研究実績
英文
- Yang J H＊, Hayano M, Griffin P T, Amorim J A, Bonkowski M S, Apostolides J K, Salfati E L, Blanchette M, Munding E, Bhakta M, Chew Y, Blanchette M, Munding E M, Bhakta M, Chew Y C, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross J M, Coppotelli G, Meer M V, Rogers-Hammond R, Vera D L, Lu Y R, Pippin J W, Creswell M L, Dou Z, Xu C, Mitchell S J, Das A, O’Connel B L, Thakur S, Kane A E, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta A-M, Rego M A, Gregory-Ksander M, Jakobs T C, Zhong L, Wakimoto H, Andari J E, Grimm D, Mostoslavsky R, Wagers A J, Tsubota K, Bonasera S J, Palmeira C M, Seidman J G, Seidman C E, Wolf N S, Kreiling J A, Sedivy J M, Murphy G, Green R E, Garcia B A, Berger S L, Oberdoerffer P, Shankland S J, Gladyshev V N, Ksander B R, Pfenning A R, Rajman L A, Sinclair D A＊.
Loss of epigenetic information as a cause of mammalian aging.
Cell, 186(2):305-326, 2023 - Karigane D, Haraguchi M, Toyama-Sorimachi N, Nishimura EK, Takubo K.
Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
Biochem Biophys Res Commun., 596: 29-35, 2022 - Nanba D, Toki F, Asakawa K, Matsumura H, Shiraishi K, Sayama K, Matsuzaki K, Toki H, Nishimura EK.
EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis.
J Cell Biol., 220(11): e202012073, 2021 - Eshiba S, Namiki T, Mohri Y, Aida T, Serizawa N, Shibata T, Morinaga H, Nanba D, Hiraoka Y, Tanaka K, Miura K, Tanaka M, Uhara H, Yokozeki H, Saida T, Nishimura EK＊.
Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi.
Cell Reports, 36(5):109492, 2021 -
Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK.
Dynamic stem cell selection safeguards the genomic integrity of the epidermis.
Developmental Cell, 56,3309-3320, 2021 - Morinaga H, Mohri Y, Grachtchouk M, Asakawa K, Matsumura H, Oshima M, Takayama N, Kato T, Nishimori Y, Sorimachi Y, Takubo K,
Suganami T, Iwama A, Iwakura Y, Dlugosz AA, Nishimura EK.
Obesity accelerates hair thinning by stem cell-centric converging mechanisms.
Nature, 595:266-271, 2021（和訳） - Hirose T, Kotoku J, Toki F, Nishimura EK, Nanba D.
Label-free quality control and identification of human keratinocyte stem cells by deep learning-based automated cell tracking.
Stem Cells, Online ahead of print, 2021 Stem Cells, 2021 - Matsumura H, Liu N, Nanba D, Ichinose S, Takada A, Kurata S, Morinaga H, Mohri Y, De Arcangelis A, Ohno S, Nishimura EK.
Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles.
Nature Aging, 1:190-204, 2021 - Al-Busani H, Al-Sobaihi S, Nojima K, Tanemura A, Yaguchi T, Kawakami Y, Matsumura H, Nishimura EK, Yokozeki H, Namiki T
NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP.
J Dermatol Sci., 97(2): 143-151, 2020 - Sakaue T, Hamaguchi M, Aono J, Nakashiro K, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H
Valve interstitial cell-spesific cyclooxygenase-1 associated with calcification of aortic valves.
The Annals ofThoracic Surgery, 110(1):40-49, 2020 - Toki F, Nanba D, Nishimura EK, Matsuzaki K
Evalution of the proliferative potential of skin keratinocytes and fibroblasts isolated from critical limb ischemia patients. Regenerative Therapy, 14:222-226,2020 - Sun Q, Lee W, Mohri Y, Takeo M, Lim CH, Xu X, Myung P, Atit RP, Taketo MM, Moubarak RS, Schober M, Osman I, Gay DL, Saur D,?Nishimura?EK, Ito M.
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.
Nat Commun., 10(1): 5023, 2019 - Kinoshita K, Munesue T, Toki F, Issiki M, Higashiyama S, Barrandon Y, Nishimura EK, Yanagihara Y, Nanba D
Automated collective motion analysis validates human keratinocyte stem cell cultures.
Scientific Reports, 9(1):18725, 2019 -
Muraguchi T, Nanba D, Nishimura EK, Tashiro T
IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance.
Journal of Dermatological Science, 94(2):298-305, 2019 - Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis, Geroges-Labouesse E, Nanba D, Nishimura EK.
Stem cell competition orchestrates skin homeostasis and ageing.
Nature, 568(7752):344-350, 2019. - Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura EK, Akira S, Shimizu S.
Beclin 1 regulates recycling endosome and is required for skin development in mice.
Communications Biology, 2:37, 2019. - Sasaki M, Shinozaki S, Morinaga H, Kaneki M, Nishimura EK, Shimokado K.
iNOS inhibits hair regeneration in obese diabetic(ob/ob) mice.
Biochemical and Biophysical Research Communications, 504(4):893-897, 2018. - Hiraoka C, Toki F, Shiraishi K, Sayama K, Nishimura EK, Miura H, Higashiyama S and Nanba D.
Two clonal types of human skin fibroblasts with different potentials for proliferation and tissue remodeling ability.
J. Dermatol. Sci., 82(2):84-94, 2016 -
Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sasaki M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, and Takubo K.
p38α Activates purine metabolism to initiate hematopoetic stem/progenitor cell cycling in response to stress.
Cell Stem Cell, 19(2):192-204, 2016 -
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, Nishimura EK.
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.
Science, 351(6273):575, 2016. - Tate S, Imai M, Matsushita N, Nishimura EK, Higashiyama S, Nanba D.
Rotation is the primary motion of paired human epidermal keratinocytes.
Journal of Dermatological Science, 79(3):194-202, 2015 -
Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H, Miyachi Y, Saida T, Nishimura EK.
A melanocyte-melanoma precursor niche in sweat glands of volar skin.
Pigment Cell & Melanoma Research, 27(6):1039-1050, 2014 -
Ueno M, Aoto T, Mohri Y, Yokozeki H, Nishimura EK.
Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during a hair cycle.
Pigment Cell & Melanoma Research, 27(4):540-551, 2014 -
Mohammad Kodama Y, Noda A, Booth C, Breault D, Suda T, Hendry J, Shinohara T, Rube C, Nishimura EK, Mitani H, Nakamura N, Niwa O.
International workshop:radiation effects on mutation in somatic and germline stem cells.
Int J Radiat Biol., 88(6)501-6, 2012 -
Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y,
McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK.
Hair follicle stem cells provide a functional niche for melanocyte stem cells.
Cell Stem Cell, 8(2):177-187, 2011 -
Nishimura EK.
Melanocyte stem cells:a melanocyte reservoir in hair follicles for hair and skin pigmentation.
Pigment Cell Melanoma Res., 24(3):401-410, 2011 -
Nishimura EK, Suzuki M, Igras V, Du J, Lonning S, Miyachi Y, Roes J, Beermann F, Fisher DE.
Key roles for transforming growth factor beta in melanocyte stem cell maintenance.
Cell Stem Cell, 6(2):130-40, 2010 -
Miura M, Ueda A, Takao Y, Nishimura EK, Koide H, Yokota T.
A stem cell-derived gene(Sddr) negatively regulates differentiation of embyronic stem cells.
Int J Dev Biol., 54(1):33-9, 2010 -
Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E,
Masunaga T, Shimizu H, Nishimura EK.
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Cell, 137(6):1088-99, 2009 -
Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R.
Inhibition of PAX3 by TGF-beta modulates melanocyte viability.
Mol Cell, 32(4):554-63, 2008 -
Sato-Jin K§, Nishimura EK§, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, Hanada K, Sawamura D, Fisher DE, Imokawa G.
Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders.
(§: co-first author)
FASEB J., 22(4):1155-68, 2008 -
D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE.
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning.
Nature, 443(7109):340-344, 2006 -
McGill GG, Haq R, Nishimura EK, Fisher DE.
c-Met expression is regulated by Mitf in the melanocyte lineage.
J Biol Chem., 14;281(15):10365-73, 2006 -
Nishimura EK, Granter SR, Fisher DE.
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche.
Science, 307(5710):720-724, 2005 -
Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE.
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.
Cancer Cell, 6(6):565-576, 2004 - McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S,
Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE.
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
Cell, 109(6):707-18, 2002. -
Nishimura EK, Jordan SA, Oshima H, Yoshida H, Osawa M, Jackson IJ, Barrandon Y, Miyachi Y, Nishikawa S.
Dominant role of the niche in melanocyte stem-cell fate determination.
Nature, 416(6883):854-60, 2002. - Yoshida H, Kunisada T, Grimm T, Nishimura EK, Nishioka E, Nishikawa SI.
Melanocyte migration and survival controlled by SCF/c-kit expression
J Invest Dermatol Symp Proc., 6(1):1-5, 2001. -
Nishimura EK.*, Yoshida H, Kunisada T, Nishikawa SI.
Regulation of E- and P-cadherin expression correlated with melanocyte migration and diversification.
Dev Biol., 215(2):155-66, 1999 - Kunisada T, Yoshida H, Yamazaki H, Miyamoto A, Hemmi H, Nishimura EK, Shultz LD, Nishikawa SI, Hayashi SI.
Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors.
Development, 125(15):2915-23, 1998. - Nishimura EK, K Ikai, S Imamura.
Eruptive syringoma developed on the entire body.
The Acta Dermatologica., 92: 359-361, 1997 - Kawabata E, Fujii H, Koreeda, S. Yoneda, K., Tachibana, T. K. Ohta, Ikai, K. and
Imamura. S.
Epitheloid sarcoma of the occipital region.
Acta Dermatologica., 91:529-535, 1996 - Kawabata E*, Morita K, Matsuyoshi N, Ohta K, Okamoto H, Ikai K, Imamura S.
Bilateral inguinal scrofuloderma during steroid therapy in a patient with bullous pemphigoid.
J Dermatol., 22(8):582-6, 1995
