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Evaluating the Safety and Efficacy of a Smallpox Vaccine for Preventing Mpox

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Press Release

Published Article

"Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox "

eBioMedicine Online 01 May 2025 doi:10.1016/j.ebiom.2025.105703

Kouji Kobiyama,a,b Daichi Utsumi,c Yu Kaku,d Eita Sasaki,e Fumihiko Yasui,f Tomotaka Okamura,c Taishi Onodera,e Asuka Joy Tobuse,a,l Areej Sakkour,a Ahmad Faisal Amiry,f Tomoya Hayashi,a Burcu Temizoz,a Kaiwen Liu,a Hideo Negishi,n Noriko Toyama-Sorimachi,g,o Michinori Kohara,f Tatsuya Sawasaki,h Junichi Takagi,i Kei Sato,b,d,j,k,l Yoshimasa Takahashi,e Yasuhiro Yasutomi,c and Ken J. Ishiia,b,k,l,m

aDivision of Vaccine Science, The Institute of Medical Science, The University of Tokyo, Japan
bInternational Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan
cLaboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Japan 
dDivision of Systems Virology, The Institute of Medical Science, The University of Tokyo, Japan 
eResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Japan 
fDepartment of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Japan 
gDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
hProteo-Science Center (PROS), Ehime University, Japan
iLaboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Japan 
jInternational Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Japan 
kGraduate School of Medicine, The University of Tokyo, Japan 
lDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan 
mThe University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Japan
nInstitute for Quantitative Biosciences, The University of Tokyo, Japan
oDivision of Human Immunology, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan

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