"Long-term Immunoprophylaxis by TLR9 Ligand Mediates Macrophage-ILC Crosstalk Against Respiratory Viral Infection"
Science Advances Online 9 October 2026 doi:10.1126/sciadv.aeh6480
Could a Vaccine Adjuvant Help Prepare for Future Pandemics?
Description
Published Article
Asuka Joy Tobuse1,2, Kouji Kobiyama1,3,4, Jun Tsuchida1, Masamitsu N. Asaka5,6, Daichi Utsumi5, Mariana Silva Almeida3,7,8, Yaeko Nakajima-Takagi9, Motohiko Oshima9, Tomoya Hayashi1,3,8, Burcu Temizoz1,3,8, Etsushi Kuroda10, Cevayir Coban2,3,7,8, Yasuhiro Yasutomi5,11, Atsushi Iwama2,8,9, and Ken J. Ishii1,2,3,8
1Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
2Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Japan
3International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan
4Division of Rheumatology, Department of medicine, University of California San Diego, United States
5Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Japan
6Leprosy Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan
7Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
8The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Japan
9Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
10Department of Immunology, Hyogo Medical University School of Medicine, Japan
11Institute for Vaccine Research and Development, Hokkaido University, Japan
1Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
2Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Japan
3International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan
4Division of Rheumatology, Department of medicine, University of California San Diego, United States
5Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Japan
6Leprosy Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, Japan
7Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
8The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Japan
9Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Japan
10Department of Immunology, Hyogo Medical University School of Medicine, Japan
11Institute for Vaccine Research and Development, Hokkaido University, Japan
