.


Nakahara, F. et al. (2010) Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia. Blood. 115:2872-2881.


Kawashima, T. et al. (2009) A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol. 29:1796-1813.


Izawa, K. et al. (2009) Activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments LPS response through association with FcRg in mast cells. J. Immunol. 183:925-936.


Doki, N. et al. (2009) A Rac GTPase activating protein MgcRacGAP is constitutively phosphorylated on serine 387 in the v-Src-transformed NIH3T3 cells. Cancer Science. 100:1675-1679.


Oki, T. et al. (2009) Evidence that integrin alpha 2b beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J. Biol. Chem. 284:31463-31472.


Ono, R. et al. (2009) Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia. 23:2197-2209.


Watanabe-Okochi, N. et al. (2008) AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Int J. Hematology. 89:470-481.


Yamanishi, Y. et al. (2008) Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human. Blood. 111:688-698.


Hiwatari, M. et al. (2008) Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia. 22:2279-2280.


Sugano, Y. et al. (2008) Blood. 111:1167-1172.


Izawa, K. et al. (2007) Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3. J. Biol. Chem. 25:17997-18008.


Lu, Y. et al. (2007) Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21:2246-2257.


Oki, T. et al. (2006) Integrin alpha-IIb-beta-3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J. Immunol. 176:52-60.


Kawashima, T. et al. (2006) Rac1 and a GTPase activating protein MgcRacGAP are required for nuclear translocation of STAT transcription factors. J. Cell Biol. 175:937-946.


Ono, R. et al. (2005) Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J Clin. Invest. 115:919-929.


Urano, A. et al. (2005) Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol. 15:6834-6845.


Minoshima, Y. et al. (2005) The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol. Cell. Biol. 25:10315-10328.


Ono, R. et al. (2005) Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4. Mol. Cell. Biol. 25:10965-10978.


Tonozuka, Y. et al. (2004) A GTPase activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and differentiation of a leukemic cell line. Blood. 104:3550-3557.


Ikeda, Y. et al. (2004) Vasorin, a novel TGF-beta binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc. Natl. Acad. Sci. USA. 101:10732-10737.


Minoshima, Y. et al. (2003) Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell. 4:549-560.


Hirose, K. et al. (2001) MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J. Biol. Chem. 276:5821-5828.


Kawashima, T. et al. (2001) STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF- B p65. J. Immunol. 167:3652-3660.


Tonozuka, Y. et al. (2001) Molecular cloning of a human novel type I cytokine receptor related to Delta1. Cytogenetics and Cell Genetics. 93:23-25.


Yamada, K. et al. (2000) Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int. J. Hematol. 71:46-54.


Fujio, K. et al. (2000) Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain. Blood. 95:2204-2211.


Misawa, K. et al. (2000) Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenetics and Cell Genetics. 89:89-91.


Misawa, K. et al. (2000) A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97:3062-3066.


Morita, S. et al. (2000) Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Therapy. 7:1063-1066.


Fujio, K. et al. (2000) Functional reconstitution of Class-II MHC-restricted T cell immunity mediated by retroviral transfer of the αβTCR complex. J. Immunol. 165:528-533.


Kojima, T. et al. (2000) Troy, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275:20742-20747.


Ariyoshi, K. et al. (2000) Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275:24407-24413.


Kawashima, T. et al. (2000) MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood. 96:2116-2124.


Sugiyama, T. et al. (2000) A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Biochemistry. 39:15817-15825.


Kojima, T. et al. (1999) A signal sequence trap based on a constitutively active cytokine receptor. Nat. Biotechnol. 17:487-490.