2018 |2017 |2016 |2015 | 2014 | 2013 | 2012 | 2011 | 2005-2010 | 1999-2004
2018
- Nakahashi-Ouchida R, Yuki Y, Kiyono H. 2018. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum Vaccin Immunother. [Epub ahead of print]
- Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K,Kiyono H, Uematsu S. 2018. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 30(4):141-154.
- Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME,Kiyono H, Akira S, Uematsu S. 2018. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med. 10(429).
- Hirukawa S, Sagara H, Kaneto S, Kondo T, Kiga K, Sanada T, Kiyono H, Mimuro H. 2018. Characterization of morphological conversion of Helicobacter pylori under anaerobic conditions. Microbiol Immunol. 62(4):221-228.
- Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, Kunisawa J. 2018. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Sci Rep. 8(1):2904.
- Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K,Kiyono H. 2018. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity.
Mucosal Immunol. [Epub ahead of print]
2017
- Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H. 2017. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Mucosal Immunol. [Epub ahead of print]
- Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T,Kiyono H. 2017. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System. Front Immunol. 8:1787.
- Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata SI, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J. 2017. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. J Allergy Clin Immunol. pii: S0091-6749(17)32949-4.
- Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T,Kiyono H. 2017. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 10(1):314-328.
- Shibata N, Kunisawa J,Kiyono H. 2017. Dietary and Microbial Metabolites in the Regulation of Host Immunity. Front Microbiol. 8:2171.
- Azegami T, Yuki Y, Nakahashi R, Itoh H,Kiyono H. 2017. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol. pii: S0161-5890(17)30551-5.
- Nakahashi-Ouchida R, Yuki Y, Kiyono H. 2017. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev Vaccines. 16(12):1231-1240.
- Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y. 2017. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Clin Invest. 127(10):3784-3795.
- Azegami T, Yuki Y, Hayashi K, Hishikawa A, Sawada SI, Ishige K, Akiyoshi K,Kiyono H, Itoh H. 2017. Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents. J Hypertens. 36(2):387-394.
- Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. 2017. IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 214(10):3037-3050
- Takahashi Y, Sato S, Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T,Kiyono H. 2017. Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. EBioMedicine. 23:34-45.
- Ogawa T, Kashima K, Yuki Y, Mejima M, Kurokawa S, Kuroda M, Okazawa A, Kiyono H, Ohta D. 2017. Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit. Sci Rep. 7(1):5196.
- Kim SH, Cho BH, Kiyono H, Jang YS. 2017. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches. Sci Rep. 7(1):3980.
- Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H. 2017. Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Immunity 46(5):863-874.e4.
- Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H. 2017. MicroRNA-mediated dynamic control of mucosal immunity. J Exp Med. 214(6):1607-1618.
- Park EJ, Shimaoka M, Kiyono H. 2017. MicroRNA-mediated dynamic control of mucosal immunity. Int Immunol. 29(4):157-163.
- Nakajima-Adachi H, Shibahara K, Fujimura Y, Takeyama J, Hiraide E, Kikuchi A, Murakami H, Hosono A, Nochi T, Wakatsuki Y, Shimojo N, Kaminogawa S, Sato R, .Kiyono H, Hachimura S. 2017. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy. PLoS One 12(2):e0172795.
- Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. 2017. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One 12(2):e0172509.
- Kishikawa S, Sato S, Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. 2017. Allograft inflammatory factor 1 is a regulator of transcytosis in M cells. Nat Commun. 8:14509.
- Toyoshima S, Wakamatsu E, Ishida Y, Obata Y, Kurashima Y, Kiyono H, Abe R. 2017. The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol. 29(1):31-45.
- Kurashima Y,Kiyono H. 2017. Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing. Annu Rev Immunol. 35:119-147.
- Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K, Itoh H,Kiyono H. 2017. Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunol. 10(5):1351-1360.
- Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF,Kiyono H. 2017. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 10(4):901-911.
- Nelson S, Kiyono H, Kurashima Y. 2017. Epithelial extracellular ATP: an initiator of immunity to parasitic infections.
Immunol Cell Biol. 95(2):117-118.
2016
- Goto Y, Uematsu S, Kiyono H. 2016. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol. 17(11):1244-1251.
- Kogure Y, Kurashima Y, Kiyono H. 2016. MAST CELL MEDIATED HOMEOSTATIC AND BARRIER SYSTEM. Arerugi 65(2):104-12.
- Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. 2016. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity 44(3):634-646.
- Lee J, Park EJ,Kiyono H. 2016. MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation. BMB Rep. 49(5):263-9.
- Kunisawa J,Kiyono H. 2016. Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy. Front Nutr. 27;3:3.
- Yuki Y, Kurokawa S, Kozuka-Hata H, Tokuhara D, Mejima M, Kuroda M, Oyama M, Nishimaki-Mogami T, Teshima R, Kiyono H. 2016. Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody. Regul Toxicol Pharmacol. 76:128-36.
- Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H, Hasegawa H.2016. The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine.
Vaccine. 34(9):1201-7.
2015
<< First< PrevPage of 25Next >Last >>- Takeyama N, Kiyono H, Yuki Y.2015. Plant-based vaccines for animals and humans: recent advances in technology and clinical trials. Ther Adv Vaccines. 3(5-6):139-54.
- Kashima K, Yuki Y, Mejima M, Kurokawa S, Suzuki Y, Minakawa S, Takeyama N, Fukuyama Y, Azegami T, Tanimoto T, Kuroda M, Tamura M, Gomi Y,Kiyono H.2015. Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants. Plant Cell Rep. Epub ahead of print
- Lee J, Park EJ, Yuki Y, Ahmad S, Mizuguchi K, Ishii KJ, Shimaoka M, Kiyono H.2015. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis. Sci Rep. 5:18174.
- Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T,Kiyono H.2015. Identification and Analysis of Natural Killer Cells in Murine Nasal Passages. PLoS One. 10(11):e0142920.
- Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J,Kiyono H.2015. IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut. Sci Rep. 5:15918.
- Kiyono H, Azegami T.2015. The mucosal immune system: From dentistry to vaccine development. Proc Jpn Acad Ser B Phys Biol Sci. 91(8):423-39.
- Goto Y, Kurashima Y, Kiyono H.2015. Roles of the gut mucosal immune system in symbiosis and immunity. Rinsho Ketsueki. 56(10):2205-12.
- Tada R, Hidaka A, Iwase N, Takahashi S, Yamakita Y, Iwata T, Muto S, Sato E, Takayama N, Honjo E, Kiyono H, Kunisawa J, Aramaki Y.2015. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PLoS One. 10(10):e0139785.
- Fukuyama Y, Okada K, Yamaguchi M, Kiyono H, Mori K, Yuki Y.2015. Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice. PLoS One. 10(9):e0139368.
- Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, Shikata S, Honda K, Hashimoto E, Suzuki Y, Setou M, Suematsu M,Kiyono H.2015. Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1. Cell Rep.13(1):122-31.
- Takeyama N, Yuki Y, Tokuhara D, Oroku K, Mejima M, Kurokawa S, Kuroda M, Kodama T, Nagai S, Ueda S,Kiyono H.2015. Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs. Vaccine.33(39):5204-11.
- Park EJ, Yuki Y, Kiyono H, Shimaoka M.2015. Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci.22:51.
- Kunisawa J, Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M,Kiyono H.2015. Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut. Sci Rep.5:9750.
- Suzuki H, Watari A, Hashimoto E, Yonemitsu M, Kiyono H, Yagi K, Kondoh M, Kunisawa J.2015. C-Terminal Clostridium perfringens Enterotoxin-Mediated Antigen Delivery for Nasal Pneumococcal Vaccine. PLoS One.10(5):e0126352.
- Goto Y, Kurashima Y, Kiyono H.2015. The gut microbiota and inflammatory bowel disease. Curr Opin Rheumatol.27(4):388-96.
- Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J,Kiyono H.2015. Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One.10(5):e0127460.
- Kurashima Y, Kiyono H, Kunisawa J.2015. Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation. Mediators Inflamm. 427125
- Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, Tsukada H, Akiyoshi K,Kiyono H. 2015. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 8(5):1144-53.
- Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. 2015. Negative regulation of DSS-induced experimental colitis by PILRα. Int Immunol. 27(6):307-14.
- Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K. 2015. The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells. Immunity. 42(2):279-93.
- Kashima K, Mejima M, Kurokawa S, Kuroda M, Kiyono H, Yuki Y. 2015. Comparative whole-genome analyses of selection marker?free rice-based cholera toxin B-subunit vaccine lines and wild-type lines. BMC Genomics. 16(1):48.
- Sato S, Kiyono H, Fujihashi K. 2015. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 61(4):336-42.
- Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K.2015. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 194(1):398-406.
- Kunisawa J,Kiyono H.2015. Vitamins mediate immunological homeostasis and diseases at the surface of the body. Endocr Metab Immune Disord Drug Targets. 15(1):25-30.
2014
- Kurashima Y, Kiyono H, Kunisawa J. 2014. Purinergic signaling mediates mast cell activation in intestinal inflammation. Seikagaku 86(6):798-802.
- Sato S, Kiyono H, Fujihashi K. 2014. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology Dec 20. Epub ahead of print.
- Lamichhane A, Azegami T, Kiyono H. 2014. The mucosal immune system for vaccine development. Vaccine.32(49):6711-6723.
- Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K. 2014. Loss of Lymph Node Fibroblastic Reticular Cells and High Endothelial Cells Is Associated with Humoral Immunodeficiency in Mouse Graft-versus-Host Disease. J Immunol 194(1): 398-406.
- Kunisawa J,Kiyono H.2014. Vitamins Mediate Immunological Homeostasis and Diseases at the Surface of the Body. Endocr Metab Immune Disord Drug Targets Epub ahead of print.
- Nakajima-Adachi H, Kikuchi A, Fujimura Y, Shibahara K, Makino T, Goseki-Sone M, Kihara-Fujioka M, Nochi T, Kurashima Y, Igarashi O, Yamamoto M, Kunisawa J, Toda M, Kaminogawa S, Sato R, Kiyono H, Hachimura S. 2014. Peyer's Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy. PLoS One. 9(10):e107492.
- Okura H, Sato S, Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H. 2014. Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids. PLoS One. 9(9):e108294.
- Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H. 2014. Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol. JVI.02279-14.
- Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld J, Sasakawa C, Umesaki Y, Benno Y,Kiyono H. 2014 Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science 12;345(6202):1254009.
Free Access to Paper Abstract
Free Access to Full Paper - Kurokawa S, Kuroda M, Mejima M, Nakamura R, Takahashi Y, Sagara H, Takeyama N, Satoh S, Kiyono H, Teshima R, Masumura T, Yuki Y. 2014. RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds. Plant Cell Rep 33(1):75-87.
- Azegami T, Itoh H, Kiyono H, Yuki Y. 2014. Novel Transgenic Rice-Based Vaccines. Arch Immunol Ther Exp (Warsz) Jul 16. Epub ahead of print.
- Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H. 2014. Regulation of intestinal IgA responses by dietary palmitic Acid and its metabolism. J Immunol 193(4):1666-71.
- Mejima M, Kashima K, Kuroda M, Takeyama N, Kurokawa S, Fukuyama Y, Kiyono H, Itoh K, Mitsui T, Yuki Y. 2014. Determination of genomic location and structure of transgenes in marker-free rice-based cholera vaccine by using whole genome resequencing approach. Plant Cell Tiss Org Cult Jul 30. Epub ahead of print.
- Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H. 2014 Enzyme Cyp26b1 Mediates Inhibition of Mast-Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis. Immunity Apr 17;40(4):530-541.
- Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. 2014 Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun 5:3492.
- Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K. 2014 Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun 5:3704.
- Fujihashi K, Sato S, Kiyono H. 2014 Mucosal Adjuvants For Vaccines To Control Upper Respiratory Infections In The Elderly. Exp Gerontol. S0531-5565(14):00009-6.
- Abe M, Yuki Y, Kurokawa S, Mejima M, Kuroda M, Park EJ, Scheller J, Nakanishi U, Kiyono H. 2014 A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice. J Biotechnol S0168-1656(14)00078-9.
- Kurashima Y, Kiyono H. 2014 New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development. Exp Mol Med 46:e83.
- Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H. 2014 Role of Lactobacillus pentosus Strain b240 and the Toll-Like Receptor 2 Axis in Peyer's Patch Dendritic Cell-Mediated Immunoglobulin A Enhancement. PLoS One 9(3):e91857
- Azegami T, Yuki Y, Kiyono H. 2014 Challenges in Mucosal Vaccines for the Control of Infectious Diseases. Int Immunol. Jun 9. pii: dxu063.
- Tokuhara D, Nochi T, Matsumura A, Mejima M, Takahashi Y, Kurokawa S, Kiyono H, Yuki Y. 2014 Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine.Dig Dis Sci. May 18.
- Suzuki H, Kondoh M, Yagi K, Kiyono H, Kunisawa J.2014 The development of mucosal vaccine using bacterial function for targeting mucosal tissues. Yakugaku Zasshi. 134(5):629-34.
2013
- Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K. 2013 Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 190(2):774-83.
- Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H. 2013 Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae.Infect Immun. 81(5):1625-34.
- Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihasji K. 2013 Potential Roles of CCR5(+) CCR6(+) Dendritic Cells Induced by Nasal Ovalbumin plus Flt3 Ligand Expressing Adenovirus for Mucosal IgA Responses. PLoS One 8(4):e60453
- Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Takahashi Y, Tokuhara D, Nochi T, Katakai Y, Kuroda M, Takeyama N, Kashima K, Abe M, Chen Y, Nakanishi U, Masumura T, Takeuchi Y, Kozuka-Hata H, Shibata H, Oyama M, Tanaka K, Kiyono H. 2013 Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.Plant Biotechnol J 11(7):799-808.
- Kunisawa J, Gohda M, Hashimoto E, Ishikawa I, Higuchi M, Suzuki Y, Goto Y, Panea C, Ivanov II, Sumiya R, Aayam L, Wake T, Tajiri S, Kurashima Y, Shikata S, Akira S, Takeda K, Kiyono H. 2013 Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice. Nat Commun 2013;4:1949
- Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H. 2013 Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer's Patches. J Immunol Jul 15;191(2):942-8
- Kurokawa S, Nakamura R, Mejima M, Kozuka-Hata H, Kuroda M, Takeyama N, Oyama M, Satoh S,Kiyono H, Masumura T, Teshima R, Yuki Y. 2013 MucoRice-cholera Toxin B-subunit, a Rice-based Oral Cholera Vaccine, Down-regulates the Expression of α-Amylase/trypsin Inhibitor-like Protein Family as Major Rice Allergens. J Proteome Res Jul 5;12(7):3372-82
- Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. 2013 An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun Jun 11(4):1949
- Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. 2013 Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8(+) T cells. PLoS One Aug 12;8(8):e72050
- Tokuhara D, Rholvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, Kuroda M, Oyama M, Kozuka-Hata H, Nochi T, Sagara H, Aladin F, Marcotte H, Frenken LG, Iturriza-Gomara M, Kiyono H, Hammarstrom L, Yuki Y. 2013 Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest Sep 3;123(9):3829-3838
- Kunisawa J, Kiyono H. 2013 Vitamin-Mediated Regulation of Intestinal Immunity. Front Immunol Jul 11;4:189
- Kishino S, Takeuchi M, Park SB, Hirata A, Kitamura N, Kunisawa J, Kiyono H, Iwamoto R, Isobe Y, Arita M, Arai H, Ueda K, Shima J, Takahashi S, Yokozeki K, Shimizu S, Ogawa J. 2013 Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci USA 110(44):17808-13
- Lamichhane A, Kiyono H, Kunisawa J. 2013 Nutritional components regulate the gut immune system and its association with intestinal immune disease development. J Gastroenterol Hepatol Suppl 4:18-24
- Korneychuk N, Ramiro-Puig E, Ettersperger J, Schulthess J, Montcuquet N, Kiyono H, Meresse B, Cerf-Bensussan N. 2013 Interleukin 15 and CD4+ T Cells Cooperate to Promote Small Intestinal Enteropathy in Response to Dietary Antigen. Gastroenterology S0016-5085(13)01807-6
- Kurashima Y, Goto Y, Kiyono H. 2013 Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation.Eur J Immunol 43(12):3108-15
- Yuki Y, Nochi T, Kong IG, Takahashi H, Sawada S, Akiyoshi K, Kiyono H. 2013 Nanogel-based antigen-delivery system for nasal vaccines.Biotechnol Genet Eng Rev 29(1):61-72
2012
- Goto Y. and Kiyono H. 2012 Epithelial barrier: an interface for the cross-communication between gut flora and immune system. Immunol Rev. 245(1): 147-63
- Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH,and Kiyono H. 2012 Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy. 67(4):502-509.
- Kunisawa J, Hashimoto E, Ishikawa I, and Kiyono H. 2012 A pivotal role of vitamin b9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 7(2):e32094
- Fukuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. 2012 Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 11(3):367-79
- Sato S, and Kiyono H. 2012 The mucosal immune system of the respiratory tract. Curr Opin Virol.2(3):225-232.
- Yuki Y, Mejima M, Kurokawa S, Hiroiwa T, Kong IG, Kuroda M, Takahashi Y, Nochi T, Tokuhara D, Kohda T, Kozaki S, and Kiyono H. 2012 RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine. Vaccine. 13;30(28):4160-4166.
- Kunisawa J, and Kiyono H. 2012 Alcaligenes is Commensal Bacteria Habituating in the Gut-Associated Lymphoid Tissue for the Regulation of Intestinal IgA Responses. Front Immunol. 3:65
- Kunisawa J, and Kiyono H. 2012 Immunological function of sphingosine 1-phosphate in the intestine.Nutrients 4(3):154-66
- Tanaka S, Saito Y, Kunisawa J, Kurashima Y, Wake T, Suzuki N, Shultz LD, Ishikawa F.and Kiyono H. 2012 Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice. J Immunol. 188(12):6145-55
- Kunisawa J, Kiyono H. 2012 Immune regulation and monitoring at the epithelial surface of the intestine. Drug Discov Today. 18;(1-2):87-92.
- Kumagai T, Kiyono H. 2012 Summary for symposium I on the development of a more efficacious influenza vaccine held at the 15th annual meeting of the Japanese society for vaccinology, Tokyo, 2011.Vaccine. 30(44):6338-9
- Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H. 2012 Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun. 3:1034.
- Nakajima-Adachi H, Koike E, Totsuka M, Hiraide E, Wakatsuki Y, Kiyono H, Hachimura S. 2012 Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4(+)T Cells into the Th2 or Th1 Phenotype. Biosci Biotechnol Biochem. 76(10):1979-81.
- Sato S, Kaneto S, Shibata N, Takahashi Y, Okura H, Yuki Y, Kunisawa J, Kiyono H. 2012 Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells. Mucosal Immunol. 6(4):838-846. *. Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K and Kiyono H. 2011 Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun 404(3): 822-8
2011
- Kunisawa J. and Kiyono H. 2011 Peaceful mutualism in the gut: revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe 9(2): 83-4
- Goto Y. and Kiyono H. 2011 Epithelial cell microRNAs in gut immunity. Nat Immunol 12(3): 195-7
- Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH and Kiyono H. 2011 The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens. J Immunol 186(7): 4253-62
- Ogawa M, Yoshida M, Goto Y, Nagatake T, Kiyono H, Sasakawa C. 2011 A tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe 9(5): 376-89
- Yamamoto M, Pascual DW and Kiyono H. 2011 M Cell-Targeted Mucosal Vaccine Strategies. Curr Top Microbiol Immunol 534:39-52.
- Burggraf M, Nakajima-Adachi H, Hachimura S, Ilchmann A, Pemberton AD, Kiyono H, Vieths S, Toda M. 2011 Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model offoodallergy. Mol Nutr Food Res. 55(10):1475-1483.
- Kunisawa J, Kurashima Y and Kiyono H. 2012 Gut-associated lymphoid tissues for the development of oral vaccines. Adv Drug Deliv Rev. 1;64(6):523-530.
- Stappenbeck T and Kiyono H. 2011 Editorial overview. Curr Opin Immunol. 23(4):445-7
- Okada K, Yamasoba T and Kiyono H. 2011 Craniofacial mucosal immune system: importance of its unique organogenesis and function in the development of a mucosal vaccine. Adv Otorhinolaryngol.72:31-6
- Kim SH, Jung DI, Yang IY, Kim J, Lee KY, Nochi T, Kiyono H, Jang YS. 2011 M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery. Eur J Immunol.41(11):3219-3229.
- Takeyama N, Yuki Y, and Kiyono H. 2011 Current progress in the development of mucosal vaccines.Nihon Rinsho 69(9):1555-60
2005-2010
- Kobayashi, R., Kohda, T., Kataoka, K., Ihara, H., Kozaki, S., Pascual, DW., Staats, HF., Kiyono, H., McGhee, JR., and Fujihashi, K. 2005. A novel neurotoxoid vaccine prevents mucosal botulism. J. Immunol. 174: 2190-2195
- Nonaka, S., Naito, T., Chen, H., Yamamoto, M., Moro, K., Kiyono, H., Hamada, H. and Ishikawa, H. 2005. Intestinal γδ T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J. Immunol. 174: 1906-1912
- Kweon, MN., Yamamoto, M., Rennert, P.D., Park, EJ., Lee, AY., Chang, SN., Hiroi, T., Nanno, M. and Kiyono, H.2005 Prenatal blockage of LTbR and TNFRp55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J. Immunol. 174: 4365-4372.
- Ueta, M., Hamuro, J., Kiyono, H. and Kinoshita, S. 2005. Triggering of TLR3 by poly:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem. Biophy. Res. Commun. 331: 285-294.
- Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., and Kiyono, H. 2005. Colitis in mice lacking hte common cytokine receptor γ chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology 128: 922-934.
- Hino, A., Fukuyama, S., Kataoka, K., Kweon, M., Kataoka, K., and Kiyono, H. 2005 Nasal IL-12p70 prevents and treats intestinal allergic diarrhea. J. Immunol. 174: 7423-7432.
- Ohmura, M., Yamamoto, M., Tomiyama-Miyaji, C., Yuki, Y., Takeda, Y. and Kiyono, H. 2005. Nontoxic Stx derivatives from Escherichia coli possess adjivant activity for augmentation of antigen-specific immune responses via DC activation. Infect. Immunol. 73: 4088-4097.
- Kunisawa, J., and Kiyono, H. 2005. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell. Mol. Life. Sci. 62: 1308-1321.
- Ishikawa, H., Kanamori, Y., Hamada, H.,, and Kiyono, H. 2005 Book chapter: Development and function of organized gut-associated lymphoid tissues.. In: Mestecky,J., Lamm, M. E., Strober, W., Bienenstock, J., McGhee, J. R., and Mayer, L.. editors. Mucosal Immunology 3rd Ed. Amsterdam, ELSEVIER; 385-406.
- Kweon, M. N. and Kiyono, H. 2005 Book chapter: Allergic diseases in the gastrointestinal tract. Mucosa-associated lymphoid tissues in the aerodigestive tract. In: Mestecky,J., Lamm, M. E., Strober, W., Bienenstock, J., McGhee, J. R., and Mayer, L.. editors. Mucosal Immunology 3rd Ed. Amsterdam, ELSEVIER; 1351-1360.
- Yuki, Y., Hara-Yokoyama, C., Guadiz, A.A., Udaka, S., Kiyono, H., and Chatterjee, S. 2005 Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.. Biotechnol. Bioeng. Sep 2 (Epub ahead of print)
- Kunisawa, J., Fukuyama, S., and Kiyono, H. 2005 Mucosa-associated lymphoid tissues in the aerodigestive tract: Their shared and divergent traits and their importance to the orchestration of the mucosal immune system.. Curr. Mol. Med. 5: 557-572.
- Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., and Takaiwa, F.. 2005 A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.. Proc. Natl Acad. Sci. USA. 102: 17525-17530.
- Duverger, A.., Jackson, RJ., van Ginkel, FW., Fischer, R., Tafaro, A., Leppla, SH., Fujihashi, K., Kiyono, H.., McGhee, JR., and Boyaka, PN. 2006. Bacillus anthracis Edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J. Immunol. 176(3):1776-83.
- Jang, MH., Sougawa, N., Tanaka, T., Hirata, T., Hiroi, T., Tohya, K., Guo, Z., Umemoto, E., Ebisuno, Y., Yang, BG., Seoh, JY., Lipp, M.., Kiyono, H.. and Miyasaka, M. 2006. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J. Immunol. 176(2):803-10.
- Hagiwara, Y., Kawamura, Y., Kataoka, K., Rahima, B., Jackson, R.J., Komase, K., Dohi, T., Boyaka, P.N., Takeda, Y., Kiyono, H., McGhee, J.R., and Fujihashi, K . 2006. A socond generation of double mutant cholera toxin adjuvants: Enhanced immunity without intracellular trafficking.. J. Immunol. 177(5): 3045-54.
- Fukuyama, S., Nagatake, T., Kim, D.Y., Takamura, K., Park, E.J., Kaisho, T., Tanaka, N., Kurono, Y., and Kiyono, H. 2006. Cutting Edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J. Immunol. 177(7): 4276-80.
- Maddaloni, M., Staats H.F., Mierzejewska, D., Hoyt, T., Robinson, A., Callis, G., Kozaki, S., Kiyono, H., McGhee, J.R., Fujihashi, K., and Pascual, D.W. 2006. Mucosal vaccine targeting imoproves onset of mucosal and systemic immunity to Botulinum nuurotoxin A (BoTN/A). J. Immunol. 177(8): 5524-32.
- Nochi, T. and Kiyono, H.. 2006. Innate Immunity in the mucosal immune system. Curr. Pharm. Des. 12:4203-13.
- Kunisawa, J., Takahashi, I., and Kiyono, H. 2007. Intraepithelial lymphocytes: Their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215(1):136-153.
- Kim, N.J., Kunisawa, J., Kweon, M.N., Ji, G.E.., and Kiyono, H. 2007. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RBhigh T cell-mediated inflammatory bowel disease by inhibition of disordered T Cell Activation. Clin.. Immunol.123(1):30-9.
- Tanaka, N.., Fukuyama, S., Fukuiwa.. Kawabata, M., Sagara, Y., Ito, H., Miwa, Y., Nagatake, T., Kiyono, H. and Kurono, Y. 2007 Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine 30;25(14):2680-7.
- Tamagawa, H., Hiroi, T., Mizushima, T., Ito, T., Matsuda, H., and Kiyono, H. 2007. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm. Bowel Dis. 13(5):547-56.
- Kunisawa, J., Kurashima, Y., Gohda, M., Higuchi, M,. Ishikawa, I,. Miura, F., Ogahara, I., and Kiyono, H. 2007. Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production. Blood1;109(9):3749-56.
- McGhee, J.R., Kunisawa, J., and Kiyono, H. Gut lymphocyte migration: we are halfway 'home'. Trend. Immunol. 28(4):150-3.
- Takayama, N., Igarashi, O., Kweon, M.N., and Kiyono, H. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin. Immunol. 123(2):199-208.
- Kunisawa, J., McGhee, J.R.., and Kiyono, H. 2007. Mucosal s-IgA enhancement: development of safe and effective mucosal adjuvants and mucosal antigen delivery vehicles. Mucosal Immune Defense: Immunoglobulin A. (Edited by Charlotte S. Kaetzel), Kluwer Academic/Plenum Publishers, New York. 345-389.
- Makita, S., Kanai, T., Nemoto, Y., Totsuka, T., Okamoto, R., Tsuchiya, K., Yamamoto, M., Kiyono, H., and Watanabe, M. 2007. Intestinal Lamina Propria Retaining CD4+CD25+ Regulatory T Cells Is ASuppressive Site of Intestinal Inflammation J. Immunol. 178(8):4937-46.
- Fukuyama, S.,Kiyono, H.. 2007.Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 26(4):393-5.
- Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C., Koyasu, S.. 2007. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A.. 104(21):8971-6.
- Ohka, S., Igarashi, H., Nagata, N., Sakai, M., Koike, S., Nochi, T., Kiyono, H., Nomoto, A.. 2007. Establishment of a poliovirus oral infection system in human poliovirus receptor (hPVR/CD155)-expressing transgenic mice that are deficient in interferon-{alpha}/{beta} receptor. J Virol. 81(15):7902-12.
- Nochi, T., Takagi, H., Yuki, Y., Yang, L., Masumura, T., Mejima, M., Nakanishi, U., Matsumura, A., Uozumi, A., Hiroi, T., Morita, S., Tanaka, K., Takaiwa, F., Kiyono, H.. 2007. From the Cover: Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.
Proc Natl Acad Sci U S A. 26;104(26):10986-91. - Kurashima, Y., Kunisawa, J., Higuchi, M., Ghoda, M., Ishikawa, I., Takayama, N., Shimizu, M., Kiyono, H.. 2007. Sphingosine 1-phosphate-mediated trafficking of pathogenic th2 and mast cells for the control of food allergy.
J Immunol.179(3):1577-85. - Yuki, Y., Nochi, T., Kiyono, H.. 2007. Progress towards an AIDS mucosal vaccine: An overview.
Tuberculosis (Edinb). - Kunisawa, J., Kurashima, Y., Higuchi, M, Gohda, M., . Ishikawa, I,. Ogahara, I., Kim, N., and Kiyono, H. 2007. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med.204(10):2335-48
- Kiyono, H., Kunisawa, J., McGhee, J.R., and Mestecky, J.. 2007. The mucosal immune system, Fundamental Immunology (Edited by William, E., Paul,). Lippincott-Raven, Philadelphia.
- Nochi,T., Yuki,Y., Matsumura,A., Mejima,M., Terahara,K., Kim,D., Fukuyama,S., Iwatsuki-Horimoto,K., Kawaoka,Y., Kohda,T., Kozaki,S., Igarashi,O., and Kiyono, H.. 2007. A novel M-cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.J Exp Med.204(12):2789-96
- Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, MN., Kiyono, H., Yamamoto, M.. 2007. Peyer's Patches Are Required for Intestinal IgA Responses to Salmonella.Infect Immun.
- Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN.. 2008. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol 180 3:1609-18.
- Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells. Blood.
- Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. 2008. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli.Fish Shellfish Immunol.24(5):506-13.
- Kurashima Y, Kunisawa J, Kiyono H. 2008. Applicable strategies for the mucosal immune system in the regulation of allergic diseases. Arerugi.57(2):87-94.
- Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. 2008. Cutting edge: langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 180(7):4361-5.
- Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. 2008. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 180(8):5335-43.
- Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. 2008. Nasal Vaccination with Outer Membrane Protein of Porphyromonas gingivalis and Nontoxic Chimeric Enterotoxin Adjuvant Induces Long-Term Protective Immunity with Reduced IgE Antibodies. Infect Immun.
- Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol.
- Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K.. 2008. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.Int Immunol. 20 7:881-91.
- Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 25 1-2:170-80.
- Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. 2008. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 97:769-76.
- Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. 2008. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 15;180(12):7840-6.
- Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol.
- Kunisawa J, Nochi T, Kiyono H.. 2008. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol.
- Fehervari Z, Kiyono H.. 2008.The mucosa: at the frontlines of immunity.Trends Immunol.
- Yuki Y, Kiyono H.. 2008.MucoRice: development of rice-based oral vaccine.Nihon Rinsho Meneki Gakkai Kaishi
- Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. 2009. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 383(3):340-6
- Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. 2009 Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 150(2):164-71
- Takahashi I, Nochi T, Yuki Y, Kiyono H. 2009 New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 21(3):352-8
- Fujihashi K, Kiyono H. 2009 Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol.30(7):334-43
- Yuki Y, Kiyono H. 2009 Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines.8(8):1083-97
- Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. 2009 Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine.27(43)5982-8
- Mavichak R, Takano T, Kondo H, Hirono I, Wada S, Hatai K, Inagawa H, Takahashi Y, Yoshimura T, Kiyono H, Yuki Y, Aoki T. 2009 The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus. J Fish Dis.33(1)69-74
- Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. 2009 Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine.Histochem Cell Biol.132(6):577-84
- Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. 2009 Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med.206(11):2351-64
- Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. 2009 RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.J Immunol. 183(9):5738-47
- Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. 2009 A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.J Immunol.183(10):6538-44
- Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. 2009 Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.Nature.462(7270):226-30
- Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. 2009 Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 49(4):253-7 68.Takahashi I.., Nochi T., Kunisawa J., Yuki Y., and Kiyono H. 2010 The mucosal immune system for secretory IgA responses and mucosal vaccine development. Inflammation and Regeneration 30: 40-47
- Takahashi I., Fujihashi K. and Kiyono H. 2010 Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontology 54(1): 247-56
- Fuglem B.., Kiyono H., Nochi T., Yuki Y.., and Koppang EO. 2010 Antigen-sampling cells in the salmonid intestinal epithelium. Developmental and Comparative Immunology 34(7): 768-74
- Obata T., Goto Y., Kunisawa J., Sato S.., Shibata N., Gohda M., Kagiyama Y., Nochi T., Yuki Y., Fukuyama Y.., and Kiyono H. 2010 Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 107(16): 7419-24
- Tokuhara D., Yuki Y., Nochi T.., Mejima M., Kurokawa S., Takahashi Y.., Nakanishi U.., and Kiyono H. 2010 Secretory IgA-mediated protection against V. Cholerae and heat-labile enterotoxin-producing enterotoxigenicEscherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 107(19): 8794-9
- Kunisawa J. and Kiyono H. 2010 Aberrant Interaction of the Gut Immune System with Environmental Factors in the Development of Food Allergies. Curr Allergy Asthma Rep 10(3): 215-21
- Malamut G..,Kiyono H.., and Meresse B. 2010 IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 120(6): 2131-43
- Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K and Kiyono H. 2010 Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater 9(7): 572-8
- Omoe K.., Kiyono H.., and Imanishi K. 2010 High affinity of interaction between superantigen and TCR Vβ molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem.285(40): 30427-35
- Kayamoto H.., Kunisawa J., Kiyono H.., and Tsunoda SI. 2010 Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 84(24): 12703-12
- Yuki Y., Nochi T., Harada N., Katakai Y., Shibata H., Mejima M., Kohda T., Tokuhara D., Kurokawa S., Takahashi Y., Ono F., Kozaki S., Terao K., Tsukada H. and Kiyono H. 2010 In Vivo Molecular Imaging Analysis of a Nasal Vaccine That Induces Protective Immunity against Botulism in Nonhuman Primates. J Immunol 185(9): 5436-43
1999-2004
- Boyaka, P.N., Marinaro, M., Jackson, R.J., Menon, S., Kiyono, H. and McGhee, J.R. 1999. Interleukin 12 is an effective adjuvant for induction of mucosal immunity. J. Immunol. 162 : 122-128.
- Marinaro, M., Boyaka, P.N., Jackson, R.J., Finkelman, F.D., Kiyono, H., Jirillo, E. and McGhee, J.R. 1999. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. J. Immunol. 162 : 114-121.
- Hiroi, T., Yanagita, M., Iijima, H., Iwatani, K., Yoshida, T., Takatsu, K. and Kiyono, H. 1999. Deficiency of IL-5 receptor α chain selectively influences on the development of the commun mucosal immune system independent IgA producing B-1 cells in mucosal-associated tissues. J. Immunol. 162 : 821-828.
- Takahashi, I., Iijima, H., Katashima, R., Itakura, M. and Kiyono, H. 1999. Clonal expansion of ββT cells in intestinal inflammatory regions of T cell receptor α-chain deficient mice. J. Immunol. 162 : 1843-1850.
- Kweon, M-N., Fujihashi, K., Wakatsuki, Y., Koga, T., Yamamoto, M., McGhee, J.R. and Kiyono, H. 1999. Mucosally-induced systemic T cell unresponsiveness to ovalbumin requires CD40L-CD40 interactions. J. Immunol.162 : 1904-1909.
- Yanagita, M., Hiroi, T., Kitagaki, N., Hamada, S., Ito, H., Shimauchi, H., Murakami, S., Okada, H. and Kiyono, H.1999. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity : fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J. Immunol. 162 : 3559-3565.
- Tori, M., Ito, T., Yumiba, T., Maeda, A., Sawai, T., Miyasaka, M., Kiyono, H., Matsuda, H., Nozawa, M. and Shirakura, R. 1999. Significant role of intragaft lymphoid tissues in preventing insulin-dependent diabetes mellitus recurrence in whole pancreaticoduodenal transplantation. Micro Surgery. 19 : 338-343.
- McGhee, J.R., Kiyono, H., Kubota, M., Kawabata, S., Miller, C.J., Lehner, T., Imaoka, K. and Fujihashi, K. 1999. Mucosal Th1-versus Th2-type responses for antibody or cell mediated immunity to SIV rhesus macaques. J. Infect. Dise. 179 : 5480-5484.
- Dohi, T., Fujihashi, K., Rennert, P.D., Iwatani, K., Kiyono, H. and McGhee, J.R. 1999. Hapten-induced colitis is associated with colonic patch hypertrophy and Th2 helper-type responses. J.Exp. Med. 189 : 1169-1179.
- Kurono, Y., Yamamoto, M., Fujihashi, K., Kodama, S., Suzuki, M., Mogi, G., McGhee, J.R. and Kiyono, H. 1999. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. J. Infect. Dise. 180 : 122-132.
- Sugimoto, M., Shimaoka, M., Taenaka, N. Kiyono, H. and Yoshiya, I. 1999. Lymphocyte activation is attenuated by stellate ganglion block. Regional Anethesia and Pain Medicine. 24 : 30-35.
- van Ginkel, F.W., Wahl, S.M., Kearney, J.F., Kweon, M-N., Fujihashi, K., Burrows, P.D., Kiyono, H. and McGhee, J.R. 1999. IgA-deficiency with increased Th2-type cytokines in TGF-β1 knockout mice. J. Immunol. 163 : 1951-1957.
- Iijima, H., Takahashi, I., Kishi, D., Kim, J-K., Kawano, S., Hori, M. and Kiyono, H. 1999. Alteration of interleukin 4 production results in the inhibition of Th2 dominated inflammatory bowel disease in T cell receptor αchain-deficinet mice. J. Exp. Med. 190 : 607-616.
- Mbawuike, I.N., Fujihashi, K., DiFavio, S., Kawabata, S., McGhee, J.R., Couch, R.B., and Kiyono, H. 1999. IL-12 modulate IFN-γ synthesis and influenza-specific cytotoxic activity by human CD45RO+ but not CD45RA, CD8+ T cells. J. Infect. Dis. 180 : 1477-1486.
- Fujihashi, K., Doi, T., Kweon, M-N., McGhee, J.R., Cooper, M.D., Tonegawa, S. and Kiyono, H. 1999. γδT cells regulate mucosally induced tolerance in a dose dependent fashion large dose of ovalbumin, while regulate IL-10-mediated small dose systemic unresponsiveness. Int. Immunol. 11 : 1907-1916.
- Yamamoto, M., Kiyono, H., Yamamoto, S., Batanero, E., Kweon, M-N., Otake, S., Azuma, M., Takeda, Y. and McGhee, J.R. 1999. Direct effects on antigen-presenting cells and T lymphocytes explain the adjuvanticity of a nontoxic cholera toxin mutant. J. Immunol. 162 : 7015-7021.
- Tori, M., Ito, T., Uchikoshi, F., Yumiba, T., Sakakida, T., Miyasaka, M., Kiyono, H.,
Matsuda, H., Nozawa, M. and Shirakura, R. 1999. IL-4 production in IDDM- nonrecurrent pancreas-transplanted BB rats with donor-derived NKR-P1+ TCRαβ+(NKT) cells but not in IDDM-recurrent BB rats. Transplant. Proc.31 : 1940-1941. - Pascual, D.W., Hall, S., Hone, D.M., van Ginkel, F.W., Yamamoto, M., Fujihashi, K., Powell, R.J., Wu, S., VanCott, J.L., Kiyono, H. and McGhee, J.R. 1999. Extracellular expression of recombinant enterotoxigenic colonization factor antigen I by Salmonella elicits distinct T helper 2 followed by T helper 1 cell responses. Infect. Immun. 67 : 6249-6256.
- Tori, M., Ito, T., Yumiba, T., Okawa, A., Maeda, A., Sawai. T., Kimoto, T., Akamaru, Y., Miyasaka, M., Kiyono, H., Matsuda, H., Nozawa, M. and Shirakura, R. 1999. Proliferation of donor-derived NKR-P1+TCR αβ+(NKT) cells in the nonrecurrent spontaneous diabetic BB rats transplanted with pancreaticoduodenal grafts of Wistar-Furth donors. Transplant. Proc. 31 : 2741-2742.
- Host, D.F., Kemp, E.B., Marinaro, M., Cruz, O., Kiyono, H., McGhee, J.R., Belisle, J.T., Milligan, T.W., Miller, J.P. and Belshe, R.B. 1999. A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guerin vaccination. J. Lab. Clin. Med. 134 : 244-252.
- Higuchi, K., Fujihashi, K., Kweon, M-N., McGhee, J.R., and Kiyono, H. 2000. Comparison of inhibitory effects of intranasal and oral administration of bovine type II collagen on collagen induced arthritis in DBA1/J mice. J. Rheumatol. 27 : 1038-1044.
- Saitoh-Inagawa, W., Hiroi, T., Yanagita, M., Iijima, H., Uchio, E., Ohno, S., Aoki, K. and Kiyono, H. 2000. Immunological characterization of lacrimal glands as a part of mucosal immune network. Invest. Ophthalmol. Visual Sci. 41 : 138-144.
- Yamamoto, M., Rennert,P.D., Kweon, M-N., Yamamoto, S., Dohi, T., Bluethmann ,H., Fujihashi, K., McGhee, J.R. and Kiyono, H. 2000. Alternate mucosal immune system : organized Peyer's patches are not required for mucosal IgA antibody responses in the gastrointestinal tract. J. Immunol. 164 : 5184-5191.
- Hiroi, T., Yanagita, M., Ohta, N., Sakaue, G. and Kiyono, H. 2000. Interleukin 15 and IL-15R selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses. J. Immunol.165 : 4329-4337.
- Simeka, J.W., Jackson, R.J., Kiyono, H. and McGhee, J.R. 2000. Mucosally-induced immunoglobulin E associated inflammation in the respiratory tract. Infect. Immun. 68 : 672-679.
- Kishi, D., Takahashi, I., Kai, Y., Tamagawa, H., Iijima, H., Obunai, S., Nezu, R., Ito, T., Matsuda, H. and Kiyono, H. 2000. Alteration of Vβ usage and cytokine production of CD4+ ββT cells by elimination of Bacteroides vulgatus prevents the development of colitis in TCRα-chain deficient mice. J. Immunol. 165 : 5891-5899.
- Yamamoto, M., Kiyono, H., Kweon, M-N., Yamamoto, S., Fujihashi, K., Kurazono, H., Imaoka, K., Bluethmann, H., Takahashi, I., Takeda, Y., Azuma, M. and McGhee, J.R. 2000. Enterotoxin adjuvants have direct effects on T cells and APC which result in either IL-4 dependent or-independent immune responses. J. Infect. Dis. 182 : 180-190.
- Dohi, T., Fujihashi, K., Kiyono, H., C.O. Elson. and McGhee, J.R. 2000. Mice Dificient in Th1 and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 119 : 724-733.
- Kweon, M-N., Yamamoto, M., Kajiki, M., Takahashi, I. and Kiyono, H. 2000. Systemically derived large intestinal CD4+ Th2 cells play a central role for the development of STAT6-mediated allergic diarrhea. J. Clin. Invest. 106 : 199-206.
- Kunisawa, J., Okudaira, A., Tsutsumi, Y., Takahashi, I., Nakanishi, T., Kiyono, H., and Mayumi, T. 2000. Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine 19 : 589-594.
- Koga, T., McGhee, J.R., Kato, H., Kato, R., Kiyono, H. and Fujihashi, K. 2000. Evidence for early aging in the mucosal immune system. J. Immunol. 165 : 5352- 5359.
- Boyaka, P. N., Wright, P.F., Marinaro, M., Kiyono, H., Johnson, JAE., Gonzales, R., Ikizler, M.R., Werkhaven, J.A., Jackson ,R.J., Fujihashi, K., Di Fabio, S., Staats, H. F. and McGhee, J.R. 2000. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. Am. J. Pathol. 157 : 2023-2035.
- Hinoshita, F., Hashimoto, H., Ishikawa, H., Hiroi, T., Kiyono, H., Marushige, F. and Ueno, Y. 2000. Nivalenol as a possible risk in IgA nephropathy. Mycotoxins 50 : 45-51.
- Fujihashi, K., Dohi, T., Rennert, P.D., Yamamoto, M., Koga, T., Kiyono, H. and McGhee, J.R. 2001. Peyer's patches are required for oral tolerance to proteins. Proc. Natl. Acad. Sci. USA. 98 : 3310-3315.
- Byun Y., Ohmura, M., Fuhihashi, K., Yamamoto, S., McGhee, J.R., Udaka, S., Kiyono, H., Takeda, Y., Kohsaka, T. and Yuki, Y. 2001. Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizin antibodies. Vaccine 19 : 2061-2070.
- Saito, M., Otake, S., Ohmura, M., Hirasawa, M., Takeda, K., Mega, J., Takahashi, I., Kiyono, H., McGhee, J.R., Takeda, Y. and Yamamoto, M. 2001. Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant. J. Infect. Dis. 183 : 823-826.
- Simizu, M., Minakuchi, K., Tuda, A., Hiroi, T., Tanaka, N., Koga, J. and Kiyono, H. 2001. A role of stem cell factor and c-kit signaling for the organogenesis of intesine : regulation of fetal intestinal epithelial cell adhesion to fibronectin. Exp. Cell Res. 266 : 311-322.
- Hodge, L. M., Marinaro, M., Jones, H. P., McGhee, J.R., Kiyono, H. and Simecka, J.W 2001. IgA responses and IgE associated inflammation along the repiratory tract after mucosal but not systemic immunization. Infect. Immun.69 : 2328-2338.
- Imaoka, H., Shimaoka, M., Matsuura, N., Nishimura, M., Ohta, N. and Kiyono, H. 2001. Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-β1 mRNA upregulation in rat lungs. Aneth Analg. 92 : 428-436.
- Ohta, N., Shimaoka, M., Imanaka, H., Nishura, M., Taenaka, N. and Kiyono, H. 2001.Steroid attenuates ventilator-induced lung injury. Crit. Care Med. 29 : 1012-1016.
- Kim, J-K., Takahashi, I., Okuda, Y., Itakura, M., McGhee, J.R. and Kiyono, H. 2001. T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin. J. Infect. Dis. 184 : 43-51.
- Yuki, Y., Byun, Y., Fujita, M., Jaurigue, M., Izutani, W., Suzuki, T., Udaka, S., Fujihashi, K., McGhee, J.R. andKiyono, H. 2001. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and protelipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotech. Bioeng. 74 :62-69.
- Kunisawa, J., Nakanishi T., Takahashi, I., Okudaira, A., Tsutsumi, Y., Katayama, K., Nakagawa, S., Kiyono, H., and Mayumi, T. 2001. Novel antigen delivery system using Fusogenic liposome for the induction of mucosal and systemic immune responses. J. Immunol. 167 : 1406-1412.
- Kim, J-K., Takahashi, I. Kai, Y. and Kiyono, H. 2001. Influence of enterotoxin on mucosal intranet : selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin. Eur. J. Immunol. 31: 2960-2969.
- Yura, M., Takahashi, I., Serada, M., Koshino, T., Nakagami, K., Yuki, Y. and Kiyono, H. 2001. Role of MOG-stimulated Th1 type "light-up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis. J. Autoimmunity 17:17-25.
- Yura, M., Takahashi, I., Terawaki, S., Hiroi, T., Kweon, M., Yuki, Y. and Kiyono, H. 2001. Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE). Vaccine. 12 : 134-139.
- Dohi, T., Rennert, P.D., Fujihashi, K., Kiyono, H., Shirai, Y., Kawamura, Y.I., Browning, J.L. and McGhee, J.R. 2001. Elimination of colonic patches with lymphotoxin βreceptor-Ig prevents Th2 cell-type colitis. J. Immunol. 167:2781- 2790.
- Sakaue, G., Shimaoka, M., Fukuoka, T., Hiroi, T., Inoue, T., Sakaguchi, T., Sawa, Y., Morishita, T., Kiyono, H.and Mashimo, T. 2001. NF-kB "decoy" suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport 12: 2079-2084.
- Jones, H.P., Hodge, L.M., Fujihashi, K., Kiyono, H., McGhee, J.R. and Simecka, J.W. 2001. The pulmonary enviroment promotes Th2 cell responses after nasal- pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J. Immunol. 167: 4518-4526.
- Hiroi, T., Goto, H., Someya, K., Yanagita, M.,Honda, M., Yamanaka, N. and Kiyono, H. 2001. HIV mucosal vaccine : nasal immunization with rBCG-V3J1 induces a long- term V3J1-peptide-specific neutralizing immunity in Th1 and Th2 deficient conditions. J. Immunol. 167 : 5862-5867.
- Ohmura, M., Yamamoto, M., Kiyono, H., Fujihashi, K., Takeda, Y. and McGhee, J.R. 2001. Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine 20: 756-762.
- Hamada, H., Hiroi, T., Nishiyama, Y., Takahashi, H., Masunaga, Y., Hachimura, S., Kaminogawa, S., Takahashi-Iwanaga, H., Iwanaga, T., Kiyono, H., Yamamoto, H. and Ishikawa, H. 2002. Identification of multipe isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J. Immunol. 168 : 57-64.
- Kweon, M-N., Takahashi, I., Yamamoto, M., Jang, M-H., Suenobu, N. and Kiyono, H. 2002. Development of antigen-induced enterocolitis in SCID mice reconstituted with spleen-derived memory type CD4+ CD45RB+ T cells. Gut 50 :299-306.
- Takahashi, I., Matsuda, J., Gapin, L., DeWinter, H., Kai, Y., Tamagawa, H., Kronenberg, M. and Kiyono, H. 2002. Colitis-related public T cells are selected in the colonic lamina propria of IL-10 deficient mice. Clin. Immunol. 102 : 237-248.
- Kunisawa, J., Takahashi, I., Okudaira, A., Tsutsumi, Y., Katayama, K., Hiroi, T., Nakagawa, S., Kiyono, H. and Mayumi, T. 2002. Lack of antigen-specific immune responses in anti-IL-7α antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur. J. Immunol. 32 :2347-2355.
- Ueta, M., Kweon, M-N., Sano, Y., Sotozono, C., Yamada, J., Koizumi, N., Kiyono, H. and Kinoshita, S. 2002. Immunosuppressive properties of human aminiotic membarane for mixed lymphocyte reaction. Clin. Exp. Immunol.129 : 464-470.
- Ohta, N., Hiroi, T., Kweon, M-N., Kinoshita, N., Jang, M-H., Miyazaki, J. and Kiyono, H. 2002. IL-15 induced CD8αβ+ NK1.1+T cells in the development of small itestinal inflammation in T3b-IL-15 Tg mice. J.Immunol. 169 : 4 60-468.
- Suenobu, N., Kweon, M-N. and Kiyono, H. 2002. Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitis. Vaccine 20 : 2972-2980.
- Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P.D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y. and Kiyono, H. 2002. NALT organogenesisn is independent of the IL-7R, LT α1β2/LTβR and NIK signaling pathways but does require the Id2 gene and CD3- CD4+CD45+ cells. Immunity 17: 31-40.
- Watanabe, I., Hagiwara, Y., Kadowaki, S., Yoshikawa, T., Komase, K., Aizawa, C., Kiyono, H., Takeda, Y., McGhee, J.R., Chiba, J., Sata, T., Kurata, T. and Tammura, S. 2002. Characterization of protective immune responses induced by nasal influenza vaccine ccontaining mutant cholera toxin as a safe adjuvant (CT112K). Vaccine 20 : 3443-3455
- Yanagita, M., Shimabukuro, Y., Nozaki, T., Yoshimura, N., Watanabe, J., Koide, H., Terakura, M., Saho, T., Takedachi, M., Jang, M-H., Kiyono, H. and Murakami, S. 2002. IL-15 up-regulates iNOS expression and NO production by gingval epithelial cells. Biochem. Biophysical. Res. Commun. 297 : 329-334.
- Kweon, M-N., Yamamoto, M., Watanabe, F., Tamura, S., F.W, van Ginkel., Miyauchi, A., Takagi, H., Takeda, Y., Hamabata, T., Fujihashi, K., J.R. McGhee. and Kiyono, H. 2002. A non-toxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE Ab. J. Infect. Dis. 186 : 1261-1269.
- Kinoshita, N., Hiroi, T., Ohta, N., Fukuyama, S., E. J. Park. and Kiyono, H. 2002. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J. Immunol. 169 : 6187-6192.
- Sakaue, G., Hiroi, T., Nakagawa, Y., Someya, K., Iwatani, K., Sawa, Y., Takahashi, H., Honda, M., Kunisawa, J. and Kiyono, H. 2002. HIV mucosal vaccine: nasal immunization with gp160 enapsulated HVJ-liposome induces antigen-specific CTL and neutralizing antibody responses. J. Immunol. 170 : 495-502.
- Kweon, M-N. and Kiyono, H. 2002. CD40L in auto immunity and mucosally induced tolerance. J. Clin. Invest.109 : 171-173.
- Kawahara, M., Matsuo, K., Nakasone,T., Hiroi,T.,Kiyono,H., Matsumoto, S., Yamada, T., Yamamoto, N. and Honda, M. 2002. Combined intrarectal/intradermal inoculation of recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) induces enhanced immune responses against the inserted HIV-1 V3 antigen. Vaccine 21: 158-66.
- Okuda, Y., Takahashi, I., Kim, J-K., Ohta, N., Iwatani, K., Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M-N., Kawano, S., Sasaki, Y., Hori, M.,Takeda, K., Akira, S. and Kiyono, H. 2003. Development of colitis in STAT6-deficient TCRα-/- mice : A potential of STAT6-independent IL-4 signaling for the generation of Th2-biased pathologic CD4+ββT cells. Am. J. Pathol. 162 : 263-271.
- Boyaka, P.N., Ohmura, M., Fujihashi, K., Koga, T., Yamamoto, M., Kweon, M-N., Takeda, Y., Jackson, R.J., Kiyono, H., Yuki, Y. and Kiyono, H. 2003. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. J. Immunol. 170 : 454-462.
- Hagiwara, Y., McGhee, J.R., Fujihashi, K., Kobayashi, R., Yoshino, N., Kataoka, K., Etani, Y., Kweon, M-N., Tamura, S., Kurata, T., Takeda, Y., Kiyono, H. and Fujihashi, K. 2003. Protective mucosal immunity in aging is associated with functional CD4+T cells in nasopharyngeal-associated lymphoreticular tissue. J. Immunol. 15: 1754-1762.
- Kobayashi, M., Kweon, M-N., Kuwata, H., Schreiber, R.D., Kiyono, H., Takeda, K., and Shizuo, A. 2003. Toll-like recepter-dependent production of IL-12p40 causes Chronic enterocolitis in myeloid cell-specific Stat3-dificient mice. J. Clin. Invest. 111:1297-1308.
- Tamagawa, H., Takahashi, I., Furuse, M., Yoshitake-Kitano, Y., Tsukita, S., Itoh, T., Matsuda, H., and Kiyono, H.2003. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region. Lab. Invest. 83 : 1045-1053
- Yuki, Y. and Kiyono, H. 2003. New generation of mucosal adjuvants for the induction of protective immunity. Rev. Med. Virol. 13: 293-310
- Jang, MH., Kweon, M-N., Hiroi T., Yamamoto, M., Takahashi, I. and Kiyono, H. 2003. Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells. Vaccince 21: 1613-1619
- Kweon, M-N. and Kiyono, H. 2003. Eosinophilic gastroenteritis: a problem of the mucosal immune system? Curr. Allergy Asthma Rep. 3: 79-85
- Park, EJ., Takahashi, I., Ikeda J., Kawahara, K., Okamoto, T., Kweon, M-N..,Fukuyama, S., Groh, V., Spies, T., Obata, Y., Miyazaki, J. and Kiyono, H. 2003. Clonal expansion of double-positive (DP) IELs by MICA expressed in mouse small intestinal epithelium. J. Immunol. 171: 4131-4139
- Jang, M.H., Kweon, M-N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P.D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and Kiyono, H. 2004. Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. USA 101: 6110-6115.
- Hino, A., Kweon, M-N., Fujihashi, K., McGhee, J.R., and Kiyono, H. 2004. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. Am. J. Pathol. 164: 1327-1335.
- Shikina,T., Hiroi,T., Iwatani,K., Jang,MH., Fukuyama,S., Tamura,M., Kubo,T., Ishikawa,H. and Kiyono,H. 2004 IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J. Immunol. 172: 6259-6264
- Yamamoto, M., Kweon, M-N., Rennert, P.D., Hiroi, T., Fujihashi, K., McGhee, J.R. and Kiyono, H. 2004. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J. Immunol. 173: 762-769
- Ohmura-Hoshino, M., Yamamoto, M., Yuki, Y., Takeda, Y. and Kiyono, H. 2004. Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity. Vaccine. 22: 3751-3761
- Ueta, M., Nochi, T., Jang, M.H., Perk, E.J., Igarashi, O., Hino, A., Kawasaki, S., Shikina, T., Hiroi, T., Kinoshita, S. and Kiyono, H. 2004. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 173: 3337-3347
- Kiyono, H. and Fukuyama, S. 2004. Nalt- versus peyer's-patch-mediated mucosal immunity. Nat. Rev. Immunol. 4: 699-710
- Nochi, T., Yuki, Y., Terahara, K., Hino, A., Kunisawa, J., Kweon, MN., Yamaguchi, T. and Kiyono, H. 2004. Biological role of Ep-CAM in the physical interaction between epithlial cells and lymphocytes in intestinal epithelium. Clin. Immunol. 113: 326-339
- Yoshino, N., Lu, FX., Fujihashi, K., Hagiwara, Y., Kataoka, K., Lu, D., Hirst, L., Honda, M., van Ginke., FW., Tekeda, Y., Miller, CJ., Kiyono, H. and McGhee, JR. 2004. A novel adjuvant for mucosal immunity to HIV-1gp120 in nonhuman primates. J. Immunol. 173: 6850-6857