Evaluating the Safety and Efficacy of a Smallpox Vaccine for Preventing Mpox

"Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox "

eBioMedicine Online 01 May 2025 doi:10.1016/j.ebiom.2025.105703

Kouji Kobiyama,^a,b Daichi Utsumi,^c Yu Kaku,d Eita Sasaki,^e Fumihiko Yasui,^f Tomotaka Okamura,^c Taishi Onodera,^e Asuka Joy Tobuse,^a,l Areej Sakkour,^a Ahmad Faisal Amiry,^f Tomoya Hayashi,^a Burcu Temizoz,^a Kaiwen Liu,^a Hideo Negishi,ⁿ Noriko Toyama-Sorimachi,^g,o Michinori Kohara,^f Tatsuya Sawasaki,^h Junichi Takagi,ⁱ Kei Sato,^b,d,j,k,l Yoshimasa Takahashi,^e Yasuhiro Yasutomi,^c and Ken J. Ishii<sup>a,b,k,l,m

a</sup>Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo, Japan
^bInternational Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan
^cLaboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Japan 
^dDivision of Systems Virology, The Institute of Medical Science, The University of Tokyo, Japan 
^eResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Japan 
^fDepartment of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Japan 
^gDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
^hProteo-Science Center (PROS), Ehime University, Japan
ⁱLaboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Japan 
^jInternational Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Japan 
^kGraduate School of Medicine, The University of Tokyo, Japan 
^lDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Japan 
^mThe University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Japan
ⁿInstitute for Quantitative Biosciences, The University of Tokyo, Japan
^oDivision of Human Immunology, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Japan