Division of Genome Engineering

Genome engineering technologies, such as Zinc finger nucleases (ZFNs), TAL effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) nucleases (CRISPR/Cas), have widely used in life science and medical science. We are developing novel genome editing tools to overcome technical and patent limitation of CRISPR-Cas9 system. We are also developing the efficient genome editing strategies with these tools in rodents. These technologies facilitate easy and flexible gene editing in living organisms.