Phage-Derived Enzyme Targets E. faecalis Biofilms to Mitigate Acute Graft-Versus-Host Disease

"An enterococcal phage-derived enzyme suppresses graft-versus-host disease"

Nature Online 10 July 2024 doi:10.1038/s41586-024-07667-8

Kosuke Fujimoto^1,2,*, Tetsuya Hayashi^1,3,*, Mako Yamamoto⁴, Noriaki Sato⁴, Masaki Shimohigoshi¹, Daichi Miyaoka¹, Chieko Yokota¹, Miki Watanabe¹, Yuki Hisaki¹, Yukari Kamei¹, Yuki Yokoyama¹, Takato Yabuno¹, Asao Hirose³, Mika Nakamae^3,5, Hirohisa Nakamae³, Miho Uematsu¹, Shintaro Sato^1,6, Kiyoshi Yamaguchi⁷, Yoichi Furukawa⁷, Yukihiro Akeda⁸, Masayuki Hino^3,5, Seiya Imoto^4,9, and Satoshi Uematsu<sup>1,2,9,10,11

1</sup>  Department of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University
²  Division of Metagenome Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo
³  Hematology, Graduate School of Medicine, Osaka Metropolitan University
⁴  Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo 
⁵  Department of Laboratory Medicine and Medical Informatics, Graduate School of Medicine, Osaka Metropolitan University
⁶  Department of Microbiology and Immunology, School of Pharmaceutical Sciences, Wakayama Medical University
⁷  Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo
⁸  Department of Bacteriology I, National Institute of Infectious Diseases
⁹  Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
¹⁰  Reseach Institute for Drug Discovery Science, Osaka Metropolitan University
¹¹  International Research Center for Infectious Diseases, Osaka Metropolitan University