"Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan"
Blood Online 25 March 2025 doi:10.1182/blood.2024025776
Clusterin Expression Marks Aging in Hematopoietic Stem Cells
Description
Published Article
Shuhei Koide1, Motohiko Oshima1, Takahiro Kamiya1, Zhiqian Zheng1, Zhaoyi Liu1, Ola Rizq1, Akira Nishiyama2, Koichi Murakami2,3, Yuta Yamada1, Yaeko Nakajima-Takagi1, Bahityar Rahmutulla4, Atsushi Kaneda4,5, Kazuaki Yokoyama6, Nozomi Yusa7, Seiya Imoto8, Fumihito Miura9, Takashi Ito9, Tomohiko Tamura2,3, Claus Nerlov10, Masayuki Yamashita1,11, and Atsushi Iwama1,12,13
1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
2Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
3Advanced Medical Research Center, Yokohama City University, Yokohama, Japan
4Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
5Health and Disease Omics Center, Chiba University, Chiba, Japan
6 Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
7 Department of Laboratory Medicine, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
8 Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
9 Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
10 MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
11 Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
12 Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
13 The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan
1Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
2Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
3Advanced Medical Research Center, Yokohama City University, Yokohama, Japan
4Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
5Health and Disease Omics Center, Chiba University, Chiba, Japan
6 Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
7 Department of Laboratory Medicine, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
8 Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
9 Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
10 MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
11 Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
12 Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
13 The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan
