A study led by Toshihiro Kobayashi, a project associate professor at the division of mammalian embryology, The Institute of Medical Science, The University of Tokyo revealed rabbit embryos provide an essential surrogate model for the inaccessible human embryo, as exemplified by observations on the emergence of primordial germ cells (PGCs), precursors of sperm and eggs, in gastrulating rabbit embryos. Published in Cell Reports on October 12th, 2021, the study establishes rabbits as a highly accessible experimental model for other crucial aspects of early human development.
Press release
Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells
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Published Article
"Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells"
Cell Reports Volume 37, ISSUE 2, 109812, October 12, 2021 doi:10.1016/j.celrep.2021.109812
Toshihiro Kobayashi*, Aracely Castillo-Venzor, Chris A. Penfold, Michael Morgan, Naoaki Mizuno, Walfred W.C. Tang, Yasuyuki Osada, Masao Hirao, Fumika Yoshida, Hideyuki Sato, Hiromitsu Nakauchi, Masumi Hirabayashi*, M. Azim Surani*（*Corresponding author）