Herpesvirus Protein Mimics Host Enzyme to Balance Infection and Latency

"Regulatory Mimicry of Cyclin-Dependent Kinases by a Conserved Herpesvirus Protein Kinase"

Proceedings of the National Academy of Sciences Online 16 April 2025 doi:10.1073/pnas.2500264122

Naoto Koyanagi^1,2,3, Kowit Hengphasatporn⁴, Akihisa Kato^1,2,3, Moeka Nobe¹, Kosuke Takeshima^1,2, Yuhei Maruzuru^1,2,3, Katsumi Maenaka^5,6, Yasuteru Shigeta⁴ , and Yasushi Kawaguchi<sup>1,2,3,7

1</sup>Division of Molecular Virology, Department of Microbiology and Immunology, the Institute of Medical Science, The University of Tokyo, Japan
²Department of Infectious Disease Control, International Research Center for Infectious Diseases, the Institute of Medical Science, The University of Tokyo, Japan
³Research Center for Asian Infectious Diseases, the Institute of Medical Science, The University of Tokyo, Japan
⁴Center for Computational Sciences, University of Tsukuba, Japan
⁵Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
⁶Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
⁷The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center, Japan