2009年

• Sakuma T, Noda T, Urata S, Kawaoka Y, Yasuda J. Inhibition of Lassa and Marburg virus production by tetherin. J Virol 83:2382-2385, 2009.
  
• Murakami S, Horimoto T, Mai le Q, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y. Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. J Virol 82:10502-10509, 2009.
  
• Watanabe T, Watanabe S, Shinya K, Kim JH, Hatta M, Kawaoka Y. Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc Natl Acad Sci U S A 106:588-592, 2009.
  
• Marsolais D, Hahm B, Walsh KB, Edelmann KH, McGavern D, Hatta Y, Kawaoka Y, Rosen H, Oldstone MB. A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc Natl Acad Sci U S A 106:1560-1565, 2009.
  
• Ozawa M, Maeda J, Iwatsuki-Horimoto K, Watanabe S, Goto H, Horimoto T, Kawaoka Y. Nucleotide sequence requirements at the 5' end of the influenza A virus M RNA segment for efficient virus replication. J Virol (in press).
  
• Kakugawa S, Shimojima M, Goto H, Horimoto T, Oshimori N, Neumann G, Yamamoto T, Kawaoka Y. The MAPK-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. J Virol (in press).
  
• Fan S, Deng G, Song J, Tian G, Suo Y, Jiang Y, Guan Y, Bu Z, Kawaoka Y, Chen H. Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice. Virology (in press).
  
• Halfmann P, Ebihara H, Marzi A, Hatta Y, Watanabe S, Suresh M, Neumann G, Feldmann H, Kawaoka Y. Replication-Deficient Ebolavirus as a Vaccine Candidate. J Virol (in press).
  
• Li Z, Watanabe T, Hatta M, Watanabe S, Nanbo A, Ozawa M, Kakugawa S, Shimojima M, Yamada S, Neumann G, Kawaoka Y. Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein. J Virol (in press).
  
• Neumann G, Watanabe S, Kawaoka Y. Characterization of Ebolavirus Regulatory Genomic Regions. Virus Res (in press).
  
• Le QM, Sakai-Tagawa Y, Ozawa M, Ito M, Kawaoka Y. Selection of H5N1 influenza virus PB2 during replication in humans. J Virol (in press).
  
• Tamura D, Mitamura K, Yamazaki M, Fujino M, Nirasawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Hiroi S, Takahashi K, Hatta M, Minagawa H, Kimura Y, Kaneda S, Sugita S, Horimoto T, Sugaya N, Kawaoka Y. Oseltamivir-Resistant Influenza A Viruses Circulating in Japan. J Clin Micro (in press).
  
• Takano R, Nidom CA, Kiso M, Muramoto Y, Yamada S, Shinya K, Sakai-Tagawa Y, Kawaoka Y. A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia. Arch Virol (in press)
  
• Fan S, Gao Y, Shinya K, Li CK, Li Y, Shi J, Jiang Y, Suo Y, Tong T, Zhong G, Song J, Zhang Y, Tian G, Guan Y, Xu XN, Bu Z, Kawaoka Y, Chen H. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates. PLoS Pathogens (in press).
  
• Hatta M, Kohlmeier CK, Hatta Y, Ozawa M, Kawaoka Y. The region required for protein expression from the stop-start pentanucleotide in the M gene of influenza B virus. J Virol (in press).
  
• Watanabe S, Watanabe T, Kawaoka Y. Influenza A virus lacking M2 protein as a live attenuated vaccine. J Virol (in press).
  
• Fujii F, Ozawa M, Iwatsuki-Horimoto K, Horimoto T, Kawaoka Y. The incorporation of influenza A virus genome Segments Does Not Absolutely Require Wild-Type Sequences. J Gen Virol (in press).
  
• Kakugawa S, Shimojima M, Neumann G, Goto H, Kawaoka Y. RuvB-like 2 protein is a suppressor of influenza A virus polymerases. J Virol (in press).
  
  

　2008年

• Murakami S, Horimoto T, Yamada S, Kakugawa S, Goto H, Kawaoka Y. Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus: its application for H5N1 vaccine production. J Virol 82:1605-1609, 2008.
  
• Zhu Q, Yang H, Chen W, Cao W, Zhong G, Jiao P, Deng G, Yu K, Yang C, Bu Z, Kawaoka Y, Chen H. A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens. J Virol 82:220-228, 2008.
  
• Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H. A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine 26:562-572, 2008.
  
• Watanabe T, Watanabe S, Kim JH, Hatta M, Kawaoka Y. A novel approach to the development of effective H5N1 influenza A virus vaccines: the use of M2 cytoplasmic tail mutants. J Virol 82:2486-2492, 2008.
  
• Halfmann P, Kim JH, Ebihara H, Noda T, Neumann G, Feldmann H, Kawaoka Y. Generation of biologically contained Ebolaviruses. Proc Natl Acad Sci USA 105: 1129-1133, 2008.
  
• Yamayoshi S, Noda T, Ebihara H, Goto H, Morikawa Y, Lukashevich IS, Neumann G, Feldmann H, Kawaoka Y. Ebola virus matrix VP40 protein uses the COPII transport system for its intracellular transport. Cell Host&Microbe 3:168-177, 2008.
  
• Iwatsuki-Horimoto K, Hatta Y, Hatta M, Muramoto Y, Chen H, Kawaoka Y, Horimoto T. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Res 135:161-165, 2008.
  
• Sakabe S, Sakoda Y, Haraguchi Y, Isoda N, Soda K, Takakuwa H, Saijo K, Sawata A, Kume K, Hagiwara J, Tuchiya K, Lin Z, Sakamoto R, Imamura T, Sasaki T, Kokumai N, Kawaoka Y, Kida H. A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens. Vaccine 26:2127-2134, 2008.
  
• Sawai T, Itoh Y, Ozaki H, Isoda N, Okamoto K, Kashima Y, Kawaoka Y, Takeuchi Y, Kida H, Ogasawara K. Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin. Immunology 124:155-165, 2008.
  
• Sugaya N, Tamura D, Yamazaki M, Ichikawa M, Kawakami C, Kawaoka Y, Mitamura K. Comparison of the clinical effectiveness of oseltamivir and zanamivir against influenza virus infection in children. Clin Infect Dis 47:339-345, 2008.
  
• Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, Newton MA, Ahlquist P, Kawaoka Y. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454:890-893, 2008.
  
• Murakami S, Iwasa A, Iwatsuki-Horimoto K, Ito M, Kiso M, Kida H, Takada A, Nidom CA, Mai le Q, Yamada S, Imai H, Sakai-Tagawa Y, Kawaoka Y, Horimoto T. Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model. Vaccine 26:6398-6404, 2008.
  
• Marsolais D, Hahm B, Edelmann KH, Walsh KB, Guerrero M, Hatta Y, Kawaoka Y, Roberts E, Oldstone MB, Rosen H. Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol Pharmacol 74:896-903, 2008.
  
• WHO/OIE/FAO H5N1 Evolution Working Group. Toward a unified nomenclature system for highly pathogenic avian influenza virus (H5N1). Emerg Infect Dis. 14:e1, 2008.
  
• Jia B, Shi J, Li Y, Shinya K, Muramoto Y, Zeng X, Tian G, Kawaoka Y, Chen H. Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons. Arch Virol 153:1821-1826, 2008.
  
• Li C, Hatta M, Watanabe S, Neumann G, Kawaoka Y. Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses. J Virol. 82:11880-11888, 2008.
• Gambotto A, Barratt-Boyes SM, de Jong MD, Neumann G, Kawaoka Y. Highly pathogenic H5N1 influenza virus infection in humans. Lancet 371:1464-1475, 2008.
• Neumann G, Horimoto T, Kawaoka Y. Reverse Genetics of Influenza Viruses - Applications in Research and Vaccine Design. In: Avian Influenza. Monogr Virol. Klenk H-D, Matrosovich MN, Stech J, eds. Karger, vol 27, pp.118-133, 2008.
• de Wit E, Kawaoka Y, de Jong MD, Fouchier RA. Pathogenicity of highly pathogenic avian influenza virus n mammals. Vaccine Suppl 4:D54-58, 2008.
  
  

　2007年

• Darwyn K, Jones, SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:23, 2007.
  
• Takada A, Ebiharab H, Jones S, Feldmannd H, Kawaoka Y. Protective efficacy of neutralizing antibodies against Ebola virus infection. Vaccine 25:993-999, 2007.
  
• Ozawa M, Fujii K, Muramoto Y, Yamada S, Yamayoshi S, Takada A, Goto H, Horimoto T, Kawaoka Y. Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication. J Virol 81:30-41, 2007.
  
• Neumann G, Geisbert TW, Ebihara H, Geisbert JB, Daddario-Dicaprio KM, Feldmann H, Kawaoka Y. Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Critical for Ebola Virus Replication in Nonhuman Primates. J Virol 81, 2995-2998, 2007.
  
• Noda T, Watanabe S, Sagara H, Kawaoka Y. Mapping of theVP40-binding regions of the Nucleoprotein of Ebola virus. J Virol 81, 3554-3562, 2007.
  
• Garulli B, Meola M, Stillitano MG, Kawaoka Y, Castrucci MR. Efficient vagina-to-lower respiratory tract immune trafficking in a murine model of influenza A virus infection. Virology 361, 274-282, 2007.
  
• Kurosaki Y, Takada A, Ebihara H, Grolla A, Kamo N, Feldmann H, Kawaoka Y, Yasda J. Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification. J Virol Methods 141, 78-83, 2007.
  
• Sugaya N, Mitamura K, Yamazaki M, Tamura D, Ichikawa M, Kimura K, Kawakami C, Kiso M, Ito M, Hatakeyama S, Kawaoka Y. Lower clinical effectiveness of oseltamivir against influenza B contrasted with influenza A infection in children. Clin Infect Dis 44:197-202, 2007.
  
• Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y. Emergence of Influenza B Viruses with Reduced Sensitivity to Neuraminidase Inhibitors. JAMA 297, 1435-1442, 2007.
  
• Urata S, Noda T, Kawaoka Y, Morikawa S, Yokosawa H, Yasuda J. Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP. J Virol 81:4895-4899, 2007.
  
• Horimoto T, Murakami S, Muramoto Y, Yamada S, Fujii K, Kiso M, Iwatsuki-Horimoto K, Kino Y, Kawaoka Y. Enhanced growth of seed viruses for H5N1 influenza vaccines. Virology 366:23-27, 2007.
  
• Ozawa M, Goto H, Horimoto T, Kawaoka Y. An adenoviral vector-mediated reverse genetics system for influenza A virus generation. J Virol 81:9556-9559, 2007.
  
• Hatta M, Hatta Y, Kim JH, Watanabe S, Shinya K, Kawaoka Y. Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice PLoS Pathog 3:1374-1379, 2007.
  
• Rigoni M, Shinya K, Toffan A, Milani A, Bettini F, Kawaoka Y, Cattoli G, Capua I. Pneumo- and eurotropism of avian origin Italian highly pathogenic avian influenza H7N1 isolates in experimentally infected mice. Virology 364, 28-35, 2007.
  
• Guo CT, Takahashi N, Yagi H, Kato K, Takahashi T, Yi SQ, Chen Y, Ito T, Otsuki K, Kida H, Kawaoka Y, Hidari KI, Miyamoto D, Suzuki T, Suzuki Y. The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors. Glycobiology 17, 713-724, 2007.
  
• Sawada T, Hashimoto T, Nakano H, Suzuki T, Suzuki Y, Kawaoka Y, Ishida H, Kiso M. Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor. Biochem Biophys Res Commun 355:6-9, 2007.
  
• Shinya K, Watanabe S, Ito T, Kasai N, Kawaoka Y. Adaptation of an H7N7 equine influenza A virus in mice. J Gen Virol 88, 547-532, 2007.
  
• Takada A, Ebihara H, Feldmann H, Geisbert TW, Kawaoka Y. Epitopes required for antibodydependentenhancement of Ebola virus infection. J Infect Dis 196 Suppl 2:S347-356, 2007.
  
• Ebihara H, Theriault S, Neumann G, Alimonti JB, Geisbert JB, Hensley LE, Groseth A, Jones SM, Geisbert TW, Kawaoka Y, Feldmann H. in vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein. J Infect Dis 196 Suppl 2:S313-322, 2007.
  
• Yamayoshi S, Kawaoka Y. Mapping of a region of Ebola virus VP40 that is important in the production of virus-like particles. J Infect Dis 196 Suppl 2:S291-295, 2007.
  
• Watanabe S, Noda T, Halfmann P, Jasenosky L, Kawaoka Y. Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome. J Infect Dis 196 Suppl 2:S284-290, 2007.
  
• Shimojima M, Ikeda Y, Kawaoka Y. The mechanism of Axl-mediated Ebola virus infection. J Infect Dis 196 Suppl 2:S259-263, 2007.
  
• Noda T, Halfmann P, Sagara H, Kawaoka Y.Regions in Ebola virus VP24 that are important for nucleocapsid formation. J Infect Dis 196 Suppl 2:S247-250, 2007.
  
• Jiao P, Tian G, Li Y, Deng G, Jiang Y, Liu C, Liu W, Bu Z, Kawaoka Y, Chen H. A single amino acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. J Virol 82:1146-1154, 2007.
  
• Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, Kozaki S, Igarashi O, Kiyono H. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med 204:2789-2796, 2007.
• Neumann G, Kawaoka Y. Influenza Viruses: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester. (in press).
  
• Wright PF, Neumann G, Kawaoka Y. Orthomyxoviruses. In: Fields Virology. Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE, eds. Wolters Kluwer, Lippincott Williams & Wilkins, Philadelphia, 2007. Chapter 48, pp. 1691-1740.
  
• Gabriele Neumann, Kyoko Shinya, Yoshihiro Kawaoka. Molecular pathogenesis of H5N1 influenza virus infections. Antiviral Therapy 12:617-626, 2007.
  
  

　2006年

• Horimoto T, Takada A, Fujii K, Goto H, Hatta M, Watanabe S, Iwatsuki-Horimoto K, Ito M, Tagawa-Sakai Y, Yamada S, Ito H, Ito T, Imai M, Itamura S, Odagiri T, Tashiro M, Lim W, Guan Y, Peiris M, Kawaoka Y. The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate. Vaccine 24:3669-3676, 2006.
  
• Muramoto Y, Ozaki H, Takada A, Park CH, Sunden Y, Umemura T, Kawaoka Y, Matsuda H, Kida H. Highly pathogenic H5N1 influenza virus causes coagulopathy in chickens. Microbiol Immunol 50:73-81, 2006.
  
• Urata S, Noda T, Kawaoka Y, Yokosawa H, Yasuda J. Cellular factors required for Lassa virus budding. J Virol 80:4191-4195, 2006.
  
• Watanabe S, Noda T, Kawaoka Y. Functional mapping of the nucleoprotein of Ebola virus. J Virol 80:3743-3751, 2006.
  
• Muramoto Y, Takada A, Fujii K, Noda T, Iwatsuki-Horimoto K, Watanabe S, Horimoto T, Kida H, Kawaoka Y. Hierarchy among vRNA segments in their role in vRNA incorporation into influenza A virions. J Virol 80:2318-25, 2006.
  
• Bar S, Takada A, Kawaoka Y, Alizon M. Detection of cell-cell fusion mediated by the Ebola virus glycoproteins. J Virol 80:2815-22, 2006.
  
• Iwatsuki-Horimoto K, Horimoto T, Noda T, Kiso M, Maeda J, Watanabe S, Muramoto Y, Fujii K, Kawaoka Y. The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. J Virol 80:5233-5240, 2006.
  
• Chen H, Li Y, Li Z, Shi J, Shinya K, Deng G, Qi Q, Tian G, Fan S, Zhao H, Sun Y, Kawaoka Y. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J Virol 80:5976-5983, 2006.
  
• Muramoto Y, Le TQ, Phuong LS, Nguyen T, Nguyen TH, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Horimoto T, Kida H, Kawaoka Y. Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005. J Vet Med Sci 68:527-531, 2006.
  
• Kogure T, Suzuki T, Takahashi T, Miyamoto D, Hidari KI, Guo CT, Ito T, Kawaoka Y, Suzuki Y. Human trachea primary epithelial cells express both sialyl(alpha2-3)Gal receptor for human parainfluenza virus type 1 and avian influenza viruses, and sialyl(α2-6)Gal receptor for human influenza viruses. Glycoconj J 23:101-106, 2006.
  
• Noda T, Sagara H, Yen A, Takada A, Kida A, Cheng RH, Kawaoka Y. Architecture of ribonucleoprotein complexes in influenza A virus particles. Nature 439:490-492, 2006.
  
• Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y. Influenza virus receptors in the human airway. Nature 440:435-436, 2006.
  
• Ebihara H, Takada A, Kobasa D, Jones S, Neumann G, Theriault S, Bray M, Feldmann H, Kawaoka Y. Molecular determinants of Ebola virus virulence in mice. PLoS Pathog 2: 705-711, 2006.
  
• Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. J Virol 80: 10109-10116, 2006.
  
• Noda T, Ebihara H, Muramoto Y, Fujii K, Takada A, Sagara H, Kim JH, Kida H, Feldmann H, Kawaoka Y. Assembly and budding of Ebolavirus. PLoS Pathog 2:864-872, 2006.
  
• Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso K, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y. Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378-382, 2006.
  
• Co DO, Hogan LH, Karman J, Heninger E, Vang S, Wells K, Kawaoka Y, Sandor M. Interactions between T cells responding to concurrent mycobacterial and influenza infections. J Immunol 177:8456-8465, 2006.
• Neumann G, Kawaoka Y. Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis 12:881-886, 2006.
  
• Horimoto T, Kawaoka Y. Strategies for developing vaccines against H5N1 influenza A viruses. Trends Mol Med 12:506-154, 2006.
  
• Neumann G, Kawaoka Y. Influenza Epidemics. In: ENCYCLOPEDIA OF LIFE SCIENCES. John Wiley & Sons, Ltd: Chichester. http://www.els.net/ [doi:10.1002/9780970015902.a0002241.pub2], 2006.
  
  

　2005年

• Shinya K, Suto A, Kawakami M, Sakamoto H, Umemura T, Kawaoka Y, Kasai N, Ito T. Neurovirulence of H7N7 influenza A virus: brain stem encephalitis accompanied with aspiration pneumonia in mice. Arch Virol 150:1653-1660, 2005.
  
• Noda T, Aoyama K, Sagara H, Kida H, Kawaoka Y. Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography. J Vet Med Sci 67:325-328, 2005.
  
• Mase M, Tsukamoto K, Imada T, Imai K, Tanimura N, Nakamura K, Yamamoto Y, Hitomi T, Kira T, Nakai T, Kiso M, Horimoto T, Kawaoka Y, Yamaguchi S. Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan. Virology 332:167-176, 2005
  
• Fujii K, Fujii Y, Noda T, Muramoto Y, Watanabe T, Takada A, Goto H, Horimoto T, Kawaoka Y. The importance of both the coding and segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions. J Virol 79:3766-3774, 2005.
  
• Maeda Y, Hatta M, Takada A, Watanabe T, Goto H, Neumann G, Kawaoka Y. Live bivalent vaccine for parainfluenza and influenza virus infections. J Virol 79:6674-6679, 2005.
  
• Shinya K, Hatta M, Yamada S, Takada A, Watanabe S, Halfmann P, Horimoto T, Neumann G, Lim W, Guan Y, Peiris M, Suzuki T, Suzuki Y, Kawaoka Y. Characterization of a human H5N1 influenza A virus isolated in 2003. J Virol 79:9926-9932, 2005.
  
• Hatakeyama S, Sakai-Tagawa Y, Kiso M, Goto H, Kawakami C, Mitamura K, Sugaya N, Suzuki Y, Kawaoka Y. Enhanced expression of an α2,6-linked sialic acid on MDCK cells improves the isolation of human influenza viruses and the evaluation of their sensitivity to a neuraminidase inhibitor. J Clin Micro 43:4139-4146, 2005.
  
• Neumann G, Ebihara H, Takada A, Noda T, Kobasa D, Jasenosky LD, Watanabe S, Kim JH, Feldmann H, Kawaoka Y. The Ebola virus VP40 late domains are not essential for viral replication in cell culture. J Virol 79:10300-10307, 2005.
  
• Mase M, Eto M, Tanimura N, Imai K, Tsukamoto K, Horimoto T, Kawaoka Y, Yamaguchi S. Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China. Virology 339:101-109, 2005.
  
• Suzuki T, Takahashi T, Guo C-T, K.I.-P. J Hidari, Miyamoto D, Goto H, Kawaoka Y, Suzuki Y. Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication. J Virol 79: 11705-11715, 2005.
  
• Neumann G, Fujii K, Kino Y, Kawaoka Y. An improved reverse genetics system for influenza A virus generation and its implications for vaccine production. Proc Natl Acad Sci 102:16825-16829, 2005.
  
• Le QM, Kiso M, Someya K, Sakai YT, NguyenTH, Nguyen KHL, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y. Emergence of an oseltamivir-resistant H5N1 influenza A virus. Nature 437:1108, 2005.
• Matrosovich MN, Klenk, HD, Kawaoka Y. Receptor specificity, host-range, and pathogenicity of influenza viruses. In: Influenza Virology Current Topics, Kawaoka ed., Horison press. p.95-137, 2005
  
• Ebihara H, Groseth A, Neumann G, Kawaoka Y, Feldmann H. The role of reverse genetics systems in studying viral hemorrhagic fevers. Thromb Haemost, 94:240-253, 2005.
  
• Parrish C, Kawaoka Y. The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu. Rev. Microbiol 59:553-86, 2005.
  
• Kawaoka Y. How Ebola virus infects cells. New Eng J Med 352:2645-2646, 2005.
  
• Horimoto T, Kawaoka Y. Influenza: Lessons from past pandemics, warnings from current incidents. Nature Rev Microbiol 8:591-600, 2005.
  
  

　2004年

• Kondo T, McGregor M, Chu O, Chen D, Horimoto T, Kawaoka Y. Protective effect of epidermal powder immunization in a mouse model of equine herpesvirus-1 infection. Virology 318:414-419, 2004.
  
• Watanabe S, Watanabe T, Noda T, Takada A, Feldmann H, Jasenosky LD, Kawaoka Y. Production of novel Ebola virus-like particles from cDNAs: an alternative to Ebola virus generation by reverse genetics. J Virol 78: 999-1005, 2004.
  
• Maeda Y, Goto H, Horimito T, Takada A, Kawaoka Y. Biological significance of the U residue at the -3 position of the mRNA sequences of influenza A viral segments PB1 and NA. Virus Res 100:153-157, 2004.
  
• Takada A, Fujioka K, Tsuiji M, Morikawa A, Higashi N, Ebihara H, Kobasa D, Feldmann H, Irimura T, Kawaoka Y. A human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry. J Virol 78:2943-2947, 2004.
  
• Garulli B, Kawaoka Y, Castrucci MR. Mucosal and systemic immune responses to a human immunodeficiency virus type 1 epitope induced upon vaginal infection with a recombinant influenza A virus. J Virol 78:1020-1025, 2004.
  
• Horimoto T, Takada A, Iwatsuki-Horimoto K, Kawaoka Y. A protective immune response in mice to viral components other than hemagglutinin in a live influenza A virus vaccine model. Vaccine 22:2244-2247, 2004.
  
• Horimoto H, Fukuda N, Iwatsuki-Horimoto K, Guan Y, Lim W5, Peiris M, Sugii S, Odagiri T, Tashiro M, Kawaoka Y. Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003. J Vet Sci 66:303-305, 2004.
  
• Iwatsuki-Horimoto K, Kanazawa R, Sugii S, Kawaoka Y, Horimoto T. The index influenza A virus subtype H5N1 isolated from a human in 1997 differs in its receptor binding properties from a virulent avian influenza virus. J Gen Virol 85:1001-1005, 2004.
  
• Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y. PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 320:258-266, 2004.
  
• Shinya K, Fujii Y, Ito H, Ito T, Kawaoka Y. Characterization of a neuraminidase-deficient influenza A virus as a potential gene delivery vector and a live vaccine. J Virol 78:3083-3088, 2004.
  
• Hatta M, Goto H, Kawaoka Y. Influenza B virus requires BM2 protein for replication. J Virol 78: 5576-5583, 2004.
  
• Barman S, Adhikary L, Chakrabarti AK, Bernas C, Kawaoka Y, Nayak DP. Role of transmembrane domain and cytoplasmic tail amino acid sequences of influenza A virus neuraminidase in raft association and virus budding. J Virol 78: 5258-5269, 2004.
  
• Iwatsuki-Horimoto K, Horimoto T, Fujii Y, Kawaoka Y. Generation of influenza A virus NS2(NEP) mutants with an altered nuclear export signal sequence. J Virol 78:10149-10155, 2004.
  
• Horimoto T, Iwatsuki-Horimoto K, Hatta M, Kawaoka Y. Influenza A viruses possessing type B hemagglutinin and neuraminidase: potential as vaccine components. Microbes and Infection 6:579-583, 2004.
  
• Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, Hayden FG, Sugaya N, Kawaoka Y. Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet 364:759-765, 2004.
  
• Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Maeda Y, Watanabe S, Suresh M, Suzuki T, Suzuki Y, Feldmann H, Kawaoka Y. Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature 431:703-707, 2004.
  
• Theriault S, Groseth A, Neumann G, Kawaoka Y, Feldmann H. Rescue of Ebola virus from cDNA using heterologous support proteins. Virus Res 106:43-50, 2004
• Neumann G, Noda T, Takada A, Jasenosky LD, Kawaoka Y. Roles of filovirus matrix- and glycoproteins in the viral life cycle. In: Ebola and Marburg Viruses: Molecular and Cellular Biology, Feldmann and Klenk, Eds., Horizon Bioscience, Wymondham, U.K. pp 137-179, 2004.
  
• Neumann G, Kawaoka, Y. Reverse genetics systems for the generation of segmented negative-sense RNA viruses entirely from cloned cDNA. In: Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics, Kawaoka ed., Springer-Verlag, Heidelberg. Curr Top Microbiol Immunol 283:43-60, 2004.
  
• Neumann G, Brownlee G, Fodor E, Kawaoka Y., Orthomyxovirus replication, transcription, and polyadenylation. In: Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics, Kawaoka ed., Springer-Verlag, Heidelberg. Curr Top Microbiol Immunol 283:121-143, 2004.
  
• Jasenosky LD, Kawaoka Y. Filovirus budding. Virus Res 106:181-188, 2004.
  
  

　2003年

• Takada A, Feldmann H, Stroeher U, Bray M, Watanabe S, Ito H, Mcgregor M, Kawaoka Y. Identification of protective epitopes on Ebola virus glycoprotein at the single amino acid level using recombinant vesicular stomatitis viruses. J Virol 77:1069-1074, 2003.
  
• Mueller SN, Jones CM, Chen W, Kawaoka Y, Castrucci MR, Heath WR, Carbone FR. The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells. J Virol 77: 2445-2451, 2003.
  
• Barman S, Adhikary L, Kawaoka Y, Nayak DP. Influenza A virus hemagglutinin containing basolateral localization signal does not alter the apical budding of a recombinant influenza A virus in polarized MDCK cells. Virology 305:138-52, 2003.
  
• Shiraishi K, Mitamura K, Sakai-Tagawa Y, Goto H, Sugaya N, Kawaoka Y. High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza. J Inf Dis 188:57-61, 2003.
  
• Fujii Y, Goto H, Watanabe T, Yoshida T, Kawaoka Y. Selective incorporation of influenza virus RNA segments into virions. Proc Natl Acad Sci USA 100:2002-2007, 2003.
  
• Ogino M, Ebihara H, Lee BH, Araki K, Lundkvist A, Kawaoka Y, Yoshimatsu K, Arikawa J. Use of vesicular stomatitis virus pseudotypes bearing Hantaan or Seoul Virus envelope proteins in a rapid and safe neutralization test. Clin Diagn Lab Immunol 10:154-160, 2003.
  
• Hatta M, Kawaoka Y. The NB protein of influenza B virus is not necessary for virus replication in vitro. J Virol 77:6050-6054, 2003.
  
• Takada A, Feldmann H, Ksiazek TG, Kawaoka Y. Antibody-dependent enhancement of Ebola virus infection. J Virol 77:7539-7544, 2003.
  
• Horimoto T, Takada A, Iwatsuki-Horimoto K, Hatta M, Goto H, Kawaoka Y. Generation of influenza A viruses with chimeric (type A/B) hemagglutinins. J Virol 77:8031-8038, 2003.
  
• Takada A, Matsushita S, Ninomiya A, Kawaoka Y, Kida H. Intranasal immunization with formalin- inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice. Vaccine 21:3212-3218, 2003.
  
• Watanabe T, Watanabe A, Noda T, Fujii Y, Kawaoka Y. Exploitation of nucleic acid packaging signals to generate a novel influenza virus-based vector stably expressing two foreign genes. J Virol 77:10575-10583, 2003.
  
• Yasuda J, Nakao M, Kawaoka Y, Shida H. Nedd4 regulates egress of Ebola virus-like particles from host cells. J Virol 77:9987-9992, 2003.
• Neumann G, Hatta M, Kawaoka Y. Reverse genetics for the control of avian influenza. Avian Dis 47(3 Suppl):882-887, 2003.
  
• Takada A, Kawaoka Y. Antibody-dependent enhancement of viral infection: molecular mechanisms and in vivo implications. Rev Med Virol 13:387-398, 2003.
  
  

　2002年

• Neumann G, Feldmann H, Watanabe S, Lukashevich I, Kawaoka Y. Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture. J Virol 76:406-410, 2002.
  
• Watanabe T, Watanabe S, Neumann G, Kida H, Kawaoka Y. Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles. J Virol 76:767-773, 2002.
  
• Noda T, Sagara H, Suzuki E, Takada A, Kida H, Kawaoka Y. Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP. J Virol 76:4855-4865, 2002.
  
• Ito T, Kobayashi Y, Morita T, Horimoto T, Kawaoka Y. Virulent influenza A viruses induce apoptosis in chickens. Virus Res 84:27-35, 2002.
  
• Hatta M, Halfmann P, Wells K, Kawaoka Y. Human influenza A viral genes responsible for the restriction of its replication in duck intestine. Virology 295:250-255, 2002.
  
• Watanabe T, Watanabe S, Kida H, Kawaoka Y. Influenza A virus with defective M2 ion channel activity as a live vaccine. Virology 299:266-270, 2002.
  
• Shengqing Y, Kishida N, Ito H, Kida H, Otsuki K, Kawaoka Y, Ito T. Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens. Virology 301:206-211, 2002.
• Neumann G, Kawaoka Y. Generation of influenza A virus from cloned cDNAs - historical perspective and outlook for the new millennium. Rev Med Virol 12:13-30, 2002.
  
• Neumann G, Kawaoka Y. Synthesis of influenza virus: new impetus from an old enzyme, RNA polymerase I. Virus Res 82:153-158, 2002.
  
• Hatta M, Kawaoka Y. Continued pandemic threat posed by avian influenza A viruses in Hong Kong. Trends Microbiol 10:340-344, 2002.
  
• Neumann G, Whitt MA, Kawaoka Y. A decade after the generation of a negative-sense RNA virus from cloned cDNA - what have we learned? J Gen Virol 83:2635-2662, 2002.
  
  

　2001年

• Ito H, Watanabe S, Takada A, Kawaoka Y. Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies. J Virol 75:1576-1580, 2001.
  
• Takada A, Watanabe S, Okazaki K, Kida H, Kawaoka Y. Infectivity-enhancing antibodies to Ebola virus glycoprotein. J Virol 75:2324-2330, 2001.
  
• Ito T, Goto H, Yamamoto E, Tanaka H, Takeuchi M, Kuwayama M, Kawaoka Y, Otsuki K. Generation of a highly pathogenic avian influenza A virus from an avirulent field isolate by passaging in chickens. J Virol 75:4439-4443, 2001.
  
• Hughes MT, McGregor M, Suzuki T, Suzuki Y, Kawaoka Y. Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity. J Virol 75:3766-3770, 2001.
  
• Mase M, Imada T, Sanada Y, Etoh M, Sanada Y, Tsukamoto K, Kawaoka Y, Yamaguchi S. Imported parakeets harbor H9N2 influenza A viruses that are genetically closely related to those transmitted to humans in Hong Kong. J Virol 75:3490-3494, 2001.
  
• Jasenosky LD, Neumann G, Lukashevich I, Kawaoka Y. Ebola virus VP40-induced particle formation and association with the lipid bilayer. J Virol 75:5205-5214, 2001.
  
• Watanabe T, Watanabe S, Ito H, Kida H, Kawaoka Y. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity. J Virol 75:5656-5662, 2001.
  
• Schultz-Cherry S, Dybdahl-Sissoko N, Neumann G, Kawaoka Y, Hinshaw VS. Influenza virus NS1 protein induces apoptosis in cultured cells. J Virol 75: 7875-7881, 2001.
  
• Goto H, Wells K, Takada A, Kawaoka Y. Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus. J Virol 75:9297-9301, 2001.
  
• Kobasa D, Wells K, KawaokaY. Amino acids responsible for the absolute sialidase activity of the influenza A virus neuraminidase: relationship to growth in duck intestine. J Virol 75:11773-11780, 2001.
  
• Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 298:1840-1842, 2001.
• Kawaoka Y. Influenza viruses, Encyclopedia of Life Sciences, Nature Publishing Group, 2001, www.els.net.
  
• Kawaoka Y. Influenza epidemics, Encyclopedia of Life Sciences, Nature Publishing Group, 2001, www.els.net.
  
• Horimoto T, Kawaoka Y. Pandemic threat posed by avian influenza viruses. Clin Microbiol Rev 14:129-49, 2001.
  
• Neumann G, Kawaoka Y. Reverse genetics of influenza virus. Virology 287:243-250, 2001.
  
• Suzuki Y, Ito T, Suzuki T, Miyamoto D, Kazuya I.-P. J. Hidari, Guo C.-T, Kida H, Webster R.G, Chambers T.M, Kawaoka Y. Sialyl sugar chains as receptors and determinants of host range of influenza A viruses. In Options for the Control of Influenza IV pp521-525, 2001.
  
• Neumann G, Kawaoka Y. Genetic approach to studying influenza pathogenesis. In Options for the Control of Influenza IV pp587-590, 2001.
  
• Goto H, Kawaoka Y. Role of plasminogen-binding NA in influenza pathogenicity: knockout of plasminogen binding activity by reverse genetics. In Options for the Control of Influenza IV pp591-594, 2001.
  
• Hatta M, Halfmann P, Wells K, Kawaoka Y. Host range restriction of influenza A virus replication in duck intestine. In Options for the Control of Influenza IV pp1019-1021, 2001.
  
• Watanabe T, Watanabe S, Kida H, Kawaoka Y. Replication-incompetent influenza virus for vaccines. In Options for the Control of Influenza IV pp1015-1017, 2001.　
  
• Takada A, Kawaoka Y. Recent insights into the pathogenesis of Ebola hemorrhagic fever. Trends Microbiol 9:506-511, 2001.
  
• Hatta M, Neumann G, Kawaoka Y. Reverse genetics approach towards understanding pathogenesis of H5N1 Hong Kong influenza A virus infection. Philos Trans R Soc Lond B Biol Sci 356:1841-1843, 2001
  
  

　2000年

• Neumann G, Watanabe T, Kawaoka Y. Plasmid-driven formation of influenza virus-like particles. J Virol 74:547-51, 2000.
  
• Masuda H, Suzuki T, Sugiyama Y, Horiike G, Murakami K, Miyamoto D, Jwa Hidari KI, Ito T, Kida H, Kiso M, Fukunaga K, Ohuchi M, Toyoda T, Ishihama A, Kawaoka Y, Suzuki Y. Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl-oligosaccharides containing N-glycolylneuraminic acid FEBS Lett 464:71-4, 1999.
  
• Hoffmann E, Neumann G, Hobom G, Webster RG, Kawaoka Y. "Ambisense" approach for the generation of influenza A virus: vRNA and mRNA synthesis from one template. Virology 267:310-317, 2000.
  
• Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci U S A 97:6108-6113, 2000.
  
• Hatta M, Asano Y, Masunaga K, Ito T, Okazaki K, Toyoda T, Kawaoka Y, Ishihama A, Kida H. Epitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies. Arch Virol 145:957-964, 2000.
  
• Mitnaul LJ, Matrosovich MN, Castrucci MR, Tuzikov AB, Bovin NV, Kobasa D, Kawaoka Y. Balanced hemagglutinin and neuraminidase activities are critical for efficient replication of influenza A virus. J Virol 74:6015-6020, 2000.
  
• Hughes MT, Matrosovich M, Rodgers ME, McGregor M, Kawaoka Y. Influenza A viruses lacking sialidase activity can undergo multiple cycles of replication in cell culture, eggs, or mice. J Virol 74:5206-5212, 2000.
  
• Matrosovich M, Tuzikov A, Bovin N, Gambaryan A, Klimov A, Cox N, Castrucci M, Donatelli I, Kawaoka Y. Alterations of receptor-binding properties of H1, H2 and H3 avian influenza virus hemagglutinins upon introduction into mammals. J Virol 74:8502-8512, 2000.
  
• Ito T, Suzuki Y, Suzuki T, Takada A, Horimoto T, Wells K, Kida H, Otsuki K, Kiso M, Ishida H, Kawaoka Y. Recognition of N-glycolylneuraminic acid linked to galactose by the α2,3 linkage is associated with intestinal replication of influenza A virus in ducks. J Virol 74:9300-9305, 2000.
  
• Watanabe S, Takada A, Watanabe T, Ito H, Kida H, Kawaoka Y. Functional importance of the coiled-coil of the Ebola virus glycoprotein. J Virol 74:10194-10201, 2000.
  
• Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y. Downregulation of β1 integrins by Ebola virus glycoprotein: Implication for virus entry. Virology 278:20-26, 2000.
  
• Neumann G, Hughes MT, Kawaoka Y. Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. EMBO J 19:6751-6758, 2000.
  
• Chen D, Endres RL, Erickson CA, Weis KF, McGregor MW, Kawaoka Y, Payne LG. Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice. Nature Medicine 6:1187-1190, 2000.
  
• Suzuki Y, Ito T, Suzuki T, Holland Jr, RE, Chambers TM, Kiso M, Ishida H, Kawaoka Y. Sialic acid species as a determinant of the host range of influenza A viruses. J Virol 74:11825-31, 2000.
  
• Hatta M, Asano Y, Masunaga K, Ito T, Okazaki K, Toyoda T, Kawaoka Y, Ishihama A, Kida H. Mapping of functional domains on the influenza A virus RNA polymerase PB2 molecule using monoclonal antibodies. Arch Virol 145: 1947-1961, 2000.
• Ito T, Kawaoka Y. Host range barrier of influenza A viruses, Vet Microbiol 74:71-75, 2000.
  
• Neumann G, Kawaoka Y. Reverse genetics for the control of influenza. Influenza Bulletin 12:6, 2000.
  
• Shortridge KF, Gao P, Guan Y, Ito T, Kawaoka Y, Markwell D, Takada A, Webster RG, Interspecies transmission of influenza viruses: H5N1 virus and a Hong Kong SAR perspective. Vet Microbiol 74:141-147, 2000.
  
• Goto H, Kawaoka Y. Assays for functional binding of plasminogen to viral proteins. Methods 21:159-163, 2000.
  
• Nichol ST, Arikawa J, Kawaoka Y. Emerging viral diseases. Proc Natl Acad Sci U S A 97:12411-2, 2000.