High Body Temperature Increases Resistance to Pathogenic Viral Infections, New Study Finds

"High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection "

Nature Communications Online June 30, 2023 doi:10.1038/s41467-023-39569-0

Minami Nagai¹, Miyu Moriyama¹, Chiharu Ishii², Hirotake Mori³, Hikaru Watanabe⁴, Taku Nakahara⁴, Takuji Yamada^4,5, Dai Ishikawa^4,6,7, Takamasa Ishikawa², Akiyoshi Hirayama², Ikuo Kimura^8,9, Akihito Nagahara^6,7, Toshio Naito¹⁰, Shinji Fukuda ^{11,12,13,14,15}, Takeshi Ichinohe¹⁶
 

• ¹Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
• ²Institute for Advanced Biosciences, Keio University, Yamagata, Japan.
• ³Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.
• ⁴Metagen Therapeutics, Inc., Yamagata, Japan.
• ⁵Department of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
• ⁶Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
• ⁷Department of Gastroenterology, Juntendo University Faculty of Medicine, Tokyo, Japan.
• ⁸Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
• ⁹Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
• ¹⁰Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan. 
• ¹¹Institute for Advanced Biosciences, Keio University, Yamagata, Japan. 
• ¹²Metagen Therapeutics, Inc., Yamagata, Japan. 
• ¹³Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. 
• ¹⁴Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan. 
• ¹⁵Transborder Medical Research Center, University of Tsukuba, Ibaraki, Japan. 
• ¹⁶Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.